Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,686
- Phase 21,188
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Hepatocellular Carcinoma (HCC)114
- Colon Cancer112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Chinese University of Hong Kong56
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona190
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,606 total
- NCT06306196RecruitingPhase 2
Hepatitis E vaccine study in healthy adults, children, and people with HIV
This study tests a hepatitis E vaccine called Hecolin in healthy people (ages 2–45) and in adults (18–45) living with HIV who are on antiviral treatment. It aims to see how well the vaccine works and if it's safe for different groups.
Ga-RankuwaAges 2–45 - NCT06783244Recruiting
Low vs standard belly pressure for robot colorectal cancer surgery
This trial is testing whether using lower air pressure inside the belly during robot-assisted colorectal cancer surgery helps patients recover better compared to the standard pressure. It aims to find a gentler approach that might reduce pain and improve recovery.
Copenhagen NVAges 18 years+ - NCT06904196RecruitingPhase 2
Lenvatinib with or without internal radiation for TACE-resistant liver cancer
This trial compares two treatments for liver cancer (HCC) that has stopped responding to TACE. One group gets lenvatinib (a targeted therapy pill) plus SIRT (internal radiation beads placed in the liver), and the other gets lenvatinib alone. The goal is to see which combination works better.
Guangzhou, GuangdongAges 18–75 - NCT07178587Recruiting
New PET scan for liver and neuroendocrine tumors
This trial tests a new PET imaging method that uses two different tracers to find and stage liver cancer (HCC) or neuroendocrine tumors (GEP-NET) more accurately. It may help doctors decide on the best treatment for you.
BrestAges 18 years+ - NCT07175155Recruiting
Breathing device and oxygen for endoscopy in severe obesity
This study tests a special breathing device (a tube placed in the throat) combined with high-flow oxygen through the nose during sedation for endoscopy in people with severe obesity. It aims to see if this combination helps keep oxygen levels stable and makes the procedure safer.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07183280Recruiting
A pancreas tumor database study
This study collects information from multiple centers about a rare pancreas tumor called solid pseudopapillary neoplasm (SPN). It will help doctors learn more about this condition and how to best care for patients.
Shanghai, Special Administrative RegionAges Any age - NCT07181070Recruiting
Green dye to improve surgery for swallowing disorder
This trial tests whether a special fluorescent dye called indocyanine green (ICG) can help surgeons see better during laparoscopic Heller-Dor surgery for achalasia. It may improve the safety and success of the procedure.
NaplesAges 18 years+ - NCT07176715Recruiting
Same-day discharge after robotic colon surgery: is it safe?
This study tests whether it is safe for patients to go home the same day after robotic colon surgery. If you are healthy enough and have help at home, you may be able to recover there instead of staying in the hospital overnight.
Phoenix, ArizonaAges 18–70 - NCT07176962Recruiting
Blood test for early detection of bile duct cancer
This study is testing a new blood test that looks for signs of DNA changes linked to biliary tract cancer. It aims to see if the test can find these cancers early. If you have biliary tract cancer or a high suspicion of it, you may be able to help.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07174570RecruitingPhase 2
Celecoxib with immunotherapy for advanced liver cancer
This trial tests a combination of two immunotherapy drugs (durvalumab and tremelimumab) plus a pain reliever (celecoxib) for people with advanced liver cancer that cannot be removed by surgery. The goal is to see if this three-drug combination works better than standard treatments.
Atlanta, GeorgiaAges 18 years+ - NCT07176312RecruitingPhase 2
Zanidatamab with pembrolizumab and chemo for HER2+ and PD-L1+ stomach cancer
This trial tests a new combination of targeted therapy (zanidatamab), immunotherapy (pembrolizumab), and chemotherapy for people with HER2-positive and PD-L1-positive advanced stomach or gastroesophageal cancer. It aims to see if this combination is more effective than current treatments.
BerlinAges 18 years+ - NCT07182565RecruitingPhase 1/Phase 2
Short radiation plus chemotheapy and immunotherapy before surgery for junction cancer
This trial tests a combination of shortened radiation therapy, immunotherapy, and chemotherapy given before surgery for cancer at the junction of the esophagus and stomach. The goal is to see if this approach is safe and improves outcomes.
Xiamen, FujianAges 18 years+ - NCT07179159Recruiting
14-day stomach infection treatment study
This study compares two treatments for an H. pylori stomach infection: taking two medicines (vonoprazan and amoxicillin) versus taking four medicines. Both treatments are given for 14 days.
Jinan, ShandongAges 18–70 - NCT07176078Recruiting
Osteopathic care plus low-FODMAP diet for fibromyalgia and IBS
This trial tests whether adding osteopathic care (a hands-on therapy) to a low-FODMAP diet helps people with both fibromyalgia and irritable bowel syndrome feel better. It compares the diet alone to the diet plus osteopathic sessions.
Brussels, Brussels CapitalAges 18 years+ - NCT07183150Recruiting
Lymph node removal range for advanced stomach cancer
This study is looking at how far surgeons should remove lymph nodes during surgery for advanced stomach cancer. It may help doctors decide the best way to remove cancer while reducing side effects.
Tianjin, Tianjin MunicipalityAges 18–80 - NCT07178626Recruiting
Biomarkers and feeding tolerance in ICU patients
This study looks at whether certain biomarkers and stomach motility measurements can help predict feeding intolerance in critically ill patients who cannot eat by mouth. It aims to improve how patients are fed in the ICU.
ChangchunAges 18 years+ - NCT07181525Recruiting
Predicting how well biologics work for IBD
This study builds a model to predict which biologic drug will work best for people with active inflammatory bowel disease (IBD). It uses data from patients already treated with biologics to help guide future treatment decisions.
BeijingAges 18 years+ - NCT07177742Recruiting
Study of protein in blood to predict liver spread of colon cancer
This study looks at whether a substance in your blood (called PRDX1, found in tiny particles called exosomes) can help predict if colon cancer will spread to the liver after surgery. It may help doctors understand who needs more monitoring or treatment.
Shanghai, Shanghai MunicipalityAges 1.6 years–6.7 years - NCT07176182RecruitingPhase 2
Chemotherapy with alvenor for rectal cancer with high YWHAB
This trial tests adding the drug alvenor to standard chemotherapy before surgery for rectal cancer patients whose tumors have high levels of a protein called YWHAB. The goal is to see if this combination can improve treatment outcomes.
Guangzhou, GuangdongAges 18–75 - NCT07177794RecruitingPhase 3
Toripalimab and capecitabine after chemoradiotherapy for esophageal cancer
This trial tests whether adding the immunotherapy drug toripalimab and the chemotherapy pill capecitabine after standard chemoradiotherapy can help prevent esophageal cancer from coming back. It's for people with squamous cell esophageal cancer that hasn't spread far and who have just finished chemoradiotherapy.
Guangzhou, GuangdongAges 18–75 - NCT07179900RecruitingPhase 2
Radiation plus two drugs for liver cancer that can't be removed
This trial tests a combination of radiation therapy with two drugs (QL1706 and bevacizumab) for people with liver cancer that hasn't spread to other parts of the body but can't be surgically removed. The goal is to see if this approach can shrink or control the tumor.
Shijiazhuang, HebeiAges 18 years+ - NCT07178340RecruitingPhase 2
Perioperative therapy for HER2-negative stomach cancer
This trial tests a treatment given before and after surgery for a rare type of stomach cancer called hepatoid adenocarcinoma. It aims to improve outcomes for patients whose tumors are HER2-negative and have not spread too far.
BeijingAges 18–75 - NCT07179484Recruiting
Study of CT041 for advanced stomach or junction cancer after first treatment
This trial tests a new cell therapy (CT041) for people with advanced stomach or gastroesophageal junction cancer that has a specific marker called CLDN18.2. It is given after initial chemotherapy to try to keep the cancer from growing.
BeijingAges 18–75 - NCT07175272RecruitingPhase 2/Phase 3
Holy basil for treating stomach discomfort (dyspepsia)
This study tests whether the herb holy basil can help relieve chronic stomach discomfort (dyspepsia) without the side effects of standard acid-reducing drugs. If you have ongoing upper belly pain and are not on certain medications, this trial may offer a natural alternative.
Bangkok Noi, BangkokAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 12,023 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.