Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,838 recruiting studies in this area right now.
By phase
- Not applicable3,969
- Phase 2224
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 276
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis87
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,838 total
- NCT05199740Recruiting
Testing treatment for people with certain mitochondrial DNA changes
This study looks at how much “mitochondrial DNA” mutation is in your body and what that means for people with specific genetic changes in muscle. It may help researchers better understand the condition and how to track response over time.
MaastrichtAges 18 years+ - NCT05200715Recruiting
Registry study for inherited and inflammatory eye and joint diseases
This study is a registry, meaning it collects your medical information to better understand several inflammatory (auto-inflammatory) conditions. It may help doctors and researchers improve diagnosis and future treatments for people with these disorders.
AlgiersAges Any age - NCT05202210Recruiting
Biobank study for people with Noonan syndrome
This study collects biological samples to better understand what causes Noonan syndrome. If you qualify, your participation could help researchers learn how the condition works and guide future care.
ToulouseAges 18–99 - NCT05202678Recruiting
Check a new therapy for osteoporosis-related hip bone loss
This trial studies AGN1 LOEP, a treatment being tested to improve bone strength in people with osteoporosis-related bone loss in the hip. If you qualify, you would be followed over time with clinic visits and testing to see how the treatment affects your bone health.
Sint-Niklaas, AntwerpenAges Any age - NCT05206838Recruiting
Treating gluteus medius tendon weakness after hip replacement
This trial looks at treating a specific hip muscle-tendon problem (gluteus medius insufficiency) after total hip replacement. It may help people who have had ongoing limping despite surgery by using an Achilles tendon–based approach.
MölndalAges 40–80 - NCT05209776Recruiting
Studying heart inflammation patterns in specific heart rhythm conditions
This study compares inflammation-related signals in people with arrhythmogenic right ventricular cardiomyopathy versus people having certain heart procedures for non-cancer, non-inflammatory reasons. It may help researchers better understand what drives abnormal heart rhythms in this condition.
ToulouseAges 18–99 - NCT05211661Recruiting
Study breathing muscle changes in people on a ventilator
This study looks at how the diaphragm (a key breathing muscle) changes during and after being on a breathing machine in the ICU. It may help researchers understand why breathing can get weaker after ventilation and how to measure it safely (including with MRI).
AachenAges 18–75 - NCT05214547Recruiting
Focal vibration therapy for frozen shoulder pain and motion
This trial studies whether a vibration device applied to the shoulder can reduce pain and improve range of motion in people with frozen shoulder (also called adhesive capsulitis). If you fit the specific shoulder and symptom pattern, it may be an option to consider alongside standard care.
BitlisAges 18 years+ - NCT05216666Recruiting
Surgery type and leftover limping after hip replacement
This study looks at whether the kind of hip surgery approach affects how much limping remains after a total hip replacement. You may benefit by helping researchers find the approach that leads to better walking after surgery.
MölndalAges 40–80 - NCT05216679Recruiting
Stretching device versus night splints for plantar fasciitis
This trial compares a new at-home stretching device to standard night splints for plantar fasciitis (heel pain from inflammation). It may help find which approach works better and is easier or safer to use.
Carterville, IllinoisAges 18 years+ - NCT05221554Recruiting
Testing a plan for hip replacement surgery timing
This study involves people with hip osteoarthritis who are planning a first total hip replacement. It tests a “pre-op modelling” approach—likely helping plan care around surgery—to see if it improves how patients do.
London, OntarioAges 40 years+ - NCT05221450Recruiting
Study of what affects root canal treatment outcomes
This study looks at which factors can change how well root canal (endodontic) treatment works. It may help improve future care by understanding what leads to better healing.
LjubljanaAges 18 years+ - NCT05224778Recruiting
Study for young children with neonatal myotonic dystrophy type 1
This study looks at measurements and child-focused outcomes in babies and toddlers with myotonic dystrophy type 1 (DM1) that started in the newborn period. It may help researchers better track how the condition affects children and evaluate care plans more accurately.
Los Angeles, CaliforniaAges Up to 4.9 years - NCT05226637Recruiting
Shockwave plus botox-like treatment versus standard care for arm spasticity
This study tests whether adding shockwave treatment to botulinum toxin type A (a botox-like injection) improves outcomes for people with stiff, tight upper-arm muscles after brain injury, stroke, or cerebral palsy. It also compares this to standard botulinum toxin care alone.
Edmonton, AlbertaAges 18–99 - NCT05227924Recruiting
Testing safety and performance of a hip implant device type
This study checks how safe and well a specific brand of hip implant (SYMBOL range) works in people getting a total hip replacement. It may help by confirming the device performs as expected for primary or revision surgeries.
BeaumontAges 18 years+ - NCT05228340Recruiting
Treating toe ulcers by releasing tight tendons to prevent recurrence
This study looks at whether a minor procedure on a toe (called a flexor tenotomy) can reduce the chance that diabetic toe ulcers come back. It is for adults with diabetes who have nerve damage in the feet and have had toe ulcers before.
Amsterdam, North HollandAges 18 years+ - NCT05228262Recruiting
Testing blood-vessel function and muscle strength in osteoporosis
This study looks at how well your blood vessels work and how strong your muscles are, in women after menopause with osteoporosis. You may be asked to start standard osteoporosis treatment, and the researchers will study pain and changes related to vascular function and sarcopenia (loss of muscle and strength).
Clermont-FerrandAges 50 years+ - NCT05232604Recruiting
Exercise vs local pain exercises for jaw and neck pain
This study compares two types of treatment: aerobic exercise versus exercises aimed at the painful jaw/neck area. It may help people with long-term jaw and neck pain by testing which approach improves pain and function.
Osnabrück, Lower SaxonyAges 18–60 - NCT05236465Recruiting
3-day course for CFS/ME to help you manage symptoms
This trial tests whether a short, structured 3-day course can help people with CFS/ME (myalgic encephalomyelitis/chronic fatigue syndrome) through education and support for symptom management. It may be most helpful if you can currently step back from work or school and are ready to try changes.
TrondheimAges 18–65 - NCT05237570Recruiting
Less invasive sinus lift for upper back teeth
This trial tests a minimally invasive procedure to lift the sinus floor to help support an upper back tooth area when the tooth cannot be rebuilt. It may help people who need bone support for a future dental restoration or implant by using a specific, less invasive pathway.
MurciaAges 18 years+ - NCT05240417Recruiting
Bone healing support after tooth extraction with a special shield
This study looks at whether a specific technique can help your jawbone stay in better shape after removing teeth in the upper and lower jaw. If you need certain front-to-back extractions, you may be offered this approach to improve healing and bone preservation.
MadridAges 18–80 - NCT05241262RecruitingPhase 1
N-acetylcysteine for people with m.3243A>G and low brain glutathione
This trial tests whether the supplement N-acetylcysteine (NAC) can help people who have the m.3243A>G mitochondrial genetic change and low levels of a brain chemical called glutathione. The study aims to see if raising glutathione in the brain is safe and potentially beneficial for these patients.
New York, New YorkAges 18–80 - NCT05242055Recruiting
Tracking and treating chronic kidney disease risk
This trial looks at how well an integrated program for identifying and treating people at risk for chronic kidney disease (CKD) can improve outcomes. It may help by catching problems earlier and guiding treatment sooner.
Beijing, Beijing MunicipalityAges 18–100 - NCT05246813Recruiting
Study blood cell changes in older adults
This study looks at how blood-forming stem cells change in people with clonal hematopoiesis (CHIP), a common age-related blood condition. It may help researchers understand what these changes mean and who might be at higher risk for future blood problems.
Bonheiden, BelgiëAges 55 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,838 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,965 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.