Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT06265636Recruiting
Nerve stimulation for jaw pain and function in TMD
This trial tests whether gentle electrical stimulation of a nerve in your jaw can reduce pain and improve chewing, talking, and mouth opening for people with temporomandibular joint disorder (TMD).
Alcorcón, MadridAges 18–65 - NCT06723106Enrolling by invitationPhase 1
Long-term safety study of RAY121 for immune conditions
This study is for people who already took RAY121 in a previous trial and did well. It tests whether continuing the treatment is safe and effective over a longer period. The goal is to manage chronic immune conditions.
Camperdown, New South WalesAges 18–85 - NCT06726096Enrolling by invitationPhase 3
Trial of VDJ001 for moderate to severe rheumatoid arthritis
This trial tests a new medicine called VDJ001 for people with moderate to severe rheumatoid arthritis who are already taking methotrexate. The goal is to see if VDJ001 helps reduce joint pain and swelling better than a placebo.
Beijing, Beijing MunicipalityAges 18–75 - NCT06720948Enrolling by invitation
ION facet screw system outcomes study
This study looks at how well the ION facet screw system works in people who already had the surgery for neck or lower back pain. It checks their progress and safety over time to see if the procedure helps them.
Fort Wayne, IndianaAges 21–80 - NCT05443100Recruiting
Testing whole-body cold therapy for metabolic, neurologic, or fibromyalgia pain
This trial studies whether a whole-body cold therapy called “WBC” can help people with certain metabolic conditions, neurologic conditions, or fibromyalgia. You may be able to join if you meet age and weight requirements and don’t have certain medical or safety risks.
Oggebbio, Verbano-Cusio-OssolaAges 18–65 - NCT06724029Recruiting
Neurosurgery outcomes research for multiple conditions
This study collects data from people having brain or spine surgery for many different conditions. It aims to understand how well different treatments work and how people recover. If you are scheduled for certain brain, spine, or nerve surgeries, you may be able to join.
Bergamo, BGAges 18 years+ - NCT06718296Recruiting
Photographic Shoulder Pain Scale Study
This study is creating a new way to measure shoulder pain using pictures. It is for people who have had shoulder pain for more than 3 months, whether from an injury or other causes.
IstanbulAges 18–64 - NCT06716931Recruiting
Exercise study for myotonic dystrophy type 2
This study tests if a structured exercise program is safe and helpful for people with myotonic dystrophy type 2 (DM2). It aims to improve strength and daily function.
Boston, MassachusettsAges 18–70 - NCT06724224Recruiting
Comparing thyroid hormone drugs for babies with low thyroid
This study compares two types of levothyroxine (a thyroid hormone medicine) to see which works better for newborns and children with congenital hypothyroidism (a condition where the thyroid gland doesn't work properly from birth). If your child was diagnosed early and lives in the Emilia-Romagna region of Italy, this trial may help find the best treatment.
Bologna, BolognaAges Up to 11 years - NCT06721299RecruitingPhase 1
Testing clenbuterol for muscle health in FSHD
This study tests a medication called clenbuterol to see if it can reduce activity of the DUX4 gene, which is believed to cause muscle damage in FSHD. If you have FSHD type 1 or 2, you may be able to join and help researchers understand if this drug can improve muscle health.
Kansas City, KansasAges 18–75 - NCT06718569Recruiting
Pain in Inflammatory Joint Diseases
This study looks at pain in people with inflammatory joint diseases. It aims to understand how pain changes when you start or switch to a newer type of arthritis medication.
OsloAges 18 years+ - NCT06725823Recruiting
Shoulder block comparison for frozen shoulder pain relief
This study tests two types of nerve blocks for frozen shoulder. It will see if one works better than the other to improve movement and reduce pain.
SohagAges 19–65 - NCT06724562Recruiting
Anti-IL1 therapy for severe FOP flare-ups
This trial is for people with FOP who have severe, frequent flare-ups. It follows those who are already starting an anti-IL1 medication (like anakinra) to see if it helps reduce flares and improve symptoms.
San Francisco, CaliforniaAges 6–30 - NCT06725199Enrolling by invitation
NMR metabolomic study in fibromyalgia
This study uses a special MRI-like test (NMR) to look at chemical changes in the body of people with fibromyalgia. It aims to better understand the condition and could help find new ways to diagnose or treat it.
Istanbul, IstanbulAges 18–65 - NCT06724497Enrolling by invitationPhase 1/Phase 2
Comparing 3D face scan methods for jaw surgery patients
This trial tests whether using a handheld 3D scanner is as accurate as a standard optical scanner for predicting soft tissue changes after corrective jaw surgery. It aims to find a more convenient and accessible way to plan surgery for patients with an underbite.
Cairo, Giza GovernorateAges 18–50 - NCT06720272Recruiting
School program to prevent rheumatic heart disease
This study tests whether a program in schools can help prevent rheumatic heart disease in children. If your child is between 5 and 16 years old and attends a participating school, they may be able to join.
KathmanduAges 5–16 - NCT06722482Recruiting
Comparing bone grafts for front tooth implants
This trial compares two types of bone graft materials used when a front tooth is removed and replaced with a dental implant. It aims to see which works better for healing and long-term success.
Rochester, New YorkAges 18 years+ - NCT06726434Recruiting
Comparing freezing vs. surgery for foot spasticity after stroke
This trial compares a freezing procedure (cryoneurotomy) with standard surgery to treat foot stiffness after a stroke. It aims to see which method better corrects the foot turning inward and downward, helping you walk more easily.
GarchesAges 18 years+ - NCT06726629Recruiting
Italian Knee Questionnaire Study
This study is testing a new Italian version of a questionnaire that measures how your knee feels and works after knee replacement. The goal is to make sure the questionnaire is accurate for Italian-speaking patients.
BolognaAges 18–85 - NCT06720142Recruiting
Magnesium bone filler study after tumor or trauma surgery
This study looks at how well a magnesium-based bone filler (Mg OSTEOCRETE) works for people who need it after bone tumor removal, to fix loose implants, or to help heal bone from injuries. Researchers want to track outcomes to see how helpful it is.
Boston, MassachusettsAges 18 years+ - NCT06714110Enrolling by invitation
Review of Limb Lengthening with Precice Nail or External Fixator in Children
This study looks back at records of children, age 12 or younger, who had surgery to lengthen a leg bone using the Precice nail or an external fixator. The goal is to understand how well these treatments work for kids with a leg length difference of at least 2 cm.
West Palm Beach, FloridaAges birth–12 years - NCT06709040Enrolling by invitation
Long-term safety of somapacitan in children with growth hormone deficiency
This study is watching children who are already taking somapacitan (a growth hormone injection) to see if it is safe over a long time. It collects information about growth and any side effects.
Glasgow, ScotlandAges Up to 18 years - NCT04445545Recruiting
Laser treatment for tight neck trigger points
This trial tests whether high-intensity laser therapy applied to specific “trigger points” in the neck muscles can help people with painful tight spots. You may be eligible if you have those trigger points and meet safety rules about recent neck/shoulder problems and skin and nerve conditions.
Santiago, Las CondesAges 18 years+ - NCT05700682Recruiting
MRI-guided artery blockage procedure for long-term joint pain
This study tests whether an MRI scan that looks at blood flow can help target a joint embolization procedure to reduce chronic shoulder, hip, or knee pain. It first uses MRI to find signs of increased blood flow, then may use the findings to guide treatment if you qualify.
Palo Alto, CaliforniaAges 25–80
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.