Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT06906289Recruiting
Resuming feeding after small bowel connection surgery
This study looks at the best time to start eating again after small bowel surgery. Patients are placed into groups that start feeding earlier or later, to see which helps recovery better.
Peshawar, KPKAges 15–65 - NCT05854914Recruiting
Smartphone hypnosis to reduce pain after emergency appendix surgery
This study tests whether guided hypnosis on a smartphone can lower pain after emergency surgery for a complicated appendicitis. If you qualify, you’ll use the app during your recovery and also answer quick questions about your pain and anxiety.
NiceAges 18 years+ - NCT06716541Recruiting
Biodegradable stent for bile duct narrowing after liver transplant
This study is testing a special temporary stent that breaks down over time to help open a narrowed bile duct after a liver transplant. It may help avoid long-term plastic stents or additional surgery.
PragueAges 18 years+ - NCT03717792Recruiting
Check how doctors follow up vascular liver disease
This study focuses on people who have vascular liver disease and aims to evaluate follow-up care and non-invasive ways to assess it. It may help improve how safely and accurately doctors monitor your liver without invasive procedures.
BonnAges 18–100 - NCT05925959Recruiting
Weight loss before abdominal hernia surgery
This trial studies whether losing weight before open abdominal wall hernia repair is safe and helpful for recovery. It may help your surgeon plan the operation more effectively, especially when a complex technique (with mesh and muscle release) is expected.
Chicago, IllinoisAges 18 years+ - NCT06902987RecruitingPhase 1
Upatinib for anal fistulas in Crohn's disease
This trial tests whether upatinib can help heal active anal fistulas in people with moderate to severe Crohn's disease. If you have an anal fistula that is causing pain or drainage, this study may offer a new treatment option.
Guangzhou, GuangdongAges 18–70 - NCT06902389RecruitingPhase 1/Phase 2
Multi-target immune cell therapy for advanced liver cancer
This trial tests a new type of immune cell therapy (multi-target Hi-TCR-T cells) for people with advanced liver cancer that hasn't responded to earlier treatments. The therapy targets several markers on your cancer cells to try to attack the tumor more effectively.
Shanghai, Yangpu DistrictAges 18–75 - NCT07163273RecruitingPhase 2
Alternating chemotherapy for first-line metastatic pancreatic cancer
This study tests a monthly rotation of two chemotherapy combinations (NALIRIFOX and GnP) as the first treatment for metastatic pancreatic cancer. The goal is to see if alternating the drugs helps control the cancer while reducing side effects.
Bay Shore, New YorkAges 18 years+ - NCT06899867Recruiting
Comparing heart monitoring methods during liver transplant
This trial compares two ways to monitor how well your heart is pumping during liver transplant surgery. One method uses a thin tube in your blood vessels, and the other uses an ultrasound probe placed in your food pipe.
France, LyonAges 18 years+ - NCT07475286RecruitingPhase 2
Chemo for stomach cancer that has spread to the abdomen lining
This trial tests giving chemotherapy into the abdomen during surgery for stomach or gastroesophageal junction cancer that has spread to the lining of the abdomen (peritoneal carcinomatosis). It aims to see if this approach can help control the disease better.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06748638Enrolling by invitationPhase 4
Lactulose and linaclotide for colonoscopy prep
This trial tests whether taking lactulose together with linaclotide can improve bowel cleansing before a colonoscopy. If you are scheduled for a colonoscopy, this study may help make the preparation more effective.
Nanjing, JiangsuAges 18–80 - NCT06876805Recruiting
Ultrasound contrast to check unclear liver spots
This trial uses a special ultrasound with contrast dye to get a clearer picture of liver spots that other scans (CT, MRI, or PET) couldn't fully identify. The goal is to see if this ultrasound can help doctors make a more accurate diagnosis.
BolognaAges 18 years+ - NCT06874413Enrolling by invitation
Exercise program for frail older adults before hernia surgery
This study tests whether a supervised exercise program before hernia repair surgery helps frail older adults recover better. The program includes physical exercises and breathing muscle training.
Greenville, South CarolinaAges 65 years+ - NCT05867225Recruiting
Synthetic mesh versus surgery alone for large hiatal hernia repair
This trial compares using a synthetic, dissolvable mesh versus doing hiatal hernia surgery without mesh during laparoscopic repair. It aims to see which approach better controls symptoms and improves outcomes for people with large, symptomatic hiatal hernias.
BayonneAges 18 years+ - NCT06869590Recruiting
Study of antibodies in anorexia with liver damage
This study looks for certain antibodies in the blood of people with anorexia nervosa who also have liver problems. It aims to understand if these antibodies contribute to liver damage, which may help find new ways to treat or prevent this complication.
MarseilleAges 6–65 - NCT03187535Recruiting
TEAS treatment to prevent nausea after spinal surgery
This trial studies whether TEAS (a noninvasive electrical stimulation you receive during surgery) can reduce nausea and vomiting after spinal surgery. You might benefit if you’re at risk of “PONV” (post-surgery nausea and vomiting) and can safely take part in an acupoint-based stimulation study.
Columbus, OhioAges 18 years+ - NCT06247046RecruitingPhase 3
Probiotic powder for IBS-D (SK08) trial
This study tests a new probiotic powder (SK08) to see if it reduces belly pain and diarrhea in people with IBS-D (irritable bowel syndrome with diarrhea). It lasts several months and involves taking the study powder twice a day.
Wuxi, JiangsuAges 18–70 - NCT06847919Recruiting
Probiotic yogurt for chronic constipation
This study tests whether eating a special probiotic yogurt can help relieve chronic constipation. It may be a simple, natural addition to your diet with minimal side effects.
Suzhou, JiangsuAges 18–65 - NCT06836960Enrolling by invitationPhase 1/Phase 2
Gegen Qinlian Tang and Probiotics for radiation gut issues
This study tests if a traditional Chinese medicine formula (Gegen Qinlian Tang) plus probiotics can help people who have gut problems from radiation treatment for cancer. It may reduce diarrhea, pain, or other bowel symptoms caused by radiation.
Jiujiang, JiangxiAges 18–80 - NCT03862781Recruiting
Quicker bowel recovery after minimally invasive right colon surgery
This study looks at whether a specific internal stitch connection (an anastomosis) helps your bowel start working sooner and may help you leave the hospital earlier after right colon surgery. It’s mainly for adults having planned, minimally invasive right hemicolectomy.
Grand Rapids, MichiganAges 18 years+ - NCT05874570RecruitingPhase 4
Doxycycline for H. pylori after prior treatment failure
This trial tests whether doxycycline can “rescue” or improve treatment for an H. pylori infection that has already not responded to previous therapy. It may help people whose stomach infection keeps coming back or never cleared.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT05877781Recruiting
Study eating-area therapy for functional stomach discomfort
This trial studies a treatment called PEA for people with functional dyspepsia—stomach discomfort without an identifiable cause. If you qualify, you may receive the study intervention and complete symptom questionnaires to see if it helps reduce symptoms.
Leuven, Vlaams-BrabantAges 18–70 - NCT05681689RecruitingPhase 3
Check how well a urea breath test works after H. pylori treatment
This Phase 3 study tests whether a urea breath test can confirm that H. pylori infection has been cleared after recent treatment. If the test works well, it may help doctors confirm cure without needing invasive procedures.
Doral, FloridaAges 18 years+ - NCT06555133RecruitingPhase 2
Study of Y-90, capecitabine, and atezolizumab for advanced colorectal cancer
This trial tests a combination of targeted radiation (Y-90), chemotherapy (capecitabine), and immunotherapy (atezolizumab) for people with colorectal cancer that has spread mainly to the liver and is no longer responding to at least two prior treatments. The goal is to see if this combination can shrink tumors or slow the disease.
Providence, Rhode IslandAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.