Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT04626674RecruitingPhase 1
Gene therapy safety study for non-ambulatory Duchenne
This Phase 1 trial studies a one-time gene therapy treatment (SRP-9001) to see if it is safe and whether it can produce the needed gene activity in people with Duchenne muscular dystrophy (DMD) who are not walking. It may help researchers understand whether this approach could be useful for DMD patients, especially in later stages.
Little Rock, ArkansasAges 2 years+ - NCT04627870Recruiting
Drug-coated balloon treatment for recurrent brain stent narrowing
This pilot study tests a catheter treatment called a drug-coated balloon to treat repeat narrowing inside a previously placed brain stent. It may help people whose stent has narrowed again and is causing reduced blood flow or stroke/TIA symptoms despite best medical therapy.
BeijingAges 18–80 - NCT04630873RecruitingPhase 1
Botox dilution options for walking in hemiplegic gait
This Phase 1 study tests whether using a lower or higher dilution of Botox injections improves walking in people with hemiplegic gait. The goal is to see which dilution works better (and is safe) for walking and leg stiffness.
IoanninaAges 18 years+ - NCT04629352Recruiting
tDCS brain-stimulation for hearing voices in schizophrenia
This study tests whether a non-invasive brain-stimulation treatment (tDCS) can improve response to care in people who experience clinically significant hearing voices. It may help by changing brain activity, aiming to reduce or improve auditory hallucinations.
Bengaluru, KarnatakaAges 18–45 - NCT04630392Recruiting
Treadmill and vibration therapy for children with spastic cerebral palsy
This study tests whether treadmill training, with or without whole-body vibration, can improve walking and movement in children with spastic cerebral palsy. If you qualify, the goal is to see whether this exercise approach is safe and helpful.
Atlanta, GeorgiaAges 6–17 - NCT04630535Recruiting
Using brief arm treatment before bypass surgery
This trial studies whether a simple, remote “arm treatment” given before scheduled aorto-bifemoral bypass surgery can help protect blood flow during surgery. If you fit the surgery plan and don’t have certain excluded conditions, the study may offer an added protective approach.
Brno, Czech RepublicAges 18 years+ - NCT04631471RecruitingPhase 3
Ibudilast for spinal cord pressure from neck wear
This Phase 3 study tests ibudilast, a medicine, to see if it can improve symptoms in people whose neck arthritis has started compressing the spinal cord. You would still have your usual surgery to relieve the pressure, and then take the study medicine to see if recovery and function improve.
CambridgeAges 18–80 - NCT04632628Recruiting
Online sleep coaching for insomnia in dementia caregivers
This trial tests an online form of cognitive behavioral therapy (a structured skills-based program) to improve insomnia for people caring for someone with dementia. It may help reduce trouble falling asleep, staying asleep, or waking too early.
Columbia, MissouriAges 18 years+ - NCT04634383Recruiting
Testing a brain-connected implant to help some blind people see
This early safety study tests an implanted device placed in the brain to help people with very limited sight (no or minimal light). It focuses on whether the implant can be safely used and whether it may support vision-related signals over time.
Chicago, IllinoisAges 19–70 - NCT04635436Recruiting
Split-walking training for one-sided leg weakness when walking hurts
This trial tests whether a “split gait” walking training method can improve walking balance and how you move when you have one-sided leg problems and pain or limitations when walking. It may help reduce walking difficulties by training your stepping pattern safely.
Milan, MIAges 18–70 - NCT04634994RecruitingEarly Phase 1
Brain scans to measure synapses in multiple sclerosis
This early study uses special brain scans (PET and MRI) to measure “synapse density” (how many connection points brain cells have) in people with multiple sclerosis (MS). It may help researchers understand MS biology and improve future treatments.
Boston, MassachusettsAges 18–60 - NCT04635657Recruiting
Testing brain function after meningioma surgery
This study measures how thinking and memory change after surgery to remove a meningioma near the front or side of the brain. It may help doctors better understand what to expect and how cognitive recovery can differ from person to person.
Columbus, OhioAges 18–89 - NCT04639336Recruiting
Pompe disease study of brain and nerve effects
This study looks at how Pompe disease affects the brain and nervous system. You may be able to join if you have a confirmed diagnosis of infantile or late-onset Pompe disease and agree to participate.
Durham, North CarolinaAges birth–18 years - NCT04639297Recruiting
Testing a brain/spine monitoring method during spinal surgery
This trial compares a new “NeuroVision” monitoring approach with the standard method while you have spinal surgery for worn-out (degenerative) problems. The goal is to see if NeuroVision helps surgeons detect nerve-related issues earlier and safer during the operation.
Chicago, IllinoisAges Any age - NCT04640584Recruiting
C-Brace care registry to track brace comfort
This registry follows people who have been assessed and fitted for a C-Brace. It helps the study team understand how well the brace process works and collect your feedback to improve care.
Harrison, ArkansasAges Any age - NCT04639622Recruiting
Study for inherited frontotemporal dementia gene risks
This study recruits adults who come from families with certain known gene changes linked to frontotemporal dementia. It aims to learn more about these inherited forms of dementia using brain scans and research blood testing, which will not provide personal results.
LilleAges 18 years+ - NCT04641286Recruiting
Tracking changes in quick recovery after acute stroke
This study looks at how stroke symptoms and recovery change over time soon after an acute stroke. It may help doctors better predict outcomes and improve care planning for stroke patients.
LondonAges 18 years+ - NCT04643327RecruitingPhase 2
Levetiracetam study to lower dementia risk in Parkinson’s
This Phase 2 study tests whether an added medication strategy can change brain targets linked to memory decline in people with Parkinson’s disease, including those with no memory problems or mild memory changes. It may help lower risk of developing dementia, but you must be able to safely do MRI scans and meet other health and medication rules.
Brisbane, QueenslandAges Any age - NCT04645160RecruitingPhase 1/Phase 2
Tivozanib for bile duct and gallbladder cancers after chemotherapy
This Phase 1/2 trial tests tivozanib (a targeted anti-cancer drug) in people with bile duct or gallbladder cancer that cannot be removed by surgery and has already been treated with first-line chemotherapy. The study looks at how well the drug works and how safe it is in this setting.
Bethesda, MarylandAges 18 years+ - NCT04647292RecruitingPhase 2
Intensive blood pressure lowering after stroke
This Phase 2 study tests whether aiming for a lower blood pressure targets after a stroke reduces the risk of future problems. You may be asked to measure your blood pressure at home and follow the study’s treatment plan.
DublinAges 40 years+ - NCT04648462Recruiting
Proton therapy planning for certain brain tumors
This study builds and tests how proton therapy planning could better protect the brain compared with standard radiation (photon therapy) for adults with certain brain tumors. It may help reduce radiation to sensitive areas like the hippocampus, with the goal of better long-term brain function.
Maastricht, LimburgAges 18 years+ - NCT04649008RecruitingEarly Phase 1
MRI and brain electrodes to map epilepsy areas
This early study looks at how MRI scans and implanted brain electrodes (intracranial EEG) can pinpoint where seizures start, especially in the temporal (side) lobe. It may help doctors better localize seizure sources for people whose seizures don’t respond well to medications.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04650932Recruiting
Study tests new stimulation settings for advanced Parkinson’s
This study looks at whether changing how deep brain stimulation (DBS) pulses are delivered can improve symptoms in people with advanced Parkinson’s disease. You may be eligible if you already have a specific Boston Scientific DBS device and have had it implanted for at least 3 months.
Sacramento, CaliforniaAges 18 years+ - NCT04650321RecruitingPhase 4
Home infusions of ocrelizumab for some people with MS
This study looks at giving ocrelizumab treatments at home instead of in a clinic for people with MS. It’s meant to see if this approach is practical and acceptable while you keep receiving a medicine your MS doctor thinks you should continue.
Centennial, ColoradoAges 18–55
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.