Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,685
- Phase 21,189
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer90
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California442
- Arizona190
- Texas140
- Alabama129
- Florida127
- New York120
- Massachusetts119
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,606 total
- NCT07672574RecruitingPhase 1
Study of how ontunisertib is processed in healthy men
This study tests how a new drug, ontunisertib, is processed by the body and eliminated. Healthy men will take a single dose with a tiny radioactive tracer so researchers can track the drug.
NottinghamAges 30–65 - NCT06389760RecruitingPhase 2
Nimotuzumab combo after pancreatic cancer surgery
This trial tests adding nimotuzumab (a targeted therapy) to standard chemotherapy for people whose pancreatic cancer was completely removed with surgery. The goal is to see if this combination helps prevent the cancer from coming back.
Nanjing, JiangsuAges 18 years+ - NCT06668727RecruitingPhase 1
Testing a new antibody for hepatitis B safety
This trial tests an experimental antibody treatment for people with chronic hepatitis B who have been on antiviral medication for at least 6 months. It aims to see if the antibody is safe and can help control the virus.
Aarhus NAges 18–70 - NCT07673861Recruiting
Using ctDNA to find resistance and guide cancer treatment
This trial uses a simple blood test to look for changes in your cancer's DNA that might show why your current treatment stopped working. The results could help your doctor choose your next treatment more precisely.
LondonAges 18 years+ - NCT07676383Recruiting
Better cancer screening with community precision navigation
This trial tests a program to help people at high risk for certain cancers get the free screening tests they need. It aims to make screening easier by providing personalized guidance in the community.
Huaihua, HunanAges 45–74 - NCT07677774Recruiting
Using a special PET/CT scan to see liver cancer
This study tests a new way to take detailed pictures of liver cancer using a special PET/CT scan. The scan aims to help doctors see the cancer more clearly, and your results may help guide your treatment.
Xiamen, FujianAges 18–90 - NCT07674732RecruitingPhase 2
Shorter radiation with immunotherapy for rectal cancer
This trial tests a shorter course of radiation followed by a combination of chemotherapy, immunotherapy, and a targeted drug (bevacizumab) for locally advanced rectal cancer that is mismatch repair proficient (pMMR) or microsatellite stable (MSS). The goal is to see if this approach can shrink the tumor enough for surgery while avoiding more extensive radiation.
Guangzhou, GuangdongAges 18–75 - NCT07678541Recruiting
Gallbladder infection treatment for people 75 and older
This study compares two ways to treat a gallbladder infection in older adults: surgery or a less invasive procedure using an endoscope and ultrasound. The goal is to see which option leads to better outcomes.
Oulu, OuluAges 75 years+ - NCT07679542RecruitingPhase 1/Phase 2
Dihydroartemisinin for metabolic fatty liver disease
This trial tests whether dihydroartemisinin, a malaria drug that may reduce liver fat, helps people with metabolic fatty liver disease. It is for adults aged 18 to 45 who have a fatty liver and at least one metabolic problem like overweight, high blood pressure, or diabetes.
Nanjing, JiangsuAges 18–45 - NCT07672691Recruiting
How diet affects gut health and inflammation
This study looks at how different types of food (fats, carbs, protein) affect your gut bacteria, inflammation, and metabolism. It may help understand how diet can improve health.
KrakowAges 18–60 - NCT07676461Recruiting
Microbiome study in advanced cancer patients starting immunotherapy
This study looks at the bacteria in your mouth, gut, and tumors to see if they affect how well first-line immunotherapy works. It is for people with advanced stomach, colorectal, breast, cervical, or head-and-neck cancer.
Bogotá, Bogota D.C.Ages 18 years+ - NCT07671937Recruiting
Sharing patient feedback in cancer care team meetings
This study gathers your feedback (like symptoms and quality of life) and shares it with your cancer care team during their group meetings, so they can better tailor your care. It is for people recently diagnosed with pancreatic, breast, or gynecologic cancer and aims to make sure your voice is heard in treatment decisions.
Birmingham, AlabamaAges 18 years+ - NCT07675967Recruiting
Blood Cell Changes During Cancer Treatment
This study is for people with solid tumors who are about to start chemotherapy or radiation. It looks at how these treatments affect blood cells and may help doctors understand changes in blood health over time.
Boston, MassachusettsAges 18 years+ - NCT07680283Recruiting
Ultrasound-guided surgery for Crohn's disease of the small intestine
This study compares two ways for surgeons to decide where to cut the intestine during surgery for Crohn's disease. One uses an ultrasound probe during the operation, and the other uses the standard method of feeling the tissue. The goal is to see if ultrasound guidance leads to better outcomes.
Cleveland, OhioAges 18 years+ - NCT07679399RecruitingPhase 2
New combo therapy vs capecitabine for biliary tract cancer after surgery
This trial tests if a combination of immunotherapy (durvalumab), chemotherapy (GEMOX or GC), and a targeted therapy (lenvatinib) works better than standard capecitabine chemotherapy to prevent cancer from coming back after surgery for bile duct or gallbladder cancer.
BeijingAges 18–75 - NCT07671872Recruiting
Testing an Anti-Inflammatory Diet for Crohn's Disease
This study tests whether a specially designed anti-inflammatory American diet can help control mild to moderate Crohn's Disease symptoms. Participants will follow a diet plan, with guidance from the research team, to see if it reduces inflammation and improves quality of life.
Miami, FloridaAges 16–75 - NCT07672145Recruiting
Gallbladder removal: belly button vs. upper belly cut
This trial compares two ways to remove the gallbladder during laparoscopic surgery: through the belly button or through a cut just below the breastbone. It aims to find which method causes less pain and recovers faster.
Lahore, Punjab ProvinceAges 18–60 - NCT06656299Recruiting
Nerve block for gallbladder removal surgery
This study tests a nerve block called EOIB to see if it helps reduce pain after gallbladder removal surgery. If you are having planned gallbladder surgery, this might be a good option for you.
IstanbulAges 18–65 - NCT06038305Recruiting
Anemia and growth in kids with stomach bug
This study looks at how common anemia (low iron levels) is in children with acute gastroenteritis (stomach bug), and how their growth is affected. It helps doctors understand if more blood tests or growth checks are needed.
AsyutAges 1 month–2 years - NCT06439563RecruitingPhase 3
Testing JP-1366 to prevent NSAID-related stomach ulcers
This trial tests a new drug called JP-1366 to see if it can prevent stomach ulcers caused by long-term NSAID use (like ibuprofen or naproxen) for conditions such as arthritis. It may be a good fit if you need to take NSAIDs for at least 24 weeks and have a higher risk of ulcers.
SeoulAges 19 years+ - NCT06595108Recruiting
Targeted therapy and radiation for advanced liver cancer
This trial tests a combination of immunotherapy (atezolizumab), targeted therapy (bevacizumab), and targeted radiation for advanced liver cancer that cannot be surgically removed. The goal is to see if this approach helps control the cancer.
Yongin-siAges 19–80 - NCT06646341Recruiting
Can scan findings predict colorectal cancer spread?
This study looks at whether signs of blood vessel involvement (called EMVI) seen on scans can predict if colorectal cancer spreads to other organs. You might join if you already had surgery to remove the cancer from the colon or rectum and any distant tumors, and your before-surgery scans are available for review.
Basingstoke, HampshireAges 16–100 - NCT06669377Recruiting
Combination therapy for liver cancer with main portal vein tumor clot
This trial tests a combination of treatments for liver cancer that has spread to the main portal vein. It uses a special stent, radiation seeds, and targeted therapies to shrink the tumor and improve blood flow. This may help patients who haven't had certain prior treatments.
Nanjing, JiangsuAges 18 years+ - NCT06670157Recruiting
Clip-assisted glue injection for stomach varices
This trial tests a new way to treat enlarged veins in the stomach (gastric varices) using a small clip and a medical glue injection. It is for people with liver cirrhosis who have these veins and are at risk of bleeding or have bled before.
Nanjing, JiangsuAges 18–80
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 11,952 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.