Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT07841236RecruitingPhase 2
Blood test-guided immunotherapy for MSI-high colon cancer
This trial tests whether using a simple blood test (ctDNA) can help guide treatment with immunotherapy drugs (PD-1 inhibitors) for people with a specific type of colon cancer (MSI-high/dMMR). The goal is to see if this approach can improve outcomes and reduce side effects compared to standard care.
ShanghaiAges 18–75 - NCT07840677RecruitingPhase 2
Cholesterol-lowering drug plus chemoimmunotherapy before surgery for advanced colon cancer
This study tests a new treatment combination for people with locally advanced colon cancer that has not spread. It combines a cholesterol-lowering drug (tafolecimab) with standard chemotherapy and immunotherapy before surgery, to see if it helps shrink the tumor and improve outcomes.
Chongqing, Chongqing MunicipalityAges 18–80 - NCT07839767Recruiting
Personalized treatment to prevent liver cancer recurrence
This study uses a 3D-printed model of your liver tumor to help doctors choose treatment that may prevent the cancer from coming back after surgery. The model predicts how your tumor might respond, so you get the most effective therapy.
Hong KongAges 18 years+ - NCT07840092Recruiting
Blood and tissue markers for liver cancer treatment response
This study looks at blood and tissue samples from people with liver cancer to find markers that can predict how well treatment works and whether the cancer might come back. It may help doctors personalize treatment and follow-up care.
TianjinAges 18 years+ - NCT07839702Recruiting
Pre-surgery exercise and nutrition program for stomach cancer
This trial tests a home-based program of exercises and nutritional drinks before stomach cancer surgery. It aims to help patients recover faster and feel stronger after their operation.
SingaporeAges 22–99 - NCT07838324Recruiting
Pain reprocessing therapy for functional dyspepsia
This study tests a type of talk therapy called Pain Reprocessing Therapy (PRT) to see if it helps reduce stomach pain and discomfort in people with functional dyspepsia. The therapy aims to retrain the brain's response to pain signals, potentially easing symptoms.
Rochester, MinnesotaAges 18 years+ - NCT07838415Recruiting
Mapping the immune landscape in liver cancer
This study uses advanced MRI scans and tumor samples to understand how the immune system behaves in liver cancer. It aims to improve personalized treatment by looking at the tumor's environment at different times.
Wuhan, HubeiAges 18–80 - NCT06462053RecruitingPhase 2
Short radiotherapy plus chemo and immunotherapy for early low rectal cancer
This study is testing whether a short course of radiation combined with chemotherapy and an immunotherapy drug works better than the standard longer radiation and chemotherapy for early-stage rectal cancer that is low in the rectum. The goal is to see if this shorter treatment can help patients avoid surgery or have a better outcome.
ShanghaiAges 18–75 - NCT04893785RecruitingPhase 2
Cabozantinib plus temozolomide for advanced neuroendocrine lung tumors
This Phase 2 study tests whether combining cabozantinib with temozolomide can control advanced lung or gastrointestinal neuroendocrine tumors that have grown after prior treatments. It also closely monitors safety, including blood counts, organ function, and other side effects.
Naples, CampaniaAges 18 years+ - NCT06464822Recruiting
Effects of weight-loss surgery on urinary symptoms
This study looks at whether weight-loss surgery can improve urinary symptoms like needing to pee often or suddenly. It is for people with severe obesity who are already being seen at a specific clinic for bariatric surgery.
Hong KongAges 18 years+ - NCT06463834RecruitingPhase 2
Sintilimab plus chemo before surgery for esophageal cancer
This study tests a combination of an immunotherapy drug (sintilimab) with chemotherapy given before surgery for a type of esophageal cancer called squamous cell carcinoma. The goal is to see if this treatment shrinks the tumor and improves outcomes.
Fuzhou, FujianAges 18–75 - NCT04340986Recruiting
Group study for bile duct or liver cancer patients
This study follows people with bile duct cancer or certain liver cancers to better understand their disease. You might be included if you meet the diagnosis and basic participation requirements.
ParisAges 18 years+ - NCT06147635RecruitingPhase 2
Tributyrin for early acute pancreatitis
This trial tests a supplement called tributyrin (related to butyrate) to see if it can help prevent complications from acute pancreatitis when given early after diagnosis. It is for people having their first episode of pancreatitis, not for those with certain causes or weakened immune systems.
Delft, South HollandAges 18 years+ - NCT06466291Recruiting
Spanish Wilson Disease Registry
This study is a registry that collects information about people with Wilson disease. By joining, you can help researchers learn more about the condition and improve care for others.
BarcelonaAges 18 years+ - NCT03198546RecruitingPhase 1
CAR T therapy for advanced liver cancer with GPC3
This Phase 1 study tests a personalized immune-cell treatment (CAR T cells) for advanced liver cancer that has the GPC3 protein. It aims to see whether these engineered cells can find and kill cancer cells safely and help shrink the cancer.
Guangzhou, GuangdongAges 18–75 - NCT07830576Recruiting
Predicting survival after liver surgery for colorectal cancer
This study uses your liver MRI scans and medical information to build a tool that predicts survival after surgery for colorectal cancer that has spread to the liver. It may help doctors better understand your outlook and plan care.
Hefei, AnhuiAges 18–80 - NCT07831317Recruiting
Probiotic for digestive comfort in women
This study tests a daily probiotic supplement to see if it helps with gas and bloating in women who also have signs of hormonal imbalance. If you qualify, you'll take the supplement and track your symptoms over the study period.
San Francisco, CaliforniaAges 25–45 - NCT07830407Recruiting
Personalized chemo response test for colorectal cancer
This study is testing a new lab test called ChemoINTEL that may help predict how well your colorectal cancer will respond to common chemotherapy drugs. The goal is to see if this test can help doctors choose the most effective treatment for you.
Liverpool, MerseysideAges 18 years+ - NCT06161207RecruitingPhase 3
Laparoscopic surgery for stomach cancer using 3D and dye
This trial tests a new way to remove stomach cancer using 3D-4K cameras and a special dye during laparoscopic (keyhole) surgery. It may help surgeons see the cancer better and remove it more precisely.
Fuzhou, FujianAges 18–75 - NCT06160778RecruitingPhase 3
Comparing two pain medicines for kids with belly pain
This study compares two common pain relievers—ketorolac and morphine—given through an IV to children with acute abdominal pain. It aims to find which works better and has fewer side effects for this condition.
Calgary, AlbertaAges 6–17 - NCT06341335RecruitingPhase 3
AK104 and AK109 plus paclitaxel for advanced stomach cancer
This trial tests a combination of two experimental immunotherapies (AK104 and AK109) with a standard chemo drug (paclitaxel) for people with advanced stomach or gastroesophageal junction cancer that has grown after initial treatment. The goal is to see if this new combination can help shrink tumors or slow the cancer better than chemo alone.
BeijingAges 18–75 - NCT07832994Recruiting
Exercise for teens with celiac disease, metabolic syndrome, and fatty liver
This trial tests whether a specific exercise program can improve metabolic syndrome and fatty liver in teenage girls with celiac disease. It may help reduce liver fat and improve overall health.
Giza, DokkiAges 13–17 - NCT07829081Recruiting
Watch-and-wait after immunotherapy for early-stage GI cancers
This study looks at whether some patients with early-stage stomach, colon, or rectal cancers that are mismatch repair-deficient (a genetic feature making them more likely to respond to immunotherapy) can safely avoid surgery and instead be monitored closely after treatment with immunotherapy. It aims to confirm if this watch-and-wait approach is as effective and helps patients avoid major operations.
BaselAges 18 years+ - NCT07828093Enrolling by invitation
Effects of agave on performance and gut health in athletes
This trial studies whether eating agave, a natural sweetener, can improve physical performance and support healthy gut bacteria in athletes. If you are an athlete, this could help you understand how diet affects your training and digestion.
Yautepec, MorelosAges 18–40
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.