Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT04911816RecruitingPhase 1/Phase 2
Pre-surgery chemo plus oral hydroxychloroquine for pancreatic cancer
This trial studies giving chemo and hydroxychloroquine before surgery for resectable pancreatic cancer. The goal is to shrink the tumor and improve the chances of successful removal.
Morgantown, West VirginiaAges 18 years+ - NCT06532110Recruiting
Gut bacteria study in chronic digestive diseases
This study looks at the bacteria in your gut (the microbiome) in people with chronic gut conditions. Researchers want to understand how gut bacteria differ in these conditions to help improve treatments.
Hamilton, OntarioAges 18–75 - NCT06802042Recruiting
Probiotic for constipation in pregnancy
This trial tests if a probiotic called Lactobacillus can help relieve constipation in pregnant women and improve gut health. It compares the probiotic to a placebo to see if it is safe and effective.
Beijing, Beijing MunicipalityAges 18–40 - NCT06531434RecruitingPhase 1/Phase 2
Best treatment plan for advanced esophageal cancer
This trial is for people with T4 esophageal cancer, where the tumor has spread to nearby organs. It aims to find the best treatment approach to improve outcomes.
Tainan, TaiwanAges 18–70 - NCT07215000RecruitingPhase 4
Better Colonoscopy Prep Options for Comfort
This trial compares different colonoscopy prep methods to see which one patients tolerate best. It aims to make the cleaning process before a colonoscopy more comfortable and acceptable.
Atlanta, GeorgiaAges 18 years+ - NCT06839209Recruiting
Add-on TOXCLEAN for recurrent C. difficile diarrhea
This trial tests an add-on treatment called TOXCLEAN for people with repeat C. difficile diarrhea. It aims to see if adding TOXCLEAN to standard antibiotics helps more than antibiotics alone.
RomaAges 18 years+ - NCT07210294Recruiting
Acupressure for stomach discomfort
This study tests if pressing on specific body and ear points can help relieve symptoms of functional dyspepsia, a condition where the stomach feels uncomfortable without any clear damage. It may offer a drug-free way to manage symptoms like pain, bloating, or nausea.
Jakarta Pusat, DKI JakartaAges 18–59 - NCT06855888Enrolling by invitation
Comparing two stitching methods for pancreas reattachment after Whipple surgery
This trial compares two different ways to reconnect the pancreas during a Whipple procedure. It is for people with a soft pancreas and a narrow pancreatic duct. The goal is to see which stitching method leads to fewer complications.
Isehara-shi, KanagawaAges 18 years+ - NCT07209501Enrolling by invitation
Aromatherapy for stem cell transplant patients
This trial tests if inhaling essential oils can help patients who are having a stem cell transplant after high-dose chemotherapy. It aims to see if this is a feasible and acceptable way to feel better during treatment.
SingaporeAges 21–99 - NCT06855082Recruiting
Stoma self-care app study for colostomy patients
This trial tests if a smartphone app can help people with a new colostomy learn to care for their stoma at home. It is designed for patients who are alert, can speak Mandarin or Minnan, and have a smartphone.
TaipeiAges 20 years+ - NCT07207434RecruitingPhase 2
Probiotic supplement for pregnant women to improve gut health
This trial tests whether taking a probiotic during pregnancy can improve gut health in women living in areas where gut infections are common. It may help reduce harmful bacteria and related health problems for both you and your baby.
Matiari, SindhAges 18–49 - NCT06567691Enrolling by invitation
Comparing two ways to bypass cancer-caused stomach blockage
This trial compares two ways to bypass a stomach or intestinal blockage caused by cancer that cannot be cured with surgery. It tests a newer, less invasive procedure (endoscopic gastroenterostomy) against the standard surgical bypass (gastrojejunostomy) to see which works better for patients like you.
Nashville, TennesseeAges 18 years+ - NCT06994871Enrolling by invitation
Exercise and liver fat in fatty liver disease
This study tests if different types of exercise can reduce fat in the liver for people with metabolic fatty liver disease. It might help if you are looking for a non-drug way to improve your liver health.
Nanjing, JiangsuAges 18–45 - NCT06843512Recruiting
How GLP-1 meds change eating habits
This study looks at how starting a GLP-1 medication (like Wegovy or Ozempic) changes your food choices and eating habits. It may help you understand if these medicines work for weight loss.
State College, PennsylvaniaAges 18 years+ - NCT07206836Recruiting
Enhanced recovery after colostomy reversal in children
This trial compares two ways to care for children after colostomy reversal surgery: standard care or an enhanced recovery program designed to speed up healing.
Faisalābad, Punjab ProvinceAges 2–13 - NCT07204665Enrolling by invitation
Emergency surgery vs. stent for colon cancer blockage
This study compares emergency surgery to placing a stent first for people with a blocked colon from cancer. It also looks at whether a special recovery program (ERAS) helps you heal faster after surgery.
Bilbao, VizcayaAges 18 years+ - NCT07205471Recruiting
Partial spleen removal via laparoscopy for cirrhosis-related hypersplenism
This study is testing a keyhole surgery to remove part of an enlarged spleen in people with cirrhosis. It aims to improve low blood counts and reduce the risk of further bleeding from stomach or esophagus veins.
Yangzhou, JiangsuAges 18 years+ - NCT07254715RecruitingPhase 4
Itopride for stomach issues from semaglutide in diabetic women
This trial tests if itopride can help with stomach problems caused by semaglutide in diabetic women having a hysterectomy. It aims to see if this combination can improve symptoms like slow stomach emptying.
Cairo, Cairo GovernorateAges 40–60 - NCT05735002Recruiting
Check tests to find chronic bowel blood flow problems early
This study looks at ways to promote early diagnosis of chronic mesenteric ischemia, a condition where the intestines don’t get enough blood over time. If you’re being evaluated for this problem, the trial may help ensure the right diagnosis happens sooner.
Enschede, OverijsselAges 18 years+ - NCT07202481Recruiting
Fiber supplements for constipation in women
This trial tests if two types of fiber—one from chicory and one from a plant husk—can help women with constipation move food through their intestines faster. It aims to find a gentle, non-drug option that might work better than what you eat now.
Belo Horizonte, Minas GeraisAges 18–59 - NCT06936488Enrolling by invitation
Study of Ivonescimab with TAS-102 for advanced colorectal cancer
This trial tests a combination of two drugs – ivonescimab (a type of immunotherapy) and TAS-102 (a chemotherapy) – for people with advanced colorectal cancer that has not responded to at least two prior chemotherapies. The goal is to see if this new combo can shrink tumors or slow cancer growth.
Huai'an, JiangsuAges 18–75 - NCT06540326RecruitingPhase 2
Second-line therapy for advanced colorectal cancer
This trial tests a combination of chemotherapy with either bevacizumab or cetuximab as a second-line treatment for advanced colorectal cancer. It aims to find which option works better for patients whose first treatment failed.
Hangzhou, ZhejiangAges 18–75 - NCT07200531Recruiting
Can therapy change gut bacteria in women?
This trial studies whether psychotherapy can affect the bacteria living in your gut. It is for women aged 19 to 53 who are not pregnant, breastfeeding, or already in regular therapy.
Omaha, NebraskaAges 19–54 - NCT06856707Enrolling by invitation
MIRA surgical system registry study
This study tracks outcomes for people having surgery with the MIRA Surgical System, a robotic tool. Joining helps doctors learn how well the system works and if it is safe.
Lincoln, NebraskaAges Any age
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.