Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT06692244Recruiting
Custom 3D-printed mesh for jawbone regrowth
This trial is testing a custom-made titanium mesh (built with a 3D printer) to help regrow bone in your jaw where teeth are missing. It may be an option if you have moderate to severe bone loss and need a strong foundation for dental implants.
Guangzhou, GuangdongAges 18–60 - NCT06845657Recruiting
Hip strengthening exercises for knee arthritis
This study tests if strengthening the hip muscles can reduce knee pain and improve function in people with knee osteoarthritis. It may help you if you have had knee pain for at least 3 months and are between 40 and 60 years old.
Islamabad, Punjab ProvinceAges 40–60 - NCT07320118Recruiting
Knee cartilage repair and osteoarthritis prevention study
This study looks at whether fixing knee cartilage damage can prevent arthritis later. It compares different treatments to see if they help avoid long-term joint problems.
OswestryAges Any age - NCT07324434Enrolling by invitationPhase 1
Study of an oral tablet for healthy adults and those with high uric acid
This trial tests a new tablet (F-02-2-Na) to see if it's safe and how the body processes it. It's for healthy volunteers and people with high uric acid levels who may need long-term treatment.
Guangzhou, GuangdongAges 18–45 - NCT07321873RecruitingPhase 2
Study of JNJ-88545223 for Active Psoriatic Arthritis
This study tests an experimental drug called JNJ-88545223 to see if it can reduce joint pain, swelling, and skin plaques in people with active psoriatic arthritis. It may help if you have both joint symptoms and psoriasis.
Searcy, ArkansasAges 18 years+ - NCT06870500Recruiting
Psoriasis gene study for Egyptian patients
This study looks at a specific gene (Card14) in Egyptian patients with psoriasis or psoriatic arthritis. It may help understand why some people get these conditions and how they could be treated better.
QinaAges 18–50 - NCT02714634RecruitingPhase 4
Methotrexate or leflunomide plus added therapy for rheumatoid arthritis
This study compares two combination treatments for rheumatoid arthritis in people whose current methotrexate or leflunomide isn’t working well enough. It aims to see whether adding a targeted therapy works better than the standard add-on of sulfasalazine plus hydroxychloroquine.
StrasbourgAges 18 years+ - NCT04934462Recruiting
Non-surgical or arthroscopic treatment for hip microinstability
This study looks at treatment options that may help people with “hip microinstability,” where the hip can feel unstable or not sit perfectly. Researchers will compare non-surgical care and a minimally invasive surgery option to see what works best and why it helps.
GothenburgAges 18 years+ - NCT07324538Recruiting
Movement training with coaching and touch for chronic low back pain
This study tests whether combining movement control exercises with verbal and manual cues (coaching and gentle touch) can improve how your back moves and reduce pain. It's for people with long-lasting (more than 12 weeks) low back pain that is not linked to a specific cause.
Taipei, TaiwanAges 18 years+ - NCT07317570Recruiting
Body awareness therapy for jaw pain and function
This study tests whether body awareness therapy (gentle exercises that help you notice how your body moves and feels) can reduce jaw pain, improve function, and help with related emotional stress. It is for people with long-term jaw joint problems.
RizeAges 18 years+ - NCT07318987Recruiting
Nerve release surgery for knee pain relief
This study tests if surgically releasing a nerve in the knee (the saphenous nerve) can reduce pain in people with patellofemoral pain syndrome (pain around the kneecap). If you've had anterior knee pain for at least six weeks and the nerve test is positive, this trial may offer relief.
CairoAges 18–35 - NCT07319091Recruiting
Cystinosis and Mitochondrial Energy Study
This study looks at how cystinosis affects the energy centers (mitochondria) in your cells. It may help doctors understand how cysteamine treatment works in patients with kidney cystinosis.
BronAges 2 years+ - NCT07316933Recruiting
Exercise with light blood flow restriction before knee replacement
This trial tests if a specific type of exercise, done with a cuff that lightly restricts blood flow to your leg, can help you get stronger and recover better while you wait for knee replacement surgery. The blood flow restriction is carefully controlled and adjusted during exercise, which may make the workout more effective.
Valencia, ValenciaAges 50–85 - NCT07320807Recruiting
Shock wave therapy after flexor tendon repair
This study tests whether a non-invasive treatment called extracorporeal shock wave therapy can help improve hand function after flexor tendon repair surgery. The therapy uses sound waves to stimulate healing and reduce scar tissue, and it may help you regain movement more quickly.
AnkaraAges 18–50 - NCT07324343Recruiting
Education for shoulder pain: which patients benefit most?
This study tests whether patients with different types of shoulder pain respond better to learning about their condition through education alone. You will receive information and advice to help you manage your pain without injections or surgery.
IstanbulAges 18–65 - NCT07318896Recruiting
Agar and collagen supplement study for knee pain
This trial tests whether a supplement made from agar and collagen can help reduce knee pain in people with mild to moderate osteoarthritis. If you are between 40 and 70 and have knee pain, this may be an option for you.
Reus, TarragonaAges 40–70 - NCT07318298Recruiting
Hyaluronic acid injection for wisdom tooth socket healing
This trial tests if injecting hyaluronic acid into the sockets after wisdom tooth removal helps bone heal faster. It may be an option if you need both lower wisdom teeth removed and are generally healthy.
IrbidAges 18–35 - NCT07320417Recruiting
Preserving sinus lining during maxillary surgery
This study tests a modified surgery technique that keeps the sinus membrane intact while removing part of the upper jaw. It aims to reduce complications and help bone healing for patients with growths in the upper jaw that haven't spread to the sinus cavity.
ShanxiAges 18–75 - NCT07321600Recruiting
Breathing muscle training with Schroth exercises for scoliosis in teens
This trial tests whether adding a special breathing exercise (inspiratory muscle training) to standard Schroth exercises improves breathing and posture in teenage girls with scoliosis. It may help strengthen the muscles used for breathing.
Kırşehir, MerkezAges 10–18 - NCT07321483Recruiting
Reflex therapy for jaw pain
This trial tests if a special reflex therapy can help people with jaw muscle pain that isn't caused by joint damage. It might be a new way to reduce discomfort and improve function.
OlomoucAges 18 years+ - NCT07315841RecruitingPhase 4
Dye Imaging for Tenosynovial Giant Cell Tumor Surgery
This trial tests whether a special dye (Indocyanine Green) used during surgery can help doctors see Tenosynovial Giant Cell Tumors more clearly. It may help make the surgery more precise.
ShanghaiAges 18–75 - NCT07320846Recruiting
Exercise and gene activity in rheumatoid arthritis
This trial tests whether exercise training can affect gene activity (lncRNA) in rheumatoid arthritis patients with lung involvement. It may show how exercise helps manage the disease.
Istanbul, TurkeyAges 18–75 - NCT07323342Recruiting
Hyaluronic acid plus fibrinogen for knee arthritis
This study tests whether a combination of two natural substances—hyaluronic acid (a joint lubricant) and fibrinogen (a blood protein that helps healing)—given as an injection into the knee, can safely reduce pain and improve function in people with knee osteoarthritis. It is for Vietnamese patients who have not recently used certain painkillers or had other knee treatments.
Ho Chi Minh CityAges 45–75 - NCT07318116Enrolling by invitation
Cabbage Leaf for Knee Osteoarthritis Pain
This study tests whether applying cabbage leaves to the knee can reduce pain in people with knee osteoarthritis. If you have had knee pain for at least 6 months and are not allergic to cabbage, you may be able to join.
Şirnak, MerkezAges 18–80
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.