Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,685
- Phase 21,189
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer90
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California442
- Arizona190
- Texas140
- Alabama129
- Florida127
- New York120
- Massachusetts119
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,606 total
- NCT06475118Recruiting
Blood tests and scans to measure muscle loss in liver cancer
This study looks at whether measuring certain proteins in your blood (myokines) can help detect muscle loss (sarcopenia) in people with liver cancer, and compares these blood tests to special CT scans. If you're newly diagnosed with liver cancer and have a CT scan already, you may be able to join.
ReimsAges 18 years+ - NCT06598033RecruitingPhase 2/Phase 3
Vitamin C and Cordyceps for quality of life in advanced pancreatic cancer
This trial tests whether a combination of high-dose vitamin C and cordyceps (a type of fungus used in traditional medicine) can improve quality of life for people with late-stage pancreatic cancer that has progressed after two prior treatments. It looks at how these supplements affect your well-being and daily living.
ShanghaiAges 18–80 - NCT05967143Recruiting
Registry study for first-time SIR-Spheres in liver tumors
This is an observational (real-world) study that follows people with certain unresectable liver tumors who are getting SIR-Spheres for the first time. It helps doctors understand how this treatment is used in routine care and what outcomes patients experience.
Clichy, CedexAges 18 years+ - NCT07617545Recruiting
Nerve blocks for pain relief in kids' upper belly surgery
This trial compares two types of numbing injections (nerve blocks) given during surgery to help reduce pain afterward in children having upper abdominal surgery. The goal is to find which method works better to keep kids more comfortable after their operation.
AlexandriaAges 6–12 - NCT07619417Enrolling by invitation
Electric pulse ablation for pancreatic growths
This trial uses a special endoscopic tool to deliver electric pulses to abnormal growths in the pancreas. It may help people who cannot have surgery for these growths.
Columbus, OhioAges 18 years+ - NCT07614633Recruiting
Understanding Eosinophilic Esophagitis Over Time
This study follows patients with eosinophilic esophagitis (a condition where too many white blood cells called eosinophils build up in the food tube) to understand how the disease changes over time and what happens with different treatments. By tracking your symptoms and test results, doctors hope to learn how to better manage this condition.
Pavia, PaviaAges 5 years+ - NCT07619313RecruitingPhase 1
AB801 with Chemotherapy and Immunotherapy for Bile Duct or Pancreatic Cancer
This study tests a new drug called AB801 combined with standard chemotherapy and immunotherapy for advanced bile duct cancer (cholangiocarcinoma) or pancreatic cancer. The goal is to see if this combination can shrink tumors and help patients live longer.
Los Angeles, CaliforniaAges 18 years+ - NCT07616297Recruiting
Higher Radiation Dose to Avoid Surgery in Rectal Cancer
This study tests whether giving a higher dose of radiation to rectal cancer tumors can help patients avoid surgery altogether. The goal is to shrink the tumor enough that surgery is no longer needed, preserving normal bowel function.
Rotterdam, South HollandAges 18 years+ - NCT07616687RecruitingPhase 4
Testing guselkumab to improve Crohn's disease control
This study tests whether guselkumab, a newer biologic medication, can better control active Crohn's disease symptoms and inflammation. You'll receive the medication and be monitored closely to see how well it works for you.
AmiensAges 18 years+ - NCT07614542Recruiting
Understanding Gut Health and Hormones in Aging Women
This study explores how your gut bacteria and hormones change as you age. Researchers will collect stool and blood samples and ask about your health to better understand women's aging.
LisbonAges 40–64 - NCT07617610Recruiting
Understanding Treatment Resistance in BRAF-Mutated Colorectal Cancer
This study looks at why some people with a specific type of colorectal cancer (BRAF V600E-mutated) stop responding to targeted drugs over time. Researchers will take small tissue samples before and during your treatment with anti-EGFR antibody and BRAF inhibitor to understand resistance and help improve future treatments.
AarauAges 18 years+ - NCT07617038Enrolling by invitation
MRI Scan to Predict Liver Cancer Treatment Response
This trial uses a special type of MRI scan to see if doctors can predict how well a liver cancer treatment (called TACE) will work for you. The scan may help doctors understand your treatment response better.
Montreal, QuebecAges 18–70 - NCT07615036Recruiting
Natural Opening Specimen Removal in Colon Surgery
This study tracks a newer surgical technique where the removed colon or rectum is pulled out through the body's natural opening (like the anus or mouth) instead of through a larger cut in the belly. Researchers want to understand how safe and effective this approach is compared to traditional methods.
SingaporeAges 21 years+ - NCT07615374Recruiting
Combined laparo-endoscopic sentinel node surgery for early stomach cancer
This trial tests a surgical technique that combines two types of minimally invasive procedures (laparoscopy and endoscopy) to find and remove the first lymph node that might contain cancer (called the sentinel lymph node) in people with early stomach cancer. The goal is to remove only the necessary lymph nodes, potentially reducing side effects while ensuring the cancer hasn't spread.
Changchun, JilinAges Any age - NCT07614061RecruitingPhase 1
Cell therapy for advanced bile duct cancer
This trial tests a new treatment called BTC-Ag-T, which uses your own immune cells enhanced in the lab to fight advanced biliary tract cancer (cancer of the bile ducts or gallbladder). It's designed for patients whose cancer has spread or cannot be surgically removed and who have already received standard chemotherapy plus immunotherapy.
ShanghaiAges 18 years+ - NCT07613827Enrolling by invitation
AI screening for fatty liver disease using CT scans
This study uses artificial intelligence to help doctors identify fatty liver disease from CT scans you may already be having. If eligible, you'll have some blood tests and possibly an ultrasound or MRI to confirm liver health, helping catch liver disease early.
Shenyang, LiaoningAges 18 years+ - NCT07616245Recruiting
Special feeding to prevent fluid leaks after esophageal surgery
This study tests whether a special type of nutritional feeding through a tube placed in your small intestine can reduce complications (fluid leaks) after surgery to remove your esophagus for cancer. Researchers hope this approach may help you recover faster and spend less time in the hospital.
Beaumont, DublinAges 18 years+ - NCT07617246RecruitingPhase 2
Preventing nausea from cancer treatment with new medications
This study tests two medications (fosrolapitant and palonosetron) to prevent severe nausea and vomiting in patients with esophageal or lung cancer who are receiving chemotherapy combined with immunotherapy. If the medications work well, they could help patients feel better during treatment and complete their cancer care more comfortably.
Hangzhou, ZhejiangAges 18 years+ - NCT07618273Recruiting
Smart phone app for tracking stomach and digestive health
This study tests a smartphone app called ALEX that helps you track digestive symptoms like bloating, stomach pain, or changes in bowel habits over four weeks. Researchers want to see if the app makes it easier to notice patterns in your symptoms and understand your gut health better.
Jacksonville, FloridaAges 18–44 - NCT07620210Recruiting
Swallowing Therapy and Pressure Ball Training After Stroke
This study tests whether a swallowing therapy program (CTAR) combined with a pressure ball exercise helps older adults who had a stroke recover their ability to swallow safely. Many stroke survivors struggle with swallowing, which can lead to serious health problems, so this research aims to find better ways to help.
Tainan, Tainan CityAges 65–90 - NCT07619235RecruitingPhase 4
Combination immunotherapy and chemotherapy for advanced bile duct cancer
This study tests a combination of four drugs—two immunotherapy drugs (iparomlimab and toripalimab), a targeted therapy (bevacizumab), and chemotherapy—as a first-line treatment for advanced biliary tract cancer (cancer of the bile ducts or gallbladder). The goal is to see if this combination can shrink tumors and help patients live longer.
Wuhan, HubeiAges 18–75 - NCT07618884Recruiting
Minimally invasive surgical repair for inguinal hernia
This trial tests a newer surgical technique called TREPP to repair inguinal hernias (bulges in the groin area). The approach may reduce pain and recovery time compared to traditional surgery.
Asyut, Asyut GovernorateAges 18 years+ - NCT07616830Recruiting
Recovery Outcomes After Temporary Midline Stoma Surgery
This study tracks how well patients recover after temporary stoma surgery (a surgically created opening for waste drainage) placed through a midline incision. Researchers want to understand healing, complication rates, and quality of life to improve surgical outcomes.
Asyut, Asyut GovernorateAges 18 years+ - NCT07612748Recruiting
Comparing two endoscopic treatments for small rectal neuroendocrine tumors
This study compares two minimally invasive endoscopic techniques—ESD and EPMR—for removing small neuroendocrine tumors (slow-growing hormone-producing tumors) in the rectum. The goal is to see which approach works better and is safer for patients.
Changchun, JilinAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 11,952 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.