Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT04522687Recruiting
Blood lymphocyte changes studied during radiation and chemotherapy for lung cancers
This study looks at how a type of white blood cell in your blood changes while you receive radiation and chemotherapy. The goal is to see whether these blood changes relate to treatment, especially in certain chest (thoracic) cancers.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT02863250Recruiting
Blood transfusion registry for people needing frequent transfusions
This registry collects information from adults who receive frequent red blood cell transfusions. It may help clinicians understand transfusion needs and improve future care.
Melbourne, VictoriaAges 18 years+ - NCT04499898RecruitingPhase 2/Phase 3
Carvedilol vs banding to prevent first bleeding from esophageal veins
This trial compares two ways to prevent bleeding from enlarged veins in the food pipe (esophageal varices) in people with cirrhosis. It tests whether carvedilol (a blood-pressure/heart medicine) works as well as an endoscopic procedure that places small bands to reduce bleeding risk.
TantaAges 18 years+ - NCT04490031RecruitingPhase 4
Ketamine sedation for ERCP procedure
This trial tests whether using ketamine as a sleep/sedation medicine during ERCP (a scope procedure to check/clear bile or pancreatic ducts) is safe and effective. If you’re scheduled for ERCP and can consent, this study may help doctors improve sedation options for patients like you.
Bandar Tun Razak, Kuala LumpurAges 16 years+ - NCT03326154Recruiting
Improving quality of life after gallbladder removal
This study focuses on how people feel after having their gallbladder removed for painful, symptomatic gallstones. You may be asked to fill out questionnaires to compare quality of life after surgery and help researchers understand what recovery feels like for patients.
EspooAges 18 years+ - NCT04556019Recruiting
Study of past and future liver and bile-pancreas surgeries
This is a research study using information from people who had certain liver, bile duct, and pancreas surgeries in the hospital’s surgical team. It aims to review surgical results and may help improve how these operations are done.
Pamplona, NavarreAges 15–90 - NCT02647879Recruiting
Preventing hepatitis C spread with treatment in Iceland
This study looks at giving hepatitis C treatment to people who test positive, to help prevent the infection from spreading. If you are 18 or older, live in Iceland, and can consent, you may be able to join.
ReykjavikAges 18 years+ - NCT04026360Recruiting
Study early lung, virus, and gut changes in children with cystic fibrosis
This study looks at how a child’s early lung function, viral infections, and gut (microbiome) changes affect cystic fibrosis over time. It may help doctors understand what predicts how lung disease develops, which could improve future care.
BernAges birth–18 years - NCT03692429RecruitingPhase 1
Testing new immune cells plus chemo for advanced colon cancer
This Phase 1 study tests CYAD-101, an immune-cell treatment made from donor T-cells, given with standard chemotherapy. It is for people with colon or rectal cancer that has spread and has not responded to prior treatments.
Tampa, FloridaAges 18 years+ - NCT03825861RecruitingPhase 2
Before-surgery chemotherapy for locally advanced stomach cancer
This Phase 2 study tests chemotherapy given before surgery (called FOLFIRINOX) for people with locally advanced stomach cancer. The goal is to shrink the tumor and improve outcomes after the surgery plan is completed.
São PauloAges 18–75 - NCT04595929Recruiting
Tested aerosol chemotherapy inside the abdomen for stomach cancer
This trial looks at a way to give chemotherapy into the abdomen (through a small tube during laparoscopy) for certain stomach cancers. It aims to see whether this approach improves cancer control and surgical outcomes for people whose tumors can potentially be removed.
Saint PetersburgAges 18–65 - NCT02193464Recruiting
Local registry study for Crohn’s and ulcerative colitis
This study keeps a health record (a registry) of people in Daegu-Gyeongbuk with Crohn’s disease or ulcerative colitis. It helps researchers understand the illnesses in this region and improve future care planning.
DaeguAges Any age - NCT03261934Recruiting
Modeling risk and progression in chronic stomach lining disease
This study looks at people with chronic atrophic gastritis to estimate who may be at higher risk of stomach cancer over time. It collects symptom and medical data, plus blood and tissue samples, to build prediction models that may improve future care.
Beijing, Beijing MunicipalityAges 18–75 - NCT01731665Recruiting
Study of Crohn’s and ulcerative colitis in Seoul
This study looks at how inflammatory bowel disease (Crohn’s disease and ulcerative colitis) affects people in a specific area of Seoul. It mainly focuses on describing patterns and health needs rather than testing a new drug.
SeoulAges Any age - NCT04483076RecruitingPhase 3
Chemo before stomach surgery with different cycles
This trial studies whether giving oxaliplatin plus S-1 (SOX) chemotherapy before stomach surgery works best when given for different cycle lengths. It may help shrink stage III gastric cancer before a standard D2 gastrectomy and improve outcomes.
Beijing, Beijing MunicipalityAges 18–70 - NCT04714957Recruiting
Personalized study for cancer spread in the belly lining
This trial studies people whose cancer has spread to the lining of the abdomen (the “belly lining”), including cancers from the digestive tract or ovaries. You may be asked to join because the study aims to learn how to better match care to different patterns of this belly lining cancer spread.
LyonAges 18 years+ - NCT04573283Recruiting
Study of fatty liver in adults in China
This study follows adults with fatty liver to learn more about how it progresses and what patterns are common. It may help improve future ways of identifying and monitoring fatty liver.
Guangzhou, GuangdongAges 18–80 - NCT04746534Recruiting
Study for blood-flow problems in the intestines
This study follows adults with intestinal blood-flow problems (from artery or vein issues) to better understand these conditions. It may help doctors plan future diagnosis and treatments for people with sudden or long-lasting intestinal ischemia.
ClichyAges 18 years+ - NCT03609398RecruitingPhase 2
Phase 2 study of a Rift Valley fever vaccine for safety
This study tests how safe a Rift Valley fever (RVF) vaccine is and how strongly it triggers the body’s immune response. You may be eligible if you are at risk of RVF exposure and your blood test shows you don’t already have strong protection.
Fort Deterick, MarylandAges 18–65 - NCT04777942Recruiting
New liver cancer treatment plan for high-risk early-stage patients
This trial studies a treatment approach (a combination given through the liver) for people with early liver cancer that can be surgically removed but has a high chance of coming back. It may help reduce the risk of recurrence after treatment.
Guangzhou, GuangdongAges 18–75 - NCT04782557Recruiting
Ultrasound-guided blood sampling to track cancer DNA
This study uses an ultrasound-guided procedure to collect blood and check for cancer DNA (small bits of tumor material in the bloodstream). It aims to see whether this method can better track how gastric, pancreatic, or colorectal cancer responds to treatment.
Hong KongAges Any age - NCT04706611Recruiting
Stool transplant to treat gut and immune-related conditions
This trial studies fecal microbiota transplantation (a stool-based treatment) to improve symptoms and safety in people with certain gut and immune conditions. It aims to see whether changing gut bacteria can help you feel better.
Guangzhou, GuangdongAges 18–70 - NCT04043897RecruitingPhase 2
Oral rifaximin for active microscopic colitis flare
This trial tests whether an oral antibiotic called rifaximin can improve symptoms during a microscopic colitis flare. It aims to see if it is safe and effective for people whose colitis was confirmed by colon biopsy.
Evanston, IllinoisAges 18 years+ - NCT03961776Recruiting
MRI to monitor treatment response in rectal cancer
This trial tests whether an MRI scan done during chemoradiation can help doctors track how rectal cancer treatment is working. It may improve how they measure response early so treatment planning can be better tailored.
Los Angeles, CaliforniaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.