Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,685
- Phase 21,189
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer90
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California442
- Arizona190
- Texas140
- Alabama129
- Florida127
- New York120
- Massachusetts119
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,606 total
- NCT05424692Recruiting
Test tumor drug sensitivity to guide after-surgery colon cancer care
This study looks at whether testing a small tumor sample can identify which medicines are more likely to work for colorectal cancer after surgery. The results are used to help choose the best “after-surgery” treatment plan, when you have not had chemotherapy before surgery.
Beijing, Beijing MunicipalityAges 18–75 - NCT04103372Recruiting
MRI check for early rectal cancer or large polyps
This trial uses a special MRI before treatment to better understand early rectal cancer or suspicious large polyps. It may help doctors choose care that avoids bigger surgery when possible.
Reading, BerkshireAges 16–100 - NCT06039917Recruiting
Automatic reminders for stomach precancer follow-up
This study tests whether an automatic reminder system can help more people with stomach precancerous changes get the follow-up checks they need after an upper endoscopy. The goal is to see if the system improves how often patients return for surveillance.
Quanzhou, FujianAges 18 years+ - NCT06672913Recruiting
Skin-to-skin care study for premature babies
This study looks at how holding your baby skin-to-skin affects their health and development, for babies born at 32 weeks or earlier.
AnkaraAges 1 day+ - NCT06530303RecruitingPhase 1/Phase 2
Personalized immune cell therapy for colorectal cancer
This trial tests a treatment made from your own immune cells (called TILs) that are taken from your tumor, grown in a lab, and given back to you along with immunotherapy. It is for people with advanced colon or rectum cancer who have run out of standard options.
Beijing, Beijing MunicipalityAges 16–90 - NCT06303752RecruitingPhase 1/Phase 2
Tissue therapy for complex anal fistula
This trial tests whether a special tissue therapy can help heal complex anal fistulas that involve a large part of the sphincter muscle. It is for adults who need surgery for this condition and do not have certain other health issues.
OdenseAges 18 years+ - NCT06468865Recruiting
Glucose monitoring for low blood sugar after gastric bypass
This trial tests whether a new way of using glucose monitoring can help manage low blood sugar that happens after meals in people who have had gastric bypass surgery. It aims to find better ways to track and treat these episodes.
Tønsberg, VestfoldAges 18 years+ - NCT06675201RecruitingPhase 2
Personalized vaccine for advanced esophageal cancer after treatment
This trial tests a personalized vaccine made from your tumor's unique markers (neoantigens) to help prevent your advanced esophageal cancer from coming back. It's for people who have already completed strong treatment and are currently cancer-free, but have a high risk of recurrence.
Chengdu, Please SelectAges 18–80 - NCT07669519RecruitingPhase 3
Supplement for fatigue in stage IV colon cancer
This study tests an oral supplement (Nuvastatic) to see if it helps reduce fatigue in people with stage IV colon cancer who are starting chemotherapy for the first time. If you are 18–65 and have fatigue that is affecting you, this trial might offer a way to feel better.
Srikakulam, Andhra PradeshAges 18–65 - NCT07663526RecruitingPhase 4
Tabellvi for moderate to severe Crohn's disease in adults
This trial tests Tabellvi (adalimumab) for adults with moderate to severe Crohn's disease who haven't responded well to steroids or other treatments. It aims to see if this medication can help control symptoms and improve quality of life.
Fuyang, AnhuiAges 18–70 - NCT07665723RecruitingPhase 1
Study of afimkibart and other medicines in ulcerative colitis
This study looks at how afimkibart affects the way your body processes certain other medicines. It is for people with moderate to severe ulcerative colitis and helps researchers understand how to use this treatment safely.
Chula Vista, CaliforniaAges 18–60 - NCT07669454RecruitingPhase 3
Nuvastatic® for metastatic colorectal cancer
This trial tests a new capsule (Nuvastatic®) added to standard chemotherapy for people with metastatic colorectal cancer. The goal is to see if it helps shrink tumors and improve well-being.
Visakhapatnam, Andhra PradeshAges 18–65 - NCT07670312RecruitingPhase 1/Phase 2
Testing XYA02 for advanced solid tumors
This study tests an experimental drug called XYA02 for people with advanced solid tumors (like lung, ovarian, stomach, colorectal, or pancreatic cancer) that have come back or not responded to other treatments. The goal is to see if XYA02 can shrink tumors or slow their growth, and to find the best dose.
Sydney, New South WalesAges 18 years+ - NCT05254171RecruitingPhase 2/Phase 3
Trial adds SBP-101 to standard chemo for pancreatic cancer
This trial studies whether adding SBP-101 to standard chemotherapy (gemcitabine plus nab-paclitaxel) can improve outcomes in people with metastatic pancreatic cancer. You may be eligible if you have not yet started treatment for metastatic disease and meet other health and test requirements.
Hot Springs, ArkansasAges 18 years+ - NCT07671625Recruiting
Prehabilitation program for esophageal or gastric cancer
This trial tests a comprehensive program that includes exercise, nutrition, and psychological support before and after surgery for patients with locally advanced esophageal or gastric cancer. It aims to improve recovery and outcomes.
BrnoAges 18 years+ - NCT07668453RecruitingPhase 2
Adebrelimab plus chemo for advanced bile duct cancer
This study tests adding the immunotherapy adebrelimab to standard chemotherapy (gemcitabine and nab-paclitaxel) as a first treatment for advanced biliary tract cancer that can't be removed by surgery. The goal is to see if this combination helps shrink tumors and improve outcomes.
Nanjing, JiangsuAges 18–75 - NCT07663422RecruitingPhase 2
Treating immunotherapy-related liver inflammation with mycophenolate and prednisone
This trial tests a combination of two drugs, mycophenolate mofetil and prednisone, to treat moderate to severe liver inflammation caused by immunotherapy. The goal is to see if this treatment can help control the inflammation without needing long-term high-dose steroids.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07670286Recruiting
Spotting early warning signs of pancreatic cancer wasting
This study checks if advanced computer analysis of your tumor and body can predict severe weight loss and muscle wasting (cachexia) from pancreatic cancer. If you join, you may help doctors find earlier warning signs to improve treatment.
BeijingAges 18 years+ - NCT07670611RecruitingPhase 4
Vitamin D2 alone or with calcitriol for children with liver disease
This trial compares two types of vitamin D—one is plain vitamin D2, the other is vitamin D2 plus a more active form (calcitriol)—to see which works better for children with liver problems and low vitamin D levels.
BangkokAges Up to 18 years - NCT07670988Recruiting
Kidney health in kids with inflammatory bowel disease
This study checks if children with inflammatory bowel disease (IBD) are more likely to have kidney problems. Researchers will look at medical records to compare kidney health in kids with IBD and those without.
Alessandria, PiedmontAges 2–17 - NCT07665528Recruiting
Botox vs Botox with surgery for chronic anal fissure
This trial compares two treatments for a long-lasting anal fissure: Botox injections alone versus Botox combined with a small surgery (fissurectomy and anoplasty). It aims to see which works better and may help patients who have not healed with standard care.
Islamabad, FederalAges 18–65 - NCT07671339RecruitingPhase 1
Vaccine for pancreatic cancer with KRAS mutations
This trial tests a cancer vaccine (ELI-002 7P) for people with pancreatic cancer that hasn't spread to other parts of the body. It may be given alone or with another drug (tislelizumab) that helps the immune system fight cancer. The goal is to see if these treatments can help keep the cancer from coming back after surgery or chemotherapy.
Basking Ridge, New JerseyAges 18 years+ - NCT07670975Recruiting
Energy use in children with new IBD diagnosis
This study measures how many calories children with newly diagnosed inflammatory bowel disease (Crohn's or ulcerative colitis) burn at rest. It helps doctors understand and manage their energy needs.
Alessandria, PiedmontAges 6–17 - NCT07670273RecruitingPhase 2
Drug combo for advanced HER2 bile duct cancer
This trial tests a combination of three drugs (trastuzumab rezetecan, adebrelimab, and lenvatinib) as a first treatment for people with advanced HER2-positive or HER2-low bile duct or gallbladder cancer. The goal is to see if this combination helps shrink or control the cancer.
BeijingAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 11,952 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.