Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,686
- Phase 21,188
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Hepatocellular Carcinoma (HCC)114
- Colon Cancer112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Chinese University of Hong Kong56
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona190
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,606 total
- NCT07177794RecruitingPhase 3
Toripalimab and capecitabine after chemoradiotherapy for esophageal cancer
This trial tests whether adding the immunotherapy drug toripalimab and the chemotherapy pill capecitabine after standard chemoradiotherapy can help prevent esophageal cancer from coming back. It's for people with squamous cell esophageal cancer that hasn't spread far and who have just finished chemoradiotherapy.
Guangzhou, GuangdongAges 18–75 - NCT07179484Recruiting
Study of CT041 for advanced stomach or junction cancer after first treatment
This trial tests a new cell therapy (CT041) for people with advanced stomach or gastroesophageal junction cancer that has a specific marker called CLDN18.2. It is given after initial chemotherapy to try to keep the cancer from growing.
BeijingAges 18–75 - NCT07179900RecruitingPhase 2
Radiation plus two drugs for liver cancer that can't be removed
This trial tests a combination of radiation therapy with two drugs (QL1706 and bevacizumab) for people with liver cancer that hasn't spread to other parts of the body but can't be surgically removed. The goal is to see if this approach can shrink or control the tumor.
Shijiazhuang, HebeiAges 18 years+ - NCT07179237RecruitingPhase 2
Testing carminal for H. pylori stomach infection
This trial tests a new medicine called carminal for people with stomach inflammation caused by H. pylori bacteria. It aims to see if the drug can help improve symptoms like indigestion and get rid of the infection.
Belgrade, Central SerbiaAges 18 years+ - NCT07179692RecruitingPhase 1
CEA-targeted CAR-T therapy for advanced solid tumors
This trial tests a type of immunotherapy called CAR-T, which is designed to recognize and attack cancer cells that have a protein called CEA on their surface. It's for people with advanced cancers like colorectal, esophageal, gastric, pancreatic, lung, or bile duct cancer who have tried at least two standard treatments.
Hefei, AnhuiAges 18 years+ - NCT07176923RecruitingEarly Phase 1
Gene editing for familial chylomicronemia syndrome (FCS)
This study tests a new gene-editing treatment called CS-121 for people with FCS whose triglycerides remain very high despite standard therapy. It aims to lower triglyceride levels by editing the APOC3 gene.
Hefei, AnhuiAges 18–55 - NCT07181473RecruitingPhase 1
Safety of TJ101 for advanced solid tumors
This trial tests a new drug called TJ101 for people with advanced solid tumors who have tried standard treatments or have no standard options. It aims to see if the drug is safe and how well it works.
Orlando, FloridaAges 18 years+ - NCT07176650RecruitingPhase 1
Testing a biosimilar ipilimumab for advanced liver cancer
This trial tests a new version of the immunotherapy drug ipilimumab (called HLX13) against the approved version (YERVOY) for people with advanced liver cancer that cannot be removed by surgery. The goal is to see if the new version works similarly and is as safe.
Glendale, CaliforniaAges 18–65 - NCT07181876Recruiting
Study of robotic hernia repair with Dexter system
This study tests a robotic system for fixing groin hernias (inguinal hernias) using small incisions. It is for adults scheduled for hernia repair surgery who want to see how well the robot helps.
Buffalo, New YorkAges 22 years+ - NCT06307938Recruiting
Liquid biopsy test for colorectal cancer before colonoscopy
This trial tests a simple blood test (liquid biopsy) to find cancer signals in the DNA of people being called for a colonoscopy. If you are scheduled for a colonoscopy, your blood sample could help doctors detect colorectal cancer earlier and plan better treatment.
LevangerAges 18 years+ - NCT06948071Recruiting
Enhanced recovery after surgery for complicated appendicitis
This study tests a special recovery program for people having laparoscopic surgery for a severe type of appendicitis. It aims to help you heal faster and leave the hospital sooner.
Los Angeles, CaliforniaAges 18 years+ - NCT02614911Recruiting
Genetics and health profile study for early severe bowel disease
This study looks at how an early-onset bowel illness looks and what genetic changes may be involved. It may help researchers better understand inherited causes and improve future care for families affected by these conditions.
BordeauxAges Any age - NCT05065957RecruitingPhase 2/Phase 3
Study of two oral chemo medicines for advanced bile duct cancer
This trial tests a combination of two oral chemotherapy medicines (D07001 softgel plus Xeloda/TS-1) in people with advanced bile duct tract cancer that can’t be removed by surgery. It’s for situations where first-line gemcitabine plus cisplatin chemotherapy no longer worked.
Kaohsiung CityAges 18 years+ - NCT05827796RecruitingPhase 1/Phase 2
Testing IN10018 plus chemo with an added antibody in pancreatic cancer
This Phase 1/2 trial tests a new medicine (IN10018) and a specific added antibody (KN046) together with standard chemotherapy for advanced pancreatic cancer. It aims to see whether this combination can better control the cancer and how safely it can be given.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06895200Recruiting
Smart reminders for safer gallbladder surgery
This trial tests a smart reminder system to help surgeons follow safety steps during laparoscopic gallbladder removal. It aims to reduce risks and improve outcomes for patients with non-cancerous gallbladder disease.
StrasbourgAges 18 years+ - NCT06403540Recruiting
Pain relief after belly surgery and diaphragm function
This study looks at how different pain relief methods after major abdominal surgery affect the diaphragm, a muscle that helps you breathe. It may help doctors choose the best way to manage pain while protecting your breathing.
IstanbulAges 18 years+ - NCT06798545Recruiting
Study of a new navigation system for pancreas EUS
This trial is testing a new navigation system to help doctors see the pancreas during an endoscopic ultrasound (EUS) exam. The system may make it easier to spot lesions or other problems in the pancreas.
StrasbourgAges 18 years+ - NCT07171515Enrolling by invitation
Pancreatic Cancer Registry Study
This study collects information from people diagnosed with pancreatic cancer. It aims to improve care by learning from your medical records.
Goyang, GyeonggidoAges 19 years+ - NCT07170345Recruiting
AI to detect hidden spread in liver cancer from scans
This trial uses a computer program to help doctors find signs of microscopic tumor spread in blood vessels (microvascular invasion) from liver cancer images. It aims to improve treatment planning for patients who are having surgery.
Fuzhou, FujianAges 18–18 - NCT07168876Recruiting
A blood test to screen for colon cancer
This trial studies a new blood test that looks for specific markers of colon cancer. If it works well, it could offer an easier way to screen for the disease without a colonoscopy.
Mendoza, Mendoza ProvinceAges 45–75 - NCT07165002RecruitingPhase 1
Study of LY3537031 in people with and without liver problems
This trial tests how a new medicine, LY3537031, moves through the body and how safe it is for people with different levels of liver function. It includes people with normal livers and those with mild, moderate, or severe liver impairment.
KistarcsaAges 18–85 - NCT07165886RecruitingPhase 2/Phase 3
Study of sirolimus and octreotide for advanced neuroendocrine tumors
This trial tests a combination of two drugs, sirolimus and octreotide, for people with advanced neuroendocrine tumors in the digestive system that cannot be removed by surgery and are not making excess hormones. The goal is to see if this combination can help control the tumors.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07168434RecruitingPhase 3
Yeast supplement for irritable bowel syndrome (IBS)
This trial tests if a yeast supplement called Saccharomyces boulardii can help people with irritable bowel syndrome (IBS), except for those with constipation as their main symptom. Participants take the supplement and see if their symptoms improve.
BragaAges 18–65 - NCT07170748Recruiting
Testing a new blood test for HIV, hepatitis B/C, and syphilis
This study evaluates a new blood test that checks for HIV, hepatitis B, hepatitis C, and syphilis all at once. It is designed to see how well the test works in different groups of people, including those with known infections and those without.
AbidjanAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 12,023 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.