Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT04898491Recruiting
Pain behavior scale study for adults who cannot speak
This study checks whether a “pain behavior” checklist works well and gives consistent results in adults who can’t communicate verbally and who have an artificial airway. It may help clinicians better recognize pain in people who cannot tell them directly.
Madrid, MadridAges 18 years+ - NCT04899908RecruitingPhase 2
Brain radiation with or without gadolinium nanoparticles for brain metastases
This trial tests whether adding tiny gadolinium-containing nanoparticles to standard brain radiation can better control brain metastases from certain cancers. It is for people with tumors that have grown after immunotherapy, are from certain cancers (like melanoma, GI, or HER2+ breast), are cystic, are large, or have come back after prior radiation.
Boston, MassachusettsAges 18 years+ - NCT04899947Recruiting
Registry for children with narcolepsy
This trial is a registry (a study database) that collects information from children and teens with narcolepsy. It helps researchers better understand the condition and who is affected, which can support future studies.
Phoenix, ArizonaAges Up to 17 years - NCT04900064Recruiting
Self-help CBT added to primary care behavioral health
This trial studies whether adding a Swedish self-help version of “CBT” (a structured talking-therapy approach) improves care for adults getting behavioral health support in primary care. It may help people who want support for mental health without needing fully guided therapy sessions.
Varberg, Halland CountyAges 18 years+ - NCT04900493Recruiting
Rett syndrome global patient and family registry
This registry collects health and family information about people with Rett syndrome (or specific changes in the MECP2 gene). It helps researchers understand the condition better and plan future studies. Participation may include sharing information for living individuals or those who have passed away.
Trumbull, ConnecticutAges Any age - NCT04903015Recruiting
Study brain effects in retiring pro soccer players
This study looks at how years of playing professional soccer may affect the brain and thinking, using MRI (brain scans) and comparisons to people who had little head-impact sports exposure. You might join if you are a retiring Ligue 1 or Ligue 2 player and meet the injury and health criteria.
StrasbourgAges 32–55 - NCT04902703RecruitingPhase 2
GM-CSF drug trial for mild to moderate Alzheimer’s disease
This Phase 2 study tests whether sargramostim (a GM-CSF related medicine) is safe and can slow or improve Alzheimer’s symptoms. You might be a good fit if you have mild or moderate Alzheimer’s, positive amyloid testing, and can complete frequent visits with a close caregiver who knows you well.
Aurora, ColoradoAges 60–85 - NCT04905264Recruiting
Studying factors and care quality after severe brain injury
This study looks at how outcomes and care quality vary for people with serious acquired brain injuries while in a rehabilitation unit. It may help clinicians understand what care works best and why.
AlessandriaAges 18 years+ - NCT04903951RecruitingPhase 2
Check if early breathing support after stroke helps sleep apnea
This trial tests whether starting a breathing-support treatment soon after a first stroke improves outcomes in people who also have sleep apnea. It may help reduce complications and support recovery if you meet the specific timing and health criteria.
Matosinhos MunicipalityAges 18–80 - NCT04905745Recruiting
Integrative Korean medicine for new one-sided Bell’s palsy
This trial studies whether an integrative Korean medicine treatment can safely improve symptoms of Bell’s palsy. It’s meant for people whose facial weakness started recently, to see if treatment helps recovery.
Seoul, Gangnam-GuAges 19–69 - NCT04906460RecruitingPhase 1/Phase 2
Testing WVE-N531 for Duchenne muscular dystrophy exon 53
This early-phase study tests WVE-N531 in people with Duchenne muscular dystrophy (DMD) whose genetics specifically match an “exon 53” change. It may help by targeting the muscle disease process, and it includes procedures like muscle biopsies and regular heart/lung checks.
Little Rock, ArkansasAges 4–18 - NCT04906863Recruiting
Genetic study for early dementia in adults and families
This trial studies genes to better understand why some people develop dementia and memory problems earlier in life. It may help researchers find clearer causes and improve future testing and treatments for families affected by dementia.
New York, New YorkAges 35 years+ - NCT04906928Recruiting
MRI study to better scan spinal inflammation
This study tests new MRI scan settings to see inflammatory changes in the spinal cord more clearly. It may help doctors choose better MRI images when first checking—or re-checking—spinal inflammation.
ParisAges 18 years+ - NCT04908423RecruitingPhase 4
Xeomin to improve walking after stroke
This trial tests Xeomin (a type of botulinum toxin) to improve walking and leg mobility after stroke-related muscle stiffness. It’s for people who have spasticity (tight, stiff muscles) that affects how they clear their toes during walking.
Charlotte, North CarolinaAges 18–79 - NCT04908319Recruiting
Studying liver tissue in urea cycle disorders
This study looks at liver tissue (under a microscope) in people with urea cycle disorders to better understand liver changes from the condition. It may help clinicians learn what to watch for and how to manage liver health, especially around liver biopsy or transplant.
Washington D.C., District of ColumbiaAges Any age - NCT04909138Recruiting
Intermittent nerve stimulation instead of daily low-frequency therapy
This study tests whether switching from continuous implanted nerve stimulation to an intermittent schedule can keep pain relief for people with chronic back and/or leg pain. You would be compared in a structured study plan to see if the alternate dosing works for you and is safe.
Chicago, IllinoisAges 18–90 - NCT04911738Recruiting
Virtual reality glasses to improve balance after stroke
This trial studies whether virtual reality glasses training can improve balance and body alignment after a recent stroke. It will also compare how stroke participants with balance problems respond versus people without stroke.
GrenobleAges 18–80 - NCT04912843RecruitingPhase 2/Phase 3
Gene therapy for inherited optic nerve vision loss
This trial tests a gene therapy injection into the eye to improve vision in people with a specific type of inherited optic nerve disease called Leber’s hereditary optic neuropathy (LHON). It is aimed at people who have a particular genetic change and a history of vision loss lasting long enough to measure change, while checking for safety first.
BeijingAges 12–75 - NCT04915027Recruiting
Digital follow-up tool for people recovering after stroke
This trial studies a patient-centered digital check-in tool to support follow-up care after stroke. It may help people track recovery and stay connected to support during the months after stroke.
UmeåAges 18 years+ - NCT04915183RecruitingPhase 2
Atorvastatin to help prevent cisplatin-related hearing loss
This Phase 2 trial tests whether a cholesterol medicine called atorvastatin can protect hearing in people with head and neck cancer receiving cisplatin plus radiation. If it works, it may reduce the chance or severity of treatment-related hearing damage.
Atlanta, GeorgiaAges 18–100 - NCT04916210Recruiting
Study how stroke type affects thinking and recovery
This study looks at what predicts memory and thinking problems after different types of stroke or brain bleeding, and how blood-vessel changes relate to recovery. You may be invited if you recently had a stroke/bleed and can complete a baseline check within 6 weeks.
Phoenix, ArizonaAges 18 years+ - NCT04916197RecruitingPhase 4
Dexmedetomidine sedation after stroke clot removal
This Phase 4 study tests whether using a specific calming medicine (dexmedetomidine) for a longer period after a successful clot-removal procedure helps people do better in the long term. It may help improve outcomes after ischemic stroke where the clot is successfully treated.
Beijing, Beijing MunicipalityAges 18–80 - NCT04917705Recruiting
Blood and tissue tests to find markers in muscle and skin disease
This study looks for blood and tissue “biomarkers” (measurable clues in samples) to help diagnose and predict outcomes in inflammatory muscle diseases and systemic sclerosis (a skin/organ condition). If you’re being evaluated for myopathy or early scleroderma, it may help doctors sort out the cause and follow your health more closely.
Strasbourg, Bas-RhinAges 18 years+ - NCT04920318Recruiting
Study to improve language in primary progressive aphasia
This trial looks at ways to improve language abilities in people with primary progressive aphasia (a long-term brain condition that affects speech and language). It may help if your communication problems come from this condition and you can safely take part in the study activities, which likely involve language practice and MRI scanning.
Tucson, ArizonaAges 45–80
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.