Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT07588386Recruiting
Early Colonoscopy After Low Rectal Cancer Surgery
This study tests whether doing a colonoscopy (camera exam of the colon) early after surgery for low rectal cancer helps catch a serious complication called anastomotic leakage—when the surgical connection between bowel segments breaks down. Early detection might help prevent severe infections and improve outcomes.
Nanchong, SichuanAges 18–80 - NCT06674187Recruiting
Comparing stoma hernia prevention in colostomy surgery
This trial tests whether sewing the belly lining in a special way during colostomy surgery can lower the chance of a hernia near the stoma. It may help you if you need a colostomy and are in generally good health.
Nanjing, JiangsuAges 18–75 - NCT06671275Enrolling by invitationPhase 1
Testing CUD005 Injection for Advanced Liver Cirrhosis
This study tests an injection called CUD005 for people with advanced liver cirrhosis that is causing complications. The goal is to see if it is safe and can help improve liver function.
Hefei, AnhuiAges 18–75 - NCT07102550RecruitingPhase 2
Amniotic tissue for bile duct repair in living donor liver transplant
This trial tests whether using amniotic tissue during bile duct connection surgery can improve outcomes for people receiving a liver transplant from a living donor.
Cleveland, OhioAges 18 years+ - NCT07165444Recruiting
Comparing two acid-blocking drugs for H. pylori treatment
This trial tests if a newer acid-blocking medicine works better than a standard one when given with antibiotics and bismuth for treating H. pylori infection, a bacteria that can cause stomach ulcers. It is for adults who have not had treatment for H. pylori before.
Tanta, El-GharbiaAges 18 years+ - NCT07558083RecruitingPhase 3
Tracking colorectal cancer response using blood tests
This study tests whether a simple blood test can track how well your colorectal cancer is responding to first-line chemotherapy. By monitoring cancer markers in your blood, doctors may be able to detect treatment changes earlier than traditional imaging.
Mechelen, AntwerpenAges 18 years+ - NCT06731439Recruiting
Starting feeds on day 1 for very small premature babies
This study is for very premature babies (weighing about 2 pounds or less) to see if starting small feedings on the first day of life helps them reach full feeds sooner. If your baby is very small and otherwise healthy, this option may help them grow faster.
Memphis, TennesseeAges 1 minute–6 hours - NCT06381362Recruiting
Italian registry of minimally invasive pancreas surgery
This study is a registry that collects information on people who have had minimally invasive pancreas surgery. It helps doctors learn more about how these surgeries work and how to improve them.
MilanAges 18 years+ - NCT07569068RecruitingPhase 2
Combination Cancer Drugs Before Surgery for Stomach Cancer
This trial tests whether giving immunotherapy and chemotherapy drugs before surgery can help treat stomach cancer that has a specific protein marker (claudin 18.2). The goal is to shrink the tumor and improve outcomes for patients whose cancer can be surgically removed.
Shanghai, Huangpu DistrictAges 18 years+ - NCT07568223Recruiting
Testing artisanal bread tolerance in bread-sensitive adults
This study compares how your body responds to artisanal (handmade) bread versus conventional store-bought bread if you've experienced discomfort after eating regular bread. Researchers will track symptoms and measure markers in your blood and stool to understand why artisanal bread might be better tolerated.
BobignyAges 18–65 - NCT07416240RecruitingEarly Phase 1
Targeted immune cell therapy for Claudin18.2-positive advanced pancreatic cancer
This early-phase trial is testing a new kind of immune cell therapy—dendritic cells and CAR-T cells—that specifically targets a protein called Claudin18.2 on your cancer cells. It is for people with advanced pancreatic cancer who have already tried standard treatments.
Haikou, HainanAges 18–80 - NCT06737887Recruiting
Stoma simulation before surgery for anxiety and adaptation
This study tests whether a simulation of having a stoma before surgery can help reduce anxiety and make it easier to adapt afterward. It is for adults having planned stoma surgery who can communicate in Turkish.
IstanbulAges 18–65 - NCT06734780Recruiting
Vaping and Crohn's disease return after surgery
This study looks at how vaping versus smoking tobacco affects the return of Crohn's disease after surgery. It may help doctors understand which habit is safer for people who have had their intestine reconnected.
Milan, MichiganAges 18 years+ - NCT07091539Recruiting
Fruit and vegetable vouchers for kids with fatty liver disease
This trial tests whether providing fruit and vegetable vouchers can help children with fatty liver disease (MASLD) improve their liver health. Families living in California with a child who has elevated BMI and liver enzymes may be eligible.
San Francisco, CaliforniaAges 6–17 - NCT06387147RecruitingPhase 3
Oral antibiotics for acute mesenteric ischemia
This trial tests whether taking oral antibiotics (gentamicin and metronidazole) can treat acute mesenteric ischemia caused by an artery blockage, instead of using IV antibiotics. It's for people who don't need emergency surgery and don't have a serious infection.
Clichy, FranceAges 18–90 - NCT06736314Recruiting
Removable clip treatment for stomach varices bleeding
This trial tests a removable titanium clip to stop bleeding from enlarged veins in the stomach caused by cirrhosis. It may be an option for patients who are stable enough for this procedure.
Nanjing, JiangsuAges 18–75 - NCT06660342Recruiting
Safety of vonoprazan in pregnant women study
This study looks at the safety of vonoprazan (a medicine for acid reflux) when taken during pregnancy. It follows pregnant women who took the drug and those who didn't, to see how it affects mothers and their babies.
Wilmington, North CarolinaAges 15–50 - NCT07537491Recruiting
AI tool to predict surgery outcomes in colorectal cancer
This study uses artificial intelligence to analyze tissue samples from your colorectal cancer surgery to help predict how you'll recover and what your long-term outlook might be. Researchers will examine your tumor tissue under a microscope to build a computer model that could help doctors personalize your care plan.
Brandenburg an der HavelAges 18 years+ - NCT07574398Recruiting
Growth and Development Study After Infant Liver Transplant
This study tracks how babies grow and develop after receiving a liver transplant. Researchers want to understand how transplantation affects children's physical growth and overall development in early infancy.
Shanghai, Shanghai MunicipalityAges Up to 1 year - NCT06396897Recruiting
Hospital at Home for Cirrhosis Recovery
This study tests whether recovering from cirrhosis at home, with a nurse visiting daily, works as well as staying in the hospital. You'll be enrolled in the Hospital at Home program and need a caregiver to help for the first two days.
Indianapolis, IndianaAges 18 years+ - NCT07083596Recruiting
Fermented milk drink for constipation relief in Filipino adults
This study tests if a special fermented milk drink can help relieve constipation symptoms like hard or lumpy stools. Researchers want to see if it works for adults who have constipation without a known medical cause.
Manila, ManilaAges 18–59 - NCT06739330Recruiting
Thyroid function and fatty liver disease study
This study looks at how your thyroid might be linked to fatty liver disease (MAFLD). It aims to help researchers understand if thyroid problems play a role in this condition, which could lead to better treatments.
Tanta, El-GharbiaAges 18 years+ - NCT07381257RecruitingEarly Phase 1
Rifaximin for fatty liver disease
This trial tests if rifaximin, a gut medication, can help reduce liver fat in people with metabolic fatty liver disease. It may be an option if you have at least one metabolic risk factor and a certain amount of liver fat.
ShanghaiAges 18–75 - NCT06533852RecruitingPhase 3
Fecal transplant trial for liver cirrhosis complications
This study tests whether stool from healthy donors can help people with advanced liver disease (cirrhosis) who have had complications like fluid buildup. You would receive the transplant through a colonoscopy or enema.
BarcelonaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.