Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT06475794Recruiting
Q angle in women with osteoporosis
This study explores the Q angle (a measure of knee alignment) in women with osteoporosis. It may help understand how bone health affects knee mechanics.
ElâzığAges 18–65 - NCT06477094Recruiting
Comparing two radiofrequency tools for lower back pain
This trial compares two techniques for radiofrequency ablation (a heat treatment) to relieve lower back pain from the small joints of the spine. It is for people whose pain did not improve with physical therapy or medications and who have had successful test injections.
Little Rock, ArkansasAges 18 years+ - NCT06476977Recruiting
Numbing method for trigger finger injection
This trial tests a special way of numbing the finger before a corticosteroid injection for trigger finger. The goal is to see if it makes the injection more comfortable and effective.
Toronto, OntarioAges 18 years+ - NCT06477965Recruiting
Registry for artery embolization to treat chronic pain
This is a registry study that gathers information from people who have had an artery embolization procedure to treat long-term pain from conditions such as arthritis. The goal is to track outcomes and better understand the procedure's effectiveness.
Cary, North CarolinaAges 18 years+ - NCT06478186RecruitingPhase 4
Knee Osteoarthritis Steroid Injection Study for People with Type 2 Diabetes
This study compares two different steroid knee injections—Zilretta and Kenalog—to see which works better for people with both knee osteoarthritis and type 2 diabetes. It uses a continuous glucose monitor to track blood sugar changes.
Kansas City, KansasAges 40 years+ - NCT06479863RecruitingEarly Phase 1
Testing a new drug combo for inclusion body myositis
This trial tests a combination of two investigational drugs (pozelimab and cemdisiran) to see if they can help people with sporadic inclusion body myositis, a muscle disease that causes progressive weakness. If the drugs work, they may slow down the disease and help you stay stronger longer.
Austin, TexasAges 45–75 - NCT06480175Recruiting
Neck Pain Relief: Radiofrequency Plus Nerve Block
This study tests whether a procedure that uses radiofrequency (a type of heat) plus a nerve block can reduce neck pain from arthritic joints in the spine. It is for people who have not gotten enough relief from other treatments.
CairoAges 30–70 - NCT06483269Recruiting
Platelet-rich plasma injection for knee arthritis in young athletes
This trial tests using your own platelet-rich plasma (PRP), made from a blood sample, as an injection to treat knee osteoarthritis in active young adults. The goal is to see if it reduces pain and helps you stay active.
BolognaAges 18–40 - NCT06485206Recruiting
Hybrid disc replacement and fusion for two-level neck disease
This study tests a combination of a disc replacement (Mobi-C) and a spinal fusion (ACDF) for people with degenerative disc disease at two levels in the neck. The goal is to see if this approach is safe and effective for relieving pain and nerve symptoms.
Sacramento, CaliforniaAges 22–69 - NCT06485843RecruitingPhase 2
Testing a new injection for moderate to severe knee osteoarthritis
This study tests the safety of an experimental injection called OA-SYS for people with moderate to severe knee osteoarthritis. It may help if you have not had recent injections or certain other health problems.
Las Vegas, NevadaAges 35–75 - NCT07691580Recruiting
Study of forces during ERCP
This study measures the physical forces doctors apply during an ERCP procedure. It aims to understand how different techniques affect the procedure's success and safety.
Amiens, PicardieAges 18 years+ - NCT07693634Recruiting
Online rehab for knee pain in active adults
This study tests a home-based tele-rehabilitation program for people with front knee pain (patellofemoral pain syndrome) who are recreational athletes. It aims to see if online guided exercises can reduce pain and improve function.
Faisalābad, PunjanAges 18–35 - NCT07692113Recruiting
Taping vs. movement control for big toe stiffness in athletes
This study compares two treatments for athletes with a stiff big toe (functional hallux limitus) that affects running. It tests whether a special tape or a movement retraining technique works better to improve toe motion and reduce pain.
Cairo, Zahraa AlmaadyAges 18–35 - NCT06549686RecruitingPhase 3
Knee osteoarthritis treatment study with cell therapy
This trial tests a new cell-based treatment (CLS2901C) for knee osteoarthritis. It combines the treatment with a realignment surgery (proximal tibial osteotomy) to help repair cartilage damage and reduce pain.
Ebina, KanagawaAges 20–79 - NCT04867317RecruitingPhase 3
Growth hormone treatment for veterans with mild TBI and deficiency
This Phase 3 study tests whether replacing growth hormone in veterans with mild traumatic brain injury (mTBI) and low adult growth hormone can improve quality of life. If you qualify, you’ll be screened with hormone blood tests and memory/mental health checks before starting treatment.
Birmingham, AlabamaAges 21–55 - NCT06420336Recruiting
Pain relief after cleft palate surgery
This study compares two ways to manage pain after cleft palate repair surgery that uses a bone graft from the hip. The goal is to see which method provides better pain control for children and teens.
Charleston, South CarolinaAges 6–18 - NCT07575555Recruiting
Lipedema's role in knee arthritis in women
This study compares women with knee arthritis who do or don't have lipedema (a condition causing painful fat buildup, usually in the legs) to understand how lipedema affects knee joint health. Results may help doctors better treat knee arthritis in women with lipedema.
Izmir, İzmirAges 30–65 - NCT06788717Enrolling by invitation
Study on Hip Revision Stem Performance
This study is checking how well a specific hip implant (the Comprehensive Revision Stem) works in people who need hip replacement. It helps make sure the implant is safe and effective over time.
Los Angeles, CaliforniaAges 18–100 - NCT07692061Enrolling by invitation
Speech therapy study for Cantonese-speaking kids with cleft palate
This study tests a new speech therapy program for children and teens (ages 4–17) who had cleft palate repair before age 2 and have certain speech sound errors. It aims to improve their speech clarity and communication.
Shatin, New TerritoriesAges 4–17 - NCT07138898RecruitingPhase 2
Managing immune medications for shoulder replacement in rheumatology patients
This trial tests two ways of managing your immunosuppressant medication around the time of shoulder replacement surgery. The goal is to see if one approach leads to fewer infections while still controlling your rheumatic disease.
New York, New YorkAges 18 years+ - NCT06902285RecruitingPhase 4
Magnesium supplement for better sleep after joint replacement
This study tests whether taking magnesium L-threonate can improve sleep quality after total knee or hip replacement surgery. It may help you sleep better during recovery.
Miami, FloridaAges 18 years+ - NCT07062588RecruitingPhase 2
AGA2115 for osteogenesis imperfecta in adults with COL1A1/COL1A2 variations
This trial tests a new drug called AGA2115 for people with osteogenesis imperfecta (also known as brittle bone disease) who have a confirmed genetic change in the COL1A1 or COL1A2 genes. The study aims to see if the drug can help strengthen bones and reduce fracture risk.
Phoenix, ArizonaAges 18–75 - NCT04214561Enrolling by invitation
Studies how sleep measures relate to teeth grinding
This study looks at sleep testing results to understand what relates to sleep bruxism, which is teeth grinding or clenching during sleep. It may help researchers better understand the causes and patterns behind this condition.
WroclawAges 18–70 - NCT07693998Enrolling by invitation
Pain education class for fibromyalgia or chronic back pain
This trial tests a class to help people with fibromyalgia or chronic low back pain learn about their pain and how to manage it. It might help you feel better and understand your pain.
Valencia, ValenciaAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.