Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT06500780Recruiting
Pain and depression support for African Americans
This study tests a program that helps people with both long-term pain and depression. It includes coaching and support to help you feel better and manage your health. The study is for Black or African American adults.
Indianapolis, IndianaAges 18 years+ - NCT06501430Recruiting
Treatment for shin splints in amateur football players
This trial tests two muscle-relaxation techniques to reduce pain from shin splints in amateur football players. It may help you recover faster and get back to playing.
Lahore, Punjab ProvinceAges 18–30 - NCT06502015Recruiting
Biomarkers in nervous system autoimmune diseases
This study looks for biomarkers (biological clues) in people with autoimmune diseases of the nervous system. It aims to discover better ways to diagnose and treat these conditions.
WuhanAges 18 years+ - NCT06502795Recruiting
Quad Strengthening for Knee Pain at Different Angles
This study tests whether strengthening your quadriceps (front thigh muscles) at different knee angles can reduce pain behind or around your kneecap. If you have had this type of knee pain for at least 3 months, you may be eligible.
Fortaleza, CearáAges 18–35 - NCT06502587Recruiting
Blood flow restriction with low-intensity exercises for knee osteoarthritis
This study tests if using a special cuff to slightly reduce blood flow while doing gentle exercises can help reduce knee pain and improve function in people with knee osteoarthritis. It may offer a way to get stronger without heavy weights.
Lahore, Punjab ProvinceAges 40–65 - NCT06502613Recruiting
Scoliosis and Sleep Cycle in Children
This study looks at how sleep timing (melatonin levels) might be linked to new cases of scoliosis in children. If you have scoliosis and are between 6 and 15, you may help researchers understand this connection.
Wenzhou, ZhejiangAges 6–15 - NCT06503302Recruiting
Ultrasound effect on calcified shoulder tendinitis
This trial tests if using Doppler ultrasound to guide treatment can help people with long-term shoulder pain caused by calcified deposits. It may offer a more targeted way to relieve pain.
TaipeiAges 18–80 - NCT06503224Recruiting
Cell therapy for refractory autoimmune diseases
This trial tests a new type of cell therapy (SCAR02) that targets two proteins on immune cells to help calm down overactive autoimmune diseases like rheumatoid arthritis, lupus, Sjögren's syndrome, or systemic sclerosis. It may be an option if standard treatments haven't worked well enough.
Changsha, HunanAges 18 years+ - NCT06503237Recruiting
SWK002 for tough-to-treat rheumatoid arthritis
This trial tests a new treatment called SWK002 for people with rheumatoid arthritis that hasn't improved after trying multiple medications. It aims to see if SWK002 can help when other treatments have failed.
Changsha, HunanAges 18 years+ - NCT06505330Recruiting
Probiotics for kids with cleft palate
This study looks at whether giving probiotics (helpful bacteria) to children with cleft palate can improve the bacteria in their airways and possibly prevent infections. Researchers want to see if this simple treatment helps keep kids healthier.
Edegem, AntwerpAges 6 months–2 years - NCT06506201Recruiting
Hip replacement methods and leg length difference
This study compares two ways to perform hip replacement to see which one helps reduce leg length differences after surgery. The findings could help people with severe arthritis get better alignment and feel more comfortable.
BolognaAges 50–80 - NCT06506656Recruiting
Testing Hyadrol gel for hip or thumb arthritis pain
This study tests whether a combination of hyaluronic acid and adelmidrol (a gel called Hyadrol) can reduce pain and improve joint function in people with arthritis of the hip or thumb. It may help if you have persistent pain and are not already on other treatments.
RomaAges 40 years+ - NCT06507046Recruiting
Personalized total knee replacement study in Norway
This trial is studying a more personalized approach to total knee replacement surgery. It is for people with moderate to severe knee arthritis who are already scheduled for a knee replacement at Kristiansund Hospital in Norway.
Kristiansund, Møre and RomsdalAges 18–80 - NCT06507072Recruiting
Adaptive rock climbing for kids with arm differences
This study tests whether adaptive rock climbing can help children with arm or hand differences improve their physical function and confidence. It aims to find fun and effective ways to support your child's development.
Los Angeles, CaliforniaAges 6–16 - NCT06508385Recruiting
How improvement affects fibromyalgia: A brain study
This study looks at how women with fibromyalgia perceive their improvement. It uses a brain scan (fMRI) to understand this better. The goal is to help improve treatments.
Istanbul, KartalAges 25–55 - NCT06511050RecruitingPhase 1/Phase 2
Testing Lumbrokinase for Long COVID, Lyme, and Chronic Fatigue
This trial tests a supplement called Lumbrokinase (derived from earthworms) to see if it helps reduce symptoms in people with Long COVID, post-treatment Lyme disease syndrome, or ME/CFS. It may benefit those whose daily life is significantly affected by these conditions.
New York, New YorkAges 18 years+ - NCT06511362Recruiting
Balance or strength training for front knee pain
Researchers want to see which type of exercise program better helps people with front knee pain. You will do either balance challenge training or strengthening exercises to see which reduces your pain more.
Lahore, Punjab ProvinceAges 15–30 - NCT06511557Recruiting
Virtual reality vs. leg exercises for knee arthritis
This study compares virtual reality exercises with standard leg-strengthening moves to see which better reduces pain and improves function in people with knee osteoarthritis (OA).
Rawalpindi, Punjab ProvinceAges 50 years+ - NCT06512506Recruiting
Hip Arthroscopy for Mild Hip Dysplasia Study
This study is for people with mild hip dysplasia and a labral tear. Doctors will use a camera (arthroscopy) to look inside the hip and fix the problem, aiming to ease pain and improve function.
BeijingAges Any age - NCT06512727Recruiting
Pain management study for Black older adults with long-term joint pain
This study tests two different approaches to help Black adults aged 50–92 manage chronic muscle or joint pain in their hips, knees, lower back, or ankles. It aims to find which method works better to reduce pain and improve daily life.
Gainesville, FloridaAges 50–92 - NCT06512870Recruiting
Detecting perfusion problems in leg injuries
This trial tests two devices to see if they can quickly detect when a leg muscle is not getting enough blood after a serious leg injury.
Gainesville, FloridaAges 18–75 - NCT06513039RecruitingPhase 4
Erythropoietin for preserving jawbone after tooth extraction
This trial tests whether a medicine called erythropoietin can help preserve the bone in your jaw after a tooth is pulled. It may help keep the area strong for future dental work.
CairoAges 18–40 - NCT06514365Recruiting
Comparing nerve blocks for pain after knee replacement
This trial compares two different ways of numbing the leg to provide better pain relief after total knee replacement surgery. It tests whether adding a popliteal sciatic nerve block (behind the knee) to a saphenous block (inner thigh) works better than adding an IPACK block (back of the knee).
Badalona, BarcelonaAges 18 years+ - NCT06514716Recruiting
Steroid shot vs. standard procedure for knee arthritis
This study tests whether a corticosteroid shot (a strong anti-inflammatory medicine) into the knee joint works better than the standard GAE procedure for people with knee osteoarthritis. It aims to see which approach provides better pain relief and function.
ZagazigAges 18–80
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.