Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,832 recruiting studies in this area right now.
By phase
- Not applicable3,967
- Phase 2222
- Phase 4195
- Phase 1191
- Phase 3151
- Phase 1/Phase 273
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee73
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain34
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California208
- New York94
- Florida80
- Arizona76
- Massachusetts76
- Maryland73
- Texas64
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,832 total
- NCT06727643Enrolling by invitation
Tape types for better core strength in young adults
This study compares two types of tape (flexible and rigid) applied to the back to see which one improves core muscle strength more in healthy young adults. It's a short-term test to help understand how tape might support better movement or exercise.
Kırşehir, CentreAges 18–25 - NCT06692543Recruiting
How longtime exercise habits affect aging muscles and metabolism
This study compares the health of older adults (over 55) who have been very active their entire adult lives with those who have been mostly inactive. The goal is to see how exercise affects muscle, nerves, and immune-metabolic health over time.
NiceAges 55 years+ - NCT06688279Recruiting
Plyometric exercises for female fast bowlers
This trial tests plyometric exercises (jumping and explosive moves) to see if they can improve strength and performance for female fast bowlers in cricket. If you are a healthy, active bowler between 19 and 28, you may be able to join.
Lahore, Punjab ProvinceAges 19–28 - NCT06660706Recruiting
Exercise study for older adults with slow walking or weak grip
This study tests whether a supervised exercise program can help improve muscle strength and overall health in people aged 65 and older. It also looks for certain markers in the blood that may be linked to the benefits of exercise.
TaipeiAges 65 years+ - NCT06596993Recruiting
Balance training with AI for older adults
This study tests a new balance training system that uses sensors and artificial intelligence to create personalized exercises. It aims to help older adults improve their balance and prevent falls.
TaipeiAges 18–80 - NCT06538766Recruiting
How focus instructions affect strength training and walking in older adults
This study tests whether different types of mental focus during strength training can improve walking ability in older adults. It may help find better ways to stay steady and prevent falls.
Monte de Caparica, AlmadaAges 18 years+ - NCT06321263Recruiting
Comparing muscle training for older adults: limbs vs. breathing
This study compares two types of muscle training for older adults: one focuses on muscles in your arms and legs, and the other on your breathing muscles. The goal is to see which helps improve your ability to walk and stay active.
ÇanakkaleAges 65–80 - NCT05878275Recruiting
Helping babies learn early movement with tummy time coaching
This study teaches parents how to use tummy time and safe positioning, and it checks whether these changes support healthy early infant development. You might join if your baby is very young, you live nearby, and you can do online sessions by phone video.
Memphis, TennesseeAges 1 day–4 years - NCT05853406Recruiting
Testing a simple reach test change that matters in seniors
This trial looks at how much change on a simple balance “reach” test is meaningful for people over 65 with balance problems. It aims to set a clear target for what improvement (or worsening) on the test should be considered important.
CaenAges 65–100 - NCT05279547Recruiting
Bed-cycle exercise study to test muscle oxygen during ICU care
This trial tests whether brief “interval” bed-cycling changes how well your leg muscles use oxygen compared with steady cycling. It’s meant for carefully selected ICU patients who can safely do active cycling while on ventilator support.
LeuvenAges 18 years+ - NCT06884865RecruitingPhase 2
Study of an experimental knee injection for osteoarthritis pain
This study tests a new investigational medicine injected into the knee to see if it is safe and tolerable for people with painful knee osteoarthritis. It may help reduce pain and improve knee function.
Birmingham, AlabamaAges 45–80 - NCT07753122Recruiting
Hydrogen water for chronic fatigue syndrome
This trial tests whether drinking hydrogen water can help with symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). If you have ME/CFS, this study might show if hydrogen water is a helpful treatment.
Stony Brook, New YorkAges 18–65 - NCT07753460Recruiting
Low-level laser therapy for trigger finger pain
This study tests a low-level laser treatment (a form of light therapy) to see if it helps reduce pain and improve movement in people with trigger finger. It is a non-invasive option that may offer symptom relief without shots or surgery.
Izmir, BalçovaAges 18 years+ - NCT07752849Recruiting
Platelet-rich fibrin gel for cleft palate repair
This study compares two types of gel made from the patient's own blood, with or without an antibiotic, applied during cleft palate surgery to see if they improve healing and reduce complications.
SanaaAges 3 months–18 years - NCT07388498RecruitingPhase 3
Study of pegloticase with methotrexate for uncontrolled gout
This trial tests a new way of giving pegloticase (a drug that breaks down uric acid) by injection under the skin, combined with methotrexate, to see if it works better for people with uncontrolled gout. It might help if you have painful flares that don't go away with usual treatments.
Birmingham, AlabamaAges 18 years+ - NCT07254806RecruitingPhase 3
Cell therapy for low back pain from disc disease
This study tests if injecting a special cell therapy into a damaged spinal disc can reduce chronic low back pain. It is for people who have had low back pain for at least 6 months and haven't gotten enough relief from other treatments like physical therapy or pain medication.
Birmingham, AlabamaAges 18–75 - NCT07532785Recruiting
Water and Land Exercise Before Knee Replacement Surgery
This trial tests whether a 6-week program combining weekly water-based exercise and three times weekly land-based training can help reduce knee pain and improve strength before total knee replacement surgery. The program aims to help you recover better after your operation.
London, EnglandAges 18 years+ - NCT05554835Recruiting
Mitochondrial disease registry and history study
This study collects information about people who have a suspected or confirmed mitochondrial disease. It aims to better understand how the disease looks over time, which can help future treatments.
InnsbruckAges Any age - NCT06328062Recruiting
Comparing two pain medicines for knee replacement
This study compares two medicines, mirogabalin and pregabalin, to see which works better for pain after total knee replacement. It may help you find more effective pain relief after surgery.
Khlong Luang, Changwat Pathum ThaniAges 50–85 - NCT06782165Recruiting
Long-term follow-up of jaw joint surgery
This study follows up on patients who had jaw joint (TMJ) surgery. It looks at how the joint is doing after 6 months to predict long-term results. It may help understand if earlier checkups can guide care.
HuddingeAges 18 years+ - NCT07052929RecruitingPhase 1/Phase 2
Gene therapy study for young boys with XLMTM on ventilators
This study tests a new gene therapy called ASP2957 in young boys with X-linked myotubular myopathy who are dependent on a ventilator. The goal is to see if it can help improve their breathing and muscle strength.
Chicago, IllinoisAges Up to 3 years - NCT03773965RecruitingPhase 3
Baricitinib study for kids with juvenile arthritis
This study tests baricitinib, a medicine, in children and teens with juvenile idiopathic arthritis. It includes only families who already took baricitinib in an earlier study and did not stop it permanently or develop an allergy.
RosarioAges 1–18 - NCT07733518Recruiting
Exercise comparison for knee osteoarthritis
This trial compares two types of exercise—eccentric training and low-load blood flow restriction training—to see which is better for reducing pain and improving function in people with knee osteoarthritis.
Rawalpindi, Punjab ProvinceAges 40–70 - NCT06687551RecruitingPhase 4
Testing lower doses of JAK inhibitors for rheumatoid arthritis
This study tests whether people with rheumatoid arthritis whose disease is well controlled can safely take a lower dose of their JAK inhibitor medication. It aims to see if reducing the dose still keeps inflammation down and prevents flare-ups.
Toulouse, OccitanieAges 18–65
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,832 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,923 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.