Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT06724679Recruiting
Virtual reality for chronic back pain treatment
This trial tests if using a virtual reality (VR) headset can help people with long-term lower back pain during a spine rehabilitation program. It will see if VR is a practical and helpful addition to the program.
AngersAges 18–65 - NCT05786235Recruiting
Pregnant people with or without antiphospholipid antibodies
This study is looking at pregnancy outcomes in people who are pregnant and either have antiphospholipid antibody syndrome (APS) or do not have APS but do have prior full-term pregnancies. It may help doctors understand risks and how to manage pregnancies in these groups.
MilanAges 18–45 - NCT01166854Recruiting
Study of muscle and bone conditions in families
This study looks at how certain muscle and bone diseases show up in people and in their family members. It may help researchers better describe these conditions and improve future diagnosis and care.
Irvine, CaliforniaAges 18 years+ - NCT06320158Recruiting
Understanding muscle loss and obesity in older adults
This study looks at the link between muscle loss (sarcopenia) and obesity in older adults. It aims to understand why some older people who are overweight or obese also lose muscle strength and function, and how this affects recovery after hip surgery.
MilanAges 65–99 - NCT06854809Recruiting
Cognitive therapy vs. exercises for chronic shoulder pain
This study compares two non-surgical treatments for long-lasting shoulder pain: a new approach called cognitive functional therapy that combines movement with education, versus standard exercises. If you have chronic shoulder pain and are looking for a drug-free option, this trial may help you find which treatment works better.
São Carlos, São PauloAges 18–65 - NCT01353430Recruiting
Study of a rare muscle condition linked to Paget bone disease
This study looks at people and families with a rare muscle weakness condition that can be linked with Paget disease of the bone (and sometimes frontotemporal dementia). It aims to better describe how these conditions appear and relate, which can help future research and care.
Irvine, CaliforniaAges 18 years+ - NCT04354649RecruitingPhase 2
Test triage and treatment for immune-related arthritis from immunotherapy
This trial studies how doctors assess and manage immune-related arthritis or joint pain that happens after PD-1/PD-L1 cancer immunotherapy (sometimes with CTLA-4). It may help people get faster, more targeted care while monitoring safety.
Edmonton, AlbertaAges 18 years+ - NCT05807256Recruiting
Fertility treatments for people with immune system joint diseases
This trial looks at fertility (“medically assisted fertilization,” such as IVF) for people with certain immune-related rheumatology conditions (like lupus, rheumatoid arthritis, or vasculitis). It may help patients and their clinicians understand which fertility approach works best and is safe for this group.
MilanAges 18–50 - NCT06029374Recruiting
Comparing treatments for hand bone fractures
This trial compares two treatments for a common hand fracture—the boxer's fracture—to see if one is better. It will help people recover quickly without surgery.
ViennaAges 18–70 - NCT06928948Enrolling by invitation
Medium-term results of LPS thigh bone replacement
This study looks at how well the LPS™ system works for replacing the lower part of the thigh bone. It aims to find out the medium-term results for people who had this surgery.
BrestAges Any age - NCT06927869Enrolling by invitation
Pully exercise for managing muscle stiffness
This trial tests whether special pulley-based exercises can reduce muscle stiffness (spasticity) in children. Children with mild spasticity (grade 1 on a standard scale) who can follow instructions may participate.
TantaAges 5–10 - NCT06928727Recruiting
Eye health in craniosynostosis study
This study looks at eye features in people with craniosynostosis (a condition where skull bones fuse too early). It may help doctors better understand eye problems that can occur with this condition.
AmiensAges Any age - NCT06924658RecruitingPhase 2
Metformin for gout patients study
This trial tests if metformin, a common diabetes drug, can help people with gout. It aims to see if the drug is safe and effective for reducing gout symptoms.
TantaAges 18–60 - NCT06929598Recruiting
Shiatsu for chronic pain in children and teens
This study tests whether Shiatsu—a gentle, hands-on therapy—can help reduce chronic, non-inflammatory pain in children and adolescents. If you or your child have had long-term pain without inflammation and are already being seen at a specific pain clinic in Tel Aviv, this trial might be a good fit.
Tel Aviv, Tel AvivAges 10–18 - NCT06923800Recruiting
Exercise and Diet Advice for Fibromyalgia and IBS
This study tests whether combining exercise with dietary advice can help people who have both fibromyalgia and irritable bowel syndrome (IBS). It aims to see if this approach improves symptoms and quality of life.
Castellana Grotte, BariAges 30–65 - NCT06929871Recruiting
Cementless vs. cementless knee replacement for osteoarthritis
This trial compares two types of knee replacements: one where the implant is glued in (cemented) and one where it locks into the bone without glue (cementless). It is for people with knee osteoarthritis who need a first-time total knee replacement.
LondonAges 18 years+ - NCT06925880Recruiting
Can creatine help seniors recover strength after knee replacement?
This trial tests if taking creatine supplements can help people aged 65+ rebuild muscle mass and strength more quickly after total knee replacement surgery. Participants will take creatine during their standard outpatient rehab program.
Mataró, BarcelonaAges 65 years+ - NCT06927206Recruiting
Vibration and muscle stimulation for leg function after stroke
This trial tests if adding a gentle vibrator to standard muscle-stimulation therapy can improve leg movement in people recovering from a stroke. It's for those who had a stroke 2 weeks to 3 months ago and have mild to moderate thinking and movement issues.
Lahore, Punjab ProvinceAges 45–60 - NCT06924164Recruiting
Strength training for snapping hip syndrome
This trial tests if progressive strength training can reduce pain and snapping in adults with external snapping hip. If you have a snapping or popping sensation on the outside of your hip with discomfort, this study may help find a non-surgical treatment option.
AalborgAges 18–40 - NCT06930027Enrolling by invitation
Low-oxygen training for ice hockey players
This study tests whether training in a low-oxygen environment (hypoxia) can boost strength and power in ice hockey players. Researchers want to see if it helps improve your explosive movements and muscle function.
Katowice, Silesian VoivodeshipAges 18–35 - NCT06926621Enrolling by invitationPhase 2
Long-term safety and effectiveness of VX-670 for myotonic dystrophy
This study is for people who already received VX-670 in a previous trial and want to continue treatment. It will check the drug's long-term safety and how well it works for myotonic dystrophy type 1.
St Louis, MissouriAges 18 years+ - NCT06930677Recruiting
Knee osteoarthritis treatment study using embolization
This trial tests a new treatment called embolization using a special material (NBGM200) to block certain blood vessels in the knee. It may help reduce pain and improve function in people with knee osteoarthritis.
GhentAges 50 years+ - NCT06930625RecruitingPhase 3
Study of Debio 4126 for acromegaly patients on current therapy
This trial tests a new medication, Debio 4126, for people with acromegaly who are already being treated with octreotide or lanreotide. The goal is to see if it can help control hormone levels and is safe to use.
Los Angeles, CaliforniaAges 18 years+ - NCT06925542RecruitingPhase 1
Study of CTX112 for adults with autoimmune disease
This trial tests an experimental cell therapy called CTX112 for people with lupus, scleroderma, or inflammatory myositis that hasn't responded well to standard treatments. The goal is to see if it's safe and if it can help control the disease.
La Jolla, CaliforniaAges 18–70
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.