Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT05895981Recruiting
Sacral nerve stimulation for ulcerative colitis symptoms
This trial tests whether sacral nerve stimulation—a device that sends small electrical signals near nerves in the lower back—can be safe and helpful for ulcerative colitis. It is meant for people whose ulcerative colitis has not improved enough with medicines.
Xi'an, ShaanxiAges 18 years+ - NCT05898789Recruiting
Virtual rehab program for cancer survivors
This trial tests a virtual (online) rehabilitation and exercise program for people after breast, colorectal, head and neck, or certain blood cancers. It may help improve recovery and daily functioning by supporting safe activity and targeted rehab after treatment.
Toronto, OntarioAges 18 years+ - NCT05899231Recruiting
Online strengthening program while you wait for a liver transplant
This trial tests an online prehabilitation program (strength and fitness training delivered digitally) to help people who are likely to need a liver transplant become stronger before transplant. It may benefit people who feel “frail” or “pre-frail,” since improving strength before surgery can help recovery.
Calgary, AlbertaAges 18 years+ - NCT05899842Recruiting
Compare daily versus symptom-based acid reflux medicine after POEM
This study tests whether taking a stomach acid–reducing medicine every day (a protein pump inhibitor, or PPI) works better than taking it only when symptoms happen after POEM for achalasia. It aims to prevent gastroesophageal reflux after the procedure.
MarseilleAges 18 years+ - NCT05901519RecruitingPhase 2
Prednisone to protect the liver during focused radiation for liver cancer
This trial tests whether prednisone (an anti-inflammatory steroid) can help protect the liver in people with hepatocellular carcinoma who are getting stereotactic body radiation therapy. It may reduce liver stress from radiation and help you tolerate treatment safely.
Ann Arbor, MichiganAges 18 years+ - NCT05903066Recruiting
MRI-based healing study in Crohn’s disease
This study looks at how Crohn’s disease healing shows up on a special MRI (MRE) and tries to better define what “healed” means. It may help your care team track healing more accurately, especially inside the bowel.
LiègeAges 18–75 - NCT05903742Recruiting
Standard care for hepatitis delta in the Netherlands
This trial focuses on improving and standardizing how hepatitis delta is cared for in the Netherlands. To take part, you must have confirmed active hepatitis delta and be an adult.
RotterdamAges 18 years+ - NCT05903885Recruiting
Colorectal cancer screening help for Black adults in Nebraska
This study looks at how to improve colorectal cancer prevention and health equity for Black or African American adults. You may be invited because you may be due for colorectal cancer screening based on age and screening history.
Omaha, NebraskaAges 45–75 - NCT05904301Recruiting
Registry for autoimmune and autoinflammatory disease patients
This study builds a nationwide list (registry) of people with certain autoimmune or inflammation-related illnesses. It helps researchers understand these diseases better over time, which can guide future care.
YerevanAges Any age - NCT05905172RecruitingPhase 3
Hydronidone for long-term treatment of hepatitis B scarring
This Phase 3 study tests whether hydronidone capsules can help people with long-term hepatitis B–related liver scarring (fibrosis). It aims to track whether treatment reduces or delays serious liver complications over time.
Beijing, Beijing MunicipalityAges 18–65 - NCT05904626RecruitingPhase 2
ELGN-2112 safety study for very preterm and small babies
This Phase 2 trial studies whether ELGN-2112 is safe in babies born very early or smaller than expected before birth. It may help doctors understand how to better care for these high-risk newborns.
NetanyaAges 1 day–5 days - NCT05905016Recruiting
Testing an endoscopy procedure for gut movement problems
This study looks at how useful the POEM procedure is for people with gut “motility” (trouble moving food through the digestive tract). If you’re already scheduled for POEM, your team will also track how well it helps and whether it’s practical in real care.
Orlando, FloridaAges 18 years+ - NCT05905887RecruitingPhase 2
Rivoceranib and paclitaxel for advanced gastrointestinal stromal tumor
This Phase 2 trial tests whether combining rivoceranib with paclitaxel can shrink or control advanced metastatic gastrointestinal stromal tumor (GIST) after standard medicines have stopped working. It may help people whose GIST has progressed despite prior treatments like imatinib, sunitinib, and regorafenib.
Seoul, SeoulAges 20 years+ - NCT05906576RecruitingPhase 4
Infliximab monitoring study for children with Crohn’s disease
This study keeps track of how infliximab works and how safe it is in Chinese children with moderate-to-severe active Crohn’s disease. You may be eligible if this is the first time your child is starting infliximab and you agree to provide study information.
BeijingAges 6–17 - NCT05908643RecruitingPhase 1/Phase 2
First test of pTTL for advanced colorectal cancer
This trial tests pTTL, a personalized cancer treatment made from your tumor and immune cells, in people with advanced (stage IV) colorectal cancer. It’s designed to see whether pTTL is safe and potentially effective when standard treatments have been used or can’t be used.
Stockholm, Stockholm CountyAges 18 years+ - NCT05911217RecruitingPhase 1
CT041 treatment after chemotherapy for resected pancreatic cancer
This Phase 1 study tests whether CT041 is safe and may help prevent pancreatic cancer from coming back after it’s been removed and you’ve completed standard chemotherapy. You may be eligible if your tumor is positive for CLDN18.2 and your recovery and blood tests meet key requirements.
Beijing, Beijing MunicipalityAges 18–79 - NCT05912387RecruitingEarly Phase 1
Testing statin treatment in primary sclerosing cholangitis
This early study looks at how a statin (cholesterol-lowering medicine) affects people with primary sclerosing cholangitis (PSC) by measuring changes using multiple types of health data. It may help researchers understand which people benefit and how PSC biology changes with treatment.
Stanford, CaliforniaAges 18–80 - NCT05913674RecruitingPhase 2
Feasibility of modified chemotherapy after bowel surgery
This Phase 2 study tests whether a modified chemotherapy given inside the abdomen soon after surgery is practical and safe. It may help people with appendix or colon cancer that has spread within the abdomen (peritoneal carcinomatosis) by targeting cancer cells after tumor removal.
Montreal, QuebecAges 18 years+ - NCT05913141Recruiting
Testing immune-cell treatments for liver cancer
This study tests immune-based treatments (called PDO, PDO-TIL, and PDOTS) for people with liver cancer that has spread or can’t be removed by surgery. It aims to see how well these treatments work and how safely they can be given.
Shanghai, Shanghai MunicipalityAges 18–90 - NCT05913882Recruiting
Breathing training for people with ALS to improve cough
This study tests a breathing and expiratory muscle training program to help people with ALS cough more effectively. It may help reduce breathing and airway trouble by strengthening the muscles used for cough in early-stage ALS.
Fort Lauderdale, FloridaAges 18–90 - NCT05914116RecruitingPhase 1/Phase 2
Early study of DB-1311 with BNT324 for advanced solid tumors
This Phase 1/2a study tests a combination treatment (DB-1311 with BNT324) in people with advanced or metastatic solid cancers that have grown despite standard treatments. It aims to find a safe dose and look for signs the treatment can shrink tumors or slow growth.
Tucson, ArizonaAges 18 years+ - NCT05914389RecruitingPhase 2
Immunotherapy plus chemotherapy before surgery for colon cancer
This Phase 2 trial studies giving chemotherapy plus immune therapy before surgery for certain colon cancers that do not have mismatch repair defects (MSS/pMMR). The goal is to shrink and control the tumor and improve outcomes compared with standard approaches.
Hangzhou, ZhejiangAges 18–75 - NCT05914766Recruiting
Support program for newly diagnosed rectal cancer patients
This trial tests an informational and supportive care program for people with newly diagnosed, locally advanced rectal cancer. It may help by providing education and practical support around next steps in treatment.
Boston, MassachusettsAges 18 years+ - NCT05914987Recruiting
Personalized treatment approach for pancreatic cancer patients
This trial studies how doctors choose individualized cancer treatment for people with pancreatic cancer. It may help them learn which treatment choices work best for different patients.
Milwaukee, WisconsinAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.