Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,407 recruiting studies in this area right now.
By phase
- Not applicable9,742
- Phase 2782
- Phase 1577
- Phase 3534
- Phase 4342
- Phase 1/Phase 2307
- Phase 2/Phase 3123
Top conditions
- Stroke843
- Parkinson Disease429
- Alzheimer Disease342
- Multiple Sclerosis342
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea156
- Spinal Cord Injuries153
- Insomnia152
- Sarcopenia150
- Traumatic Brain Injury150
- Acute Ischemic Stroke138
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Migraine114
- Pain Management113
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic98
- Xuanwu Hospital, Beijing93
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California680
- Massachusetts299
- New York292
- Florida274
- Texas267
- Maryland246
- Arizona213
- Alabama209
- Illinois189
- Pennsylvania177
Recruiting studies12,405 total
- NCT07143019Recruiting
A new device for treating wide-necked brain aneurysms
This trial tests a special device (p48/64 MW HPC) to treat certain brain aneurysms that are wide-necked or have a shape that makes them hard to treat. It might help people with aneurysms that haven't ruptured or that have been treated before and are now coming back.
Phoenix, ArizonaAges 18 years+ - NCT07251491RecruitingPhase 1/Phase 2
Psilocybin for depression after spinal cord injury
This trial tests whether psilocybin (a substance found in certain mushrooms) can help treat depression in people with a spinal cord injury. You would receive the study drug in a controlled setting, and your progress would be monitored closely.
The Bronx, New YorkAges 22 years+ - NCT07513441RecruitingPhase 1
Testing Lu AF28996 for Parkinson's disease motor fluctuations
This early-stage trial tests a new medication called Lu AF28996 in Chinese patients with Parkinson's disease who experience predictable on-off episodes (times when medication works well versus poorly). The study aims to see if this drug can help reduce those difficult off periods.
Beijing, Beijing MunicipalityAges 35–85 - NCT05477862Enrolling by invitation
Improvised music for Alzheimer's anxiety
This study looks at how creating music in the moment (improvisation) affects anxiety and brain function in people with mild to moderate Alzheimer's disease. It may help reduce agitation and improve quality of life.
Chicago, IllinoisAges 55–100 - NCT07383649RecruitingPhase 2
Anti-CMV therapy for breast cancer with brain metastases
This trial tests a treatment targeting a common virus (CMV) in breast cancer that has spread to the brain. The goal is to see if anti-CMV therapy can shrink or slow these brain tumors.
Houston, TexasAges 18 years+ - NCT06660394RecruitingPhase 3
LP352 for Dravet syndrome in children and adults
This study tests a new medicine called LP352 for children and adults with Dravet syndrome. It compares the study drug to a placebo (a pill with no medicine) to see if it helps reduce seizures.
Little Rock, ArkansasAges 2–65 - NCT06704074Recruiting
Virtual Reality Training for Arm Recovery After Stroke
This trial tests whether virtual reality (VR) games and tasks can help improve arm and hand movement after a stroke. It is for people who had a first stroke 1 to 6 months ago and have some arm weakness but can sit up for 30 minutes.
Jinan, ShangdongAges 18–80 - NCT05195398Recruiting
Brain stimulation to improve thinking after stroke
This study tests whether a noninvasive brain stimulation treatment can improve thinking and memory problems after an acute ischemic stroke. It also uses brain scans to better understand how the treatment may help.
Baltimore, MarylandAges 18–100 - NCT07505823RecruitingPhase 3
Meningococcal vaccine trial for infants 6-11 months old
This study tests whether a new vaccine safely protects infants aged 6 to 11 months against four types of meningococcal bacteria that can cause serious infections like meningitis and blood infections. It is designed for healthy babies who have not yet received any meningococcal vaccine.
Nanning, GuangxiAges 6 months–11 months - NCT07540104Recruiting
Pain block vs morphine injection for chest surgery
This study compares two ways to manage pain after video-assisted chest surgery (VATS): a numbing injection near the shoulder blade (serratus posterior superior intercostal plane block) versus a small dose of pain medicine in the spine (intrathecal morphine). The goal is to find which approach works better and has fewer side effects.
Atakent, SamsunAges 18–75 - NCT07745972Recruiting
Pain relief block for gallbladder surgery
This trial tests a numbing injection near the ribs to reduce pain after laparoscopic gallbladder removal. It may help you recover with less discomfort.
IstanbulAges 18–80 - NCT07286292RecruitingPhase 2
Vorasidenib for children with IDH-mutated low-grade glioma
This trial studies an oral drug called vorasidenib for children and teens with a slow-growing brain tumor (Grade 2 astrocytoma or oligodendroglioma) that has an IDH1 or IDH2 mutation. The drug is taken daily and may help keep the tumor from growing, avoiding the need for immediate chemotherapy or radiation.
SydneyAges 12–17 - NCT07616128RecruitingPhase 2
Testing EVO756 to prevent migraines in adults
This study tests a new medication called EVO756 to help prevent migraines in adults who haven't had success with other preventive treatments. Researchers want to see if this new drug can reduce how often migraines happen.
Chandler, ArizonaAges 18–64 - NCT07665307Recruiting
Delayed side effects after CAR-T for multiple myeloma
This study looks at late side effects that may happen after CAR-T therapy (cilta-cel) for multiple myeloma. It aims to better understand these delayed toxicities so doctors can manage them more effectively.
San Francisco, CaliforniaAges 18 years+ - NCT07688213RecruitingPhase 2
Study of an investigational drug for early Alzheimer's disease
This trial tests an investigational injection for people in the early stages of Alzheimer's. It aims to see if the drug can safely slow down memory loss and brain changes.
The Villages, FloridaAges 55–85 - NCT05926011Recruiting
Test RGn600 in mild to moderate Alzheimer’s patients
This trial studies whether RGn600 can help people with mild to moderate Alzheimer’s disease. You may be able to join if you meet age, test-score, scan, bloodwork, and safety requirements and can attend study visits with a regular caregiver.
CastresAges 55–85 - NCT07103746RecruitingPhase 2
Ublituximab for antibody-positive IMNM
This study tests an investigational medication called ublituximab (an infusion) for people with a rare autoimmune muscle disease called IMNM. It aims to reduce muscle weakness and damage by targeting specific immune cells (B cells). To join, you need a recent diagnosis (within 1 year), specific antibodies, and be on limited other medications.
Birmingham, AlabamaAges 18 years+ - NCT07736092Recruiting
Light Therapy Before and After Surgery for Older Adults
This trial tests a gentle light treatment to help prevent thinking problems after surgery in older patients. It involves using a special light on your head before and after your operation.
Beijing, Beijing MunicipalityAges 65 years+ - NCT05001750RecruitingPhase 1
Preventing EVD infections with antibiotics before device placement
This early-stage study tests whether giving preventive (prophylactic) antibiotics helps prevent infections when an external brain fluid drain (EVD) is placed and used. It may help lower the chance of serious infections around the drain.
The Bronx, New YorkAges 18 years+ - NCT06840015Recruiting
Testing Airpod Pros as a hearing aid for mild to moderate loss
This study tests whether Apple Airpod Pros can work as an assistive hearing device for people with mild to moderate hearing loss. If you haven't used hearing aids before, you may be able to join and help find a new, affordable option.
Richardson, TexasAges 18–60 - NCT03243448Enrolling by invitation
Check how the body’s stress nerve system works
This study measures “sympathetic nerve activity,” which is part of your body’s automatic stress-response system. It looks at how active that system is in people with certain conditions (or in healthy volunteers), which may help researchers understand symptoms and risks.
Ages 20–85 - NCT05511285Recruiting
Improving sleep and learning after arm stroke rehab
This study tests a sleep-improvement program (Sleepio) to see if better sleep can help people learn and recover after a stroke that affects the arm. You may be able to join if you’re recently out of hospital and can use the internet reliably.
OxfordAges 18 years+ - NCT06926621Enrolling by invitationPhase 2
Long-term safety and effectiveness of VX-670 for myotonic dystrophy
This study is for people who already received VX-670 in a previous trial and want to continue treatment. It will check the drug's long-term safety and how well it works for myotonic dystrophy type 1.
St Louis, MissouriAges 18 years+ - NCT06666881Recruiting
Exercise training for head and neck cancer patients
This trial studies if exercise training can improve outcomes for people with head and neck squamous cell cancer who need chemotherapy and radiation. It uses body scans to see if muscle changes from exercise are linked to better prognosis.
New Taipei CityAges 20–80
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,407 recruiting neurology studies from the U.S. registry right now, out of 19,276 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.