Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT07750275Enrolling by invitation
Safer, cheaper liver surgery with small incisions
This study looks at different ways doctors cut and seal the liver during keyhole surgery. It aims to find the safest and most cost-effective method for removing liver tumors or other growths.
Campobasso, CBAges 18 years+ - NCT07751302Recruiting
Follow-up vs. chemo after surgery for early stomach cancer
This trial compares two approaches after surgery for early-stage stomach or GEJ cancer: close monitoring (follow-up) vs. adjuvant chemotherapy (chemo given after surgery). It aims to see if follow-up alone is as good as chemo for patients with this stage, potentially avoiding chemo side effects.
Xi'an, ShaanxiAges 18 years+ - NCT07750535Recruiting
Liver fat and scarring in wheat-sensitive patients
This study looks at whether people with non-celiac wheat sensitivity or other digestive conditions have more fat in their liver or liver scarring. It aims to understand if wheat-related issues are linked to liver health.
Palermo, PalermoAges 18–65 - NCT07754955Recruiting
Two tools for removing large colon polyps compared
This trial compares two special tools used to remove large, flat colon polyps during a colonoscopy. The goal is to see which tool is safer and more effective at removing the entire polyp in one piece, which may help avoid surgery.
Bangkok Noi, BangkokAges 18 years+ - NCT07750379Recruiting
Acid-reducing medicine for aspiration in children with laryngomalacia
This study tests whether giving a common acid-reducing medicine (a proton pump inhibitor) to children with laryngomalacia can reduce choking and aspiration. It may help if your child has frequent choking episodes.
Minya, Minya GovernorateAges 6 months–5 years - NCT07755696Recruiting
Robotic repair for two hernias at once
This study tests the use of a robotic device to fix two hernias at once—one in the groin and one near the belly button. The goal is to see if this approach is safe and effective for people who need both hernias repaired.
Ghent, East-FlandersAges 18 years+ - NCT07754721Recruiting
Diet and lifestyle program for chronic acid reflux
This study tests a comprehensive program that combines diet and lifestyle changes to help people with chronic acid reflux (heartburn, acid regurgitation, or chest pain) feel better. It looks at how these changes can improve your overall health and reduce symptoms.
Hualien City, TaiwanAges 18–79 - NCT07756476Recruiting
Fluid treatment guided by heart response for acute pancreatitis
This study tests whether giving IV fluids based on how your heart responds can improve recovery from acute pancreatitis, compared with usual care. It may help your body handle fluids better during treatment.
Los Angeles, CaliforniaAges 18–75 - NCT07752446Recruiting
Mediterranean diet and time-restricted eating for ulcerative colitis
This study tests whether following a Mediterranean diet and limiting eating to a certain time window each day can help maintain remission in people with ulcerative colitis. It aims to see if this lifestyle change can keep the condition from flaring up.
Santiago, Santiago MetropolitanAges 18–60 - NCT07749989Recruiting
Review of patients with gastroesophageal reflux disease
This study looks at patients who came to Beijing Friendship Hospital with stomach acid issues (GERD). Researchers want to understand how treatments like medications or anti-reflux surgery work over time. By joining, you help them improve care for others with the same condition.
Beijing, Beijing MunicipalityAges 18–90 - NCT07757347Recruiting
Fructose and aging in healthy adults
This trial is testing how healthy adults process fructose (a type of sugar) as they age. You may participate if you are generally healthy and don't have certain conditions like gut diseases or metabolic problems.
ViennaAges 18 years+ - NCT07755384Recruiting
Stomach and throat exam study at high altitude
This study looks at what doctors see in the upper digestive tract (stomach and food pipe) of people living at high altitude, using a sedated endoscopy (a camera tube down the throat while you sleep). It helps understand how high altitude affects the digestive system.
Yushu, QinghaiAges 18 years+ - NCT07751055RecruitingPhase 2
Chemotherapy and radiation with immunotherapy before surgery for esophageal cancer
This trial tests whether adding two immunotherapy drugs to standard chemotherapy and radiation before surgery can help shrink esophageal cancer and improve outcomes. It is for people with a certain type of esophageal cancer that can be removed with surgery.
Guangzhou, GuangdongAges 18–75 - NCT07750951RecruitingPhase 2
Combination therapy before surgery for advanced rectal cancer
This trial tests a combination of two immunotherapy drugs and chemotherapy given before surgery for a type of rectal cancer that has a specific genetic marker (MSI-H/dMMR). The goal is to shrink the tumor and improve the chances of successful surgery.
Xi'an, ShaanxiAges 18 years+ - NCT06510660RecruitingPhase 2
Immunotherapy and Chemoradiation for Advanced Esophageal Cancer
This trial tests a combination of immunotherapy (adebrelimab) plus standard chemotherapy and radiation for people with advanced esophageal cancer that cannot be removed by surgery. The goal is to see if adding the immunotherapy before and during chemoradiation helps control the cancer better.
Fuzhou, FujianAges 18–70 - NCT07751250RecruitingPhase 1
Casdatifan in moderate liver impairment
This study looks at how a new drug, casdatifan, is processed in the body in people with moderate liver problems compared to healthy people. Understanding this helps doctors decide if the drug is safe and how to dose it for patients with liver issues.
San Antonio, TexasAges 18–84 - NCT07752407RecruitingPhase 3
Heartburn relief study for people with non-erosive GERD
This study tests a new medicine called vonoprazan to see if it can reduce episodes of heartburn in people who have GERD but no damage to their esophagus. It compares the medicine to a placebo (a pill with no active ingredient) over 24 weeks.
Mentor, OhioAges 18 years+ - NCT07749781Recruiting
Smart monitoring software for safer sedation during endoscopy
This study tests a computer program that helps doctors watch your vital signs while you are sedated for a routine gastrointestinal procedure, with the goal of making sedation safer and more personalized.
Barcelona, BarcelonaAges 18 years+ - NCT07749768RecruitingPhase 1
Oral drug for ulcerative colitis safety study
This study tests an investigational oral drug for ulcerative colitis. It is an early-stage trial to check safety and how the drug is processed by the body in both healthy volunteers and patients with active ulcerative colitis.
Miami, FloridaAges 18–55 - NCT07758101RecruitingPhase 1
Study of a new medicine for ulcerative colitis
This trial tests a new medicine to see if it's safe for people with moderate to severe ulcerative colitis. It also tests the medicine in healthy volunteers to check for side effects. If you have ulcerative colitis, this might offer a new treatment option.
Hangzhou, ZhejiangAges 18–55 - NCT07750158RecruitingPhase 3
Zanzalintinib for colorectal cancer with residual tumor dna
This trial is testing a new drug (zanzalintinib) alone or with pembrolizumab to see if it can stop cancer from coming back in people with colorectal cancer who have no visible cancer on scans but still have tumor DNA in their blood.
Council Bluffs, IowaAges 18 years+ - NCT06586242RecruitingPhase 2
Penpulimab, anlotinib, and chemo before surgery for esophageal cancer
This trial tests a combination of three drugs (penpulimab, anlotinib, and chemotherapy) given before surgery to shrink esophageal cancer. It is for people with locally advanced cancer who have not had treatment before.
Xi'an, Shaan'xiAges 18–75 - NCT06590142Recruiting
Studying bowel tissue for future Hirschsprung's treatments
This trial collects leftover intestine tissue from children having bowel surgery to help develop future treatments using a child's own cells. It aims to find better ways to repair the bowel without needing donor tissue.
Liverpool, MerseysideAges birth–15 years - NCT06597526Recruiting
PET/CT scanning to guide treatment for stomach cancer with abdominal spread
This trial uses two types of PET/CT scans (FDG and FAPI) to see how well chemotherapy or other treatments work before surgery for stomach cancer that has spread to the lining of the abdomen. The goal is to find the best way to measure treatment response and help guide your care.
Shanghai, Shanghai MunicipalityAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.