Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT05216666Recruiting
Surgery type and leftover limping after hip replacement
This study looks at whether the kind of hip surgery approach affects how much limping remains after a total hip replacement. You may benefit by helping researchers find the approach that leads to better walking after surgery.
MölndalAges 40–80 - NCT06357741Recruiting
Desuzumab for knee osteoarthritis
This study tests a new medicine called Desuzumab for knee osteoarthritis. It looks at whether the medicine can help reduce pain and improve joint function.
Wuhan, HubeiAges 45–75 - NCT06780293RecruitingPhase 2
Laser acupuncture for dry eye and Sjogren's dry eye
This study tests if laser acupuncture can help people with dry eye symptoms, including those with Sjogren's syndrome, which causes dryness in the eyes and mouth. It may be a good fit if you have dry eye or Sjogren's and meet the age and eye test requirements.
Taipei, TaiwanAges 20–75 - NCT06827496Recruiting
Starting with oral antibiotics for kids' bone and joint infections
This study tests if starting treatment for uncomplicated bone or joint infections in children with oral (by mouth) antibiotics is effective. It focuses on kids who are not severely ill and do not have certain risk factors, and who can begin oral antibiotics right away or after a short course of IV (intravenous) antibiotics.
Copenhagen ØAges 3 months–17 years - NCT06914960Recruiting
Ultrasound-guided nerve radiofrequency for knee pain
This trial tests a treatment that uses radio waves to reduce pain signals from the nerves around the knee. It might help if you have long-lasting knee pain from osteoarthritis and find certain movements very painful.
Ankara, AnkaraAges 30–75 - NCT05992064Recruiting
Wearable sensors to track recovery after knee replacement
This study uses a small wearable sensor placed on your leg after knee replacement surgery to track your recovery. It helps doctors see how well you are moving and healing, without extra visits to the hospital.
Frederikshavn, North DenmarkAges 18 years+ - NCT06696027Recruiting
Loss of Y chromosome in autoimmune and lung disease
This study looks at how the loss of the Y chromosome in blood cells may be linked to autoimmune and lung diseases in older men. By joining, you help researchers understand this connection better.
Bonn, North Rhine-WestphaliaAges 50 years+ - NCT06460142Recruiting
Biomarker study for giant cell arteritis and polymyalgia rheumatica
This study is looking for biomarkers (biological clues) in people with newly diagnosed or flaring giant cell arteritis (GCA) or polymyalgia rheumatica (PMR). Participating may help researchers find better ways to diagnose and monitor these conditions.
Bonn, North Rhine-WestphaliaAges 18 years+ - NCT06922370Recruiting
Study of bone and joint problems in Gitelman syndrome
This study looks at bone and joint problems in people with Gitelman syndrome, a rare kidney disorder. It aims to understand how this condition affects the body's bones and joints.
Hangzhou, ZhejiangAges Any age - NCT05196906Recruiting
Compare ankle stabilization surgery techniques for ligament injury
This trial compares two ways to surgically stabilize an ankle that feels unstable and causes pain. It may help patients by identifying which technique leads to better ankle function and outcomes.
BeijingAges 18–60 - NCT06685042RecruitingPhase 1/Phase 2
CAR T-cell therapy for severe autoimmune diseases
This study tests a new treatment called CAR T-cell therapy for people with severe autoimmune diseases that haven't gotten better with standard treatments. The goal is to see if it can help control the disease by reprogramming your immune cells.
Rome, LazioAges 18–65 - NCT06776965Recruiting
Ultra-processed foods and rheumatic disease study
This study explores how eating ultra-processed foods affects people with chronic rheumatic diseases like rheumatoid arthritis, spondyloarthritis, or osteoarthritis. It aims to understand if diet plays a role in symptom management.
LyonAges 18 years+ - NCT06838793Recruiting
Comparing two nerve block methods for lung surgery
This trial compares two techniques for numbing the chest during lung cancer surgery to see which provides better pain relief. It may help patients recover with less discomfort.
New TerritoriesAges 18–80 - NCT06924125Recruiting
Natural history study for LAMA2 muscular dystrophy
This study follows people with LAMA2-related muscular dystrophy over time to better understand the condition. It may help with future treatments by learning more about how the disease progresses.
Barcelona, BarcelonaAges birth–100 years - NCT04397484RecruitingPhase 4
Compare two local anesthetics after foot nerve blocks
This study tests whether lidocaine or levobupivacaine works better for how a nerve block behaves after foot surgery. It may help doctors choose the anesthetic that provides more reliable pain control after surgery.
Shatin, New TerritoriesAges 18–75 - NCT05649644Recruiting
Testing two anesthesia types for arm surgery
This trial compares two methods of numbing the arm and chest area during upper-extremity surgery. It may help you and your care team choose the option that works best and feels easiest for breathing and movement.
Hong KongAges 18–75 - NCT06912061Recruiting
New needle technique for Achilles tendon lengthening in kids
This study tests a new needle-based method to lengthen a tight Achilles tendon in children, which can help with toe walking or foot pain. The goal is to see if it works well and is safe.
DrammenAges 5–16 - NCT06917235Recruiting
Wrist fusion study: 1-year follow-up.
This study follows patients for one year after wrist fusion surgery to see how well the procedure works. It may help if you have severe wrist arthritis that hasn't improved with other treatments.
DrammenAges Any age - NCT06881498Recruiting
Blood thinning technique for bone tumor surgery
This trial tests a technique called 'acute normovolemic hemodilution' during bone tumor surgery. It involves temporarily thinning your blood by removing some red blood cells and replacing them with fluid, which may reduce the need for blood transfusions.
Hangzhou, ZhejiangAges 18–75 - NCT07204288Recruiting
Lumbar and sacroiliac fusion study for people with previous implants
This study looks at how well certain Spinal Simplicity implants work over time for people who have already received them. You must have received a specific implant between 2022 and 2025 to qualify.
Overland Park, KansasAges 18 years+ - NCT07208448Recruiting
Study on a new shoulder spacer for torn rotator cuff
This trial tests a new biodegradable spacer for the shoulder in people with a full-thickness rotator cuff tear. It may help relieve pain and improve shoulder function without the need for more invasive surgery.
AshdodAges 50 years+ - NCT07209033Recruiting
Testing FlexiOss for bone repair in leg and foot fractures
This trial tests a new material called FlexiOss to help heal broken bones in the leg or foot. It aims to see if the material is safe and effective for bone regeneration.
KrakowAges 18–75 - NCT07207187Enrolling by invitation
Long-term outcomes of the Karma fixation system
This study looks at how patients are doing one year or more after spinal surgery with the Karma Fixation System. It may help doctors understand the long-term safety and effectiveness of this treatment.
Gilbert, ArizonaAges 18 years+ - NCT07209332Enrolling by invitationPhase 2
Long-term safety study of WVE-N531 for Duchenne muscular dystrophy
This trial is for people who have already taken WVE-N531 in an earlier study. It continues to check the medicine's safety and effects over a longer period.
AmmanAges Any age
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.