Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT05935124Recruiting
White light or narrow-band imaging for colon polyp detection
This trial compares two camera light styles during screening colonoscopy to see which one better finds polyps on the right side of the colon. If you’re having a routine screening and have no concerning symptoms, the results may help improve how doctors spot polyps early.
Sydney, New South WalesAges 18 years+ - NCT06824363RecruitingEarly Phase 1
Intra-tumor injection study for stomach and esophagus cancer with ARID1a mutation
This trial tests a new approach where immune cells are injected directly into the tumor in people with a specific genetic change (ARID1a mutation) in their stomach or esophagus cancer. It aims to see if this treatment can help when used before any other cancer therapy.
Orange, CaliforniaAges 18 years+ - NCT07484724RecruitingPhase 2
JS212 combination therapy for advanced esophageal cancer
This trial tests a new combination of drugs (JS212 plus another medicine) for people with advanced esophageal squamous cell carcinoma who have not had prior treatment. It aims to see if the combination is safe and effective.
Beijing, Beijing MunicipalityAges 18–75 - NCT07089615Recruiting
Capsule vs colonoscopy for polyp detection
This trial tests a new capsule that you swallow to take pictures of your colon. It may help find polyps (growths that can turn into cancer) as well as a standard colonoscopy does.
Chula Vista, CaliforniaAges 45–75 - NCT07124754Recruiting
Predicting lymph node spread in early stomach cancer
This study tests if artificial intelligence can predict whether early-stage stomach cancer has spread to lymph nodes. It also evaluates how well doctors assess the cancer. If the technology works, it could help guide treatment decisions.
Shijiazhuang, None SelectedAges 18 years+ - NCT07474324RecruitingPhase 2
Targeted therapy plus chemo vs chemo alone for stage 3 stomach cancer
This trial tests adding disitamab vedotin (a drug that targets HER2) to standard chemotherapy (SOX) after surgery for stage 3 stomach cancer. The goal is to see if the combination works better than chemo alone to prevent cancer from coming back.
Nanjing, JiangsuAges 18–75 - NCT07038148Recruiting
Single-stage conversion of gastric bypass to sleeve gastrectomy
This trial is testing a single surgery that converts a previous gastric bypass into a sleeve gastrectomy, and checking if there is a higher risk of leaks. It may be an option for people who need this change and are in good overall health.
Cairo, Old CairoAges 18–70 - NCT07123207Recruiting
Probiotic with infliximab for Crohn's disease
This study is testing whether adding a probiotic (Bacillus subtilis) to standard infliximab treatment can improve outcomes for people with active Crohn's disease. It aims to see if the probiotic helps the medication work better.
Changsha, HunanAges 18–75 - NCT07462923RecruitingPhase 1
A study of HS-20093 for advanced stomach or gastroesophageal cancer
This trial tests a new drug, HS-20093, in people with advanced stomach or gastroesophageal junction cancer that has not responded to other treatments. The goal is to see if it can help shrink or slow the growth of the cancer.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05653453RecruitingPhase 3
Tumor treatment device plus chemo for locally advanced pancreatic cancer
This trial tests whether a home-wearable tumor-treating device (Tumor Treating Fields) combined with gemcitabine and albumin-bound paclitaxel works better as first treatment for locally advanced pancreatic cancer. It may help by targeting cancer cells while also using standard chemotherapy.
Harbin, HeilongjiangAges 18–75 - NCT07117435RecruitingPhase 1
Targeted chemo into liver for colorectal cancer spread
This trial is testing a new way to give the chemotherapy drug paclitaxel directly into the liver (through a tiny tube) along with standard systemic treatment for people whose colorectal cancer has spread only to the liver and cannot be surgically removed. The goal is to see if this targeted approach works better than standard treatment alone.
Lishui, ZhejiangAges 18–75 - NCT05651386Recruiting
Six-food elimination diet for meal-related stomach distress
This trial tests whether removing six common food groups helps people whose stomach symptoms get worse after meals. You would follow a structured diet plan and answer questionnaires to see if your symptoms improve.
LeuvenAges 18–70 - NCT06711471RecruitingPhase 2
Combination therapy for advanced stomach cancer after prior treatments
This trial tests a combination of three drugs — trifluridine/tipiracil (a chemotherapy pill), bevacizumab (avastin, a targeted therapy), and camrelizumab (an immunotherapy) — as a later treatment option for people with advanced stomach cancer who have already tried other therapies. It may help patients whose cancer has not responded to previous treatments.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07114861RecruitingPhase 1/Phase 2
KN510713 with mFOLFIRINOX for advanced pancreatic cancer
This study tests a new drug (KN510713) combined with the standard chemotherapy mFOLFIRINOX for people with advanced pancreatic cancer that hasn't had prior chemotherapy. The goal is to see if adding the new drug can improve outcomes.
Goyang-siAges 19–75 - NCT05624918RecruitingPhase 2
Testing a tumor-treatment device plus chemotherapy for pancreatic cancer
This trial studies NovoTTF-200T(P), a portable treatment device, combined with standard chemotherapy (gemcitabine and nab-paclitaxel) for people with resectable pancreatic adenocarcinoma. It aims to improve treatment results by trying this combination before surgery.
Columbus, OhioAges 18 years+ - NCT07556718RecruitingPhase 2
Amitriptyline for IBS-like Symptoms in Stable Crohn's Disease
This study tests whether a medication called amitriptyline can help reduce belly pain and bowel problems in people whose Crohn's disease is well-controlled. Amitriptyline is an older antidepressant that may help with pain and bowel symptoms even when inflammation is quiet.
Ann Arbor, MichiganAges 18–65 - NCT07109440Recruiting
FAPI PET/CT scan for colorectal cancer liver spread
This study uses a special type of PET/CT scan (FAPI) to get a better look at the environment around colorectal cancer that has spread to the liver. It may help doctors learn more about the tumor and plan treatment.
BrusselsAges 18 years+ - NCT06009211Enrolling by invitation
Does aromatherapy help nausea in rehab kids?
This study tests whether aromatherapy (using scents like lavender or peppermint) can help reduce nausea in children during their hospital stay. If your child is in rehab and often feels sick, this simple treatment might offer relief without extra medicine.
Little Rock, ArkansasAges 8–17 - NCT06723197RecruitingPhase 4
Comparing treatment lengths for H. pylori infection
This trial compares different lengths of treatment with two or four medications to see which works best for clearing H. pylori, a stomach bacteria that can cause ulcers. It is for people who have not been treated for this infection before.
Jinan, ShandongAges 18–70 - NCT07439718Recruiting
Nutrition drink study for healthy adults
This study tests how a special nutritional drink affects the tiny organisms living in your small intestine. You will take the drink and provide stool samples to help researchers understand gut health.
LausanneAges 18–60 - NCT06369259RecruitingPhase 2
Study of avutometinib, defactinib, and cetuximab for advanced colorectal cancer
This trial tests a combination of three drugs for people with advanced colorectal cancer that has not responded to standard treatments. The goal is to see if combining these drugs can shrink tumors or slow cancer growth.
Houston, TexasAges 18 years+ - NCT07557173Recruiting
Better Bowel Prep for Repeat Colonoscopy After Failed Cleaning
This trial tests three different bowel-cleaning preparations for patients who need a repeat colonoscopy because their bowel wasn't clean enough the first time. The goal is to find which preparation works best to get your colon ready for a successful second procedure.
BeneventoAges 18 years+ - NCT07576959RecruitingPhase 3
Bismuth with dual therapy for H. pylori infection treatment
This trial tests whether adding bismuth (a mineral compound) to standard two-drug therapy helps cure H. pylori, a common stomach bacteria that can cause ulcers and inflammation. The goal is to see if this combination works better than dual therapy alone.
TaipeiAges 20 years+ - NCT05122078Recruiting
Test pain treatment guided by a heart-based index after bowel surgery
This trial studies whether using a monitor-based pain number (called the ANI) to guide pain medicine can improve bowel function after laparoscopic surgery for colorectal cancer. It may help reduce constipation or slow gut recovery by matching pain treatment to your body’s signals.
SeoulAges 19 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.