Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT05762991Recruiting
AI test to help diagnose stomach bacteria and early stomach changes
This trial checks whether an artificial intelligence (computer) system can help diagnose Helicobacter pylori (a common stomach bacteria) and early stomach “premalignant” changes using endoscopy results. It may help doctors spot problems more accurately when you have a scheduled scope.
TaipeiAges 20–80 - NCT07246460Recruiting
Ultrasound and protein tests to see if guselkumab works for Crohn's
This study tests whether guselkumab (a targeted drug) can effectively treat Crohn's disease in the ileum (last part of the small intestine). You will have ultrasound scans and blood tests to measure your response, which may help find the right dose and monitor for bowel healing.
Calgary, AlbertaAges Up to 80 years - NCT05763446Recruiting
Predicting heavy blood transfusion during liver transplant
This study looks for factors that can predict when a person might need a very large blood transfusion during a liver transplant. The results may help the transplant team prepare sooner and better manage transfusions during surgery.
RomeAges 18 years+ - NCT07043855Enrolling by invitation
Shorter antibiotics after Whipple surgery
This study tests whether a shorter course of antibiotics after Whipple surgery works as well as the standard longer course to prevent infections. It aims to reduce unnecessary antibiotic use and side effects.
SeoulAges 18–80 - NCT07244575Recruiting
Metformin and nausea after general anesthesia study
This study looks at whether the diabetes medicine metformin, taken before surgery, affects the risk of nausea and vomiting after general anesthesia. If you take metformin and are having planned surgery, this trial may help understand its effects.
Guangzhou, GuangdongAges 18 years+ - NCT06879912Recruiting
Study of force feedback tools in robot-assisted surgery
This trial tests new force feedback instruments in the da Vinci 5 robot during surgery. It aims to see if they help surgeons perform procedures more precisely for conditions like cancer or other diseases.
Miami, FloridaAges 22 years+ - NCT07242456RecruitingPhase 2/Phase 3
Comparing two treatments for H. pylori infection
This study tests two different combinations of medications to treat H. pylori, a stomach bacteria that can cause ulcers. You would take one of the two combinations for a short time to see which works better at getting rid of the infection.
Hangzhou, ZhejiangAges 18–70 - NCT06656767Enrolling by invitation
Studying liver cell changes in chronic liver disease
This trial uses already collected liver tissue samples from adults to study how cells change over time in chronic liver disease. It could help researchers understand the disease better and find new ways to treat it.
CambridgeAges 18 years+ - NCT06921811Enrolling by invitation
Chickpea meal absorption study for ileostomy patients
This study tests how well your body absorbs nutrients from chickpeas after you have an ileostomy. You will eat chickpea-based meals, and researchers will measure what passes through your stoma to learn about digestion.
Coleraine, N.IrelandAges 18–60 - NCT05744713Enrolling by invitation
Study of adults with long-term liver disease using health records
This observational study looks at adults with chronic liver disease (including cirrhosis) to better understand how people are managed and how they feel over time. Because it does not change your treatment, it may help researchers improve care and patient support.
Los Angeles, CaliforniaAges 18 years+ - NCT06596616Enrolling by invitation
Comparing two MRI contrast agents for liver imaging
This trial tests whether a newer contrast agent, gadopiclenol, works as well as the standard one for liver scans. It might be an option if you need an MRI to check for liver disease, tumors, or treatment response.
New York, New YorkAges 18–89 - NCT05529940RecruitingPhase 3
FOLFIRINOX around surgery for resectable pancreatic cancer
This trial compares giving chemotherapy with FOLFIRINOX before and after surgery versus giving it mainly after surgery for people with resectable pancreatic duct cancer. It aims to improve outcomes by timing the treatment around the operation.
SeoulAges 19–80 - NCT05360069Recruiting
Stapler type choice for stomach cancer surgery connection
This trial compares two surgical stapler methods used to connect the esophagus to the small intestine after stomach cancer surgery. It may help find which method works better and is safer for certain stomach cancer patients.
Nanchong, SichuanAges 18–90 - NCT06833619Recruiting
A new way to get a liver biopsy using endoscopic ultrasound
This trial tests a new method for taking a small piece of liver tissue using a special ultrasound camera on a thin, flexible tube. It is for adults who need a liver biopsy because their liver function tests are not normal.
SohagAges 18–100 - NCT07315893Recruiting
Closing stomach defects with a stitching device
This trial tests a special stitching tool to close holes in the stomach after removing abnormal growths. It may help patients heal better after a routine procedure to remove suspicious tissue.
Tel AvivAges 18 years+ - NCT07232095RecruitingPhase 4
7-Day treatment for H. pylori with new acid blocker and antibiotics
This trial tests a 7-day combination of vonoprazan, high-dose amoxicillin, and bismuth to treat Helicobacter pylori infection in people who have never been treated for it before. The goal is to see if this short course is effective and safe for curing the infection.
Nanjing, JiangsuAges 18–70 - NCT06456073RecruitingPhase 1
Cell therapy for chronic anal fissures
This trial tests a new treatment made from special cells (called E-CEL UVEC) for people with long-lasting anal fissures that haven't healed with standard treatments. The goal is to see if this cell-based therapy can reduce pain and help the fissure heal.
New York, New YorkAges 18 years+ - NCT06526767Recruiting
Vibrating capsule for chronic constipation dose comparison
This study tests three different doses of a vibrating capsule (Vibrabot) to see which works best for relieving chronic constipation. If you have had constipation for at least 6 months and meet the Rome IV criteria, you may be able to join.
Beijing, Beijing MunicipalityAges 18–85 - NCT07334080RecruitingPhase 1
Study of how food affects ECC4703 in healthy adults
This trial tests how taking the study drug ECC4703 with or without food affects its levels in the body, and how well the body absorbs it. It helps find the best way to take the drug.
Adelaide, South AustraliaAges 18–65 - NCT07388264Recruiting
Probiotic for bloating and gut health
This study tests a probiotic (a good bacteria) called Weizmannia coagulans to see if it helps reduce bloating and improves gut health. Researchers will check how your digestion changes by looking at your stool and gut bacteria.
Saint Charles, MissouriAges 18–50 - NCT06599255Enrolling by invitation
Pain relief after gallbladder surgery: one shot vs. multiple shots
This trial compares two ways of giving a numbing injection (nerve block) to ease pain after laparoscopic gallbladder removal. One method uses a single injection, the other uses several smaller injections. The goal is to see which provides better pain control with fewer side effects.
Zagazig, Elsharkia,, Egypt,Ages 18–45 - NCT07269301RecruitingPhase 1
Liver function and study drug processing
This study looks at how the medicine PF-07328948 is processed by people with different levels of liver function. It includes both healthy people and those with stable liver disease (classified as mild, moderate, or severe). The goal is to see if the liver condition affects how the drug works in the body.
Lake Forest, CaliforniaAges 18–74 - NCT06531278RecruitingPhase 2
Adebelimab plus chemo for first-line pancreatic cancer with liver spread
This trial tests a combination of immunotherapy (adebelimab) and chemotherapy drugs (irinotecan liposome, oxaliplatin, fluorouracil, and calcium folinate) as a first treatment for pancreatic cancer that has spread to the liver. The goal is to see if this combination is safe and effective.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06846359Recruiting
Hypnotherapy for Upper Gut Symptoms
This study tests whether hypnotherapy sessions, delivered through a smartphone app, can help relieve upper digestive symptoms like nausea, bloating, and indigestion. It's for people whose symptoms are not caused by a known disease and who have already had normal stomach-emptying tests.
Rochester, MinnesotaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.