Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,832 recruiting studies in this area right now.
By phase
- Not applicable3,967
- Phase 2222
- Phase 4195
- Phase 1191
- Phase 3151
- Phase 1/Phase 273
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee73
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain34
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California208
- New York94
- Florida80
- Arizona76
- Massachusetts76
- Maryland73
- Texas64
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,832 total
- NCT05902221RecruitingPhase 3
Rifampicin add-on for knee, hip, or shoulder implant infections
This Phase 3 trial tests whether adding rifampicin improves outcomes for implant infections caused by a specific germ (Cutibacterium acnes) after surgery. If you have such an infection and the germ is susceptible, you may be able to receive a rifampicin-based treatment plan.
AnnecyAges 18 years+ - NCT05721859Recruiting
Study of a hip implant viewing feature during revision surgery
This study checks how well a specific hip implant component (the M‑Vizion femoral component) can be used during revision total hip replacement. It aims to see whether the implant’s intended design works reliably for patients who need hip revision surgery.
Chicago, IllinoisAges 21–80 - NCT05704751Recruiting
Test of targeted nerve stimulator placement for long-term back pain
This study tests a way to place and program a spinal cord stimulator to reduce long-term (chronic) back pain. It’s for people whose back pain has lasted at least 6 months and is severe enough to measure.
LondonAges 18–75 - NCT05436600Recruiting
Exercise program for people with narrowed neck arteries
This trial studies whether a supervised exercise program can improve mobility and balance in people who have narrowed carotid arteries in the neck but no stroke symptoms. If you fit the criteria, the goal is to see whether exercise helps your movement and safety without increasing risks.
Baltimore, MarylandAges 18–89 - NCT05542069Recruiting
Training with a breathing device measured in healthy adults
This study measures how the diaphragm (main breathing muscle) works while you do breathing training using a special breathing device (IMT). It’s done in healthy adults to better understand how the training affects breathing.
Buenos AiresAges 18 years+ - NCT05314491Recruiting
Follow-up study after knee replacement with a specific implant
This study follows people after they get a total knee replacement using the Multigen Plus system, sometimes with special cone pieces. It looks at how well the implant performs over time and whether results meet expectations.
GuimarãesAges 18 years+ - NCT05595148Enrolling by invitation
Earlier vs later walking after certain bone fractures
This study compares starting to put weight on your injured leg sooner versus waiting before walking. It aims to see which approach is safer and helps recovery after specific pelvic, hip, knee, and ankle fractures treated with surgery.
Baltimore, MarylandAges 18 years+ - NCT05334862Recruiting
8-plate surgery study for pediatric knock-knees after correction
This trial looks at children who have had surgery to correct knock-knees (genu varum) and may still have a remaining twist or shape problem. It tests a specific growth-modifying technique (an 8-plate hemi epiphysiodesis) to help improve bone alignment as the child grows.
Asyut, Asyut GovernorateAges 2.5 years–12 years - NCT05378841Recruiting
Surgery to reduce pain in finger osteoarthritis
This trial tests whether surgical “nerve disconnection” (joint denervation) can reduce pain from osteoarthritis in a finger joint. It focuses on people who have ongoing finger pain despite usual treatments for at least 3 months.
ParisAges 18 years+ - NCT05447819Recruiting
Shoulder replacement for worn rotator cuff joint
This trial studies a specific type of reverse shoulder implant to improve shoulder function after severe joint wear. It’s for people whose shoulder pain and loss of function did not improve enough with non-surgical treatments and who need shoulder arthroplasty.
Hellerup, DenmarkAges 50 years+ - NCT05395767Recruiting
Living-donor tendon graft for ACL repair in teens
This study tests whether an ACL reconstruction using a tendon from a living donor works well and is safe in children and teens. It may help families compare this approach while closely tracking knee function after surgery.
Pembury, KentAges 8–17 - NCT05580315Recruiting
Study of treatment for a painful discoid meniscus in children
This trial is for children who have a painful discoid meniscus (a cartilage in the knee) confirmed by an orthopedic exam and MRI. It tests whether a specific study approach can help symptoms in children, while avoiding people who may need different knee treatments.
LeuvenAges 1–18 - NCT05351112Recruiting
Shoulder fracture replacement study for adults using a Zimmer Biomet system
This trial studies how safe and well a specific shoulder replacement system works after certain serious shoulder injuries or failed prior treatments. You may be considered if you need shoulder surgery for complex proximal humerus fractures or related post-injury problems, and you can return for follow-up visits.
SalamancaAges 18 years+ - NCT05614908Enrolling by invitation
Testing outcomes after non-surgical Achilles tendon rupture care
This trial looks at how well people do after an Achilles tendon rupture when they are treated without surgery. It may help improve recovery guidance for others by comparing outcomes based on how care is followed.
AarhusAges 18 years+ - NCT05332249Recruiting
Registry for Degenerative Spine Disease in the Neck and Low Back
This study is a registry (a way to collect health information) for people with wear-and-tear (“degenerative”) problems in the neck and/or low back. It may help doctors better understand these conditions and improve future care plans.
Seoul, KoreaAges 18–100 - NCT05407194Recruiting
Collagen and vitamin C for jumper’s knee pain
This trial tests whether taking collagen plus vitamin C can improve “jumper’s knee” pain in active teens and young adults. It compares a supplement plan to see if symptoms and sports ability improve over time.
Ede, GelderlandAges 16–40 - NCT05287646Recruiting
Track how your residual limb moves while walking with a prosthesis
This study uses a special X-ray and markers to measure how your leg and skin move inside your prosthetic socket while you walk. It may help researchers better understand fit and comfort for people with transtibial (below-knee) amputations.
New York, New YorkAges 18 years+ - NCT05516381Recruiting
Navigation-assisted knee replacement with two alignment methods
This study tests a computer-guided technique for total knee replacement and compares two ways of aligning the new joint. It may help improve how accurately the surgery is done, which could affect comfort and function afterward.
BarcelonaAges 18 years+ - NCT05590494Recruiting
New treatment for partial rotator cuff shoulder tears
This trial tests a new approach for people with a partial (not full) tear of the rotator cuff, found on MRI. It may help improve shoulder function if your tear matches the study’s specific size and location rules.
Onalaska, WisconsinAges 25–75 - NCT05619588Recruiting
Long-term follow-up for a new ankle replacement (U.S. only)
This study checks how well an Exactech total ankle replacement works over many years. You may be asked to complete follow-up forms for up to 10 years to help track safety and outcomes.
Jacksonville, FloridaAges 21 years+ - NCT05611775Recruiting
Spinal surgery patients tracked for daily activity after surgery
This trial follows adults who are getting a multi-level spinal deformity correction surgery with special pelvic attachment. It looks at how well you return to real-life function and activity after surgery using follow-up visits at Mayo Clinic.
Rochester, MinnesotaAges 18 years+ - NCT05343286Recruiting
Personalized exercise plan for older adults
This study looks for health “signals” that can help tailor a physical activity program for people aged 60 and older. It may help decide which exercise approach works best for different individuals over time.
NiceAges 60 years+ - NCT07107581Enrolling by invitation
Exactech knee replacement follow-up study
This study is following patients who have or will receive an Exactech total knee replacement. It looks at how well the knee works over time and helps doctors understand long-term results.
DeLand, FloridaAges 18 years+ - NCT05400798Enrolling by invitation
Study of injected regenerative cells for rotator cuff tears safety
This study checks the long-term safety of an injection made from your own fat cells for people with a chronic rotator cuff tear. It is mainly focused on monitoring side effects and outcomes over time.
Phoenix, ArizonaAges 30–75
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,832 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,923 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.