Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT05872295RecruitingPhase 1
Study drug for HER2-positive advanced cancers
This Phase 1 trial tests IKS014 to see how safe it is and how well it works in advanced solid tumors that have HER2. You may be eligible if your tumor is HER2-positive (including certain “low HER2” types) and your body’s blood counts and organ function are strong enough.
Newport Beach, CaliforniaAges 18 years+ - NCT05875870Recruiting
Bright light and exercise program for lung or esophageal cancer
This trial tests whether a structured bright-light exposure routine combined with a specific exercise program can help people with newly diagnosed lung or esophageal cancer. You may be eligible if you’re in early-to-middle cancer stages and able to safely participate in walking-based activities.
Taipei City, TaipeiAges 20 years+ - NCT05876182RecruitingPhase 2
Vancomycin for primary sclerosing cholangitis
This Phase 2 study tests whether the antibiotic vancomycin can improve primary sclerosing cholangitis (PSC), a long-term bile-duct disease. You may be eligible if you have confirmed PSC and certain blood test and safety criteria, and you can follow medication washout rules.
Monza, Monza E BrianzaAges 15–70 - NCT05877573Recruiting
Toripalimab with chemo-radiation before surgery for rectal cancer
This trial studies whether adding toripalimab (an immunotherapy drug) to standard chemo-radiation before surgery can improve outcomes for people with higher-risk, locally advanced rectal cancer. It is meant for cancers that are mismatch-repair “MSS/pMMR,” and it checks safety plus effectiveness as a first treatment.
Guangzhou, GuangdongAges 18–75 - NCT05878236Recruiting
Blood and scan markers in acute pancreatitis
This study looks at specific blood “immune” signatures and how they relate to outcomes in people with acute pancreatitis. If you enroll early, it may help doctors better predict how the illness will go and identify who might need more care.
Los Angeles, CaliforniaAges 18–75 - NCT05878665Recruiting
Low-dose contrast dye for CT scans in suspected appendicitis
This trial tests whether using a smaller amount of contrast dye in a CT scan still gives doctors enough information to diagnose suspected appendicitis. It’s aimed at emergency department patients who are already scheduled for an abdomen and pelvis CT with dye.
SeoulAges 19–44 - NCT05879835Recruiting
EDTA lock solution to prevent line blockages in children
This trial tests whether a solution called KiteLock (4% EDTA) put into a special feeding line can help prevent blockages in children who need long-term nutrition through the vein. It may reduce line occlusions (blockages) and the complications they can cause.
Boston, MassachusettsAges 4 weeks–18 years - NCT05878964Recruiting
Study of skin health and quality of life during cancer treatment
This trial looks at how cancer treatments (anti–PD-1/PD-L1/CTLA-4 medicines or CDK inhibitors) affect your skin and overall quality of life. You may fill out questionnaires during the study to help researchers understand changes over time.
RomaAges 18 years+ - NCT05879783Recruiting
Optical biopsy during surgery for colorectal belly tumors
This trial looks at using a special light-based method (optical biopsy) to examine small growths on the lining of the abdomen during colorectal cancer surgery. It may help doctors better assess these peritoneal nodules while you are already having an operation.
Guangzhou, GuangdongAges 18–85 - NCT05880199Recruiting
Test Meal and Monitoring in Teens With GI Symptoms
This study studies how a standardized meal affects digestion using special monitoring in children and young adults with stomach or gut symptom problems (and compares them to healthy controls). It may help doctors understand what causes gut symptoms and guide better treatments.
San Diego, CaliforniaAges 8–25 - NCT05880667RecruitingPhase 1
Adaptive focused radiation for belly and pelvic cancer spread
This Phase 1 study tests an “adaptive” form of focused radiation (SBRT) for cancers that have spread in the abdomen or pelvis. It aims to treat metastatic tumor spots safely while adjusting the plan as needed during treatment.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05880992Recruiting
Pre-surgery preparation program for colorectal cancer patients
This trial tests a “trimodal” (multi-part) pre-surgery preparation program for people having major surgery for colorectal cancer. The goal is to help patients get better prepared before surgery and possibly improve outcomes.
Kingston, OntarioAges 18 years+ - NCT05882370RecruitingPhase 2
Immunotherapy plus TIPS for liver cancer with blocked portal vein
This study tests whether adding the immunotherapy drug cadonilimab (and a related treatment plan) plus TIPS can help people with advanced liver cancer that has a tumor clot causing portal vein pressure problems. It aims to improve disease control while managing the circulation pressure in the liver.
Guangzhou, GuangdongAges 18–75 - NCT05883800Recruiting
Total treatment with tailored radiation for advanced rectal cancer
This study tests a “total neoadjuvant” approach—chemotherapy first, then radiation—using adaptive (tailored) radiation planning for people with locally advanced rectal cancer. It may help improve tumor control while adjusting the radiation based on how your cancer and anatomy respond.
BergenAges 18 years+ - NCT05884723Recruiting
Ketogenic diet before liver surgery for fatty liver
This trial tests whether a ketogenic (very low-carb) diet before liver surgery can reduce fat in the liver. It is aimed at people with colorectal liver metastases who already have fatty liver seen on scans or biopsy.
London, OntarioAges 18 years+ - NCT05887661Recruiting
Personalized low-volume blood pressure care during laparoscopic liver surgery
This study looks at a customized blood-pressure and fluid strategy to help patients during laparoscopic liver tumor removal. It may help reduce complications related to blood loss and organ stress during surgery.
Nanjing, JiangsuAges 18 years+ - NCT05890365Recruiting
Study risk of fatty liver in low birth weight adults
This study looks at whether being born with low birth weight is linked to a higher chance of non-alcoholic fatty liver disease (fatty liver not caused by heavy drinking). It compares people born with low birth weight to people born with typical birth weight to better understand risk factors.
HerlevAges 34–49 - NCT05892289Recruiting
Robotic stomach surgery study for early cancer near the top
This study checks whether a specific robotic operation (proximal gastrectomy using a double-flap technique) is safe and feasible for early stomach cancer located near the top of the stomach. It may help patients by testing a surgical approach designed to remove the cancer while managing reconstruction and recovery.
Guangzhou, GuangdongAges 20–80 - NCT05893511RecruitingPhase 3
EUS drainage versus antibiotics for high-risk gallbladder inflammation
This Phase 3 study compares two approaches for people with gallstone-related acute gallbladder inflammation: a procedure called EUS drainage versus antibiotic treatment alone. It may help you avoid early surgery if you are considered high risk for immediate gallbladder removal.
Hong Kong, HONG KONGAges 18 years+ - NCT05894369Recruiting
Testing how the tumor environment affects pre-op chemo plus immunotherapy
This study looks at people with esophageal squamous cell carcinoma to see how changes in the “tumor neighborhood” may affect how well treatment works before surgery. If you’re eligible, you would receive chemotherapy plus immunotherapy as neoadjuvant (before-surgery) treatment.
Wuhan, HubeiAges 18–80 - NCT05894746Recruiting
Study to improve blood sugar and reduce inflammation
This study looks at how an intervention may improve blood sugar control and lower inflammation in the body. You may be able to take part unless you have a specific condition called celiac disease.
GothenburgAges 6 years+ - NCT05895136RecruitingPhase 2
Albumin plus blood thinner for severe cirrhosis after hospital recovery
This Phase 2 trial tests whether giving albumin together with enoxaparin (a blood thinner) can improve outcomes for people hospitalized with decompensated cirrhosis who are at high risk. It may help your recovery after certain serious liver-related complications and reduce the chance of poor outcomes.
ClichyAges 18–80 - NCT05894824RecruitingPhase 1/Phase 2
T-DXd with ramucirumab for HER2-low stomach and GEJ cancer
This trial studies T-DXd given with ramucirumab to treat stomach (gastric) or stomach–esophagus junction (GEJ) cancer that has spread or is locally advanced and is “HER2-low.” It’s mainly to test safety and early effectiveness in people whose cancer continued after first-line treatment.
Seoul, SeoulAges 19 years+ - NCT05895890Recruiting
Studying alcohol-related liver disease and addiction care
This study follows adults with alcohol-related liver disease to better understand and manage alcohol addiction and related health problems. You may be able to help researchers by sharing health information and consented care experiences.
Clamart, Île-de-France RegionAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.