Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT06572696Recruiting
Shoulder Ultrasound in Rheumatoid Arthritis Without Pain
This study uses ultrasound to look for hidden shoulder problems in people with rheumatoid arthritis who have no shoulder pain. It aims to find early changes that might need treatment before pain starts.
IstanbulAges 18–75 - NCT06574191Recruiting
Knee osteoarthritis study: pain and health outcomes
This study looks at how knee pain from osteoarthritis affects your daily life and health. You'll use a topical anti-inflammatory gel and answer questions by text or email for two months.
Sacramento, CaliforniaAges 50 years+ - NCT06574165Recruiting
Pain, mood, and brain inflammation in veterans with fibromyalgia
This study looks at how brain inflammation and mood relate to pain in veterans with fibromyalgia. It may help find new ways to treat pain by understanding these connections.
Birmingham, AlabamaAges 19–85 - NCT06574282Recruiting
Better diagnosis for hypophosphatasia in rheumatology patients
This study aims to find better ways to diagnose hypophosphatasia (HPP) in adults who see a rheumatologist. If your doctor suspects HPP and you have a low ALP blood test, you may be able to help researchers develop a screening tool.
Bonn, North Rhine-WestphaliAges 18 years+ - NCT06574594Recruiting
Testing shingles vaccine response when stopping methotrexate in RA
This trial looks at whether pausing methotrexate (a common RA medication) affects how well the shingles vaccine (Shingrix) works for people with rheumatoid arthritis. It may help decide if stopping methotrexate temporarily can improve vaccine protection.
SeoulAges 19 years+ - NCT06576557Recruiting
Exercise and education for knee pain from meniscal tear
This study tests whether a special exercise and education program, designed by experts, can help people with knee pain from meniscal tears or early arthritis feel better and move better. It is run by a university and involves working with your GP and a physiotherapist.
Tralee, KerryAges 35–69 - NCT06577350Recruiting
Bone and muscle health in axial spondyloarthritis
This study looks at bone and muscle health in people with axial spondyloarthritis. It compares their bone density and muscle strength to healthy volunteers to see if there is a link with a condition called osteosarcopenia.
AnkaraAges 18–65 - NCT06578000RecruitingPhase 1
Iontophoresis for tennis elbow pain
This trial tests whether a treatment called iontophoresis (using a mild electrical current to deliver medicine through the skin) can reduce pain in people with tennis elbow (lateral epicondylitis). If you have had elbow pain for at least 4 weeks and have not had recent treatments like injections or surgery, this study may be an option.
CairoAges 20–50 - NCT06578182RecruitingPhase 3
Can colchicine reduce knee or hip replacement?
This study tests whether a low-dose medicine called colchicine can lower the chance that people with knee or hip arthritis will need a joint replacement. If you have arthritis in your knee or hip and are not already scheduled for surgery, you may be able to join.
NijmegenAges 45–80 - NCT06579222Recruiting
Managing other health conditions in rheumatoid arthritis
This study looks at how to better manage health conditions like heart disease or diabetes in people with rheumatoid arthritis. Participants will work with their rheumatology clinic to improve overall health.
Waterloo, OntarioAges 18–80 - NCT06579261Recruiting
Shamanism for fibromyalgia pain relief
This study tests whether core shamanism (a type of guided meditation and energy work) can help reduce pain in women with fibromyalgia. If you join, you would receive shamanic treatments up to twice a week at the study site in California.
Irvine, CaliforniaAges 18–75 - NCT06579599Recruiting
Preventing surgical issues with a doctor-nurse team
This study tests whether a new team approach—where doctors and nurses work closely together in the operating room—can help prevent problems during orthopedic surgery. If you are having surgery for a bone or joint issue at this hospital, you may be able to join.
Yiwu, ZhejiangAges 18–70 - NCT06579547Recruiting
Testing MRI instead of CT for joint imaging
This study tests if a new, radiation-free MRI method can replace standard CT scans for checking joint problems like arthritis. You would get both an MRI and a CT scan, and researchers compare the results to see if the MRI works just as well without radiation.
ZurichAges 18 years+ - NCT06579560Recruiting
Hearing and balance testing in fibromyalgia
This study looks at hearing and balance problems in people with fibromyalgia. It may help understand if fibromyalgia affects the inner ear.
Asyut, Asyut GovernorateAges 15–50 - NCT06580561Recruiting
Exercise and insomnia treatment for knee pain
This study combines a gentle exercise program with a treatment for insomnia to see if it helps older adults with knee osteoarthritis feel less pain and sleep better. You will attend group exercise classes and receive sleep coaching.
Ann Arbor, MichiganAges 50 years+ - NCT06581562RecruitingPhase 1
Testing rituximab plus AB-101 for autoimmune diseases
This trial tests a new treatment (AB-101) combined with rituximab for people with certain autoimmune diseases like rheumatoid arthritis, pemphigus vulgaris, vasculitis, or lupus. It is for those who have not had success with standard therapies.
Plantation, FloridaAges 18 years+ - NCT06581978Recruiting
Early warning for foot health in children
This study looks at the health of children's feet and aims to spot early signs of foot problems. It may help guide how to prevent issues like flat feet.
Guangzhou, GuangdongAges 6–18 - NCT06583980Recruiting
Study for people with arthritis who want better symptom control
This trial is testing a new approach to help people with arthritis who are not satisfied with their symptom control. It may be a good fit if you have rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis and are still struggling with fatigue, pain, or how the disease affects your daily life.
FrederiksbergAges 18–100 - NCT06586281Recruiting
Guselkumab for psoriasis arthritis and fatty liver
This study looks at whether the drug guselkumab can help people who have both psoriatic arthritis and non-alcoholic fatty liver disease (NAFLD). If you are starting guselkumab for your psoriatic arthritis and have a fatty liver, you may be able to join.
San Diego, CaliforniaAges Any age - NCT06587035Recruiting
Study of somatrogon for pediatric growth hormone deficiency in India
This study looks at how well somatrogon works for children 3 years and older with growth hormone deficiency. It may help you understand if this treatment is an option for your child.
Bengaluru, KarnatakaAges 3–17 - NCT06587412Recruiting
Shock Wave Therapy for Chronic Tennis Elbow
This trial tests if shock wave therapy can help people with long-term tennis elbow (pain on the outside of the elbow lasting more than 3 months). The treatment is a non-invasive option that may reduce pain and improve function.
Alcalá de Henares, MadridAges 18–70 - NCT06587399Recruiting
Manual Therapy vs. Shock Waves for Shoulder Pain
This study compares two non-surgical treatments—manual therapy (hands-on techniques) and radial shock wave therapy (sound wave pulses)—to see which works better for long-lasting shoulder pain. It may be a good fit if your pain is from a common cause called impingement syndrome.
Alcalá de Henares, MadridAges 18–80 - NCT06587724Recruiting
Testing a questionnaire for myositis
This study is testing a new questionnaire called the BETY-BQ to see if it is a good tool for measuring how well people with myositis are doing—things like symptoms and function. The goal is to make it easier for doctors to track your progress over time.
Ankara, AltındağAges 18 years+ - NCT06587828Recruiting
Looking at immune cells in people with autoimmune disease
This study collects blood, tissue, and other samples from people with autoimmune diseases like Crohn's disease, multiple sclerosis, or lupus. Researchers will study your immune cells (T cells) to learn what they are attacking, which could lead to better treatments in the future.
Orange, CaliforniaAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.