Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT05889624Recruiting
Study of treatments for childhood migraine headaches
This study looks at ways to help children and teens with migraine headaches by testing a care approach that includes access to evidence-based treatment. It may help if your child has frequent migraine headaches and is starting (or not already on) certain migraine-preventive medicines.
Birmingham, AlabamaAges 10–17 - NCT05889650Recruiting
External drainage for severe TBI brain swelling
This study tests whether placing an external drainage tube in the lower back can reduce dangerous pressure in the brain after a severe traumatic brain injury. If you meet safety and brain-scan criteria, it may help the research team understand whether this approach is safe early after injury.
Gainesville, FloridaAges 18–65 - NCT05890781Recruiting
Study pediatric cancer using lab-made immune organoids
This trial uses special lab models (“immune organoids”) to study certain cancers in children and young people. It may help researchers learn what those cancers do and improve future treatment ideas.
VillejuifAges Up to 25 years - NCT05891873Recruiting
Study delirium during ICU care for stroke patients
This study looks at “delirium,” a sudden confusion that can happen during critical care, in people receiving ICU treatment for stroke. It includes both adults and children in specific ICU settings and may help clinicians better prevent or manage confusion during recovery.
BrnoAges Any age - NCT05891379Recruiting
Inebilizumab for adults with acute neuromyelitis optica attacks
This trial studies inebilizumab to treat adults with neuromyelitis optica spectrum disorder (NMOSD) who are having an acute attack. It aims to reduce ongoing nerve damage and disability after a recent flare, alongside standard steroid treatment.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05891509Recruiting
DTI-guided minimally invasive surgery for deep brain bleeding
This trial studies whether a special scan-guided, minimally invasive procedure can safely remove bleeding in the basal ganglia (deep in the brain) soon after it happens. It may help patients recover better by targeting the bleeding while protecting important brain pathways.
Ganzhou, JiangxiAges 18–80 - NCT05892952Recruiting
Scottish long-term study of aging and thinking
This study follows adults aged 50 and older over time to understand how thinking and memory change. You may help researchers learn what influences healthy aging and cognitive health.
Edinburgh, LothianAges 50–120 - NCT05892510RecruitingPhase 2/Phase 3
Tenecteplase after clot removal for no-reflow stroke
This trial tests whether giving tenecteplase directly into the brain artery after a thrombectomy can improve outcomes when blood flow doesn’t fully return (“no-reflow”) in an emergency stroke. It may help some people by reducing ongoing clot-related blockage after the main clot is removed.
Gold Coast, QueenslandAges 18 years+ - NCT05892965Recruiting
Instant-message online therapy for early post-stroke depression
This study tests whether brief online cognitive behavioral therapy (CBT) delivered through instant messages can reduce depression symptoms after a stroke. It may help if your depression started after your stroke and you have mild to moderately severe symptoms.
Hong KongAges 18 years+ - NCT05893407Recruiting
Ultrasound test of brain blood flow in ICU injury
This trial tests whether a contrast-enhanced ultrasound can measure blood flow in the brain of people admitted to the ICU for a sudden brain injury. It may help doctors better assess brain damage and guide care using a bedside imaging method.
ParisAges 18 years+ - NCT05893186RecruitingEarly Phase 1
Testing DBS settings for walking and balance in Parkinson’s
This early-phase study looks at whether adjusting deep brain stimulation (DBS) can improve posture, walking, and balance in people with Parkinson’s disease. If you already have DBS in place, the trial uses computer-based planning to try different DBS directions and settings to see what helps you most.
Minneapolis, MinnesotaAges 18–89 - NCT05893524Recruiting
Dementia and walking study using simple movement tests
This study looks at how memory problems and walking/mobility are connected. It may help researchers understand better ways to assess dementia risk and mobility changes early.
Falun, Dalarna CountyAges 37–94 - NCT05895786RecruitingPhase 3
Study drug for active dermatomyositis or polymyositis
This Phase 3 trial tests how an investigational medicine (PF-06823859) works in adults with active dermatomyositis or polymyositis. It aims to improve disease control by targeting the immune system, but you must meet several safety and diagnosis requirements.
Glendale, ArizonaAges 18 years+ - NCT05895838RecruitingPhase 3
Trial for medicines after out-of-hospital cardiac arrest
This Phase 3 trial studies treatments given after a person survives an out-of-hospital cardiac arrest to improve recovery and survival. It is for patients who stay unconscious for a short time after circulation returns, and who meet safety conditions.
Copenhagen, Capital Region of DenmarkAges 18 years+ - NCT05896592Recruiting
Ablation versus changing pacing settings for slow heartbeats
This study compares a procedure called cardioneuroablation with staying on permanent pacing in people who have symptoms from a slow heart rate. It aims to see which approach works better and is safer for reducing symptoms related to sinus node or heart conduction problems.
Radom, Masovian VoivodeshipAges 18–65 - NCT05897775RecruitingPhase 1
Testing a new deep brain stimulator approach for essential tremor
This Phase 1 study tests a coordinated reset deep brain stimulation program for people with essential tremor. It may help reduce tremor symptoms using a specific implanted brain-stimulation device, along with special high-strength MRI and CT imaging before and after surgery.
Minneapolis, MinnesotaAges 21 years+ - NCT05897645Recruiting
MRI study of artery plaque after recent stroke
This trial uses special brain MRI to look closely at plaque in certain brain arteries after an ischemic stroke (when a blood vessel is blocked). It may help researchers better understand which plaques are most dangerous soon after stroke.
ShenyangAges 40 years+ - NCT05898542Recruiting
Nature-based therapy for stroke recovery in rehab wards
This trial studies whether nature-based activities (like time outdoors or nature-focused programs) can improve recovery after a stroke. It’s aimed at people who are currently in a stroke rehabilitation setting soon after their stroke.
LahtiAges 18 years+ - NCT05898659Recruiting
Tested new cochlear fitting with or without sound timing sync
This study compares two ways of setting up a cochlear implant to deliver sound, either with or without synchronized timing. It may help improve how well French-speaking adults with newer hearing loss can hear everyday sounds.
NiceAges 18 years+ - NCT05899153Recruiting
Gait training with feedback for children with cerebral palsy
This trial tests whether walking practice with real-time feedback (“biofeedback”) can improve how people with cerebral palsy move their legs. It’s designed to help with safer, more efficient walking during treadmill training.
Saint Paul, MinnesotaAges 7–18 - NCT05899231Recruiting
Online strengthening program while you wait for a liver transplant
This trial tests an online prehabilitation program (strength and fitness training delivered digitally) to help people who are likely to need a liver transplant become stronger before transplant. It may benefit people who feel “frail” or “pre-frail,” since improving strength before surgery can help recovery.
Calgary, AlbertaAges 18 years+ - NCT05899582Recruiting
Heart-bypass–like brain surgery for artery blockage patients
This trial studies whether a special bypass surgery can improve symptoms in people with a long-term (chronic) blockage of the middle brain artery. It aims to improve brain blood flow and reduce future stroke risk in the right patients.
BeijingAges 18–65 - NCT05900778Recruiting
HABIT-ILE program for school-aged children after brain injury
This trial tests whether a structured HABIT-ILE program helps children with a brain injury improve daily functioning at school and during therapy sessions. It may help families build skills and routines, but it requires meeting specific health and timing criteria.
Ottignies-Louvain-la-Neuve, Brabant-WallonAges 5–18 - NCT05900466RecruitingPhase 2
Metformin for fibromyalgia symptom relief
This study tests whether metformin, a diabetes medicine, can reduce fibromyalgia symptoms. If you have fibromyalgia and can take pills safely, you may be able to join and help answer whether metformin can help.
Salt Lake City, UtahAges 18–75
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.