Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT04074863Recruiting
Surgery for painful wrist-joint arthritis with stable joint
This study looks at a surgical procedure to help people with painful arthritis where two forearm bones meet at the wrist. It’s for people whose joint is stable, aiming to improve pain and hand function.
Lillehammer, OpplandAges 30–75 - NCT05221450Recruiting
Study of what affects root canal treatment outcomes
This study looks at which factors can change how well root canal (endodontic) treatment works. It may help improve future care by understanding what leads to better healing.
LjubljanaAges 18 years+ - NCT05654753RecruitingPhase 2/Phase 3
Fecal transplant for stubborn axial spondyloarthritis
This trial tests whether transplanting healthy stool bacteria (fecal microbiota transplantation) can reduce symptoms in people with axial spondyloarthritis (including ankylosing spondylitis) who are not improving enough with standard medicines. If you qualify, you may receive study capsules containing processed bacteria and be closely monitored for safety and symptom changes.
Boulogne-BillancourtAges 18–75 - NCT06087341RecruitingPhase 1
CAR T-Cell Therapy for Advanced Sarcoma in Young People
This trial tests a special type of immune cell (called a CAR T-cell) that is trained to attack sarcoma cells. It is for children, teens, and young adults up to age 40 whose sarcoma has not responded to standard therapy. The treatment is given directly into the tumor, and the goal is to see if it is safe and how well it works.
MadridAges Up to 30 years - NCT06361485RecruitingPhase 1
Umbilical cord injection for chronic low back pain
This study tests whether a special injection made from umbilical cord tissue is safe and can help with long-term low back pain. It is for adults who have not had recent back procedures or certain health problems.
Scottsdale, ArizonaAges 20 years+ - NCT06352216Recruiting
Joint inflammation in hemophilia A patients
This study looks at how many adults with moderate or severe hemophilia A have inflammation in their joints (synovitis). It aims to better understand joint health in people with hemophilia A, including those with inhibitors or joint replacements.
Bonn, North Rhine-WestphaliaAges 18 years+ - NCT06367491Recruiting
National database of bone metastases
This study is a national database that collects information from people with cancer that has spread to their bones from a solid tumor. By joining, you will help doctors learn more about bone metastases and improve care for future patients.
Imola, BolognaAges 18 years+ - NCT06368154Recruiting
Studying early markers for brittle bones in newborns
This trial looks for tiny particles in the blood that might help doctors detect bone weakness in premature babies. It aims to find early signs of metabolic bone disease, which could lead to better care.
Changsha, HunanAges birth–3 days - NCT02434003Recruiting
Test a new way to predict scoliosis curve progression
This study follows adolescents with idiopathic scoliosis to see how well a new predictive model estimates whether the spinal curve will get worse over time. It may help doctors plan monitoring and treatment more accurately for young people with scoliosis.
San Diego, CaliforniaAges 10–15 - NCT05692778Recruiting
Care program for people with diabetes and foot problems
This trial is testing an improved care approach for people with diabetes who have foot complications, delivered through primary care. It may help by organizing care more effectively and supporting better diabetes and foot management.
GothenburgAges 18 years+ - NCT06373341Recruiting
Virtual reality rehab for arm and hand after ICU stay
This study tests whether using virtual reality (VR) games can help you regain movement and strength in your arms and hands after a long hospital stay in the ICU. It is designed for people who live in the Frisian region of the Netherlands and can understand Dutch.
Leeuwarden, Provincie FrieslandAges 18 years+ - NCT06074783RecruitingPhase 1/Phase 2
Stem cell therapy for muscle and joint injuries
This study tests a new therapy made from donor stem cells that may help repair damaged muscles, bones, tendons, and joints. It is for people whose injuries or degenerative conditions have not healed on their own.
Nassau, The BahamasAges 18 years+ - NCT03494374Recruiting
Foot brace and exercise for flat feet
This trial looks at whether using a foot brace (an orthosis) plus exercises can improve symptoms from flat feet. It may help by changing how your foot and heel work when you stand or walk.
Seongnam-si, Bundang-guAges 3–10 - NCT05332249Recruiting
Registry for Degenerative Spine Disease in the Neck and Low Back
This study is a registry (a way to collect health information) for people with wear-and-tear (“degenerative”) problems in the neck and/or low back. It may help doctors better understand these conditions and improve future care plans.
Seoul, KoreaAges 18–100 - NCT05070078Recruiting
Assessing recovery after lumbar disc surgery using SANE
This study uses a simple recovery questionnaire called SANE to understand how people do after lumbar discectomy (surgery to relieve a slipped or herniated disc). It may help the care team measure recovery in a clearer, more consistent way.
Windsor, OntarioAges 18 years+ - NCT04522622RecruitingPhase 4
Teriparatide for low bone turnover in advanced kidney disease
This trial tests teriparatide (a hormone-like bone medicine) to improve bone health in people with advanced chronic kidney disease who are at risk for weak, low-turnover bone. It may help by changing how quickly your bones break down and rebuild.
AalborgAges 18–120 - NCT04825522RecruitingPhase 4
Vancomycin powder during spine surgery to prevent infection
This trial studies whether placing antibiotic powder (vancomycin) directly in the surgical wound during spine surgery can lower the chance of infection. It may help patients by reducing wound infections after surgery, but it also depends on your surgery details and follow-up timeline.
Windsor, OntarioAges 18 years+ - NCT06379243Recruiting
Predicting future spinal fractures after osteoporosis treatment
This study is testing a new way to predict if your spine might break again after you have treatment for a fracture caused by osteoporosis. If you have a recent spinal fracture from weak bones and are getting a cement injection (PVP or PKP), researchers want to check your information to see how well their risk model works for people like you.
Guangzhou, GuangdongAges 50–90 - NCT06365112RecruitingEarly Phase 1
Endoscopic surgery for hip socket fractures
This trial tests a minimally invasive, endoscopic (camera-guided) surgery to fix fractures of the hip socket (acetabulum). It may help people with this type of hip fracture recover with less pain and shorter hospital stays.
TampereAges 18 years+ - NCT06379009Recruiting
Home exercise program for kidney transplant recipients
This trial tests a home-based exercise program for people who have recently had a kidney transplant. It aims to help you improve your physical function and recovery after surgery.
OsloAges 18 years+ - NCT01965132Recruiting
Biologic and targeted therapy registry for arthritis patients
This registry is collecting information about people with rheumatoid arthritis, ankylosing spondylitis, or psoriatic arthritis who are starting or needing biologic or targeted medicines. It may help researchers better understand how these treatments work in real life.
SeoulAges 18 years+ - NCT02966886Recruiting
Shoulder replacement techniques for advanced shoulder arthritis
This study compares different surgical techniques during shoulder replacement for people with advanced shoulder (glenohumeral) arthritis. It may help surgeons choose the approach that best restores function and reduces pain.
Ottawa, OntarioAges 18 years+ - NCT06388603Recruiting
Bioactive glass for diabetic foot bone infection in the forefoot
This trial tests a special glass material (bioactive glass S53P4) placed into the bone after surgery to treat a diabetic foot infection in the forefoot. It may help heal the infection better than standard care.
Monfalcone, GoriziaAges 18–100 - NCT05487274Recruiting
Shoulder arthritis surgery plan for specific shoulder bone alignment
This study compares two types of surgery for advanced shoulder osteoarthritis when the shoulder socket is turned backward more than 15 degrees. It aims to see which surgical approach works best for pain and function when the bone alignment issue can be corrected.
Ottawa, OntarioAges 65 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.