Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT07207187Enrolling by invitation
Long-term outcomes of the Karma fixation system
This study looks at how patients are doing one year or more after spinal surgery with the Karma Fixation System. It may help doctors understand the long-term safety and effectiveness of this treatment.
Gilbert, ArizonaAges 18 years+ - NCT06723639Recruiting
Restoring the torn Achilles tendon
This trial is testing a new way to repair a completely torn Achilles tendon. It uses MRI scans to make sure the repair is as good as possible, aiming for better healing and recovery.
Copenhagen, CapitalAges 18–67 - NCT06857227RecruitingPhase 1
Study of GNC-038 for active rheumatoid arthritis
This trial tests a new experimental antibody called GNC-038 for people with moderate to severe rheumatoid arthritis (RA) that hasn't responded well enough to standard treatments. It aims to see if targeting specific immune cells can reduce inflammation and improve symptoms.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06806774Recruiting
Daily living test for children with juvenile arthritis
This study tests whether a simple daily activities test works well for children and teens with juvenile idiopathic arthritis. It may help doctors better understand how the condition affects everyday tasks.
AnkaraAges 8–18 - NCT07211464Recruiting
ACT plus exercise for older adults with chronic low back pain
This study tests whether combining acceptance and commitment therapy (ACT) with exercise helps older adults manage ongoing low back pain. If you've had pain for at least 3 months and it's been bothering you, this approach might teach you new ways to cope and move better.
Hong KongAges 60 years+ - NCT07211711Recruiting
Splint therapy for tinnitus linked to jaw joint issues
This trial tests if a custom mouthpiece (occlusal splint) can relieve ringing in the ears (tinnitus) that started along with jaw or face pain (TMD). It aims to see if stabilizing the jaw helps reduce both the noise in your ears and the discomfort.
São Paulo, São PauloAges 18 years+ - NCT07212049Enrolling by invitation
Ultrasound to measure magnetic growing rods
This study tests if ultrasound can accurately measure the length of magnetically controlled growing rods used in leg bone lengthening. It may help doctors monitor treatment without extra X-rays.
Orlando, FloridaAges 8–21 - NCT07212036Recruiting
Ultrasound for elbow fractures in children
This study uses ultrasound, a sound-wave imaging tool, to diagnose elbow fractures in children. It aims to see if ultrasound works as well as X-rays, so your child might avoid radiation.
Orlando, FloridaAges Up to 18 years - NCT07203339Recruiting
Home brain stimulation vs. duloxetine for fibromyalgia pain
This trial compares a non-invasive, at-home brain stimulation technique (tDCS) to the medication duloxetine for treating fibromyalgia pain. It aims to see if the brain stimulation works as well as the drug.
Porto Alegre, Rio Grande do SulAges 18–75 - NCT07208630Recruiting
Mobilization therapy for seniors' movement and thinking
This trial tests a hands-on therapy called instrument-assisted soft tissue mobilization to see if it improves how well you move and think. It may help seniors who struggle with balance or memory.
GizaAges 65–75 - NCT07204119Recruiting
Comparing two therapies for knee stiffness after fracture surgery
This trial tests two physical therapy techniques to help people regain knee movement after surgery for a broken leg bone. It may help if you are still having trouble bending or straightening your knee a few weeks after your operation.
Rawalpindi, Punjab ProvinceAges 20–40 - NCT07208357Recruiting
Pregabalin with toludesvenlafaxine for fibromyalgia pain
This study tests a combination of two medications (pregabalin and toludesvenlafaxine) to see if it is safe and effective for people with fibromyalgia whose pain has not improved with non-drug treatments and who have not yet tried standard medications for this condition.
BeijingAges 18 years+ - NCT07206797Recruiting
Ultrasound to measure muscle activity from spinal cord stimulation
This study uses ultrasound to see how muscles respond to two types of electrical stimulation (spinal cord and functional electrical stimulation). It may help researchers better understand how to treat muscle weakness or paralysis.
Raleigh, North CarolinaAges 18–60 - NCT07207005Recruiting
Comparing wear in two hip replacement sockets
This study compares how much two different types of dual-mobility hip sockets wear down over time in people having a hip replacement. If you are between 55 and 80 and scheduled for this surgery, you may be eligible to help doctors find out which implant lasts longer.
Lyon, FranceAges 55–80 - NCT07203963Recruiting
Niel-Asher technique for frozen shoulder recovery
This trial tests a manual therapy method called the Niel-Asher technique for people with frozen shoulder (adhesive capsulitis). It aims to improve shoulder movement and reduce pain. You may qualify if your frozen shoulder has been present for at least three months and you have tender spots in certain shoulder muscles.
Islamabad, Punjab ProvinceAges 40–60 - NCT07204197Enrolling by invitation
Virtual Reality Physical Therapy After Lumbar Disc Surgery
This study tests whether using virtual reality (VR) during physical therapy after lumbar disc surgery helps you recover better in the first few days. You'll do standard exercises with or without VR games to see if it improves your movement and pain.
Ankara, AnkaraAges 18–65 - NCT07204210Enrolling by invitation
Shockwave therapy vs. massage for plantar fasciitis
This study compares two treatments for plantar fasciitis—shockwave therapy and a type of deep massage. The goal is to see which works better for reducing foot pain.
KayseriAges 18 years+ - NCT07206888Enrolling by invitation
Study to try advanced ultrasound for breast imaging
This study explores a new way to process ultrasound images of the breast. It is for women who have a finding, cyst, mass, or calcifications seen on a mammogram or ultrasound, and it uses a special ultrasound technique that may provide clearer images without extra radiation.
Baltimore, MarylandAges 18 years+ - NCT06896032Recruiting
Walking backward vs forward on an underwater treadmill for knee osteoarthritis
This study compares walking backward versus walking forward on an underwater treadmill to see which helps reduce pain and improve function in people with knee osteoarthritis. It may be a good fit if you have mild to moderate knee OA in one knee and are between 40 and 60 years old.
Cairo, Cairo GovernorateAges 40–60 - NCT06930287Recruiting
Shoe Effects for Runners with Tight Calves
This study looks at how different types of running shoes affect runners with tight calf muscles (functional equinus). It explores whether certain footwear can help improve comfort or performance.
SalamancaAges 18–50 - NCT06913088Recruiting
Ultrasound bubbles bandage for hand arthritis
This trial tests a special bandage that uses ultrasound and tiny bubbles to treat arthritis pain and stiffness in your hands. If you have hand arthritis with at least three painful finger or wrist joints, you may be able to join.
Taichung, TaichungAges 20 years+ - NCT06933004Recruiting
Long-term follow-up after lumbar spine surgery
This study will follow patients who have surgery for lower back problems. It aims to learn about their long-term recovery and outcomes.
TaipeiAges 20–80 - NCT04883411Recruiting
First-in-human test of new cervical spine plate and cage
This study tests a new implanted metal plate and cage to treat problems in the neck caused by worn spinal discs and nerve or spinal cord compression. It is aimed at people whose symptoms have not improved with non-surgical care for at least 6 weeks (or who have worsening nerve/spinal cord symptoms).
Union, New JerseyAges 22–79 - NCT06934551Recruiting
Study on patient satisfaction after jaw surgery
This trial tests how happy patients are with their dental work after having part of the upper jaw removed (hemi-maxillectomy). It also checks how healthy the nearby teeth stay. This could help doctors pick the best way to replace missing teeth in these cases.
CairoAges 30–60
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.