Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT06842355RecruitingPhase 2
TYRA-300 for children with achondroplasia (BEACH301)
This study tests an experimental oral medication (TYRA-300) for children with achondroplasia, a common form of dwarfism. The goal is to see if it can safely improve growth in children whose growth plates are still open.
Torrance, CaliforniaAges 3–10 - NCT06844214RecruitingPhase 1/Phase 2
Gene therapy trial for myotonic dystrophy type 1
This trial tests a one-time gene therapy (SAR446268) for people with non-congenital myotonic dystrophy type 1. It aims to see if the treatment is safe and can improve muscle symptoms like stiffness and weakness.
Gainesville, FloridaAges 10–55 - NCT06259890Recruiting
Salt intake and arthritis study
This study tests whether the amount of salt you eat affects inflammation and symptoms in people with certain types of arthritis (ankylosing spondylitis or psoriatic arthritis). You will be asked to follow a specific sodium diet and have some checkups to see how your arthritis responds.
BesançonAges 18–80 - NCT06839469Recruiting
Walking study for rare muscle and nerve conditions
This study looks at how children and teens with Duchenne muscular dystrophy (DMD) or spinal muscular atrophy (SMA) walk, by having them do walking tests while wearing sensors. The goal is to find better ways to track how these diseases progress and how treatments work over time, without needing blood tests or scans.
Palo Alto, CaliforniaAges 5 years+ - NCT06842849Recruiting
Exercise program for adults over 59
This study looks at how a physical exercise program can help adults over 59 in rural areas. You would wear a small activity tracker for one week and join a simple exercise routine.
ValenciaAges 59 years+ - NCT06844643Recruiting
Axial spondyloarthritis progression study in China
This study tracks how axial spondyloarthritis progresses over time in Chinese patients. It helps doctors understand the natural course of the disease and improve care.
BeijingAges 18 years+ - NCT06842316Recruiting
Study on cannabis-like compounds for inflammatory arthritis
This trial tests whether plant-based compounds similar to cannabis (called phytocannabinoids) can help calm inflammation and improve immune function in people with certain types of arthritis or autoimmune diseases like lupus or Sjögren's disease. It aims to offer a new way to treat these conditions without the 'high' of marijuana.
OrléansAges 18 years+ - NCT06836934Enrolling by invitation
Knee brace vs. wedge for osteoarthritis
This study compares two non-surgical options—a soft knee brace vs. a lateral wedge shoe insert—to see which better relieves pain and improves function in people with knee osteoarthritis. If you're between 40 and 60 and have pain on one side of your knee, this study may help you find better relief.
Giza, Giza GovernorateAges 40–60 - NCT06845735Recruiting
Comparing two types of stitches for hip surgery closure
This trial compares two types of stitches (absorbable vs. non-absorbable) used to close the hip capsule during hip arthroscopy, to see if one leads to better recovery. If you need hip arthroscopy for a hip problem, you may be able to join.
Columbia, MissouriAges 18 years+ - NCT06842017Enrolling by invitation
Shoulder exoskeleton trial for physically demanding jobs
This trial tests a wearable shoulder support device to help people with shoulder conditions do physically demanding jobs with less pain and strain. It may be a good fit if you have a shoulder problem and work in a job that requires frequent arm use.
Rome, ItalyAges 18 years+ - NCT06841562Recruiting
Home Exercise and Anti-inflammatory Program for Early RA
This study tests if a home-based exercise program, combined with anti-inflammatory strategies, can help people newly diagnosed with rheumatoid arthritis manage their symptoms and improve health. It's a remote program, so you can participate from home.
Durham, North CarolinaAges 18 years+ - NCT05200715Recruiting
Registry study for inherited and inflammatory eye and joint diseases
This study is a registry, meaning it collects your medical information to better understand several inflammatory (auto-inflammatory) conditions. It may help doctors and researchers improve diagnosis and future treatments for people with these disorders.
AlgiersAges Any age - NCT06538792Recruiting
Proprioception and strength after ACL reconstruction
This study looks at how well people regain body awareness, muscle strength, and fear of movement after ACL knee surgery. It may help understand recovery patterns in the first year after surgery.
IstanbulAges 18–35 - NCT06769633RecruitingPhase 2
Study of givinostat in young boys with Duchenne muscular dystrophy
This trial tests an experimental drug called givinostat in boys ages 2 to under 6 years with Duchenne muscular dystrophy (DMD). The study looks at how the drug works in the body and if it is safe, with the goal of finding new treatment options for young children.
BrusselsAges 2–6 - NCT06831331Enrolling by invitation
Diet and nutrition for newly diagnosed rheumatoid arthritis
This study tests whether a special diet can help manage symptoms of newly diagnosed rheumatoid arthritis. It aims to see if eating certain foods can reduce inflammation and improve your overall health.
GothenburgAges 18–85 - NCT06832878RecruitingPhase 4
Tranexamic Acid Pills After Hip Replacement
This study tests whether taking tranexamic acid (TXA) pills after hip replacement can reduce bleeding and the need for blood transfusions. It is for people having a first-time hip replacement due to severe arthritis who stay one night in the hospital.
Scottsdale, ArizonaAges 18 years+ - NCT06831045Recruiting
Bikini vs Straight Incision for Hip Replacement
This study compares two types of skin cuts (a bikini-line incision vs a straight side incision) for total hip replacement through the front of the hip. It is designed for people with a BMI of 30 or higher to see which incision heals better and leads to fewer wound problems.
Miami, FloridaAges 18 years+ - NCT06834230RecruitingPhase 4
Testing dotinurad for high uric acid in people with high blood pressure
This study tests a medicine called dotinurad to see if it helps lower high uric acid levels in people who also have high blood pressure. It may be an option if you have not taken uric acid lowering drugs recently or have been off them for over 27 days.
Saga, Saga-kenAges 20 years+ - NCT06828042RecruitingPhase 1/Phase 2
CAR-γδT cells for refractory autoimmune diseases
This trial tests a new type of immune cell therapy (CAR-γδT cells) that targets a protein called CD19 on your own B cells. It is for people with certain autoimmune diseases that have not gotten better with standard treatments. The goal is to see if this therapy can safely control the disease.
BeijingAges 18–80 - NCT06830655Enrolling by invitation
Climbing performance and body factors study
This study looks at how mobility, balance, and fatigue affect climbing performance. If you are a healthy climber, you may help researchers understand what makes a better climber.
Gdansk, GdańskAges 15–45 - NCT06828159Recruiting
Can wild blueberries improve joint health?
This study tests whether eating wild blueberries can improve joint health in people with arthritis. You would eat blueberries or a placebo daily for several weeks to see if they help with pain and stiffness.
Oklahoma City, OklahomaAges 40–75 - NCT06833372Recruiting
Shock wave therapy for knee arthritis
This trial tests if shock wave treatment can reduce knee pain from osteoarthritis. It may help people with moderate knee arthritis who haven't had recent physical therapy or joint injections.
BariAges 45–80 - NCT06831422Recruiting
Antimicrobial Wash During Shoulder Replacement
This study tests whether washing the surgical site with a special antimicrobial liquid after the incision can lower the risk of infection during shoulder replacement surgery. It may help people who are already planning a first-time shoulder replacement.
Detroit, MichiganAges 18 years+ - NCT05378815Recruiting
Platelet injections for knee arthritis pain
This study tests whether platelet-rich plasma (a treatment made from your own blood) can reduce symptoms of knee osteoarthritis. It focuses on people with specific types of knee pain and X-ray findings, and compares against rules around current pain medicines and injections.
Créteil, Val-De-MarneAges 40–79
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.