Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,874 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,178
- Phase 1584
- Phase 3466
- Phase 1/Phase 2389
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer294
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)103
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University89
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California465
- Arizona175
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,874 total
- NCT06310070Recruiting
3D printed custom ostomy pouch to reduce leaks
This trial tests whether a 3D-printed, custom-fit ostomy appliance can help people who have frequent leaks. If you have had an ostomy for at least 6 weeks and have had more than one leak in the past week, this study may offer a personalized solution.
Roanoke, VirginiaAges 18–100 - NCT06065839Recruiting
Does sucking on a pacifier help feeding in preterm babies?
This trial is testing if letting premature babies suck on a pacifier (non-nutritive sucking) helps them tolerate feedings better. It's for preterm infants born between 26 and 32 weeks who are tube-fed.
Taoyuan, Kwei-Shan DistrictAges 6 months–7 months - NCT05886218Recruiting
Monitoring nerves and breathing during gastric bypass surgery
This study uses special monitoring to better understand nerve and breathing-related signals during elective gastric bypass surgery. It may help surgeons and anesthesiology teams improve safety and care for future patients.
Sacramento, CaliforniaAges 18 years+ - NCT05817864Recruiting
Testing a breathing-monitor method to check stomach tube placement
This study checks whether capnography (a device that measures breathing gases) can quickly and accurately confirm that a nasogastric tube is in the stomach. It may help reduce the risk of placing the tube in the wrong spot while you need feeding, fluids, or medicines.
Hong Kong, Hong Kong SARAges 18 years+ - NCT05774704RecruitingPhase 1/Phase 2
Curcumin eye study for people with retinal amyloid deposits
This early-stage study tests whether curcumin (a natural plant compound) can affect eye changes in people who have amyloid deposits in the retina. It aims to see if the treatment is safe and possibly helpful for vision-related outcomes.
Lubbock, TexasAges 40–89 - NCT05486663Recruiting
Tactile and movement therapy for premature newborns
This study tests whether gentle touch and guided movement (tactile/kinesthetic stimulation) can help premature babies move toward safe oral feeding. It’s designed for babies who are stable after breathing support and whose care team has already decided to try feeding by mouth.
Ankara, Eyalet/YerleşkeAges 6 months–7 months - NCT05279170Recruiting
Mask anesthesia with gentle throat pressure to prevent stomach air
This trial studies a way to hold gentle pressure near the throat during mask anesthesia (with or without a breathing tube) to reduce air going into the stomach. It may help lower the chance of “stomach insufflation” during elective surgery in young children.
LilleAges 2–10 - NCT04576533Recruiting
Checking recovery for people after minimally invasive colon surgery
This study looks at what happens right after minimally invasive colon/rectal surgery when people leave the operating room. It may help improve recovery plans and safety for patients like you.
Guangzhou, GuangdongAges 18–65 - NCT07751783Recruiting
Exercise program for cancer survivors
This trial helps people who have finished cancer treatment start a supervised exercise routine to improve their health. It tests whether a structured program with professional guidance is safe and helpful.
Kaohsiung, TaiwanAges 18–80 - NCT07162714RecruitingPhase 2
Short-course radiation plus AK112 for mismatch repair-proficient rectal cancer
This trial tests a new immunotherapy drug (AK112) given after a short course of radiation. It is for people with a specific type of mid-low rectal cancer that has not spread and has not been treated before.
Hangzhou, ZhejiangAges 18–75 - NCT07752446Recruiting
Mediterranean diet and time-restricted eating for ulcerative colitis
This study tests whether following a Mediterranean diet and limiting eating to a certain time window each day can help maintain remission in people with ulcerative colitis. It aims to see if this lifestyle change can keep the condition from flaring up.
Santiago, Santiago MetropolitanAges 18–60 - NCT05230173Recruiting
Treat to endoscopic remission in inflammatory bowel disease
This study tests whether switching to a different treatment for inflammatory bowel disease (IBD) can achieve healing of the gut lining. It is for people whose symptoms are under control but who still have significant inflammation in their bowel.
Scottsdale, ArizonaAges 18 years+ - NCT04284943Recruiting
Surgery for stomach cancer and diabetes
This trial tests a surgery for early-stage stomach cancer that also aims to improve type 2 diabetes by changing how your body processes food. It might be an option if you have both conditions and are not using insulin.
SeoulAges 20–69 - NCT07751055RecruitingPhase 2
Chemotherapy and radiation with immunotherapy before surgery for esophageal cancer
This trial tests whether adding two immunotherapy drugs to standard chemotherapy and radiation before surgery can help shrink esophageal cancer and improve outcomes. It is for people with a certain type of esophageal cancer that can be removed with surgery.
Guangzhou, GuangdongAges 18–75 - NCT06469944RecruitingPhase 1/Phase 2
Study of drug combinations for stomach or esophagus cancer
This trial tests new combinations of drugs alongside standard chemotherapy for people with advanced stomach or esophagus cancer that has not been treated yet. It aims to see if these combinations can shrink tumors or slow down the cancer better than current options.
Tucson, ArizonaAges 18 years+ - NCT06430801RecruitingPhase 3
Study of tulisokibart for moderate to severe Crohn's disease
This trial tests a new medicine called tulisokibart for people with moderate to severe Crohn's disease. The medicine may help reduce inflammation and improve symptoms. It is for those who have not had success with other treatments.
Dothan, AlabamaAges 16–80 - NCT05713136Recruiting
Hepatitis C antibody testing at home or in clinics
This study is setting up a program to test adults for hepatitis C antibodies using quick, point-of-care tests. It helps confirm how well this testing approach works in real-world care so more people can be identified and treated earlier.
Canberra, Australian Capital TerritoryAges 18 years+ - NCT06776016RecruitingPhase 2
Dietary supplement for radiation-related rectal injury
This trial tests a dietary supplement to help heal damage inside the rectum caused by pelvic radiation therapy. If you have mild to moderate rectal bleeding but no signs of cancer recurrence, you may be able to join.
Guangzhou, GuangdongAges 18–75 - NCT06751329RecruitingPhase 1/Phase 2
Study of DM002 for advanced solid tumors
This trial tests a new drug called DM002 for people with advanced solid tumors that have not responded to standard treatments. The drug targets two proteins (MUC1 and HER3) found on some cancer cells, and may help shrink tumors or slow their growth.
San Francisco, CaliforniaAges 18 years+ - NCT07002619Recruiting
Routine vs. selective bile duct X-ray during gallbladder surgery
This trial compares two approaches to taking X-rays of the bile duct during gallbladder removal surgery. It aims to see if doing it routinely or only when needed leads to better outcomes.
StockholmAges 18 years+ - NCT03223077Recruiting
Study of gut germs in new Campylobacter stomach illness
This trial studies how your gut germs (microbiome) and gut lining change during a new bout of Campylobacter infection. It may help researchers understand what drives symptoms and how the gut recovers.
Rochester, MinnesotaAges 18–80 - NCT07733674RecruitingPhase 1
Testing a new imaging agent for brain and pancreatic tumors
This early-phase study tests a new imaging agent that may help see certain solid tumors (like brain cancer or pancreatic cancer) more clearly. You will receive a single injection of a radioactive tracer, then have several scans over a few days to see where the tracer goes and how long it stays.
Houston, TexasAges 18 years+ - NCT05248555Recruiting
Study of point-of-care hepatitis C testing in adults
This study collects basic information from adults who already had a quick, on-site hepatitis C (HCV) test. It aims to improve how point-of-care testing is done and documented, which may lead to faster follow-up and care.
Sydney, New South WalesAges 18 years+ - NCT07482696Recruiting
Biofeedback training for pelvic floor muscle issues in constipation
This trial tests whether electromyographic biofeedback therapy can help people who have trouble relaxing their pelvic floor muscles during bowel movements, a condition called dyssynergic defecation. It may improve chronic constipation and hard stools.
Kocaeli, IzmitAges 18–70
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,874 recruiting gastroenterology studies from the U.S. registry right now, out of 12,294 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.