Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT04651010Recruiting
MRI study to predict outcomes after clot removal in stroke
This study uses special MRI scans to look for patterns that may predict recovery after a specific type of stroke caused by a blocked brain artery. It may help doctors choose the best treatment and better understand who benefits most from clot removal.
PoitiersAges 18 years+ - NCT04652609Recruiting
Exercise program to prevent nerve damage from chemotherapy
This trial studies an exercise program (PRESIONA) that may help prevent nerve pain or numbness caused by a common type of breast cancer chemotherapy called taxane-based treatment. It targets people with HER2-positive breast cancer who are about to start neoadjuvant chemotherapy.
GranadaAges 18–70 - NCT04652908RecruitingPhase 1/Phase 2
Cell therapy given during pregnancy to repair spina bifida
This trial studies a cell-based treatment given during fetal surgery to help repair myelomeningocele (spina bifida) before birth. It aims to improve outcomes for the baby by supporting “in utero” repair, but you must meet strict pregnancy and health criteria to be considered.
Sacramento, CaliforniaAges 4 months–6 months - NCT04653012Recruiting
Testing brain-activity recordings in people with drug-resistant epilepsy
This study looks at brain activity using electrodes placed inside the brain in people with focal, drug-resistant epilepsy before surgery. It may help doctors better map where seizures start and improve planning for treatment.
ParisAges 18 years+ - NCT04654975Recruiting
Metastatic brain tumors after esophagus surgery study
This study looks at people who had esophageal cancer surgery and later developed brain metastases. It may help doctors better understand who benefits from treatment planning after the original cancer surgery.
Houston, TexasAges Any age - NCT04655404RecruitingEarly Phase 1
Larotrectinib for children with newly diagnosed glioma with NTRK fusion
This trial tests larotrectinib, a targeted cancer medicine, in children and teens with newly diagnosed high-grade brain glioma that has an NTRK fusion. It may help shrink or control tumors by targeting a specific genetic change in the cancer.
Aurora, ColoradoAges Up to 21 years - NCT04658290Recruiting
Sleep apnea screening and memory test study
This study looks at how common obstructive sleep apnea is and whether it’s linked to thinking and memory problems. It may help clarify which people with sleep apnea might be more likely to have cognitive difficulties.
Hong Kong, Please SelectAges 40–74 - NCT04659291Recruiting
Studying people in Hong Kong who may have sleep apnea
This study looks at people who may have obstructive sleep apnea, a breathing problem during sleep. It aims to better understand the condition in Hong Kong and what to do next for diagnosis or care.
Hong Kong, Please SelectAges 18 years+ - NCT04659317RecruitingPhase 3
Opioid-free pain plan for joint and arm surgeries
This Phase 3 study tests an opioid-free approach to pain control for certain orthopedic (bone/joint) surgeries. The goal is to help people manage surgical pain without using opioid pain medicines.
Atlanta, GeorgiaAges 18 years+ - NCT04661280RecruitingPhase 3
Donepezil compared with non-drug care for Alzheimer’s
This trial compares donepezil (a medicine for Alzheimer’s symptoms) against a non-drug treatment plan. It aims to see which approach helps people with Alzheimer’s who still have measurable thinking ability and specific Alzheimer’s test results.
ParisAges 50 years+ - NCT04660747Recruiting
Anticoagulant medication choices for cerebral venous thrombosis
This study looks at people with cerebral venous thrombosis who were treated with blood thinners taken by mouth (or started within the first 30 days). It uses observational data to understand how these treatments are used and what outcomes may follow.
Amsterdam, North HollandAges 18 years+ - NCT04663399Recruiting
Study immune changes after stroke treatment
This study looks at how the body’s immune system responds after an acute ischemic stroke that may be treated with a procedure called mechanical thrombectomy. It may help doctors understand what immune changes happen after treatment and improve future care.
Paris, ParisAges 18 years+ - NCT04664946Recruiting
Intra-arterial treatment for stroke when no reperfusion was given
This trial tests an “intra-arterial” approach (a treatment delivered through an artery to the brain) for people with ischemic stroke who were not given clot-busting therapy or a clot-removal procedure. It aims to improve neurological recovery when there wasn’t reperfusion therapy, including in cases where symptoms worsen soon after stroke.
ShenyangAges 18 years+ - NCT04664569Recruiting
Study of treatments for bacterial meningitis in children
This study enrolls children and newborns with suspected or confirmed bacterial meningitis. The goal is to understand and improve care for serious infections that affect the lining around the brain.
CréteilAges 1 day–18 years - NCT04664933Recruiting
Study to protect the brain during clot-removal stroke treatment
This trial tests a brain-protective approach given through an artery during treatment for an acute ischemic stroke when clot removal (endovascular therapy) is planned. It may help reduce brain injury related to the stroke and procedure.
ShenyangAges 18 years+ - NCT04665726Recruiting
Natural history study of Usher syndrome hearing and vision changes
This study follows people with Usher syndrome over time to better understand how hearing and vision symptoms change. It may help researchers measure disease progression and support future treatments.
ParisAges Any age - NCT04666714RecruitingPhase 3
Tested a new medicine to reduce diabetic nerve pain
This Phase 3 study tests Praga formulation to see if it safely reduces nerve pain caused by diabetes. You may qualify if you’re an adult with painful diabetic neuropathy and have certain symptom and pain scores on questionnaires.
Campinas, São PauloAges 18 years+ - NCT04671381Recruiting
More affordable adult hearing care for eligible Alabama residents
This study aims to improve access and affordability of hearing healthcare for adults who have mild to moderate hearing loss. If you live in parts of South or West Central Alabama and meet the age and health requirements, your care may be coordinated through the program being tested.
Tuscaloosa, AlabamaAges 40 years+ - NCT04672733Recruiting
Switch from IVIg to Hizentra for CIDP nerve inflammation
This study tests Hizentra® as an alternative to IV immunoglobulin (IVIg) for adults with CIDP, a condition where the immune system damages the nerves. You may be able to switch to Hizentra if your current IVIg treatment is keeping your CIDP stable and you can switch safely.
AmiensAges 18 years+ - NCT04673981Recruiting
Follow-up study for oral and throat cancer pain
This study looks at nerve-related symptoms and pain in the mouth and throat in people who have been treated for oral or oropharynx cancer. You may be able to take part if you’re within 1 to 5 years after treatment and can follow study steps.
Clermont-FerrandAges 18 years+ - NCT04675268Recruiting
Testing nighttime oxygen patterns in suspected sleep apnea
This study looks at how oxygen levels change during the night in people who might have obstructive sleep apnea (OSA). It may help doctors better understand breathing problems during sleep and improve how OSA is evaluated.
LeuvenAges 18 years+ - NCT04675216Recruiting
Measure pressure in the back part of the brain in serious illness
This study measures pressure inside the skull (intracranial pressure) in adults with serious problems in the back part of the brain. Doctors want to better understand pressure patterns in emergencies like bleeding, tumors, or stroke-related injuries, which may help guide treatment.
Valencia, ValenciaAges 18–80 - NCT04677751Recruiting
Testing acupuncture effects in people with an implanted seizure device
This study looks at how adding acupuncture may change seizure activity in people who already have an implanted RNS seizure monitor and stimulator. You might benefit by learning whether acupuncture helps with seizure patterns without changing your usual treatments.
Houston, TexasAges 15–60 - NCT04678167Recruiting
Special “ring” glasses for vestibular neuritis symptoms
This trial tests whether wearing “ring” glasses helps reduce symptoms from vestibular neuritis, a condition that causes spinning vertigo and balance problems. Participants may get the glasses being tested or look-alike placebo glasses (or not wear glasses), so the study can tell if the glasses truly help.
BrestAges 18 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.