Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT06514677Recruiting
Nonsurgical treatment for implant infection with ultrasonic carbon tip
This study tests whether using a special ultrasonic carbon tip (a gentle cleaning tool) can treat infection around a dental implant without surgery. It is for people with a single problem implant who are otherwise healthy and have good oral hygiene.
KütahyaAges 18–99 - NCT06514703Recruiting
CT vs. X-ray Guided Nerve Ablation for Knee Arthritis
This study compares two different image-guided techniques (CT scan vs. fluoroscopy) to perform a nerve ablation procedure that blocks pain signals from the knee. It aims to find which method works better for reducing pain in people with knee osteoarthritis.
Zagazig, Sharqia ProvinceAges 45–80 - NCT06514755Recruiting
Nerve block before artery treatment for knee pain
This study tests a two-step procedure for long-term knee pain that hasn't improved with other treatments. First, the nerves around the knee are numbed, and then the small arteries feeding the painful area are blocked. The goal is to see if doing the nerve treatment before the artery treatment works better for reducing pain.
ZagazigAges 18–80 - NCT06516172Recruiting
The Bern Rehabilitation Registry for Chronic Conditions
This trial is creating a registry to study how people with chronic diseases benefit from rehabilitation programs. If you are an adult with a long-term health condition and have been referred to rehab, your data could help improve care for others.
Heiligenschwendi, Canton of BernAges 18 years+ - NCT06517056Recruiting
3D Knee Assessment for Active Duty Knee Pain
This trial tests a 3D camera device that measures how your knee moves. It may help find the best way to treat your front-of-knee pain and keep you mission-ready.
Honolulu, HawaiiAges 18–50 - NCT06517498Recruiting
Understanding daily life with facioscapulohumeral muscular dystrophy
This study explores how facioscapulohumeral muscular dystrophy (FSHD) affects your daily life, health, and living situation. It does not test a new treatment, but aims to better understand the challenges patients face.
Xi'an, ShaanxiAges Any age - NCT06519955RecruitingPhase 2/Phase 3
Can a nerve block reduce pain after hip surgery?
This trial tests whether a special nerve block called PLIA can lower pain right after hip-preserving surgery (PAO) for hip dysplasia. If you are a teen or young adult having this surgery, this study could help manage your pain better.
Iowa City, IowaAges 13–50 - NCT06523400RecruitingPhase 3
Mexiletine for myotonic dystrophy types 1 and 2
This trial tests a once-daily drug called mexiletine PR to see if it can help reduce muscle stiffness (myotonia) in people with myotonic dystrophy type 1 or 2. It may be a good option if you have a confirmed genetic diagnosis and are at least 16 years old.
LeuvenAges 16 years+ - NCT06525545Recruiting
Early Motion After Total Ankle Replacement
This study tests whether starting ankle movement early after total ankle replacement helps you recover faster and with better results. It is for adults with osteoarthritis who are getting their first ankle replacement.
Bologna, ItaliaAges 18–80 - NCT06525636RecruitingPhase 1/Phase 2
Study of a new drug (KK8123) for adults with XLH
This study tests a new investigational drug called KK8123 for adults with X-linked hypophosphatemia (XLH). It aims to see if KK8123 can safely raise low blood phosphorus levels. The trial includes two parts and may offer a new treatment option if you have not used burosumab recently.
San Francisco, CaliforniaAges 18–65 - NCT06525688Recruiting
Osteoporosis study using bone tissue to find new targets
This study looks for new markers and treatment targets for osteoporosis by comparing bone tissue from women with a broken hip (due to weak bones) and women getting a hip replacement for arthritis. You may be eligible if you are postmenopausal and have one of these hip conditions.
Kifissia, AtticaAges Any age - NCT06526325Recruiting
Tendon release for cervical disc herniation
This study tests whether a tendon release technique (a specialized hands-on therapy) can help relieve symptoms for people with a herniated disc in their neck. It might be a good fit if you have a neck disc problem and are looking for a non-surgical option.
IstanbulAges 18–65 - NCT06527534RecruitingPhase 4
Filgotinib vs adalimumab for rheumatoid arthritis
This study compares two RA medications, filgotinib and adalimumab, to see how they affect your body's proteins and genetic signals. It may help your doctor know which treatment is better for your type of RA.
VeronaAges 18–65 - NCT06527547Recruiting
Ear acupuncture for sleep problems in rheumatoid arthritis
This trial tests if a gentle, non-invasive ear acupuncture device can improve sleep in people with rheumatoid arthritis (RA). If you have RA, poor sleep, and your disease is under control, this study might be a good fit.
Beijing, Beijing MunicipalityAges 18–72 - NCT06527664Recruiting
Custom hip implant for failed arthritis treatments
This trial tests a custom-made hip socket implant for people who have had a failed hip replacement or arthritis treatment. It aims to see if a personalized implant can provide a better solution.
BolognaAges 18 years+ - NCT06528431RecruitingPhase 4
Personalized tapering of adalimumab for rheumatoid arthritis
This study tests if checking the amount of adalimumab (a biologic drug) in your blood can help doctors safely lower your dose. If you have had rheumatoid arthritis under control for at least 6 months, this trial may help you take less medication while keeping symptoms away.
Caluire-et-CuireAges 18 years+ - NCT06530056Recruiting
Back mobilization for posture and lung function
This trial studies a special hands-on technique called costovertebral mobilization to see if it can improve rounded upper back posture and lung function in non-smokers with early kyphosis. It may help you breathe easier and stand taller.
IslamabadAges 20–40 - NCT06530459RecruitingPhase 2/Phase 3
The MUSE Study for Menopausal Joint Pain
This study tests whether a treatment can help women with joint pain and stiffness that started or worsened during menopause. It focuses on women who are within 5 years of menopause and have pain in multiple joints.
SingaporeAges 30–59 - NCT06530602Recruiting
3D Shoulder Mobilization for Frozen Shoulder
This study tests a new hands-on physical therapy technique (3-D shoulder mobilization) to see if it helps people with frozen shoulder move better and feel less pain.
Rawalpindi, Punjab ProvinceAges 40–65 - NCT06531590Recruiting
New emergency approach for shoulder dislocation
This trial tests a new way to treat a dislocated shoulder in the emergency room. It might help people with a first-time or repeat shoulder dislocation get back to normal faster.
Ankara, YenimahalleAges 18 years+ - NCT06532851Recruiting
Exercise therapy for knee cartilage health
This study tests whether specific exercises can improve your knee cartilage health and daily function. It is for people with a meniscus tear who are at risk for knee arthritis but don't have arthritis yet.
Ar RamthaAges 35–55 - NCT06533397Recruiting
Testing a new bone graft for sinus lifts
This study tests a new bone graft material for sinus lifts, a procedure to add bone in the upper jaw so dental implants can be placed. It may help people who are missing bone in the back of their upper jaw due to enlarged sinuses.
Budapest, BudapestAges 18 years+ - NCT06533410Recruiting
Testing a new Chinese pain scale for fibromyalgia diagnosis
This study tests a new Chinese questionnaire to help doctors diagnose fibromyalgia more accurately. It is for people with long-lasting, widespread pain who can fill out a simple form.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06533423Recruiting
Self-management help for new arthritis patients
This trial tests a self-management program for people recently diagnosed with certain types of arthritis. It aims to help you better manage your condition through education and support.
Glostrup MunicipalityAges 18–120
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.