Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT06124482Recruiting
Study of a new knee replacement implant
This trial tests a new knee replacement implant called the FHK®-CK. It is for people who need a new knee due to arthritis or to replace a failed knee implant.
BeaumontAges 18 years+ - NCT06786936Recruiting
Study of IL-17 in depression with psoriasis
This study explores whether a protein called IL-17 might link skin/joint inflammation with depressive symptoms. If you have psoriasis or psoriatic arthritis and are starting a specific biologic (secukinumab, bimekizumab, or ixekizumab), this could help understand how treatment affects your mood.
Glasgow, ScotlandAges 18–74 - NCT04552145Recruiting
Physical therapy versus surgery for lumbar spinal stenosis
This study compares physical therapy to surgery to help relieve symptoms from narrowing in the lower spine. It looks at which treatment works best for walking discomfort caused by spinal stenosis.
LillehammerAges 50–80 - NCT06860750RecruitingPhase 3
SHR-1314 injection for active non-radiographic axial spondyloarthritis
This trial tests a new injection called SHR-1314 for people with active non-radiographic axial spondyloarthritis (a type of inflammatory arthritis that doesn't show on X-rays but causes back pain and stiffness). It may help reduce inflammation and improve symptoms.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06912438Enrolling by invitation
Emotional release after dry needling for jaw and head pain
This study tests whether a dry needling technique (trigger point needling) can help release emotional tension and reduce pain from muscle knots in the head and neck. It may be a good option if you have jaw or headache pain related to muscle tightness.
Tel Aviv, IsraelAges 18 years+ - NCT06917742RecruitingPhase 1
Study of CPTX2309 for rheumatoid arthritis and lupus
This trial tests an investigational drug called CPTX2309, given intravenously, for people with moderate to severe rheumatoid arthritis or systemic lupus erythematosus. It aims to see if the drug is safe and effective.
Herston, QueenslandAges 18–65 - NCT06917365Recruiting
Testing a new liner for SERF hip replacements
This trial is testing a new liner (the inner part) for a specific brand of hip replacement called SERF. It's looking at how well it works in people who need a total hip replacement.
DijonAges 18 years+ - NCT06915363Recruiting
BioPoly implant for knee cartilage repair
This trial tests a BioPoly implant to repair a small damaged cartilage spot in your knee. If you have a specific type of cartilage injury that didn't get better with other treatments, this implant may help relieve pain and improve function.
Fort Wayne, IndianaAges 30–65 - NCT06915233RecruitingPhase 3
MACI for ankle cartilage defects in adults
This trial tests a treatment called MACI for people with damaged cartilage in their ankle. It uses your own cells to grow new cartilage, which may help reduce pain and improve how you can use your ankle.
Sacramento, CaliforniaAges 17–65 - NCT06920459Recruiting
Zimmer Biomet Shoulder Replacement Study
This study is testing a shoulder replacement system made by Zimmer Biomet to see how well it works for people with severe shoulder problems, like arthritis or fractures. If you qualify, you would receive the implant and be asked to come back for regular checkups to track your recovery.
PforzheimAges 20 years+ - NCT06920654Enrolling by invitation
Shoulder stabilization surgery study
This study looks at the long-term results of a specific shoulder surgery (Latarjet-like procedure) to treat chronic shoulder dislocations. It aims to understand how well the shoulder stays stable years after the surgery.
DrammenAges 18 years+ - NCT06915012Recruiting
Test of light therapy for long-term severe arthritis pain
This study tests a non-drug therapy called biophoton therapy to see if it can reduce chronic severe arthritis pain. It may be an option if you've had pain for at least 3 months and are not using certain medical implants.
Butler, PennsylvaniaAges 18–80 - NCT06912269Recruiting
Strength training for the calf after Achilles tendon rupture
This trial tests if strength training can improve calf muscle function in men who tore their Achilles tendon (up to 5 years ago) and had surgery. You cannot have done regular calf exercises recently or have certain health conditions.
Porto Alegre, Rio Grande do SulAges 18–64 - NCT06919913Recruiting
Probiotics for joint infection surgery
This study tests if taking probiotics before and after surgery can help your immune system fight infection in a hip or knee replacement. You would be given a probiotic or a placebo alongside your standard treatment.
New York, New YorkAges 18–90 - NCT06918860Recruiting
Nail vs. replacement for bone metastases in upper thigh
This trial looks back at past patients to compare two types of surgery for broken or weak thigh bones caused by cancer that spread. It helps doctors understand which option—a metal nail or a joint replacement—works better.
Bologna, Emilia-RomagnaAges 18 years+ - NCT06915701RecruitingPhase 2/Phase 3
Vitamin E for rheumatoid arthritis inflammation
This study tests whether adding vitamin E to standard rheumatoid arthritis treatment can reduce inflammation and disease activity. It is designed for women with early RA who are not getting enough vitamin E from their diet.
Guadalajara, JaliscoAges 18 years+ - NCT06916403Enrolling by invitation
Ketamine infusions for fibromyalgia pain
This study looks at whether ketamine given through an IV can help reduce fibromyalgia pain. It reviews past treatments and also plans new treatments to see how well they work and how safe they are.
Thornhill, OntarioAges 18 years+ - NCT06921889Recruiting
Outcomes of cartilage cell repair in the knee
This study follows adults who are already scheduled for ACI surgery (a procedure that uses your own cartilage cells to repair knee injuries). It measures how well the knee works after surgery.
BirminghamAges 18 years+ - NCT06918392Recruiting
Testing a questionnaire for teens with pectus excavatum
This study tests a questionnaire about living with pectus excavatum (sunken chest). If you are a teen (12-18) scheduled for the Nuss procedure, you and your parent can help by filling out the questionnaire to see if it works well.
HeerlenAges 12–18 - NCT06920186Recruiting
Extra nerve blocks for knee replacement pain
This study compares two ways to manage pain after knee replacement surgery: one uses a nerve block around the knee (adductor canal block), and the other adds an extra shot or nerve block. The goal is to see which approach works better for controlling pain and helping you recover.
Quincy-sous-SénartAges 18 years+ - NCT06921720Recruiting
Phosphate diabetes muscle study using phosphorus scan
This study uses a special MRI scan to look at phosphorus levels in the muscles of people with phosphate diabetes (a condition where the body loses too much phosphate through the kidneys). It aims to better understand how this condition affects muscles and may help guide future treatments.
BronAges 10 years+ - NCT06224998Recruiting
Schroth and Pilates for teenage scoliosis
This trial compares two types of exercise—Schroth and Pilates—to see which works better for teens with mild scoliosis. It may help improve posture, strength, and quality of life.
IzmirAges 10–18 - NCT06259006RecruitingPhase 3
Early Dexamethasone for Sydenham's Chorea in Children
This trial tests whether a short course of dexamethasone (a steroid tablet) can help children with Sydenham's chorea (movement tics after a strep infection) recover faster. The goal is to see if early treatment improves symptoms and reduces side effects compared to other treatments.
Darwin, Northern TerritoriesAges 4–17 - NCT06911359RecruitingPhase 2
Anti-inflammatory vs. Prolotherapy for Knee Osteoarthritis
This study tests whether anti-inflammatory medications or dextrose prolotherapy (sugar water injections) can reduce knee pain and improve function in people with knee osteoarthritis. If you are a military healthcare beneficiary with moderate to severe knee pain, you may be able to join.
Travis AFB, CaliforniaAges 45–75
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.