Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT07785401Recruiting
Platelet-rich plasma plus hyaluronic acid for knee osteoarthritis
This study tests whether adding platelet-rich plasma (PRP) to hyaluronic acid injections improves knee osteoarthritis pain and function better than hyaluronic acid alone. You may be eligible if you have moderate knee osteoarthritis and no other knee problems.
Warsaw, Masovian VoivodeshipAges 18 years+ - NCT06538974Recruiting
Long-term use of an exoskeleton for leg weakness
This trial tests a walking device called an exoskeleton to help people with leg weakness or movement problems. It's designed to see if using the exoskeleton regularly over time can help improve walking or mobility.
ParisAges 18 years+ - NCT04276181Recruiting
Nerve and tendon transfer surgery for hand function after spinal cord injury
This trial studies a specialized surgery that reroutes nerves and tendons to help restore hand and grip function after a spinal cord injury. It may help some people regain more useful hand movement if their arm muscle strength and nerve signals are strong enough.
MölndalAges 15–55 - NCT07781397Enrolling by invitation
Wearable vibration device for fall prevention in older adults
This study tests a new wearable device that uses gentle vibrations to help improve balance and prevent falls in older adults. If you qualify, you'll use the device during daily activities to see if it reduces fall risk.
Mansfield, TexasAges 55–85 - NCT07779070Recruiting
Supervised or home exercises for scoliosis in teens
This study compares two ways of doing scoliosis-specific exercises (Schroth exercises) to see if doing them at home works as well as doing them with a therapist. Teens with mild to moderate scoliosis may improve their posture and spine curve.
Siliviri, IstanbulAges 10–18 - NCT07775872Recruiting
Study of polg-related disease over time
This study follows people of all ages with a confirmed POLG-related disease to learn how the condition changes over time. The information collected may help design better care and future treatments.
San Diego, CaliforniaAges Any age - NCT07777757Recruiting
Robotic knee surgery: does implant type affect alignment accuracy?
This study compares two types of knee implants used during robotic-assisted surgery to see which one gives more accurate alignment. It may help find the best implant for your new knee.
Hong Kong, Sandy BayAges 18 years+ - NCT07778199Recruiting
Implant denture fitting: digital vs traditional dental impressions
This trial compares two ways of taking dental impressions (molds) for making a full-arch implant-supported denture. One method uses a digital scanner, the other uses traditional dental putty. The goal is to see if one results in a more comfortable and precise fit.
Al Mansurah, Dakahlia GovernorateAges 35–70 - NCT07780396Recruiting
Posture exercises for forward head posture
This study tests whether posture correction exercises improve the electrical activity of neck and jaw muscles in young adults with forward head posture. Participation may help you improve your posture and prevent future jaw or neck issues.
BeirutAges 18–30 - NCT07776327Recruiting
Therapy options for neck and shoulder pain
This study compares two treatments—positional release therapy and dry needling—for neck and shoulder pain caused by a tight muscle. It aims to see which one works better.
Karachi, SindhAges 18–40 - NCT07779278Enrolling by invitation
Custom implants for complex limb bone reconstruction
This trial tests custom-made metal implants to fix severe bone problems in the arms or legs, such as crooked bones, shortened bones, or missing pieces. The implant is designed just for you using a 3D computer model, and the goal is to help your bones heal in a better shape and work properly.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07782723Recruiting
Shock wave and blood-flow therapy for tennis elbow
This study tests two treatments for tennis elbow (lateral epicondylitis): shock wave therapy, which uses sound waves to help healing, and blood flow restriction therapy, which uses a cuff to increase blood flow during exercise. It aims to see if combining them works better than either alone, which might help reduce pain and improve your arm's function.
AnkaraAges 18–60 - NCT07776366Recruiting
Study of disc protein levels and disc wear
This study looks at a protein called periostin in the discs of the lower back to see if it relates to how worn down the discs are, which might help improve future treatments.
Daegu, DaeguAges 20–80 - NCT07779421Recruiting
Healing bone after wisdom tooth removal
This study tests whether using a patient's own blood products can help bone heal better after removing a wisdom tooth. It may help reduce the gap left behind and protect the nearby molar.
Fuzhou, FujianAges 18–60 - NCT06555237RecruitingPhase 2
MEK inhibitors for heart thickening in RASopathies
This trial tests a targeted drug (MEK inhibitor) to treat thickened heart muscle caused by a group of genetic conditions called RASopathies. It may help improve heart function in people with hypertrophic cardiomyopathy.
WarsawAges 1 day–18 years - NCT06265246Recruiting
Milk and yogurt for stronger bones in young adults
This study tests whether adding milk and yogurt to your diet can improve bone health and body composition. If you're a young adult with low calcium intake, you may qualify to join.
Saskatoon, SaskatchewanAges 19–30 - NCT06560606Recruiting
Personalized medicine for childhood arthritis
This study creates a personalized medicine network to better understand and treat childhood arthritis. If you have JIA or unexplained joint inflammation, researchers will look at your biology to find the best treatment approach for you.
Calgary, AlbertaAges Up to 18 years - NCT06516172Recruiting
The Bern Rehabilitation Registry for Chronic Conditions
This trial is creating a registry to study how people with chronic diseases benefit from rehabilitation programs. If you are an adult with a long-term health condition and have been referred to rehab, your data could help improve care for others.
Heiligenschwendi, Canton of BernAges 18 years+ - NCT06157268Recruiting
Study of muscle tiredness in congenital myopathies
This study follows patients with congenital myopathies to understand how their muscles get tired over time. It may help develop better treatments.
Nijmegen, GelderlandAges 2 years+ - NCT06562062Recruiting
New surgery for flexible flat foot
This study tests a modified surgical technique to fix a painful, flexible flat foot in adults who haven't improved with nonsurgical care. It may help by repairing a key ligament on the outside of the knee to support the arch.
Asyut, AssiuuAges 16–65 - NCT03910010Recruiting
Brain scan study to study pain-related body signals in fibromyalgia
This study uses MRI brain scans to look for body “signals” (biomarkers) that may relate to chronic pain, including fibromyalgia. It may help researchers better understand what’s going on in the brain for people with long-term pain.
Halifax, Nova ScotiaAges 18–75 - NCT06559605Recruiting
Comparing 3D Zirconia Barrier vs Titanium Mesh for Bone Growth
This study tests a new 3D-printed zirconia barrier to see if it helps grow bone better than a standard titanium mesh. It may be an option if you need more jawbone for dental implants.
CairoAges 20–70 - NCT05120492Recruiting
Program for severe knee arthritis and extreme weight
This feasibility study tests a practical approach to help people with very severe knee arthritis and very high body weight. It aims to find an effective and safe way to manage both conditions together in real-world care.
Halifax, Nova ScotiaAges 18–65 - NCT05658289Recruiting
Latarjet vs shoulder bone surgery after front dislocation
This trial compares two types of surgery that rebuild the front (anterior) shoulder bone when there has been significant bone loss. It may help find which operation works better to keep your shoulder from dislocating again.
Halifax, Nova ScotiaAges 16–40
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.