Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT06426251Recruiting
Light therapy for knee replacement recovery
This trial tests whether a special light therapy (photobiomodulation) can help reduce pain and speed healing after total knee replacement. If you're having knee replacement and don't have complications like infection or open wounds, you may be eligible.
HsinchuAges 20 years+ - NCT06426316Recruiting
Immune cells and migraines study
This study looks at how certain immune cells and inflammatory chemicals relate to migraines. If you have migraines or an autoimmune condition (like lupus, rheumatoid arthritis, or Crohn's disease), you may be able to participate. The goal is to understand what causes migraines.
Clermont-Ferrand, AURAAges 18–50 - NCT06426875Recruiting
Isometric training for shoulder pain in bowlers
This trial tests if isometric muscle training (holding still muscle contractions) can reduce shoulder pain and improve function and bowling performance in male bowlers. It may help if your pain affects your game and causes emotional distress.
Rawalpindi, Punjab ProvinceAges 18–30 - NCT06428188RecruitingPhase 1/Phase 2
CAR-T cells targeting BCMA/CD19 for autoimmune diseases
This trial tests a new treatment called CAR-T cells that target two proteins (BCMA and CD19) on immune cells. It is for people with certain autoimmune diseases that have not improved with standard treatments.
Beijing, Beijing MunicipalityAges 21–90 - NCT06429982RecruitingPhase 1
Dexamethasone for children with rhabdomyolysis
This study tests whether adding a steroid medicine called dexamethasone to the usual treatment helps children with rhabdomyolysis recover faster. It is for children whose muscle breakdown is not due to trauma and who are not already on steroids.
Washington D.C., District of ColumbiaAges 6 months–25 years - NCT06431867Recruiting
Managing osteoporosis in older women
This study tests a new way for primary care doctors to help older women manage osteoporosis. It aims to find better strategies for treatment and follow-up in the community.
Bradford, West YorkshireAges 70 years+ - NCT06440148Recruiting
Sclerostin and bone lesions in mastocytosis
This study explores how a protein called sclerostin relates to bone problems in people with mastocytosis. By understanding this link, researchers hope to improve bone health for patients with this rare condition.
Lublin, Lublin VoivodeshipAges 18 years+ - NCT06441422Recruiting
Blood flow training for people with disabilities
This trial tests if using a blood pressure cuff during arm exercises can help people with disabilities build muscle strength. It's designed to be safe and effective for those who can do upper body movements.
Milwaukee, WisconsinAges 18 years+ - NCT06442319Recruiting
PRP after ACL reconstruction
This trial tests if injecting platelet-rich plasma (a concentration of your own blood platelets) after ACL reconstruction helps with healing and reduces pain. It's for people who recently had ACL surgery and want to try an extra treatment to improve recovery.
TorunAges 18–45 - NCT06444503Recruiting
A study collecting samples from children with bone problems
This study collects blood and tissue samples from children with bone or growth plate problems to build a research database. It aims to better understand these conditions and may help improve future treatments.
ToulouseAges Up to 99 years - NCT06447792Recruiting
Success of dental implants for lower front teeth
This trial tests how well two dental implants support a bridge or partial denture in the lower jaw when you have loose or missing front teeth. The goal is to see how long the implants last with different loading schedules.
Al MansurahAges 25–65 - NCT06449742Recruiting
AI to find spine fractures on CT scans
This study is testing whether an artificial intelligence program can find broken bones in the spine (vertebral fractures) by looking at CT scans of the chest or abdomen. The goal is to see if AI can help doctors spot these fractures more easily, which could lead to earlier treatment.
Milan, ItalyAges 50 years+ - NCT06450535Recruiting
Comparing two bone grafting methods for the upper jaw
This trial tests two surgical methods to rebuild a narrow upper jaw so it can support dental implants. It compares using a solid block of your own bone versus a thin shell of bone to widen the ridge.
Cairo, Giza GovernorateAges 20–60 - NCT06451120RecruitingPhase 2
Platelet-rich plasma injections for knee arthritis
This study tests whether platelet-rich plasma (PRP) injections can help knee arthritis in both younger and older adults. If you have knee pain from arthritis and haven't had other treatments recently, you might be able to join.
San Francisco, CaliforniaAges 18–70 - NCT06451510Recruiting
Knee osteoarthritis study in Northern Sweden
This trial studies knee osteoarthritis in people from Norrbotten, Sweden, who broke their tibial plateau between 2001 and 2015. It aims to understand how the injury affects the knee over time.
Luleå, Norrbotten CountyAges 18 years+ - NCT06451562Recruiting
Pain relief methods after scoliosis surgery
This trial compares two ways to manage pain after scoliosis surgery: numbing the area near the spine (regional anesthesia) or giving lidocaine through an IV. The goal is to see which method reduces the need for morphine after surgery.
Be’er Ya‘aqovAges 12–25 - NCT06453499Recruiting
Silent Lower Back Disc Herniation Study
This study looks at people who have a herniated disc in their lower back that is pressing on a nerve, but who have no back pain or leg pain. The goal is to understand this 'silent' condition and why some people have no symptoms.
GizaAges 20–40 - NCT06454188RecruitingPhase 4
Upadacitinib for Psoriatic Arthritis with Spine Involvement
This study tests how well upadacitinib (a pill taken daily) works for people with active psoriatic arthritis that also affects the spine. It is for those who have not responded well enough to other treatments like NSAIDs or biologics.
Cleveland, OhioAges 18 years+ - NCT06454370Recruiting
New imaging vs standard biopsy for Sjögren's diagnosis
This trial compares a new, quick imaging method (called full-field optical coherence tomography) with the standard lab analysis of a saliva gland biopsy. It may help diagnose Sjögren's syndrome faster and with less discomfort.
Mâcon, Sâone-et-LoireAges 18–99 - NCT06454617Recruiting
Comparing bone density measures from routine CT scans
This study looks at simpler ways to measure bone density from routine CT scans of the lower back or abdomen. If you are already getting a CT scan, the researchers will use those images to check your bone health without extra tests or radiation.
Bologna, BoAges 18 years+ - NCT06455085Recruiting
Preventing future fractures after a bone break
This study aims to help adults over 50 who had a recent bone fracture (from a minor fall) get better follow-up care to prevent future fractures. You will work with a nurse or coordinator to connect with your primary care doctor and learn about bone health options.
Birmingham, AlabamaAges 50 years+ - NCT06455449RecruitingPhase 3
Injectable anifrolumab for polymyositis or dermatomyositis
This study tests a new injectable medicine (anifrolumab) added to your usual treatments for polymyositis or dermatomyositis. It may help reduce disease activity if you have moderate to severe symptoms and are already on stable therapy.
Phoenix, ArizonaAges 18–75 - NCT06457776Recruiting
Jaw bone health in people taking bone-strengthening drugs
This study looks at how a specific jaw problem (osteonecrosis) may happen in people taking bone-strengthening medications. It aims to better understand and manage this side effect.
RomaAges 18 years+ - NCT06459141Recruiting
Blood Thinning During Bone Tumor Surgery
This study tests whether a technique that thins your blood during surgery can help people having bone tumor removal. It may reduce the need for blood transfusions.
Hangzhou, ZhejiangAges 18–75
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.