Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT04921592Recruiting
Arm therapy for people with chronic cervical spinal cord injury
This trial looks at an upper-arm exercise program for people with long-term (at least 6 months) spinal cord injuries in the neck area. It may help improve how you use your arms and manage stiffness, while also checking if the program is safe for participants.
West Orange, New JerseyAges 18 years+ - NCT04923126RecruitingPhase 1/Phase 2
Mirdametinib for children with low-grade brain tumors
This Phase 1/2 study tests mirdametinib, a targeted medicine, in children and young adults with low-grade glioma (a slower-growing brain tumor). It aims to find the best dose and see how well the treatment works, especially for tumors with certain “MAPK pathway” changes.
Memphis, TennesseeAges 2–24 - NCT04923542RecruitingPhase 1/Phase 2
Targeted drug plus focused brain radiation for breast cancer
This study tests whether abemaciclib (a targeted pill) given with focused radiation to brain tumors can control hormone receptor–positive, HER2-negative breast cancer in the brain. It’s designed to see if the combination helps shrink or slow the growth of brain metastases while keeping side effects manageable.
Tampa, FloridaAges 18 years+ - NCT04923984Recruiting
Procedure to stop bleeding in a brain bleed using a small plug
This trial looks at a minimally invasive procedure that may stop bleeding in the space between the brain and its outer covering (a subdural hematoma). It’s being offered to people being evaluated in Canada, and the main goals are to see if the approach is safe and practical for routine use.
Winnipeg MB, ManitobaAges 18 years+ - NCT04924075RecruitingPhase 2
Belzutifan for cancers linked to VHL or HIF-2α changes
This Phase 2 study tests belzutifan (MK-6482) to treat certain advanced cancers caused by specific gene or disease changes, including VHL-related tumors and HIF-2α related tumors. It may help shrink tumors or slow their growth in people whose cancer matches these genetic or disease patterns.
Los Angeles, CaliforniaAges 12 years+ - NCT04925349Recruiting
Study blood immune patterns in several rare brain diseases
This study looks at immune cells in blood to better understand rare brain conditions caused by genetic changes. It may help researchers understand why symptoms happen and how the immune system is involved.
Le Kremlin-BicêtreAges 1.3 years–60 years - NCT04925414RecruitingPhase 4
Testing high-flow oxygen for migraine in the emergency room
This trial looks at whether breathing high-flow oxygen in the emergency department can help relieve migraine-like headaches. You may qualify if you are 18+ and are admitted to the ER for a migraine that fits standard diagnostic rules.
NiceAges 18 years+ - NCT04927156Recruiting
Check safety and use of Balt medical devices after treatment
This post-marketing study follows people after they receive Balt medical devices to make sure the devices are safe, work well, and are easy to use in real life. You may be considered if you can consent and your procedure matches their device-use rules.
AngersAges 2 years+ - NCT04928482Recruiting
Training with backward walking after stroke
This trial studies whether backward walking training can improve balance and walking speed after a stroke. It may help people who still have trouble staying steady or walking quickly during recovery.
Gainesville, FloridaAges 18–90 - NCT04930887RecruitingPhase 2
Numbing injection in the face to ease craniofacial pain
This trial tests whether an injection of a numbing medicine (bupivacaine) guided by an endoscope can reduce craniofacial pain. It may help people with certain headache or facial pain conditions by targeting the pain area more precisely.
Stanford, CaliforniaAges 18–80 - NCT04932577RecruitingPhase 2/Phase 3
Fecal transplant to treat complications of liver cirrhosis
This trial studies whether transferring healthy gut bacteria (from a donor sample) can improve outcomes for people with liver cirrhosis who have worsening complications. It may help by changing the gut microbiome, which can influence inflammation and liver health.
AarhusAges 18–75 - NCT04933552Recruiting
Safety study of Mayzent during pregnancy for babies
This study follows pregnant people with multiple sclerosis (MS) who took Mayzent (siponimod) to understand safety for pregnancy outcomes. It compares them with other groups to see whether there are any differences in birth results.
La Jolla, CaliforniaAges Any age - NCT05735717RecruitingPhase 2
T-cell transplant using depleted receptors for blood cancers
This Phase 2 study tests a specialized stem cell transplant that removes certain immune “T-cell” receptors to help treat blood cancers like acute leukemia. It may help your body rebuild a healthier immune system after high-dose treatment.
Minneapolis, MinnesotaAges Up to 60 years - NCT04629547RecruitingPhase 2
Sleep study to help prevent Alzheimer’s disease
This trial tests whether treating sleep issues and measuring sleep can help lower the risk of Alzheimer’s disease before it starts. It focuses on older adults with no dementia signs yet.
St Louis, MissouriAges 65 years+ - NCT06888817RecruitingPhase 3
Bevacizumab vs steroids for brain radiation injury
This trial tests if bevacizumab works better than steroids for people with brain swelling caused by radiation. If you have this condition and meet certain health requirements, you may join.
AmsterdamAges 18 years+ - NCT05417399Recruiting
Walking focus and distraction in cerebral palsy
This study looks at how paying attention to walking or doing another task at the same time affects walking in children with cerebral palsy. It may help understand how to improve training and therapy.
Enschede, OverijsselAges 4–16 - NCT07697664Recruiting
Memory and thinking through exercise in aging
This study looks at whether light-to-moderate physical activity (like walking or stretching) can help memory and thinking in middle-aged and older adults. People with normal thinking, mild memory problems, or Parkinson's disease may join if they aren't already very active.
Atlanta, GeorgiaAges 18–79 - NCT04601038RecruitingPhase 2
Testing a stress-blocking drug for early Alzheimer's risk
This study tests a new medication, CORT108297, that may help protect the brain from the harmful effects of stress in people at risk for Alzheimer's disease. It is looking for adults age 55 and older who either have mild memory problems or are healthy but have a family history, APOE4 gene, or memory concerns.
Baltimore, MarylandAges 55 years+ - NCT07698405Recruiting
Advanced rehab technology for arm recovery after stroke
This study tests whether advanced technology-based rehabilitation can help people who have had a stroke regain movement and use of their affected arm. It may be a good option if you have had a single stroke and still have some arm weakness but no severe muscle tightness or memory problems.
Fiorenzuola d'Arda, PiacenzaAges 18 years+ - NCT07443826RecruitingPhase 1/Phase 2
Gene therapy for age-related muscle loss and heart health
This trial tests a gene therapy that may help rebuild muscle and improve blood vessel growth in people ages 35 to 75. It's designed for those with stable health conditions and no history of cancer, heart disease, blood clots, or diabetes.
Coxen Hole, Bay IslandsAges 35–75 - NCT05579496Recruiting
Rebooting infant pain care using skin-to-skin contact
This trial tests how skin-to-skin contact affects pain and brain activity in premature babies during a routine heel prick. It may help find better ways to manage pain for infants in the NICU.
Toronto, OntarioAges 6 months–8 months - NCT04187131Recruiting
AR brain tests and rehab for stroke neglect
This trial tests an augmented reality (AR) system to find and treat “neglect” after an acute stroke. If you qualify, it may help assess attention problems and guide rehabilitation exercises.
Boston, MassachusettsAges 18 years+ - NCT07698951Recruiting
Testing a new device to close PFO after stroke
This trial tests a new device to close a PFO (a small hole in the heart) in people who have had a stroke caused by a blood clot passing through that hole. The goal is to see if the device can prevent another stroke.
BelgradeAges 18–65 - NCT07698743Recruiting
Eating disorders in phenylketonuria patients study
This study looks at eating habits and disorders in people with phenylketonuria (PKU) who are treated at a specific hospital in Nancy, France. Participating involves sharing information, which may help doctors better understand eating challenges in PKU.
NancyAges Any age
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.