Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT06685276RecruitingPhase 2
Combination therapy for advanced colorectal cancer
This trial tests a combination of three drugs (fruquintinib, chidamide, and sintilimab) for people with a specific type of metastatic colorectal cancer that has not responded to at least two prior treatments. It aims to see if this combination is safe and effective.
BeijingAges 18–75 - NCT03080974RecruitingPhase 2
Study tests immunotherapy plus electroporation for advanced pancreatic cancer
This Phase 2 study looks at whether adding immunotherapy to a procedure called irreversible electroporation can help treat stage III pancreatic cancer. You might be eligible if you have measurable tumors and can safely undergo the procedure.
Louisville, KentuckyAges 18 years+ - NCT06196697RecruitingPhase 2
New immunotherapy combo for advanced stomach cancer
This clinical trial is testing a combination of two immunotherapy drugs (AK104 and AK112) plus chemotherapy as the first treatment for advanced stomach or gastroesophageal junction cancer. It aims to see if this combination helps control the cancer better than standard therapy.
HarbinAges 18–75 - NCT06829797RecruitingPhase 2
Iparomlimab and chemotherapy vs chemotherapy alone for stomach cancer
This trial tests whether adding an immunotherapy drug (Iparomlimab and Tuvonralimab, combined as QL1706) to standard chemotherapy before surgery works better than chemotherapy alone for people with locally advanced stomach or gastroesophageal junction cancer that can be surgically removed.
Jinan, ShandongAges 18–75 - NCT07456332Enrolling by invitation
Digital lifestyle program for weight loss with HIV and fatty liver
This trial tests a digital lifestyle program (diet and activity coaching) to help people with HIV and fatty liver disease lose weight. It aims to see if the program can reduce body fat in the liver and improve overall health.
L'Hospitalet de Llobregat, BarcelonaAges 18 years+ - NCT03961373RecruitingPhase 3
Standard vs longer lymph node surgery after chemo for stomach cancer
This study compares two surgical approaches to remove lymph nodes after you’ve already had chemotherapy for stomach cancer. It aims to see whether removing lymph nodes in a more extended way improves outcomes without causing unacceptable side effects.
SienaAges 18–80 - NCT06812390RecruitingPhase 2
Albumin plus diuretics for cirrhosis-related leg swelling
This study tests whether giving albumin (a protein) along with water pills helps reduce leg swelling in people with cirrhosis and ascites. It may be an option if your leg swelling hasn't improved with standard diuretics alone.
West Haven, ConnecticutAges 18 years+ - NCT06676930Recruiting
AI's effect on trainee detection of polyps
This study tests whether using artificial intelligence (AI) helps doctors-in-training detect more polyps during colonoscopies for cancer screening or surveillance. It may help improve early detection of growths that could become cancer.
Chicago, IllinoisAges 18 years+ - NCT07288281Recruiting
Preoperative Clear Fluid Fasting in Liver Transplant
This trial looks at how long before surgery patients waiting for a liver transplant can drink clear fluids, like water. The goal is to find a safer or more comfortable fasting time.
Warsaw, WarszawaAges 18 years+ - NCT06810882Recruiting
Two ways to give nausea medicine for weight loss surgery
This study compares giving ondansetron (a nausea medicine) through a vein versus injecting it near a nerve to prevent nausea and vomiting after weight loss surgery. It may help identify which method works best for patients undergoing laparoscopic sleeve gastrectomy.
Tanta, Gharbia GovernorateAges 18–65 - NCT07619079Recruiting
Registry study of early colorectal cancer in polyps
This study collects information from patients who had a polyp removed from their colon that contained early-stage cancer. Researchers want to understand how these polyps are best managed and what happens to patients over time.
Basking Ridge, New JerseyAges 18 years+ - NCT06391359Recruiting
Gallbladder surgery to prevent repeat pancreatitis
This trial tests if removing the gallbladder can prevent future episodes of unexplained acute pancreatitis. It may help people who've had one to three episodes with no clear cause found.
Amsterdam, North HollandAges 18 years+ - NCT06656312Recruiting
EndoAim AI for colon polyp detection
This study tests an artificial intelligence (AI) system called EndoAim that helps doctors find polyps during a colonoscopy. It is for people having a routine colonoscopy with an Olympus endoscope.
Taichung, North Dist.Ages 20 years+ - NCT01697371Recruiting
Proton beam radiation for liver metastases
This trial tests whether proton beam therapy can control cancer that has spread to the liver. It may help shrink liver tumors or slow their growth while aiming to reduce harm to nearby organs.
Loma Linda, CaliforniaAges 18 years+ - NCT06799832Recruiting
Guiding fluid management during major abdominal surgery using a new index
This study tests whether a new tool, the urethral perfusion index, can help doctors better manage fluids during and after major abdominal surgery. It uses standard catheters already in place, so there's no extra device needed.
HamburgAges 45 years+ - NCT06784557RecruitingPhase 4
Study of ezetimibe's effect on gut bacteria
This trial tests whether ezetimibe, a cholesterol-lowering drug, changes the bacteria in your gut. It may help people with heart disease or high cholesterol who are already on a statin.
SeoulAges 19–80 - NCT06798376Recruiting
Immunotherapy plus chemo before stomach cancer surgery
This trial tests combining immunotherapy (PD-1 blockers) with chemotherapy before surgery for advanced stomach cancer. The goal is to find the best number of treatment cycles to shrink the tumor and improve surgery results.
BeijingAges 18–90 - NCT06782880Recruiting
Fecal transplant to prevent infections after liver transplant
This study tests if giving a fecal transplant (a procedure that transfers healthy bacteria from a donor's stool into your gut) before a liver transplant can lower the risk of serious infections after the surgery. It might help strengthen your immune system to fight off germs.
BolognaAges 18 years+ - NCT07411118Recruiting
Comparing two ways to remove stomach GIST tumors with an endoscope
This trial compares two endoscopic techniques (EFTR and STER) for removing small to medium-sized GIST tumors from the stomach wall. It aims to see which method is safer and more effective.
ShanghaiAges 18–75 - NCT06776874Recruiting
Predicting risks after an ERCP procedure
This observational study looks at patients who need an ERCP (a scope procedure for the bile ducts, liver, or pancreas). The goal is to create a score that can predict side effects after the procedure, which may help doctors better manage care.
BolognaAges 18 years+ - NCT06776536Recruiting
Testing ultrasound depth in endometriosis bowel surgery
This trial uses an ultrasound probe placed inside the rectum during surgery to see how accurately it measures how deep and how far endometriosis has spread into the bowel wall. The goal is to help surgeons decide exactly how much bowel needs to be removed.
IstanbulAges 18–55 - NCT06768216Recruiting
Mediterranean vs. low-fat diet for fatty liver in overweight kids
This trial compares two diets—a Mediterranean-style diet and a low-fat diet—to see which better reduces liver fat in overweight children and teens with fatty liver disease (MASLD). It aims to find a safe, effective eating plan for young people.
New Delhi, National Capital Territory of DelhiAges 8–18 - NCT06773520Recruiting
3D ultrasound for anal sphincter check in new mothers
This study uses a special 3D ultrasound to look at the muscle around the anus in women who are pregnant or have had one baby. It may help doctors understand and prevent muscle injuries during childbirth.
Bologna, BolognaAges 18–44 - NCT07259395Recruiting
Predicting ERCP procedure time with a new tool
This trial is testing a tool to predict how long an ERCP procedure will take. It involves ERCPs done by trainees under supervision and uses a tiny camera inside the bile duct.
BrusselsAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.