Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,896 recruiting studies in this area right now.
By phase
- Not applicable4,922
- Phase 21,186
- Phase 1581
- Phase 3466
- Phase 1/Phase 2394
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer492
- Gastric Cancer297
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer147
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer98
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic74
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California462
- Arizona177
- Texas149
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,896 total
- NCT06853496RecruitingPhase 1
RK-582 for advanced colorectal cancer
This trial tests a new type of pill called RK-582 that may help block the growth of colorectal cancer cells. It is for people whose cancer has spread and hasn't gotten better with other treatments.
Koto-ku, TokyoAges 18 years+ - NCT06853886Recruiting
Genetic study for hepatitis B patients to find new treatment pathways
This study looks at the genes of people with chronic hepatitis B (HBV) to find why some people's immune cells (B cells and NK cells) stop working properly. The goal is to discover new ways to treat the disease.
LimogesAges 18 years+ - NCT06854120Recruiting
Stomach Mapping in People with Stomach Motility Issues
This study tests a stomach mapping device (BSGM) to see how a prokinetic medication changes stomach activity in people with gastroparesis or functional dyspepsia. If you qualify, you'll have two non-invasive recordings—one before and one during your treatment.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06854679Recruiting
MRI-guided radiation for rectal cancer
This trial tests a new way of giving radiation therapy for rectal cancer, using MRI scans to aim the radiation more precisely. It's for people who need chemotherapy and radiation before surgery, and it aims to make treatment more effective while reducing side effects.
Sutton, SurreyAges 18 years+ - NCT06855056Recruiting
Studying new markers for recovery from liver cirrhosis complications
This study looks at new blood markers to better predict recovery in patients hospitalized for complications of cirrhosis (like fluid buildup, confusion, or bleeding). You may qualify if you were recently hospitalized for these issues and are expected to go home soon.
Clichy, FranceAges 18–80 - NCT06855524RecruitingPhase 2
Seaweed supplement to prevent fatigue during chemo
This trial tests whether a natural supplement called fucoidan (from seaweed) can help prevent the fatigue often caused by chemotherapy. It is for people with gastrointestinal or gynecologic cancer starting a platinum-based treatment plan.
Scottsdale, ArizonaAges 18 years+ - NCT06855485Recruiting
Stent for pancreatic pseudocyst drainage study
This trial tests a new stent device (HANAROSTEN® HOT Plumber™ with Z-EUSIT™) to drain fluid collections in the pancreas. It may help if you have a pancreatic pseudocyst or walled-off necrosis with mostly fluid content.
Seoul, SeoulAges 18 years+ - NCT06856044Recruiting
Safety of a New Surgical Method for Crohn's Disease on Biologics
This study tests whether a special surgical technique (mesentery-embedding) is safe for people with Crohn's disease who need ileocolic surgery and are already on a biologic medication. It aims to see if this method can help reduce complications.
MontpellierAges 18 years+ - NCT06856187RecruitingPhase 2
Second-line chemo plus TAS-102 combo for advanced colorectal cancer
This trial tests adding a new drug combo (TAS-102 and bevacizumab) to standard second-line treatment for advanced colorectal cancer, followed by local treatments. It may help if your first treatment stopped working and you are otherwise in good health.
Shanghai, Shanghai MunicipalityAges Any age - NCT06856252Recruiting
Studying human liver organoids for a fatty liver disease called NASH
This study takes small samples of liver tissue to grow 3D 'mini livers' (organoids) in the lab. Researchers want to learn how non-alcoholic steatohepatitis (NASH), a serious fatty liver condition, starts and progresses, which could lead to better treatments.
Milan, MilanoAges 18 years+ - NCT06856447RecruitingPhase 1
Coenzyme Q10 to prevent nerve damage from chemotherapy
This trial tests whether taking coenzyme Q10 (a natural substance) can help prevent nerve damage caused by the chemotherapy drug oxaliplatin in people with stage III colorectal cancer. If successful, it could reduce pain, numbness, or tingling during treatment.
CairoAges 18 years+ - NCT06856837RecruitingPhase 2
Fruquintinib and Tislelizumab for advanced colorectal cancer
This trial tests a combination of two drugs, fruquintinib and tislelizumab, for people with a specific type of advanced colorectal cancer that has not spread to the liver. It is for those whose cancer is stable in certain DNA repair systems (MSS/pMMR) and who have already tried other treatments.
LinzAges 18 years+ - NCT06857773RecruitingPhase 3
Combined pump therapy and chemo for liver-only colorectal cancer
This trial tests a treatment approach where you receive chemotherapy directly into your liver through a surgically placed pump, combined with standard systemic chemotherapy (given through a vein). The goal is to shrink liver tumors enough so they can be removed later with surgery. It is for people whose colorectal cancer has spread only to the liver and has not been treated before.
AmsterdamAges 18 years+ - NCT06858384Recruiting
Optimizing PPI use through education and intervention
This trial tests whether educating doctors can reduce unnecessary prescriptions of proton pump inhibitors (PPIs, a type of acid-reducing medicine). If you are an adult patient who has been prescribed a PPI that might not be needed, your doctor may join this study to improve your care.
Ras al-KhaimahAges 18 years+ - NCT06858553Recruiting
AI-assisted MRI for intestinal scarring in Crohn's disease
This trial uses AI to improve MRI scans for detecting intestinal fibrosis (scarring) in people with Crohn's disease who are scheduled for surgery. It aims to help doctors better identify and treat scarring.
Guangzhou, GuangdongAges 18–75 - NCT06858813RecruitingPhase 1
ABBV-324 for advanced liver or lung cancer
This study tests an experimental IV drug (ABBV-324) for adults with advanced liver cancer (HCC) or advanced squamous lung cancer (LUSC). It aims to see if the drug is safe and whether it can help control the disease.
Duarte, CaliforniaAges 18 years+ - NCT06860490RecruitingPhase 2
Liver cancer trial: HAIC plus immunotherapy and anti-angiogenesis
This trial tests a combination of liver-directed chemotherapy (HAIC), an immunotherapy drug (sintilimab), and a drug that blocks blood vessel growth (bevacizumab biosimilar) for advanced liver cancer that hasn't been treated with systemic therapy before. The goal is to see if this triple therapy can shrink or control the cancer.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06860919Recruiting
Transition care for young adults with esophageal atresia
This trial studies a special follow-up program for young adults born with a connection problem in their esophagus (the tube that carries food). The goal is to see if a transitional consultation helps manage long-term health needs.
ParisAges 18–30 - NCT06861010RecruitingPhase 3
Ondansetron to prevent pancreatitis after ERCP
This trial tests whether ondansetron, a medicine that helps control nausea and vomiting, can reduce the risk of pancreatitis (inflammation of the pancreas) after an ERCP procedure. If you are scheduled for an ERCP and do not have certain health issues, you may be able to join.
TantaAges 18–65 - NCT06861088RecruitingPhase 3
Kinisoquin for preventing blood clots in pancreatic cancer
This trial tests whether an investigational drug called Kinisoquin™ can help prevent blood clots in people with advanced pancreatic cancer who are starting their first chemotherapy. It may be a good option if you are looking for extra protection against clots during treatment.
Ventura, CaliforniaAges 18 years+ - NCT06862843Recruiting
Family eating habits and chronic inflammation study
This study looks at how eating habits and family health history relate to chronic inflammatory conditions like Crohn's disease, ulcerative colitis, and juvenile idiopathic arthritis. It aims to understand these links by studying families with a child or adult affected by these conditions, as well as healthy families.
Florence, ItalyAges Any age - NCT06863012Recruiting
Measuring liver pressure with endoscopy: a new method
This trial compares a newer, less invasive method (using an endoscope) to measure pressure in the liver's blood vessels with the standard technique. It may help people with liver disease or suspected cirrhosis better understand their condition.
Barcelona, BarcelonaAges 18–85 - NCT06863207Recruiting
Testing a new treatment for teens with stomach and nerve problems
This study tests whether a personalized nerve stimulation treatment can help teens with cyclic vomiting syndrome or functional dyspepsia who also have symptoms of autonomic dysfunction, like dizziness, fatigue, or heart palpitations when standing.
Milwaukee, WisconsinAges 11–18 - NCT06863376RecruitingPhase 2
Carbocisteine for fatty liver disease: safety and benefit study
This study tests a medicine called carbocisteine to see if it can help treat nonalcoholic fatty liver disease (NAFLD). If you have a fatty liver and no other liver or kidney conditions, this trial may explore whether this drug is safe and effective for you.
TantaAges 18–65
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,896 recruiting gastroenterology studies from the U.S. registry right now, out of 12,425 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.