Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,832 recruiting studies in this area right now.
By phase
- Not applicable3,967
- Phase 2222
- Phase 4195
- Phase 1191
- Phase 3151
- Phase 1/Phase 273
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee73
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain34
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California208
- New York94
- Florida80
- Arizona76
- Massachusetts76
- Maryland73
- Texas64
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,832 total
- NCT06038240Recruiting
Pain self-management program for knee replacement
This study is testing a program to help people manage pain on their own before and after total knee replacement surgery. It aims to improve recovery and reduce reliance on pain medications.
Charlottesville, VirginiaAges 18–85 - NCT05785364Recruiting
Study of a hip implant used in total hip replacement
This study follows people who get a specific hip socket implant (the Mpact 3D Metal MonoCER) after total hip replacement. It’s mainly to monitor how the device is working in real-world use.
GenevaAges 18–75 - NCT05818891Recruiting
Study of a hip implant for people needing first hip replacement
This trial studies a specific hip implant (from Medacta) for people who need their first total hip replacement. It aims to see how well the implant works and whether patients recover mobility safely.
Dracy-le-FortAges 18–80 - NCT05641597Recruiting
Free fibula bone transfer study after reconstructive surgery
This study looks at how well a specific reconstructive operation works for a person’s daily function, especially after surgery that replaces part of bone using a healthy bone and blood supply. It may help the team understand what recovery and movement outcomes to expect after this procedure.
DijonAges 18 years+ - NCT05660031Recruiting
Biceps treatment during rotator cuff repair
This study looks at how to treat the biceps tendon when someone is getting surgery for a rotator cuff tear. It may help improve outcomes after surgery and recovery, especially when there is also a supraspinatus tear.
Ann Arbor, MichiganAges 50–80 - NCT05888064Recruiting
Imaging-guided personalized radiation for skull-base chordoma
This trial studies how detailed imaging can guide personalized (custom) radiation treatment for skull-base chordoma. It may help doctors plan treatment more accurately using measurements taken before and during therapy.
Pavia, PvAges 18 years+ - NCT05679427Recruiting
Surgery-like radiation for limited bone spread
This trial compares two types of highly focused radiation (ablative radiosurgery versus stereotactic radiation in 5 sessions) for people with a small number of metastases in the bone. It aims to find which approach controls these spots with fewer side effects while keeping the treatment “radical,” meaning trying to wipe out the targeted lesions.
Milan, MIAges 18–85 - NCT05788614Recruiting
Testing shoulder implant movement after reverse shoulder arthroplasty
This study looks at how the shoulder changes position (“reverts”) after a reverse shoulder replacement. It may help doctors better understand what to expect after surgery in people with certain age-related shoulder wear and tear.
Córdoba, CordobaAges 60 years+ - NCT05831696Recruiting
Compare walking effort with two types of prosthetic knees
This trial studies how much energy it takes to walk when using passive versus powered prosthetic knees. It may help people understand which knee type could make walking feel easier depending on their needs.
Loma Linda, CaliforniaAges 18–75 - NCT05774002Recruiting
Psychological check-in for teens getting back surgery for scoliosis
This study asks teens with idiopathic scoliosis to complete psychological assessments while planning for elective back surgery. It may help doctors better understand patients’ mental and emotional needs around surgery.
The Bronx, New YorkAges 10–19 - NCT05757609Recruiting
Brain stimulation therapy for chronic low back pain
This trial tests whether a non-invasive brain stimulation treatment can improve physiotherapy results for people with long-lasting low back pain. You may be asked to do questionnaires and follow a treatment plan, and some people may be able to reduce pain or improve function.
GenevaAges 18–65 - NCT05671614Recruiting
Prevent muscle stem cell failure after critical illness
This trial studies ways to improve recovery of skeletal muscle in people who have been very sick in the ICU. It focuses on preventing problems with the body’s muscle “repair cells” after critical illness.
Prague, Czech RepublicAges 18 years+ - NCT05699031Recruiting
Shoulder replacement recovery care by telehealth
This trial tests whether follow-up care by phone or video (telehealth) helps people recover better after a total shoulder replacement. It may be helpful by making rehab guidance easier to follow at home.
GhentAges 60 years+ - NCT05714007RecruitingPhase 4
Iron infusion for anemia after spinal deformity surgery
This trial looks at whether a specific iron infusion (ferric derisomaltose) can help treat anemia after spinal deformity surgery. You may be eligible if your blood counts show anemia soon after surgery and it’s likely due to iron deficiency.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05746650Recruiting
Study to improve healing after knee muscle-tendon repair
This study looks at how to improve healing at the muscle-tendon connection after knee reconstruction surgery. You may be able to join if you’re otherwise healthy, within a certain body-size range, and not using medicines that could change muscle or tendon healing.
CopenhagenAges 18–35 - NCT05847270Recruiting
Surgery for a neck bone dislocation that can’t be put back
This study looks at surgical treatment for a specific type of neck bone dislocation that cannot be corrected without surgery. It may help patients whose imaging and traction testing show they need an operation to stabilize the neck.
Beijing, Beijing MunicipalityAges Up to 80 years - NCT05780502Recruiting
Orthotic and rehab program for lower-limb musculoskeletal problems
This study tests an integrated brace (an exoskeletal orthosis) plus a rehabilitation plan for problems in the legs/lower limbs. It may help improve how you move and function while using a custom brace.
Charlotte, North CarolinaAges 18 years+ - NCT05882591Recruiting
Treating a specific inner-knee cartilage and meniscus problem
This trial looks at a treatment for a specific knee alignment and tissue problem inside the inner (medial) part of your knee. It may help people whose deep-squat knee pain is caused by rubbing (“impingement”) between the femur and the back part of the medial meniscus.
Bełchatów, Łódź VoivodeshipAges 18–70 - NCT05716737Recruiting
Radiation treatment study for TMJ arthritis pain
This study looks at how radiotherapy (radiation treatment) may help people with arthritis in the jaw joint (TMJ). It will only consider patients whose TMJ arthritis was diagnosed by a dentist or surgeon and who have not had radiation to that area before.
ViennaAges 50–100 - NCT05848375Recruiting
Rotator cuff surgery done with special anesthesia alone
This trial studies rotator cuff repair surgery when the surgeon uses a regional anesthesia method (numbing the arm area) rather than general anesthesia alone. It may help people with certain types of rotator cuff tendon injuries who are good candidates for outpatient surgery and this anesthesia approach.
NantesAges 18 years+ - NCT05736549RecruitingPhase 2
Tested stronger pain-blocking shot for knee replacement surgery
This Phase 2 study compares two ways to reduce pain after total knee replacement (TKA): a steroid-enhanced nerve block versus a numbing shot called Exparel. It aims to see which option improves comfort and recovery after surgery done with spinal anesthesia.
New Haven, ConnecticutAges 18 years+ - NCT05642260Recruiting
Fall-prevention program after knee replacement for older women
This trial tests whether a structured fall-prevention program can reduce the number of falls in older women after total knee replacement surgery. It may help you stay safer as you recover and move around.
Kuwait CityAges 60 years+ - NCT05789784Enrolling by invitation
Using a shoulder-mobility app after shoulder replacement
This trial tests whether the Zimmer Biomet mymobility smartphone app improves outcomes after a reverse total shoulder replacement. It may help by supporting follow-up exercises and tracking progress after surgery.
Palm Beach Gardens, FloridaAges 18 years+ - NCT05858086Recruiting
Physical therapy clearance before same-day knee or hip surgery
This study looks at whether you need to be “cleared” by physical therapy before going home the same day as knee (TKA) or hip (THA) replacement surgery. It may help determine the safest and most efficient discharge plan for patients who can go home with support right after surgery.
Baltimore, MarylandAges 18–90
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,832 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,923 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.