Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT05037968Recruiting
Test bone graft materials for multi-level back fusion surgery
This trial compares two bone-graft materials to help bones heal after back fusion surgery using a rod/screw system. It may help people who have ongoing back or leg pain despite at least 3 months of non-surgical treatments.
Hartford, ConnecticutAges 18 years+ - NCT07688876Recruiting
Comparing two treatments for long-term heel pain
This trial tests two minimally invasive procedures—pulsed radiofrequency and a dextrose injection—to see which better relieves chronic heel pain from plantar fasciitis that hasn't improved with other treatments.
AnkaraAges 18–70 - NCT04895956RecruitingPhase 4
Compare injection into versus outside the tendon sheath
This study compares two ways of giving an injection to treat De Quervain’s tenosynovitis (pain and swelling near the thumb). If you qualify, you may receive one of the injection approaches to help reduce pain.
Sacramento, CaliforniaAges 18 years+ - NCT07293871Recruiting
Ultrasound treatment for rheumatoid arthritis
This trial tests whether ultrasound waves applied to the spleen can reduce inflammation in adults with rheumatoid arthritis. It is for people with moderate to severe disease who have not tried many biologic medications.
Colleyville, TexasAges 18 years+ - NCT07414745RecruitingPhase 3
Study of a bone graft for two-level lower back fusion
This trial tests a special material (rhBMP-2) placed inside a cage to help two nearby vertebrae in the lower back fuse together. It is for patients whose disc problems or deformity have not improved after at least 3 months of other treatments, and who have significant pain and limited function.
Kobe, HyōgoAges 18–80 - NCT07688902Recruiting
Comparing two injection methods for partial rotator cuff tears
This study compares two ways of injecting a sugar-water solution (5% dextrose) into the shoulder to treat partial rotator cuff tears. It may help reduce pain and improve shoulder function without surgery.
AnkaraAges 18–75 - NCT07688915Recruiting
High-intensity laser vs. steroid injection for chronic back and leg pain from a herniated disc
This study compares two treatments for long-lasting low back and leg pain caused by a herniated disc: high-intensity laser therapy and a steroid shot near the spine. Researchers want to see which option works better to reduce pain.
AnkaraAges 18–65 - NCT06855433RecruitingPhase 2
Colchicine for CPPD: reducing pain and inflammation
This trial tests if colchicine can reduce pain and swelling in people with CPPD (calcium pyrophosphate deposition disease), a type of arthritis. If you have had a swollen, red, or warm joint in the last 3 months and your pain is moderate or higher, this study may offer a possible treatment.
Birmingham, AlabamaAges 40 years+ - NCT07685418Recruiting
Pressure therapy and home exercises for neck pain
This trial tests whether a hands-on technique called ischemic compression (applying gentle pressure to trigger points) plus home exercises helps relieve long-term neck pain that has no specific medical cause.
Istanbul, BakırköyAges 17–65 - NCT06246123Recruiting
Jyseleca tablet safety study in Korean patients
This study tracks Korean patients already taking Jyseleca for rheumatoid arthritis or ulcerative colitis, making sure it's safe and working as expected. It's not testing a new drug, just watching how patients do over time.
Cheonan, Chungcheongnam-doAges 18 years+ - NCT07291388Recruiting
Retrolaminar block for lumbar fusion with multimodal pain control
This study tests whether adding a retrolaminar block (a type of back injection) to standard pain medicines helps reduce pain after lumbar spine fusion surgery. It may help you recover with less need for strong painkillers.
Santiago, Santiago MetropolitanAges 18–75 - NCT03506334Enrolling by invitation
Tether surgery to treat pediatric spine curvature
This study looks at a surgical method (an “anterior vertebral body tether”) to help straighten the spine in growing children with certain types of scoliosis. It aims to see how well the tether system works over the next 2 years, compared with expected progress without the surgery.
Rochester, MinnesotaAges 10–16 - NCT07247825Recruiting
Needle treatment for shoulder tendon pain: single vs multi-filament
This study tests two types of a needle-based treatment (percutaneous electrolysis) for shoulder tendon pain. It aims to see if a single-filament or multi-filament approach works better for people with chronic supraspinatus tendon issues.
SalamancaAges 18–65 - NCT07158554Recruiting
Emergency department test for muscle damage after a fall
This study looks at patients who come to the emergency department after a fall and have a specific type of muscle injury. Researchers want to learn more about how to quickly identify this injury so doctors can offer the best care.
Westcliff-on-Sea, EssexAges 60 years+ - NCT07688863Enrolling by invitation
Comparing breathing muscle training methods for heart failure
This trial compares two different types of breathing muscle training to see which works better for people with heart failure and weak breathing muscles. You may join if you have heart failure with reduced pumping ability and are stable overall.
Viña del Mar, ValparaisoAges 18 years+ - NCT07290036RecruitingPhase 1
Testing different ways to give bimekizumab for psoriatic arthritis or axial spondyloarthritis
This study looks at whether giving bimekizumab in different ways is safe and how it moves through the body over time. It is for adults with active psoriatic arthritis or axial spondyloarthritis who may benefit from bimekizumab treatment.
Peoria, ArizonaAges 18 years+ - NCT06906939RecruitingEarly Phase 1
Brain stimulation and tai chi for knee arthritis and depression
This pilot study tests if combining brain stimulation (rTMS) with Tai Chi can help knee arthritis pain and improve depression. It compares these two treatments to see which works better for people with both pain and low mood.
Los Angeles, CaliforniaAges 50–95 - NCT07428070Recruiting
Exercise program for rotator cuff shoulder pain
This trial tests if a specially designed exercise program can reduce shoulder pain related to the rotator cuff. It may help if you've had shoulder pain for more than three months.
IstanbulAges 18–75 - NCT06708377Recruiting
Dry needling and massage for jaw joint pain
This trial tests whether dry needling combined with myofascial massage therapy can help relieve pain and improve jaw movement in people with temporomandibular joint (TMJ) dysfunction. It compares this treatment to standard care to see which works better.
Islamabad, FederalAges 25–45 - NCT06708468Recruiting
Personalized training for rare neuromuscular disorders
This study tests a personalized exercise program for people with rare neuromuscular diseases like FSHD, DM1, or CMT to see if it improves their physical function and quality of life.
BergenAges 18–70 - NCT06709391Recruiting
Spinal fusion vs. no surgery for chronic low back pain
This trial tests whether a spinal fusion surgery is better than staying with non-surgical treatments for people with long-term, severe low back pain from worn-out discs in the lower spine. It aims to find out which approach offers better pain relief and quality of life.
GothenburgAges 25–65 - NCT06713902Recruiting
Extracellular vesicles in fibrin gel for cartilage repair
This trial studies whether adding special healing particles (extracellular vesicles) to a natural gel can help repair cartilage in people with knee or hip osteoarthritis. It looks at patients already scheduled for surgery or regenerative treatments like PRP.
Milan, MIAges 18 years+ - NCT06716281RecruitingPhase 3
Stem cell injection for knee osteoarthritis
This study tests a new stem cell treatment for knee osteoarthritis. It aims to see if injecting these cells into the knee can reduce pain and improve function compared to other treatments.
ShanghaiAges 40–80 - NCT06716931Recruiting
Exercise study for myotonic dystrophy type 2
This study tests if a structured exercise program is safe and helpful for people with myotonic dystrophy type 2 (DM2). It aims to improve strength and daily function.
Boston, MassachusettsAges 18–70
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.