Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT06553950Recruiting
Splint vs botox for jaw and neck pain
This trial compares a custom jaw splint with botox injections to see which better reduces neck muscle tension in people with jaw joint problems. It's for patients who have a displaced jaw disc that still clicks or pops and also have neck muscle spasms.
CairoAges 18–40 - NCT06554106Recruiting
Electrical stimulation for fibromyalgia pain
This trial tests whether a gentle electrical stimulation therapy can reduce pain and improve daily life in people with fibromyalgia. It aims to offer a drug-free option to manage symptoms.
ElâzığAges 18–65 - NCT06555237RecruitingPhase 2
MEK inhibitors for heart thickening in RASopathies
This trial tests a targeted drug (MEK inhibitor) to treat thickened heart muscle caused by a group of genetic conditions called RASopathies. It may help improve heart function in people with hypertrophic cardiomyopathy.
WarsawAges 1 day–18 years - NCT06555523Recruiting
Trigger point shots for muscle pain syndrome
This trial tests if injecting trigger points in the neck and shoulder muscles can relieve pain in people with fibromyalgia and chronic myofascial pain syndrome. It may help reduce muscle tightness and improve function.
ElâzığAges 18–65 - NCT06555848Recruiting
Testing a new antibiotic bone filler for chronic bone infection surgery
This study is testing whether the CERAMENT G bone filler can help treat chronic bone infections (osteomyelitis) when doctors remove the infected bone in a single surgery. It is for people who have had symptoms for at least six months and need the bone gap filled after surgery.
OxfordAges 18 years+ - NCT06557018RecruitingPhase 4
Numbing medicine injection for knee replacement pain
This study tests a long-lasting numbing medicine (liposomal bupivacaine) injected around the knee during total knee replacement surgery. It aims to see if this medicine helps control pain and reduce the need for other painkillers after surgery.
Dezhou, ShandongAges 18–80 - NCT06557369Recruiting
New light therapy for intermediate age-related macular degeneration
This trial tests a new light-based treatment for intermediate age-related macular degeneration (AMD), a common eye condition that can lead to vision loss. The goal is to see if it is safe and helps slow down the disease.
BergamoAges 50 years+ - NCT06558188RecruitingPhase 4
Combined bone-building therapy for osteoporosis
This study tests a combination of two bone-building drugs (romosozumab and teriparatide) in postmenopausal women with osteoporosis who are at high risk for fractures. The goal is to see if the combination strengthens bones faster and better than either drug alone.
Boston, MassachusettsAges 45 years+ - NCT06559605Recruiting
Comparing 3D Zirconia Barrier vs Titanium Mesh for Bone Growth
This study tests a new 3D-printed zirconia barrier to see if it helps grow bone better than a standard titanium mesh. It may be an option if you need more jawbone for dental implants.
CairoAges 20–70 - NCT06560606Recruiting
Personalized medicine for childhood arthritis
This study creates a personalized medicine network to better understand and treat childhood arthritis. If you have JIA or unexplained joint inflammation, researchers will look at your biology to find the best treatment approach for you.
Calgary, AlbertaAges Up to 18 years - NCT06565520Recruiting
Brain stimulation for kneecap pain
This study tests whether a gentle brain stimulation technique can help improve how your knee moves when you have kneecap pain. It's for people whose kneecap pain has lasted at least 3 months and whose knee tends to cave inward.
Las Vegas, NevadaAges 18–45 - NCT06565910RecruitingPhase 4
Pain relief after hip surgery: long-acting vs standard numbing medicine
This study tests if a long-acting numbing medicine (bupivacaine liposome) combined with a standard numbing medicine works better for pain control after hip fracture surgery. It compares two different combinations to see which provides more effective pain relief.
Wuhan, HubeiAges 18–60 - NCT06566066Recruiting
Thyroid hormone resistance patient registry
This study creates a registry for people with thyroid hormone resistance caused by specific genetic mutations. It helps doctors collect data to better understand and treat the condition.
BerlinAges Any age - NCT06566950Recruiting
Blood flow training for leg muscle health in athletes
This study tests a training method that uses light blood flow restriction to improve leg muscle structure. It is for young athletes (ages 15–35) who play high-level sports like martial arts, basketball, soccer, or futsal at least twice a week.
Denpasar, BaliAges 15–35 - NCT06567301Recruiting
Shockwave vs. special gel for knee osteoarthritis pain
This trial compares two treatments for knee osteoarthritis: a shockwave therapy and a gel containing chitosan nanoparticles (tiny particles) applied with ultrasound. It uses AI to detect changes in knee tissues. The goal is to find which treatment better reduces pain and improves function.
Giza, El DokkiAges 40–60 - NCT06567470RecruitingPhase 2
Study of CIT-013 for rheumatoid arthritis
This trial tests a new medicine called CIT-013 for people with rheumatoid arthritis. It aims to see if CIT-013 can help reduce joint swelling and pain when added to your current treatment.
AntwerpAges 18 years+ - NCT06567535Recruiting
Nerve-sparing surgery for jaw cysts using a camera and navigation
This trial tests a new way to remove jaw cysts using a tiny camera and special guides, which may help protect the nerve in your jaw. It is for people with a tooth-related cyst at least 2 cm wide that is pushing on that nerve.
Guangzhou, GuangdongAges 18–75 - NCT06567886Recruiting
Fibromyalgia Sleep Study: A to ZZZ
This study tests a sleep program for people with fibromyalgia. You can join from home through video calls, and the goal is to see if better sleep helps with fibromyalgia symptoms.
Ann Arbor, MichiganAges 18 years+ - NCT06569472RecruitingPhase 1
CAR-T cell therapy for tough juvenile dermatomyositis
This trial tests a treatment using your own immune cells, modified to target a protein called CD19, for children and teens with juvenile dermatomyositis that hasn't gotten better with standard treatments. The goal is to see if this therapy can help calm the inflammation and improve symptoms.
Hangzhou, ZhejiangAges 5–17 - NCT06570291RecruitingPhase 3
Stem cell injection for knee osteoarthritis
This trial tests a new treatment using donor stem cells injected into the knee for people with moderate knee osteoarthritis. It aims to see if these cells can reduce pain and improve function.
Shanghai, ChinaAges 40–75 - NCT06570577Recruiting
Nerve block for pain after cervical spine surgery
This trial tests whether a nerve block can reduce the need for opioid pain medication after back-of-neck spine surgery. It may help patients have better pain control with fewer side effects.
Stony Brook, New YorkAges 18–75 - NCT06571110Recruiting
Acupuncture for opioid pain relief in fibromyalgia
This study tests whether getting real acupuncture helps people with fibromyalgia who are already taking daily opioid pain medicine, compared to fake acupuncture (sham). The goal is to see if acupuncture can improve pain and reduce the need for opioids.
Irvine, CaliforniaAges 18–80 - NCT06571344Recruiting
Vitamin D in dialysis patients
This trial checks if measuring vitamin D in dialysis patients can lead to better treatment, then gives vitamin D supplements to those who are low. It may help improve your bone and heart health.
GdanskAges 18 years+ - NCT06571734RecruitingPhase 2
XL092 for advanced sarcoma types
This trial tests an experimental drug called XL092 (zanzalintinib) for people with advanced leiomyosarcoma, bone sarcoma, or translocation-associated soft tissue sarcoma that has spread or cannot be removed by surgery. The drug is a type of targeted therapy that may stop cancer growth.
Chicago, IllinoisAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.