Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT06802666RecruitingPhase 2
Short radiation plus combo drugs for rectal cancer
This trial tests a new combination for rectal cancer that hasn't spread far: a short course of radiation followed by two drugs (AK112 and CAPOX). The goal is to shrink the tumor before surgery and possibly avoid more aggressive treatments.
HubeiAges 18–75 - NCT07179484Recruiting
Study of CT041 for advanced stomach or junction cancer after first treatment
This trial tests a new cell therapy (CT041) for people with advanced stomach or gastroesophageal junction cancer that has a specific marker called CLDN18.2. It is given after initial chemotherapy to try to keep the cancer from growing.
BeijingAges 18–75 - NCT07179601Recruiting
Embolization for hemorrhoid symptoms study
This trial tests if blocking certain blood vessels in the rectum can reduce bleeding and other symptoms from hemorrhoids. If you have bothersome internal hemorrhoids that haven't been helped by other treatments or if surgery is not an option for you, this study may be a fit.
Los Angeles, CaliforniaAges 18–90 - NCT07271264Recruiting
New camera vs standard light for colonoscopy in IBD
This study tests a new camera system that adds texture and color enhancement to the usual white light during a colonoscopy. It aims to see if this new view helps doctors spot signs of inflammation or early cancer more clearly in people with inflammatory bowel disease.
LondonAges 16 years+ - NCT05699655RecruitingPhase 2/Phase 3
New pre-surgery treatment for advanced stomach cancer with immunotherapy
This trial tests a new combination (tislelizumab plus apatinib and chemotherapy) before surgery for certain advanced stomach cancers, compared with the standard chemotherapy plus S1. The goal is to shrink the tumor and improve outcomes before and around surgery.
Fuzhou, FujianAges 18–75 - NCT06513780Recruiting
Liver transplant and portal vein blood clot study
This study looks at how blood clots in the portal vein (the main vein to your liver) affect recovery and outcomes after a liver transplant. If you've had a liver transplant, your data may help doctors understand this better.
BeijingAges 18 years+ - NCT03930810Enrolling by invitation
Study of PFIC types and how bile diversion affects outlook
This study looks at different genetic liver conditions called PFIC and follows how they progress over time. It also studies whether a procedure called biliary diversion may improve symptoms or long-term outcomes.
Groningen, Provincie GroningenAges birth–65 years - NCT05067595RecruitingPhase 1
Fecal transplant plus fiber for gut graft-versus-host disease
This Phase 1 study tests whether a fecal microbiota transplant (a stool-based treatment from a screened donor) plus a dietary fiber supplement can improve gut symptoms after a bone marrow transplant. It is aimed at people with mild to severe gut graft-versus-host disease (GVHD).
Seattle, WashingtonAges 18 years+ - NCT07269249Recruiting
Dostarlimab before surgery for advanced rectal cancer
This study looks at how well the immunotherapy drug dostarlimab works before surgery in patients with a specific type of advanced rectal cancer that has DNA repair problems (called dMMR/MSI-H). The goal is to see if it is safe and effective in the real world.
NaplesAges 18 years+ - NCT04357600Enrolling by invitationPhase 1/Phase 2
Stem cell treatment for hepatitis B–related cirrhosis
This early-stage trial tests umbilical cord “mesenchymal” stem cells in people with liver scarring (cirrhosis) that is caused by hepatitis B. It may help improve liver function and related complications, but it is mainly designed to check safety and how well the treatment works.
Jakarta, DKI JakartaAges 18–65 - NCT06393400RecruitingPhase 1
Stool transplant with chemotherapy for advanced pancreatic cancer
This study tests if giving patients a stool transplant (also called FMT) in capsules along with their first chemotherapy can help treat advanced pancreatic cancer that cannot be removed by surgery.
London, OntarioAges 18 years+ - NCT07262515Recruiting
Blood tests and genes for alcoholic hepatitis recovery
This study looks at blood samples and genetic information from people with acute alcoholic hepatitis to understand why some recover better than others. It aims to find better ways to predict and improve outcomes.
ParisAges 18 years+ - NCT05653310Enrolling by invitationPhase 2
Study drug for functional dyspepsia symptoms
This Phase 2 study tests tradipitant to see if it can reduce symptoms of functional dyspepsia (indigestion-like discomfort without a clear cause). If you qualify, you may be asked to take the study treatment and complete study visits to measure symptom changes.
Rochester, MinnesotaAges 18–70 - NCT05759728RecruitingPhase 1/Phase 2
LGR5-targeted CAR-T for metastatic colorectal cancer
This early-phase study tests an autologous CAR-T cell treatment that is designed to recognize LGR5 on colorectal cancer cells. It aims to shrink metastatic colorectal cancer that has already been treated with up to two prior standard chemotherapy regimens.
Adelaide, South AustraliaAges 18 years+ - NCT06948656Recruiting
How low blood sugar affects muscle loss in cirrhosis
This study looks at whether low blood sugar (hypoglycemia) is linked to muscle loss (sarcopenia) in people with cirrhosis. It may help doctors better manage your health if you have this liver condition.
DijonAges 18 years+ - NCT07257796Recruiting
AI tool for finding early stomach changes
This trial tests if an artificial intelligence program can help doctors better detect certain pre-cancerous changes in the stomach lining during an advanced endoscopy procedure. It may benefit people at average risk who are already scheduled for this type of exam.
Jinan, ShandongAges 40–75 - NCT07257913Recruiting
How dairy in food guide affects gut health
This study looks at how adding dairy products to the Canadian Food Guide affects the health of your gut. If you have a larger waistline but no major health issues or food allergies, this trial may help you learn more about your digestion.
Québec, QuebecAges 40–65 - NCT06953830Enrolling by invitation
Measuring spleen stiffness in veterans with fatty liver disease
This study tests a new way to measure spleen stiffness in veterans with metabolic-dysfunction fatty liver disease. It may help doctors better understand and monitor this condition without invasive procedures.
Columbia, South CarolinaAges 18 years+ - NCT07355374Recruiting
Balloon dilation during esophageal cancer surgery
This trial tests whether expanding a balloon inside the esophagus during keyhole surgery can reduce a serious complication called anastomotic leak. If you have esophageal cancer and are scheduled for a minimally invasive Ivor Lewis esophagectomy, you may be eligible.
Basel, Canton of Basel-CityAges 18 years+ - NCT06825260RecruitingPhase 4
PEG3350 vs Senna after urogynecologic surgery
This study compares two common laxatives to see which works better for preventing constipation after surgery for pelvic organ prolapse or stress urinary incontinence. It will help find the best way to keep you comfortable during recovery.
Syracuse, New YorkAges 18 years+ - NCT07506122Recruiting
Acupuncture for chronic constipation: dose study
This trial tests different amounts of acupuncture to see which dose works best for chronic constipation. It may help if you have had constipation for at least 6 months and have fewer than 2 complete bowel movements per week without using laxatives.
Wuhan, HubeiAges 18–75 - NCT07252076Recruiting
MRI for detecting hidden liver metastases in pancreatic cancer
This trial uses an MRI scan to look for small liver metastases that may not be visible on a CT scan in people newly diagnosed with pancreatic cancer. It aims to improve the accuracy of staging before treatment begins.
Alessandria, PiedmontAges 18 years+ - NCT05761483Recruiting
Endoscopic treatment for bile duct narrowing after liver transplant
This trial tests an endoscopic (camera-based) approach to treat bile duct narrowing that happens after a liver transplant. It may help improve bile flow and liver blood test results when the narrowing is in the bile duct area near where the liver’s bile ducts split.
Roma, RMAges 18 years+ - NCT07249788RecruitingPhase 4
Resmetirom for MASH: A study on safety and effectiveness
This trial tests if resmetirom can help people with MASH, a type of fatty liver disease linked to metabolic issues like diabetes or obesity. It looks at how safe and effective the drug is over time.
Rawalpindi, Punjab ProvinceAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.