Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT05879783Recruiting
Optical biopsy during surgery for colorectal belly tumors
This trial looks at using a special light-based method (optical biopsy) to examine small growths on the lining of the abdomen during colorectal cancer surgery. It may help doctors better assess these peritoneal nodules while you are already having an operation.
Guangzhou, GuangdongAges 18–85 - NCT06006650RecruitingPhase 2
Neoadjuvant therapy for stage II-IVA esophageal cancer
This trial tests a treatment given before surgery for patients with a type of esophageal cancer called squamous cell carcinoma, stages II to IVA. The goal is to see if this approach can improve outcomes.
Xi'an, ShaanxiAges 18–75 - NCT05947669RecruitingPhase 3
Infliximab for diarrhea or colitis from immune cancer therapy
This trial studies whether infliximab can treat stomach inflammation in the colon (colitis) or frequent diarrhea caused by immune checkpoint cancer drugs. It aims to improve symptoms safely for adults with certain solid cancers.
AalborgAges 18 years+ - NCT05502198Recruiting
How muscle loss matters in advanced liver disease
This study looks at how loss of muscle strength or mass (sarcopenia) relates to advanced liver disease. It may help doctors understand which patients are at higher risk and could guide future care choices.
EksjöAges 18 years+ - NCT03183661Recruiting
Follow-up study for people previously given ALLO-ASC-CD
This study checks the long-term safety of ALLO-ASC-CD in people who already received it in an earlier phase 1 trial. It may help confirm that the treatment remains safe over time.
SeoulAges 18–65 - NCT05871762Recruiting
Choosing best treatment plans for mid-to-low rectal cancer
This trial studies how to choose the best treatment strategy for people with rectal cancer located in the middle to lower part of the rectum. It may help doctors match the right treatment plan to tumor location and your overall situation.
Beijing, Beijing MunicipalityAges Any age - NCT05956847Recruiting
Studying DNA fragments in stomach cancer tissue
This trial looks at tiny pieces of DNA found outside cells in stomach tissue to better understand how gastric (stomach) cancer starts and progresses. It may help future patients by improving how doctors study stomach cancer from biopsy and surgical samples.
Xi'an, ShaanxiAges 18–80 - NCT05336539Recruiting
Community screening study for colorectal cancer using methylation testing
This study recruits adults in Yangzhou to help screen for colorectal cancer risk using a lab test based on “methylation,” a way cells can carry disease-related changes. You would mainly complete a risk questionnaire and phone follow-ups, and agree to share any cancer diagnosis information during the study.
Yangzhou, JiangsuAges 40–74 - NCT05047510Recruiting
Fluorescent-guided surgery for liver cancer using GPC3 dye
This trial studies whether a special fluorescent dye that targets GPC3 can help surgeons find liver cancer more clearly during an operation. It may improve how accurately tumor tissue is identified while you have surgery for hepatocellular carcinoma.
Zhuhai, GuangdongAges 18–75 - NCT06026774RecruitingPhase 1
Personalized mRNA Vaccine After Digestive Cancer Surgery
This trial tests a personalized mRNA vaccine designed to train your immune system to fight your specific cancer. It's for people who have just had surgery to remove a digestive system cancer (like pancreatic or colorectal) and will also receive standard chemotherapy after surgery.
Hangzhou, ZhejiangAges 18–75 - NCT05009927RecruitingPhase 2
Check whether continuing imatinib works after long GIST control
This trial studies people with advanced or metastatic gastrointestinal stromal tumor (GIST) who have been on the drug imatinib for 10 years with stable, non-growing disease. The goal is to see how effective it is to keep imatinib going after this long period.
BesançonAges 18 years+ - NCT05962502RecruitingPhase 2
Cetuximab plus irinotecan for left-sided RAS/BRAF wild-type colon cancer
This Phase 2 trial tests whether adding cetuximab to irinotecan can control metastatic colorectal cancer that has returned or worsened after standard treatments. It targets people whose tumor is left-sided and shows “wild-type” RAS and BRAF genes on blood testing after prior therapy.
Guangzhou, GuangdongAges 18 years+ - NCT04743479Recruiting
AI screening for pancreatic cancer in higher-risk people
This trial uses an artificial-intelligence tool to help detect pancreatic cancer earlier and track people at higher risk. You may be asked to complete questionnaires and have imaging tests like MRI or CT to see how well the approach works.
ShanghaiAges 50–75 - NCT06023771Recruiting
Invasive treatments for complications of acute pancreatitis
This study tests if invasive procedures (like draining fluid or removing dead tissue) can help people with complications from acute pancreatitis that do not improve with medicines or other non-surgical care.
Beijing, Beijing MunicipalityAges Any age - NCT05264896RecruitingPhase 3
Stomach cancer surgery plus two chemo plans
This trial compares two chemotherapy schedules around stomach cancer surgery: giving chemo before and after surgery (FLOT) versus giving chemo after surgery (XELOX). It’s meant to see which plan works better and is easier to tolerate for locally advanced disease that has not spread.
Hong KongAges 18 years+ - NCT05596357Recruiting
Study during hernia surgery to understand patient experience
This trial enrolls adults who are scheduled for planned hernia/abdominal wall surgery to learn more about patients’ experiences and follow-up through questionnaires. If you qualify and agree, your study participation may help improve how care is planned around surgery.
Colombes, Île-de-France RegionAges 18–79 - NCT06043921Recruiting
Personalized blood test for pancreatic cancer
This study uses a personalized blood test to look for tiny pieces of tumor DNA in people with pancreatic cancer. It helps doctors understand how the cancer changes during treatment.
KashiwaAges 20 years+ - NCT06002425Recruiting
AI guidance for stomach and colorectal cancer treatment
This study uses a computer program (like ChatGPT) to help doctors recommend the best treatments for people with stomach or colorectal cancer. All your care must happen at one of the study hospitals.
Duarte, CaliforniaAges 18 years+ - NCT06037902Recruiting
CPAP during radiation for esophageal cancer
This study tests whether using a CPAP mask (which gently pushes air into your airways) during radiation therapy makes treatment safer and more effective for esophageal cancer. It is for adults who are planning radiation and can tolerate wearing the mask.
Ramat GanAges 18 years+ - NCT06023056Recruiting
Hepatitis B vaccine after newborn surgery
This trial tests whether giving the hepatitis B vaccine to full-term newborns who had multiple stomach or intestine surgeries is safe and works well. It aims to protect these babies from hepatitis B infection.
Chongqing, Chongqing MunicipalityAges Any age - NCT06019702RecruitingPhase 1
Personalized mRNA vaccine for advanced digestive cancers
This trial tests a personalized mRNA vaccine designed to target unique markers on your cancer cells. The vaccine is made just for you based on genetic testing of your tumor. It is for people with advanced digestive system cancers who have run out of standard options.
Hangzhou, ZhejiangAges 18–75 - NCT03187925Recruiting
Treatment studies for Zenker’s or CP bar throat pouches
This trial studies people with Zenker’s diverticulum (or a related condition called CP bar) in the throat and upper food pipe. It looks at outcomes when the “shared wall” is divided using an open or endoscopic approach, or when surgery isn’t possible but follow-up can happen.
Cincinnati, OhioAges 18–100 - NCT06026800RecruitingPhase 1
Personalized mRNA vaccine plus standard treatment for advanced digestive cancers
This trial tests a personalized mRNA vaccine (iNeo-Vac-R01) given alongside standard first-line treatment for advanced digestive system cancers. The vaccine is made specifically for your tumor's unique genetic changes (neoantigens) and aims to help your immune system fight the cancer more effectively.
Hangzhou, ZhejiangAges 18–75 - NCT06028724Recruiting
Looking for cancer mutations using a blood test
This study uses a blood test (liquid biopsy) to find genetic changes in advanced solid tumors. It may help doctors choose the right treatment and monitor how well it works over time.
Aviano, PordononeAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.