Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,832 recruiting studies in this area right now.
By phase
- Not applicable3,967
- Phase 2222
- Phase 4195
- Phase 1191
- Phase 3151
- Phase 1/Phase 273
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee73
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain34
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California208
- New York94
- Florida80
- Arizona76
- Massachusetts76
- Maryland73
- Texas64
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,832 total
- NCT05625204Recruiting
HIIT exercise program to improve frailty in older veterans
This trial tests a high-intensity interval training (HIIT) exercise program to help older veterans feel stronger and more resilient and to reduce frailty. It may help people who are not yet very frail (or are just starting to become frail) but can safely exercise.
Kansas City, MissouriAges 65 years+ - NCT05617859RecruitingPhase 2
Lenvatinib treatment for advanced bone or soft tissue sarcoma
This trial tests lenvatinib to shrink or control advanced bone or soft tissue sarcoma that can’t be safely treated with surgery. You may be eligible if your cancer has measurable spots and you’ve had specific prior drug treatments without a durable response.
Zhengzhou, HenanAges 10–70 - NCT05538416Recruiting
Back surgery approach trial for mild slip and leg pain
This trial compares a newer, “cortical bone trajectory” method with more traditional open surgery and a minimally invasive approach for treating certain low-back slips. It looks at short-term outcomes to see which approach helps patients recover better and relieve leg symptoms.
GroningenAges 18–75 - NCT05391828Recruiting
Testing a new knee robot and app support for knee arthritis
This study looks at whether a robot-assisted knee replacement plus remote tracking with an Apple Watch and a smartphone app helps people do better after surgery. You may be eligible if you’re an adult getting a planned (not replacement) knee surgery for arthritis and can use the required devices.
New York, New YorkAges 18 years+ - NCT05616312Recruiting
Study of how patients remember orthopedic injury care
This study looks at how well patients recall details after a bone fracture that required surgery, especially around the time of their injury care and follow-up. It may help improve how orthopedic teams communicate and support patients after trauma.
Cleveland, OhioAges 18–75 - NCT05502718Recruiting
Exercise program for cervical dystonia treated with botulinum toxin
This trial studies whether a structured exercise program can help people with cervical dystonia (involuntary neck muscle tightening) who are already being treated with botulinum toxin type A. It may help improve how you move and function, alongside your usual injections.
Ankara, AltındağAges 18 years+ - NCT05607966Recruiting
Knee replacement follow-up study for ORIGIN® implant
This study follows people who need a total knee replacement using the ORIGIN® implant. It’s meant to see how well the implant works and how people do over time with routine clinic visits.
AntwerpAges 18–99 - NCT05564494Recruiting
Surgery for repeat shoulder dislocations
This trial studies surgical treatment for people whose shoulder keeps dislocating forward (anteriorly). It may help by choosing a surgery plan for the amount of bone loss seen on scans, while excluding people with certain medical or instability patterns.
New York, New YorkAges 16–40 - NCT04801680Recruiting
3D metal hip cup for painful hip arthritis
This trial studies a specific type of 3D metal cup used during hip replacement surgery. It aims to see how well it works over time in people who need a first (primary) total hip replacement.
Milan, MIAges 18–75 - NCT05050409Recruiting
Program to help recovery after knee replacement surgery
This trial tests a supportive, coach-like “embedded” program designed to help you stay engaged and ready for recovery after one knee replacement. It may be helpful if you want extra support before and after surgery to follow through with your recovery plan.
Fort Sam Houston, TexasAges 18 years+ - NCT05152823Enrolling by invitationPhase 1/Phase 2
Gene therapy for IGHMBP2-related nerve conditions
This early-phase study tests a gene therapy meant to treat people who have IGHMBP2 gene changes. It aims to improve the way the nervous system works and to see if the treatment is safe, especially in young children.
Columbus, OhioAges 2 months–14 years - NCT05102916Recruiting
Registry for neuromuscular disorder patients in Switzerland
This study is a patient registry that collects health information from people diagnosed with a neuromuscular disorder in Switzerland. It helps researchers better understand these conditions and how they vary from person to person.
Aarau, Canton of AargauAges birth+ - NCT05138393Recruiting
Exercises for mild scoliosis in growing children
This trial tests scoliosis-specific exercises to improve mild “idiopathic” scoliosis, meaning the cause is not clearly identified. It is for children who are still growing and have a mild curve, and it may help reduce progression and improve how the spine works.
LinköpingAges 9–15 - NCT05159739Enrolling by invitation
Study of family genetic risk for joint implant infections
This study looks at whether certain families have a higher genetic risk for infections around joint implants. It may help researchers understand who is more at risk and how to prevent these infections.
Salt Lake City, UtahAges 18–100 - NCT04884542Recruiting
Testing a knee replacement implant for total knee arthroplasty
This study looks at outcomes after surgery using the Multigen Plus H knee replacement system, sometimes with special add-on parts called AMF TT cones. It may help improve how well these knee implants work and how patients recover after total knee replacement.
GhentAges 18 years+ - NCT04751409RecruitingPhase 2
Less versus more follow-up after sarcoma surgery
This trial compares two schedules of post-treatment check-ups to see which one better supports patient quality of life. You’d fill out surveys for up to two years to measure how you feel over time.
Houston, TexasAges 18 years+ - NCT04728542Recruiting
Observational study comparing two osteoporosis treatment approaches
This is an observational study, meaning researchers watch what happens in real life rather than assigning a treatment by chance. It compares outcomes between people using ORIGIN® and VANGUARD® PS, to better understand how these approaches perform.
MainzAges 18 years+ - NCT05013307Enrolling by invitation
Check how teens respond after a sports concussion
This study looks at how the body responds to sports exertion after a concussion in otherwise healthy teens. It may help improve concussion safety rules for returning to play and reduce the risk of symptoms coming back.
Frisco, TexasAges 10–22 - NCT04914507Recruiting
Tracking long-term results of spine tethering in growing teens
This study follows kids who have a surgery called anterior vertebral body tethering (AVBT) for growing-related, idiopathic scoliosis. It looks at how well the curve stays corrected over time and how the spine grows, which may help improve future care decisions.
Washington D.C., District of ColumbiaAges Up to 18 years - NCT04914585Recruiting
3D CT scan test to automatically identify spine bones
This study checks whether a computer can automatically spot and label the bones in your spine using 3D information from a CT scan. It may help surgeons work faster and more accurately before spine surgery.
JerusalemAges 18 years+ - NCT04904575Recruiting
Erector spinae pain-block during lumbar fusion surgery
This study tests whether a numbing pain-block in a specific back muscle area (called an “erector spinae plane block”) can improve comfort during lumbar spinal fusion surgery. You might be eligible if you need this type of back surgery and can safely receive the numbing medicine.
Saint-Jean-de-VédasAges 18 years+ - NCT04724603Recruiting
Review of side effects after phage treatment for bone infections
This study looks back at people who were treated with phage therapy for a bone, joint, or implant infection and later had a side effect. It aims to better understand how safe phage therapy is in real-life use.
LyonAges Any age - NCT05091112Recruiting
Study of nerves during low back surgery
This study looks at tiny nerves in the low back during planned lumbar spine surgery. It may help researchers better understand nerve pathways that contribute to low back pain and nerve-related symptoms.
Aberdeen, ScotlandAges 18 years+ - NCT05110729Recruiting
Check how injuries affect quality of life in young gymnasts
This study looks at how musculoskeletal injuries change quality of life and life satisfaction for gymnasts ages 8 to 18. It may help sports medicine teams understand what young gymnasts need to feel better and keep doing their sport.
Denver, ColoradoAges 8–18
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,832 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,923 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.