Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,686
- Phase 21,188
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Hepatocellular Carcinoma (HCC)114
- Colon Cancer112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Chinese University of Hong Kong56
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona190
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,606 total
- NCT07154173Recruiting
Gut bacteria study in metastatic colorectal cancer
This study looks at gut bacteria in people with colorectal cancer that has spread (metastatic). It aims to find patterns in the bacteria that may help doctors choose better treatments.
Guangzhou, GuangdongAges 18–75 - NCT05234177Recruiting
Blood test to track colorectal cancer after surgery
This study looks at a blood “DNA” test to see if it can help monitor colorectal cancer after surgery. It may benefit you by improving how doctors track cancer during routine follow-up visits.
Fort Smith, ArkansasAges 18 years+ - NCT06028737RecruitingPhase 2/Phase 3
Chemotherapy before surgery for advanced stomach cancer
This trial tests a combination of chemotherapy drugs given before surgery for locally advanced stomach or gastroesophageal junction cancer. It aims to see if this approach helps shrink the tumor and improve outcomes.
VilniusAges 18–80 - NCT05456893Recruiting
Testing blood and stool markers in active ulcerative colitis treatments
This study checks biomarkers (signals in blood and/or stool) in adults with moderate-to-severe ulcerative colitis. It compares patients starting targeted medicines and looks for marker patterns that may reflect how the disease is behaving.
Nancy, LorraineAges 18 years+ - NCT05733845Recruiting
Study of why some bowel inflammation treatments don’t work
This study looks at blood and/or tissue “molecular” (cell-level) reasons why treatments don’t fully work in adults with Crohn’s disease or ulcerative colitis. If you are starting a biologic or small-molecule medicine and still have moderate to severe symptoms, you may be able to contribute to research that helps improve future care.
Vandœuvre-lès-Nancy, CHRU de NancyAges 18 years+ - NCT06958952Recruiting
Digestive aid for new stomach upset
This study tests whether a natural digestive supplement can help people with new-onset dyspepsia (stomach upset). It's for people who haven't taken other medications and don't have other stomach problems.
TehranAges 18–75 - NCT06090994RecruitingPhase 4
Huaier vs capecitabine to prevent colon cancer return
This study compares two medicines to prevent colorectal cancer from coming back after surgery: a traditional Chinese medicine called Huaier and a standard chemotherapy pill called capecitabine. It is for people with stage 2 colon cancer that was completely removed.
Harbin, HeilongjiangAges 18 years+ - NCT06742411RecruitingPhase 1/Phase 2
Chemo plus immunotherapy and hyperbaric oxygen for advanced stomach cancer
This trial tests a combination of chemotherapy (XELOX), an immunotherapy drug (Sintilimab), and hyperbaric oxygen therapy for people with advanced or metastatic stomach or gastroesophageal junction cancer. The goal is to see if this triple therapy helps shrink or control the cancer better than current options.
Chengdu, SichuanAges 18–75 - NCT06960863Recruiting
Fibroscan to monitor immunotherapy in liver cancer
This study uses a special ultrasound (Fibroscan) to check how well immunotherapy is working for advanced liver cancer. It may help doctors see if the treatment is effective without needing a biopsy.
Tanta, GharbyeaAges 18 years+ - NCT07142122Recruiting
Comparing two types of stomach surgery for early upper gastric cancer
This trial compares two laparoscopic surgeries for early-stage stomach cancer in the upper part of the stomach. It looks at whether preserving a nerve (celiac branch of vagus nerve) during surgery leads to better recovery while still removing the cancer safely.
Fuzhou, FujianAges 18–75 - NCT06960954Recruiting
Testing a blood marker for liver cancer blood clots
This study looks at whether a substance in the blood called PIVKA-II can predict blood clots in the main vein of the liver (portal vein) in people with liver cancer. Participating could help doctors better identify who might develop this complication.
Tanta, GharbyeaAges 18 years+ - NCT07137910RecruitingPhase 2
Study of AHB-137 for chronic hepatitis B
This trial tests a new injection called AHB-137 for people with chronic hepatitis B. It aims to see if the drug is safe and helps control the virus.
Beijing, Beijing MunicipalityAges 18–65 - NCT07142343RecruitingPhase 4
Testing pozelimab safety in young children with CHAPLE disease
This trial tests if pozelimab is safe for children aged 1 to 5 with CHAPLE disease, a rare condition that causes swelling, blood clots, and protein loss. If your child has active CHAPLE disease, this study may offer a new treatment option.
IstanbulAges 1–5 - NCT07144111RecruitingPhase 1
Liver Function and Inavolisib Study
This study tests how the body processes the drug inavolisib when taken by people with moderate or severe liver problems compared to those with healthy livers. It helps doctors understand the right dose for patients with liver impairment.
Lake Forest, CaliforniaAges 18–80 - NCT07136116Recruiting
Study of risankizumab for moderate to severe ulcerative colitis in Japan
This study looks at how well risankizumab (an injected medicine) works for people with moderate to severe ulcerative colitis. It tracks your symptoms using a mobile app to see if the drug helps control the disease.
Nagakute, Aichi-kenAges 15 years+ - NCT06947356Recruiting
TAF vs TDF to prevent passing hepatitis B to babies
This trial tests if TAF is safer and as effective as TDF for pregnant women with high hepatitis B viral loads to prevent passing the virus to their babies. You may qualify if you are pregnant, between 20-28 weeks, and have high viral levels.
Guangzhou, GuangdongAges 20–40 - NCT06962267RecruitingPhase 2
Study of TQB2916 with chemo for advanced pancreatic cancer
This trial tests a new drug (TQB2916) combined with standard chemotherapy (gemcitabine and nab-paclitaxel) as a first treatment for metastatic pancreatic cancer. It aims to see if the combination works better than chemo alone.
Beijing, Beijing MunicipalityAges 18–75 - NCT07141056Recruiting
Emotional stress and immunotherapy for liver cancer
This study looks at how emotional stress affects how well immunotherapy works for liver cancer. It is for people with liver cancer who are about to start immunotherapy, either before or after surgery, or as first treatment for advanced cancer.
Zhanjiang, GuangdongAges 18 years+ - NCT07142226Recruiting
Liquid biopsy for advanced bile duct cancer
This trial uses a blood test called ctDNA to look at the genetic makeup of your cancer. It aims to learn more about bile duct cancer and may help guide your treatment choices.
Seongnam-si, Gyeonggi-doAges 19 years+ - NCT07136701Recruiting
Pancreatic neuroendocrine tumor risk factors and prognosis
This study looks at how pancreatic neuroendocrine tumors behave differently in younger versus older people. It aims to find better ways to predict outcomes and guide treatment.
Jinan, ShandongAges 18–85 - NCT07138326Recruiting
Medication absorption in people with an ostomy
This trial looks at how well your body absorbs certain medications if you have an ileostomy or colostomy. It aims to help doctors better understand dosing for people with ostomies.
Vienna, State of ViennaAges 18 years+ - NCT07139366RecruitingPhase 4
Probiotic plus bismuth combo for stubborn H. pylori
This study tests a combination of a probiotic (Saccharomyces boulardii) plus a standard bismuth-based four-drug treatment for people whose H. pylori infection has not been cured by previous treatments. It aims to see if adding the probiotic helps the treatment work better and cause fewer side effects.
Xi'an, ShaanxiAges 18–75 - NCT07143487Recruiting
Family communication after genetic testing for colon cancer
This trial studies how patients with newly diagnosed colon cancer share genetic test results with their family members. It aims to improve communication and support after learning about hereditary risk.
Anchorage, AlaskaAges 18 years+ - NCT07135544RecruitingPhase 2
Adebrelimab plus apatinib and chemo for new bile duct cancer
This study tests a combination of three medicines (adebrelimab, apatinib, and standard chemotherapy) for people with newly diagnosed bile duct or gallbladder cancer that cannot be surgically removed. The goal is to see if the combination can shrink the tumor and make it possible to remove later.
Wuhan, HubeiAges 18–80
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 12,023 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.