Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT04168099RecruitingPhase 3
Oral gemifloxacin versus IV cefotaxime for peritonitis
This trial compares two antibiotic treatments for spontaneous bacterial peritonitis—one taken by mouth (gemifloxacin) versus one given through a vein (cefotaxime). It may help find the best way to treat this infection and improve recovery.
TantaAges 18 years+ - NCT04645251Recruiting
Join a UK registry for polycystic liver disease
This registry is for people with polycystic liver disease who have a high number of liver cysts. It helps collect information about your condition to better understand and support future care.
NijmegenAges 18 years+ - NCT03904888Recruiting
Robot vs standard keyhole surgery for double groin hernia
This study compares two ways of doing keyhole surgery for hernias in the groin: the usual laparoscopic approach versus a robot-assisted approach. It may help show which method is safer or more effective for people with hernias on both sides.
GhentAges 18 years+ - NCT03905239Recruiting
Procalcitonin test to guide treatment for bowel blockage
This trial studies an approach that uses a blood test called procalcitonin to help doctors choose the best treatment for an acute small-bowel blockage caused by scar tissue (adhesions). It may help avoid unnecessary procedures and speed the right care when doctors are deciding what to do next.
AmiensAges 18 years+ - NCT03994978Recruiting
Compare bowel function after sigmoid surgery vs watchful care
This study looks at whether having elective sigmoid colon surgery helps bowel function and quality of life compared with conservative (non-surgery) care in people with recurrent, uncomplicated diverticulitis. It may help clarify which approach leads to fewer ongoing bowel problems and better daily comfort.
BaselAges 18 years+ - NCT04445883Recruiting
Eating Matters program for older rehab patients
This trial studies whether an “Eating Matters” support program improves nutrition in older adults during a short hospital rehabilitation stay. It may help patients who are struggling to eat by providing the right level of eating assistance.
Burlington, OntarioAges 65 years+ - NCT04220905Recruiting
Watching outcomes after removing large colon and duodenal polyps
This observational study follows people who have large polyps in the colon or duodenum that are removed during endoscopy. It aims to understand how safe and effective this approach is, and what outcomes patients have afterward.
White River Junction, VermontAges 18 years+ - NCT06821997RecruitingPhase 2
Chemotherapy Before Surgery for Borderline Resectable Pancreatic Cancer
This trial is testing a combination of three chemotherapy drugs (NALIRIFOX) given before surgery to shrink borderline resectable pancreatic cancer. The goal is to help make surgery more successful and improve outcomes.
Buffalo, New YorkAges 18 years+ - NCT06850740Enrolling by invitation
Spinal ondansetron for hernia repair pain relief
This trial tests if adding ondansetron to standard spinal anesthesia during hernia surgery can provide better pain relief. It may help you need less pain medicine after the procedure.
IsmailiaAges 18–60 - NCT07113795Enrolling by invitationEarly Phase 1
Chinese medicine and stem cells for Crohn's fistula
This trial tests a new approach that combines traditional Chinese medicine with stem cells to treat complex anal fistulas caused by Crohn's disease. It may help people whose Crohn's is not very active and who have not had major fistula surgery before.
Nanjing, JiangsuAges 18–60 - NCT03626194Recruiting
Tested an endoscopy method to close internal tissue openings
This study checks whether an endoscopy technique that brings tissue together safely closes several types of internal openings (like perforations or surgical leaks/defects). It also looks at whether the closures work well and have acceptable side effects.
Aurora, ColoradoAges 18–89 - NCT02016430Recruiting
Diet study to lower TMAO levels using gut microbes
This trial looks at whether a structured 12-week diet can lower a blood chemical called TMAO, which is linked to heart and kidney risk for some people. It may help you see if diet changes can shift gut microbes and reduce TMAO-related signals.
Cleveland, OhioAges 18 years+ - NCT05856474Recruiting
Treating a pancreas injury after a surgery-confirmed cut
This study focuses on people whose pancreas injury is confirmed during an abdominal surgery (laparotomy). It aims to improve how traumatic pancreas transection is managed after that confirmation.
TainanAges 1–70 - NCT01551563Recruiting
Study for people newly diagnosed with inflammatory bowel disease
This trial studies treatment approaches for inflammatory bowel disease (IBD) in people who are newly diagnosed. It may help researchers find better care by learning how well the study treatment works early in the disease.
StavangerAges 16–80 - NCT05598112RecruitingEarly Phase 1
Oral stool-based microbiome treatment for healthy aging
This early-stage study tests whether changing the gut bacteria using an oral stool-based treatment (called oral FMT) can improve health in older adults. It aims to see if this approach affects aging-related changes, including gut and body function.
Beijing, Beijing MunicipalityAges 70–85 - NCT03024775Recruiting
Study wheat triggers in people with non-celiac wheat sensitivity
This study looks at how different types (genotypes) of wheat affect gut symptoms in people who react to wheat but do not have celiac disease. It may help clarify which wheat triggers symptoms and how to confirm the trigger in a structured food challenge.
Sciacca, AgrigentoAges 18–65 - NCT02857179Recruiting
Study of Bariatric Surgery
This study is looking at people who have already had bariatric (weight-loss) surgery. If you’ve had that surgery and are within the age range, you may be eligible to participate.
LyonAges 16–80 - NCT02863172Recruiting
Genetic studies in families with inherited colon cancer
This study looks at genetic reasons some families get colon cancer due to inherited (run-in-the-family) syndromes. It may help doctors better understand risk and tailor care for you or your relatives.
Houston, TexasAges 18 years+ - NCT03686137Recruiting
Liver surgery database study for liver tumors
This study collects information from people having liver surgery for a non-cancerous tumor or for liver cancer (primary or cancer that spread to the liver). It doesn’t usually add treatment—your care is documented to help doctors learn and improve future decisions.
Marseille, Bouches Du RhoneAges 18 years+ - NCT02060565Recruiting
Test noninvasive scans to diagnose chronic liver disease
This study looks at how well noninvasive tests (tests that don’t require surgery, like scans and blood-based measurements) can diagnose chronic liver disease in people with certain liver conditions. It may help doctors choose better, less invasive ways to identify the type and stage of liver problems.
PessacAges 18 years+ - NCT02328131Recruiting
Registry study for adults with H. pylori infection
This study is a registry that follows adults who have Helicobacter pylori (a common stomach bacteria) to learn how it’s managed in real life. It may help improve care by tracking treatments and outcomes over time.
ViennaAges 18 years+ - NCT01868373Enrolling by invitationPhase 1
Fecal transplant study for hard-to-treat C. difficile diarrhea
This Phase 1 study tests defined fecal microbiota (healthy gut bacteria) given to people with C. difficile diarrhea that didn’t go away or came back soon after antibiotics. It may help by restoring a healthier balance of gut bacteria so the infection can stop recurring.
Houston, TexasAges 18 years+ - NCT01694953Recruiting
Study of how MNGIE changes over time
This study follows people with MNGIE (a rare mitochondrial disease) to better understand what happens over time and how lab markers relate to health. It does not test a new drug as part of the study.
New York, New YorkAges 5 years+ - NCT02314949Recruiting
Protocol to help the gut accept an intestine transplant
This trial studies a “tolerance” plan meant to help the body accept a new intestine after transplant. It may be aimed at reducing rejection risk for people waiting for an intestine transplant.
LeuvenAges Any age
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.