Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT06903767Enrolling by invitation
Automated vs manual tool study for hip replacement
This trial tests whether an automated surgical tool is better than a manual one for putting in hip replacement parts. If you are having a planned first-time hip replacement and are over 18, you might be able to join.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06910228Enrolling by invitation
Brain oxygen changes during spine surgery position shifts
This study measures how your child's brain oxygen levels change when they are repositioned during spine surgery. It may help make surgeries safer for teens and young adults.
Columbus, OhioAges 10–21 - NCT06902805RecruitingPhase 2/Phase 3
Testing botox injections and splints for thumb arthritis pain
This study tests if botox injections into the thumb joint, along with a custom splint, can reduce pain from thumb base arthritis. It may be an option if you have persistent pain and have not had recent thumb surgery or certain other treatments.
Paris, Île-de-France RegionAges 18 years+ - NCT06776003Recruiting
Mobility after vertebroplasty vs sham for spine fractures from osteoporosis
This trial compares a procedure called vertebroplasty (injecting bone cement into the broken bone) with a sham (fake) procedure to see how it affects your ability to move and be active. It's for people with recent painful spinal fractures caused by weak bones (osteoporosis).
KoldingAges 50 years+ - NCT04242589RecruitingPhase 2
Radiation plus bone cement for painful spinal metastasis pain
This trial tests adding a bone-cement procedure (vertebroplasty) along with radiation to reduce pain from cancer that has spread to the spine. It is for adults with painful metastatic (spread) tumors in the middle or lower spine, without current spinal cord pressure.
Edmonton, AlbertaAges 18 years+ - NCT05046600Recruiting
Hand and wrist implant registry for eligible adult patients
This registry collects information about people who need hand or wrist surgery using specific Arthrex implants. It helps the company and doctors learn how these implants are used and how patients do during healing.
Phoenix, ArizonaAges 18 years+ - NCT04832100Recruiting
Study of a fat marker in fibromyalgia
This study looks at whether a specific fat-related marker (called LPC16:0) is linked to fibromyalgia. Your participation could help researchers understand what role this marker may play in the condition.
Kaohsiung CityAges 18–70 - NCT06418217Recruiting
Exercise and education for lateral hip pain
This study tests whether exercise and patient education can help people with long-term lateral hip pain (pain on the outside of the hip). If you've had hip pain for over 6 months and an MRI confirms the cause, you may be able to join.
Horsens, HorsensAges 18–75 - NCT06707194RecruitingPhase 4
Penicillin plus etanercept for spondyloarthritis
This trial tests whether adding a common antibiotic (benzathine penicillin) to a standard biologic drug (etanercept) can better treat spondyloarthritis. It may help if you have active disease and are free of certain infections.
Hefei, AnhuiAges 18–59 - NCT06891378Recruiting
Home rehab app for patients after shoulder replacement surgery
This trial tests a digital rehab program you can do at home after reverse total shoulder replacement. The goal is to see if an app-based exercise plan helps you recover safely and effectively.
Seoul, Irwon-ro 81Ages 50 years+ - NCT05327972RecruitingPhase 2
Botox injections for painful degenerative rotator cuff disease
This Phase 2 study tests whether botulinum toxin (Botox) injections can reduce pain from long-lasting degenerative rotator cuff problems. You may be eligible if you have shoulder pain for over a month and ultrasound evidence of specific tendon irritation.
Paris, ParisAges 41 years+ - NCT05525598Recruiting
Online therapy for severe body–mind symptom disorders
This trial tests an internet-based treatment program for people with moderate-to-severe functional somatic disorders (long-lasting physical symptoms linked to how the body and brain interact). It may help reduce symptoms and improve day-to-day functioning by offering structured support online.
Aarhus C, DenmarkAges 18–60 - NCT06897787Enrolling by invitation
Jaw surgery study: how jaw position affects joint healing
This study looks at how the way the upper jaw is positioned during corrective jaw surgery affects the joint's healing over time. It may help people with a specific type of underbite who are already planning to have both upper and lower jaw surgery.
Istanbul, FatihAges 18–65 - NCT06896240Recruiting
A smoothie supplement before and after knee revision surgery
This study tests whether drinking a special smoothie each day for 2 weeks before and after your knee revision surgery helps reduce inflammation and improve recovery. It is for people who have health conditions that cause inflammation, like diabetes or heart disease, and who are getting a knee replacement.
New York, New YorkAges 40–80 - NCT06893848Recruiting
Culture Care program for mobility after chest or belly surgery
This study tests a program called 'Culture Care' that helps patients move more after chest or belly surgery. It aims to see if the program improves how much you walk and move during your hospital stay.
NeuchâtelAges 18 years+ - NCT06893302Recruiting
Bone marrow injection during knee scope for cartilage or meniscus
This trial tests if adding a bone marrow injection to standard knee arthroscopy helps your knee heal better. It is for people with a torn meniscus or damaged cartilage who have healthy knee joints without arthritis.
New York, New YorkAges 18–64 - NCT06897293Recruiting
Tape Implant vs Standard Repair for Ankle Instability
This trial tests whether adding a special tape to a standard ankle ligament repair helps people with chronic ankle instability more than the standard repair alone. If you have loose joints and a history of ankle giving way, this study may be an option.
Beijing, Beijing MunicipalityAges 15–55 - NCT06895564Recruiting
Proton radiation for hard-to-treat spine tumors
This trial tests a special type of proton radiation for people whose spine cancer has spread from another part of the body and cannot be treated effectively with standard X-ray radiation. The goal is to see if proton radiation can safely deliver a high dose of radiation to the tumor.
Baltimore, MarylandAges 18 years+ - NCT06893250Enrolling by invitationPhase 2/Phase 3
Orthobiologic treatment for knee osteoarthritis
This study tests a treatment made from your own body's healing components to reduce knee pain. It may help people with mild to moderate knee osteoarthritis who haven't had knee surgery or strong pain relievers lately.
Tromsø, TromsøAges 40–70 - NCT06892977Enrolling by invitation
Stress and pain interaction study
This study looks at how stress affects pain sensitivity and how the brain processes pain. It uses MRI scans to see brain activity while participants experience mild pain, which may help improve pain treatments.
GhentAges 18–55 - NCT06566950Recruiting
Blood flow training for leg muscle health in athletes
This study tests a training method that uses light blood flow restriction to improve leg muscle structure. It is for young athletes (ages 15–35) who play high-level sports like martial arts, basketball, soccer, or futsal at least twice a week.
Denpasar, BaliAges 15–35 - NCT06888973Enrolling by invitationPhase 1/Phase 2
Stem cell infusion for autoimmune diseases
This clinical trial is testing if infusions of special stem cells (called mesenchymal stem cells) can help people with certain autoimmune diseases where standard treatments have not worked well enough. It is an early-phase study in Pakistan for adults (and some children for one condition) with rheumatoid arthritis, lupus, systemic sclerosis, ankylosing spondylitis, or dermatomyositis/polymyositis.
RawalpindiAges 18–50 - NCT06887491Enrolling by invitation
Dual-tasking (thinking + moving) program for children with Duchenne MD
This study tests whether a special program that combines thinking tasks (like counting or remembering) with physical activities can help boys with Duchenne muscular dystrophy improve their thinking, movement, and ability to do everyday tasks independently.
Ankara, CankayaAges 6–12 - NCT06888193RecruitingPhase 1
Bimekizumab in breast milk of mothers being treated
This study measures how much bimekizumab (Bimzelx) gets into breast milk. It helps us understand if the medicine is safe for breastfeeding babies whose mothers take this drug.
Santa Monica, CaliforniaAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.