Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT06459453Recruiting
Comparing two hand therapy techniques for rheumatoid arthritis
This study compares two gentle hand and wrist therapy techniques (Kaltenborn and Mulligan) to see which works better for people with rheumatoid arthritis. If you have limited wrist movement due to RA, you may be able to join.
Lahore, Punjab ProvinceAges 18–65 - NCT06459986Recruiting
How long does spinal anesthesia last? A study in orthopedic surgery
This study tracks how long spinal anesthesia lasts during planned orthopedic surgeries. By collecting real-world data, doctors hope to improve timing and care for patients having this type of anesthesia.
HillerødAges 18–100 - NCT06460142Recruiting
Biomarker study for giant cell arteritis and polymyalgia rheumatica
This study is looking for biomarkers (biological clues) in people with newly diagnosed or flaring giant cell arteritis (GCA) or polymyalgia rheumatica (PMR). Participating may help researchers find better ways to diagnose and monitor these conditions.
Bonn, North Rhine-WestphaliaAges 18 years+ - NCT06460636Recruiting
Water therapy and relaxation for fibromyalgia pain
This trial tests if combining relaxation exercises with water therapy can help reduce fibromyalgia pain and symptoms. It is for women aged 20 to 39 who are married and have a confirmed fibromyalgia diagnosis.
Rahim Yar Khan, Punjab ProvinceAges 20–39 - NCT06460922Recruiting
3D printed wrist models to plan Kienböck's surgery
This study uses 3D printed models of your wrist to help doctors plan surgery for Kienböck's disease (a condition where a wrist bone loses blood supply and breaks down). The goal is to see if these models improve surgical results.
Barcelona, BarcelonaAges 18–85 - NCT06460805Recruiting
Diet study for active spine arthritis
This study is testing a special liquid diet called Partial Enteral Nutrition (PEN) to see if it can help calm inflammation in people with active axial spondyloarthritis. You would replace some of your regular meals with this diet drink for a period of time.
GlasgowAges 16 years+ - NCT06461000Recruiting
EULAR Survey on Rheumatic Disease Impact
This is an online survey from the European League Against Rheumatism (EULAR) to understand how rheumatic and musculoskeletal diseases affect people's lives. Anyone living with an RMD can join and share their experiences.
Kilchberg, Canton of ZurichAges 18 years+ - NCT06462040Recruiting
Dissolving Screws for Loose Knee Cartilage
This study follows patients who have a loose piece of bone and cartilage in their knee and are having it fixed with special screws that dissolve over time. The goal is to see how well the knee heals and works after surgery.
Bologna, BolognaAges 12–35 - NCT06462430Recruiting
Registry for children with PTEN Hamartoma Tumor Syndrome
This study is creating a registry (a database) of children with PTEN Hamartoma Tumor Syndrome, a condition that can cause growths, large head size, and other health issues. By joining, you help doctors learn more about the condition and how to better care for kids like yours.
IstanbulAges 1 year+ - NCT06462560Recruiting
Live fitness program for knee osteoarthritis
This trial tests a live, interactive strength training program for people recently diagnosed with knee osteoarthritis. It aims to see if this home-based program can help reduce pain and improve daily function.
Murray, UtahAges 55–85 - NCT06462625Recruiting
Knee realignment surgery for arthritis with bowed legs
This study tests how well a realignment surgery (osteotomy) works for people with mild knee arthritis and a bent knee that's at least 3 degrees off center. The surgery may also fix other knee problems like a torn meniscus or ligament at the same time.
BolognaAges 18–70 - NCT06462768Recruiting
Study of immune cell activity in systemic sclerosis
This study looks at a specific type of immune cell activity (called neutrophil extracellular traps) in the blood of people with systemic sclerosis, other connective tissue diseases, and healthy volunteers. It aims to understand how these cells may be involved in the disease and could lead to better treatments.
ReimsAges 18 years+ - NCT06462833Recruiting
Health literacy and exercise in postmenopausal osteoporosis
This study looks at how understanding health information affects exercise and taking medicine correctly in women with osteoporosis after menopause. It aims to help improve bone health.
Ankara, YenimahalleAges 45 years+ - NCT06462937Recruiting
Digital exercise program for recent spondyloarthritis diagnosis
This trial tests a digital exercise program for people newly diagnosed with axial spondyloarthritis (a type of arthritis that affects the spine and joints). If you have active disease, you may join to see if exercise helps manage symptoms.
OsloAges 18 years+ - NCT06463379RecruitingPhase 3
Intravenous pulse therapy for tough juvenile arthritis
This trial tests whether a type of intravenous medicine (called pulse therapy) can help children with arthritis that hasn't improved after other treatments. It aims to bring the disease into remission.
CairoAges 2–18 - NCT06463847RecruitingPhase 1
Stem cell therapy for knee osteoarthritis
This trial tests a new stem cell treatment (UC-MSCs) for knee osteoarthritis. It aims to see if this treatment is safe and can help reduce pain and improve knee function.
Wuhan, HubeiAges 50–70 - NCT06464757Recruiting
Laryngomalacia and breathing in children: before and after treatment study
This trial is for children with laryngomalacia (a floppy voice box) who have noisy breathing and trouble breathing. It will check how they are doing before and after treatment, and follow up for one year to see how their quality of life improves.
OsloAges 1 week–12 months - NCT06466850Recruiting
Stem cell exosomes for knee osteoarthritis
This trial studies whether a natural substance called exosomes, derived from stem cells, can help reduce pain and improve function in people with knee osteoarthritis. It may be an option if other treatments have not worked well for you.
IsfahanAges 45–75 - NCT06469632Recruiting
Radiofrequency for pelvic pain after first vaginal birth
This trial tests whether a non-surgical treatment called radiofrequency can help relieve pelvic pain that starts after a first vaginal birth. The study focuses on a type of muscle pain called myofascial pain syndrome.
Alcalá de Henares, MadridAges 18–45 - NCT06469788Recruiting
COVID-19 vaccine navigation for rheumatology patients
This study looks at helping Black and Latinx adults with autoimmune rheumatic diseases get the updated COVID-19 vaccine. It offers information and support (like testimonials and navigation help) to see what works best.
Birmingham, AlabamaAges 18 years+ - NCT06469996Recruiting
Massage therapy for fibromyalgia pain
This study tests whether a special type of massage (connective tissue massage) can reduce pain and improve well-being in women with fibromyalgia. The massage targets the soft tissues under the skin to relieve muscle tension and pain.
ElâzığAges 18–65 - NCT06472622RecruitingEarly Phase 1
Brain imaging study of pain and effort
This study uses brain scans to understand how people experience pain and effort. It compares healthy volunteers to people with ME/CFS to see if there are differences in brain activity.
Bethesda, MarylandAges 18–50 - NCT06473142Recruiting
Body posture and shoulder pain study
This study looks at how your body posture might be related to shoulder pain. It is for people with shoulder impingement (pain when lifting the arm) who are not athletes. The goal is to understand if posture plays a role in shoulder problems.
CairoAges 20–40 - NCT06474546Recruiting
Diet intervention feasibility study for juvenile arthritis
This trial tests whether a special diet can help children and teens with juvenile arthritis. If you join, you will follow the diet and provide stool samples so the researchers can see how it affects your gut and arthritis.
Winnipeg, ManitobaAges 8–18
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.