Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,832 recruiting studies in this area right now.
By phase
- Not applicable3,967
- Phase 2222
- Phase 4195
- Phase 1191
- Phase 3151
- Phase 1/Phase 273
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee73
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain34
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California208
- New York94
- Florida80
- Arizona76
- Massachusetts76
- Maryland73
- Texas64
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,832 total
- NCT07767747Enrolling by invitation
Neck and shoulder pain relief: comparing two hands-on therapies
This study compares two gentle, hands-on treatments (Emmett and Bowen techniques) to see which works better for long-lasting neck and shoulder pain caused by muscle knots (trigger points). It may help you find a non-invasive way to ease pain and improve movement.
Sialkot, Punjab ProvinceAges 18–45 - NCT06570798RecruitingPhase 2
Testing Two Drugs for Lupus and Rheumatoid Arthritis
This trial tests two study drugs, inebilizumab and blinatumomab, for people with lupus (SLE) or rheumatoid arthritis (RA) that hasn't gotten better with standard treatments. It focuses on those with active disease, especially lupus-related kidney problems.
Scottsdale, ArizonaAges 18–75 - NCT07620392RecruitingPhase 2
Long-Term Safety Study of Afimkibart for Rheumatoid Arthritis
This is a follow-up study for people who already completed a previous trial testing afimkibart (an experimental drug) for rheumatoid arthritis. It checks whether the drug continues to work safely and effectively over a longer period.
Tamarac, FloridaAges 18 years+ - NCT06945198Recruiting
Long-term sports activity after ankle surgery for chronic instability
This study follows patients for years after ankle surgery to see how well they return to sports. It compares two surgical techniques for chronic ankle instability caused by old sprains.
LyonAges 18 years+ - NCT07433322Recruiting
Preserving gum and bone after back tooth removal
This study tests a procedure to preserve the bone and gum after removing upper back teeth, which may help prepare the area for future dental implants.
Richmond, VirginiaAges 18 years+ - NCT06446336Recruiting
New score for diagnosing long biceps tendon injuries
This study is creating a new scoring system to help doctors better diagnose injuries to the long biceps tendon before surgery. If you are planning surgery for shoulder pain that hasn't improved with treatment, this research may help improve how your condition is managed.
Le HavreAges 18 years+ - NCT07486076Enrolling by invitation
Osteoporosis education for women at risk
This trial tests whether an education program can improve women's understanding and beliefs about osteoporosis. If you are a woman over 45 without osteoporosis but with risk factors, you may be able to join and learn ways to protect your bone health.
BartınAges 45–80 - NCT06269965Recruiting
Collagen membrane for rotator cuff repair
This trial tests whether using a special collagen membrane helps improve healing when repairing a torn rotator cuff tendon. It is for people who have a tear in the upper part of the rotator cuff and are having surgery to fix it.
LyonAges 18 years+ - NCT07207005Recruiting
Comparing wear in two hip replacement sockets
This study compares how much two different types of dual-mobility hip sockets wear down over time in people having a hip replacement. If you are between 55 and 80 and scheduled for this surgery, you may be eligible to help doctors find out which implant lasts longer.
Lyon, FranceAges 55–80 - NCT05285007Recruiting
Study tests whether limited ankle motion affects knee squats
This study looks at people with patellofemoral pain (kneecap pain) to see how limited ankle movement may affect how your knee works during single-leg squats. It may help clinicians better understand what to focus on for treatment.
Loma Linda, CaliforniaAges 18–59 - NCT07383740Recruiting
Reliability of a gentle bike test for hip or knee osteoarthritis
This study checks whether a simple, low-effort bike test gives consistent results for people with hip or knee osteoarthritis. It helps doctors understand how well this test can measure your fitness without pushing you too hard.
GothenburgAges 30 years+ - NCT07473232Recruiting
Comparing platelet-rich plasma and cytokine-rich serum injections for knee osteoarthritis
This trial compares two types of injections (PRP and ACS) to see which one works better for knee osteoarthritis. It may help people with knee pain who have not had these injections recently.
Pamukkale, DenizliAges 40–80 - NCT07249489Recruiting
New implant for knee cartilage repair
This study tests a new type of implant designed to repair damaged knee cartilage. It may be an option for people with a knee injury who are generally healthy and not taking certain medications.
Vancouver, British ColumbiaAges 22–60 - NCT06680297Recruiting
Drinking carbs before scoliosis surgery
This trial tests if giving teenagers a carbohydrate drink before scoliosis surgery helps them recover faster and more safely. It looks at how the drink affects things like nausea, pain, and how quickly they can get back to normal.
Kuala Lumpur, Kuala LumpurAges 10–19 - NCT06619418Recruiting
Home Device Using Sound and Body Stimulation for Back Pain
This study is testing a take-home device that uses sound and gentle body stimulation to help with long-term back pain. It is for adults with chronic low back pain who live near the University of Minnesota and are not taking certain sleep or anxiety medications.
Minneapolis, MinnesotaAges 18 years+ - NCT07260864Recruiting
rTMS for fibromyalgia pain
This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help reduce pain in people with fibromyalgia. If you join, you'll receive rTMS sessions and we'll monitor your brain activity to see how it affects your pain.
Rochester, New YorkAges 18–65 - NCT05866419Recruiting
Study of a port and catheter system for spinal muscular atrophy
This study tests a new device called the ThecaFlex DRx System, which is a small port and catheter placed under the skin to deliver Spinraza directly into spinal fluid—instead of needing repeated spinal taps. The device aims to make receiving medication easier and safer for people with SMA.
Phoenix, ArizonaAges 3 years+ - NCT07384754Recruiting
Foot exercises to improve balance and walking in older adults
This study tests whether doing simple foot exercises can improve balance and walking in older adults. It may help you feel steadier and move more easily.
Bloomington, IndianaAges 45 years+ - NCT07203001RecruitingPhase 2
MAS825 for Still's disease in children and adults
This trial tests a new drug called MAS825 for people with Still's disease that is still active despite other treatments. It aims to see if the drug can reduce symptoms like fever, rash, joint pain, or a serious complication called macrophage activation syndrome.
Cincinnati, OhioAges 1 year+ - NCT07214311RecruitingPhase 2/Phase 3
A trial of PLG0206 to prevent knee joint infection after surgery
This trial tests if a new drug called PLG0206 can stop a knee joint infection from coming back after a surgery called DAIR. DAIR cleans the infected area and keeps the artificial knee in place, and this study wants to see if adding PLG0206 helps prevent the infection from returning.
Sarasota, FloridaAges 18–80 - NCT07092540Recruiting
Baby Duchenne Study: Early Years in Boys With DMD
This study tracks development and health in young boys with Duchenne muscular dystrophy during the first three years of life. It aims to better understand early signs and how the condition progresses, which may help improve care and future treatments.
Rochester, New YorkAges birth–3 years - NCT07641517RecruitingPhase 2
Testing LY4065967 for chronic knee osteoarthritis pain
This study tests an experimental drug called LY4065967 to see if it can help reduce pain from osteoarthritis in the knee. You'll be in the trial for several months, with regular check-ins and pain assessments.
Birmingham, AlabamaAges 40 years+ - NCT07221851RecruitingPhase 3
Weekly vs daily growth hormone for short stature in children
This trial tests a weekly growth hormone injection (lonapegsomatropin) compared to the standard daily growth hormone shot in children with short stature due to certain conditions. It aims to see if the weekly shot works as well or better and is safe.
Palo Alto, CaliforniaAges 2–17 - NCT06887829Recruiting
Radiation Therapy for Knee Osteoarthritis
This study tests a low-dose radiation treatment for knee osteoarthritis pain. If you have moderate arthritis pain and are a Mayo Clinic patient in Rochester, you may be able to join.
Rochester, MinnesotaAges 50–100
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,832 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,923 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.