Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT06008119RecruitingPhase 3
Targeted pill combination for BRAF-mutated metastatic colorectal cancer
This study tests a combination of two targeted pills (tunlametinib and vemurafenib) for people with metastatic colorectal cancer that has a specific gene change (BRAF V600E) and whose cancer has grown after at least one prior treatment. The goal is to see if this drug combination can shrink tumors or slow cancer growth.
Beijing, Beijing MunicipalityAges 18–70 - NCT05587036RecruitingPhase 2/Phase 3
Rifaximin study to see how gut bacteria affect mood
This trial tests whether a gut-targeting antibiotic called rifaximin changes the gut microbiome (gut bacteria) and affects emotion. It is looking for healthy men so any mood or gut changes can be more clearly linked to the study treatment.
LeuvenAges 18–50 - NCT07651748Enrolling by invitationPhase 1/Phase 2
Testing Secretin to Improve Donated Liver Quality
This trial tests whether adding a hormone called secretin to a machine that preserves donated livers outside the body can improve liver quality and transplant outcomes. You may qualify if you're an adult receiving a standard deceased-donor liver transplant that needs special preservation techniques.
Rotterdam, South HollandAges 18 years+ - NCT06737666RecruitingPhase 1
Tong-Xie-Yao-Fang for Diarrhea-Predominant IBS
This trial tests an herbal formula called Tong-Xie-Yao-Fang for people with diarrhea-predominant irritable bowel syndrome (IBS-D). It aims to see if the treatment helps symptoms and how it works. Healthy volunteers are also needed for comparison.
Beijing, Beijing MunicipalityAges 18–70 - NCT06923813Recruiting
Measuring nutrient absorption in ICU patients on tube feeding
This study checks how well patients who are still in the hospital after an ICU stay absorb the nutrients from their tube feeding. A special test called bomb calorimetry will measure the calories in stool to see if the body is getting the energy it needs.
BrusselsAges 18 years+ - NCT07317193Recruiting
Genetic causes of adult bile duct disease
This study looks for new genes that might cause abnormal liver test results or specific bile duct diseases in adults, when standard testing hasn't found a clear cause. It also uses healthy blood donors as a comparison group.
Milan, MilanoAges 18–65 - NCT06774222RecruitingPhase 2
Fruquintinib plus chemo for HER2-negative gastric cancer
This trial tests adding fruquintinib (a targeted drug that blocks blood vessel growth) to chemotherapy after surgery for HER2-negative stomach or gastroesophageal junction cancer. It is for patients whose tumor did not respond well to previous treatment before surgery.
ZhengzhouAges 18–75 - NCT06921668Recruiting
Energy use before and after esophagus surgery
This study measures how your body uses energy before and after scheduled esophagus removal surgery to understand recovery needs. It may help doctors provide better nutritional support during your hospital stay.
AmiensAges 18 years+ - NCT06918652Recruiting
Surgery or endoscopy for high-risk gallbladder inflammation
This trial compares two minimally invasive treatments for people with severe gallbladder inflammation caused by gallstones. It aims to see which approach better helps the immune system and reduces risks for those who are too sick for standard surgery.
Pavia, PaviaAges 18 years+ - NCT06918626Recruiting
Comparing two bile duct stone removal approaches during gallbladder surgery
This trial compares two ways of checking for and removing stones from the main bile duct during gallbladder surgery. One method uses a special scope (SpyGlass) during the operation, and the other does an MRI first. The goal is to see which approach is better for people with gallstone-related inflammation of the gallbladder who might have stones in the bile duct.
Pavia, PaviaAges 18 years+ - NCT07744230Enrolling by invitation
Preventing hernias after liver transplant with a mesh
This study tests whether placing a special mesh during a liver transplant can prevent hernias from forming later. It is for patients who have certain risk factors that make hernias more likely.
Rome, LazioAges 18 years+ - NCT07352228Enrolling by invitationPhase 4
Comparing carvedilol and propranolol to prevent variceal rebleeding
This trial tests whether carvedilol or propranolol works better to prevent another bleeding episode from enlarged veins in the stomach or esophagus (varices) after they have been treated with endoscopy. If you have cirrhosis and had a variceal bleed 6 to 30 days ago, this study may help find the most effective medicine for you.
Xi'anAges 18–75 - NCT07622849Enrolling by invitation
Fecal Microbiota Transplant for Transplant-Related Intestinal Damage
This trial tests whether transferring healthy gut bacteria from a donor to patients can help heal severe intestinal damage that occurs after bone marrow or stem cell transplants. The goal is to reduce pain, inflammation, and other complications from this serious side effect.
Suzhou, JiangsuAges 15–65 - NCT06912347Enrolling by invitation
Herbal therapy to prevent infection after stem cell transplant
This trial tests whether a special herbal treatment applied to the skin can help prevent infections around the bottom that are caused by diarrhea after a stem cell transplant. It may be an option for people who are getting a transplant for the first time.
Shanghai, Shanghai MunicipalityAges 14–70 - NCT03694691Recruiting
Creating a checklist for keeping donated livers viable
This study looks at a way to predict whether a donated liver will work well after being kept alive outside the body (“machine perfused”). It may help doctors choose the best livers and improve transplant outcomes.
Boston, MassachusettsAges 18–75 - NCT03688295RecruitingPhase 3
Testing the best antibiotic length after laparoscopic appendix surgery
This study compares whether you need antibiotics after laparoscopic surgery for a complicated, “localized” appendix infection. It aims to find the safest, most effective antibiotic approach after surgery.
AmiensAges 18 years+ - NCT06909890Recruiting
Chios mastic water for stomach discomfort
This study tests whether a special water made from Chios mastic can help with dyspepsia (ongoing indigestion or stomach discomfort). It's designed for people who don't have other serious health conditions.
Kallithea, AtticaAges 30–60 - NCT07585474Enrolling by invitation
Gut Health During Long Travel for Football Players
This study looks at how long airplane trips affect the gut bacteria in professional male football players. Researchers will track changes in your digestive system during pre-season travel to understand if travel impacts your gut health.
Nashville, TennesseeAges 18–40 - NCT06908980Recruiting
Predicting survival after gallbladder removal for infected gallbladder
This study is testing a tool to predict survival after gallbladder removal for people with acute cholecystitis caused by gallstones. By joining, you help doctors better assess risk and improve care for future patients.
Pavia, PaviaAges 18 years+ - NCT06712212Enrolling by invitation
Comparing two hernia repair methods without mesh
This trial compares two ways to repair an inguinal hernia without using mesh. It may be an option if you are a man over 18 who needs a straightforward hernia repair.
Asyut, Asyut GovernorateAges 18 years+ - NCT06312982RecruitingPhase 2/Phase 3
Chemo, radiation, and immunotherapy before rectal cancer surgery
This trial tests whether a combination of chemotherapy, radiation, and an immunotherapy drug (tislelizumab) before surgery can improve outcomes for people with locally advanced rectal cancer that has specific protein/gene markers (pMMR or MSS). It’s designed for those who have not yet had any treatment for their cancer.
Beijing, Beijing MunicipalityAges 18–75 - NCT05966311Recruiting
Ultrasound-guided feeding tube placement for children
This study tests a new way to place a feeding tube directly into the stomach using ultrasound instead of an endoscope. It may be a safer and less invasive option for children who need help getting nutrition.
Washington D.C., District of ColumbiaAges birth–21 years - NCT06833684Recruiting
Comparing MOWOOT and trans-anal irrigation for constipation
This study tests two treatments for chronic constipation: a device called MOWOOT (which uses gentle abdominal massage) and trans-anal irrigation (a way to wash out the rectum). It is for people who have tried biofeedback therapy and still need help managing their constipation.
London, LondonAges 18 years+ - NCT06937814Recruiting
Effect of Humiome Post LB on Gut Comfort in Healthy Adults
This study tests a supplement called Humiome Post LB to see if it helps with mild digestive discomfort like bloating, irregular stools, and urgency. If you have frequent but not severe bowel issues (10-20 movements per week with loose stools) and are generally healthy, this may be for you.
London, OntarioAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.