Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT07276035Recruiting
Brain-stomach circuits in chronic nausea
This study looks at how the brain and stomach communicate in people with chronic nausea. It uses a noninvasive brain stimulation method called TMS to understand brain activity. You may qualify if you have chronic nausea or are a healthy volunteer.
Pittsburgh, PennsylvaniaAges 21–60 - NCT07424391Recruiting
Predicting polyp types during colonoscopy
This trial uses a digital tool to help doctors predict polyp types during a colonoscopy, avoiding unnecessary removal and speeding up results.
Charenton-le-Pont, Val de MarneAges 18 years+ - NCT07541469Recruiting
Safety Registry for Rezdiffra Use During Pregnancy and Breastfeeding
This registry collects information about the safety of a liver disease medication called Rezdiffra (resmetirom) when used during pregnancy or while breastfeeding. Researchers want to understand if the medication affects the health of pregnant women, babies, and nursing infants.
West Conshohocken, PennsylvaniaAges Any age - NCT06673550Recruiting
Best filling volume for stomach balloon in weight loss
This trial tests how much fluid should be used to fill a stomach balloon to help people with overweight or obesity lose weight. The goal is to find which volume works best and is safest.
OlbiaAges 18–80 - NCT06670157Recruiting
Clip-assisted glue injection for stomach varices
This trial tests a new way to treat enlarged veins in the stomach (gastric varices) using a small clip and a medical glue injection. It is for people with liver cirrhosis who have these veins and are at risk of bleeding or have bled before.
Nanjing, JiangsuAges 18–80 - NCT06703450Enrolling by invitation
Liver fibrosis study with MRI for MASLD patients
This study is testing whether an MRI can help doctors see liver scarring (fibrosis) in people with MASLD, a type of fatty liver disease. It is for patients who already need a liver biopsy as part of their care, to compare the MRI results with the biopsy.
New York, New YorkAges 18–89 - NCT06660095Enrolling by invitation
Measuring p50 during liver transplant surgery
This study is testing a new way to measure something called 'p50' during liver transplant surgery to see if it can help doctors better manage your care. It is for people who are having a planned liver transplant and are in relatively stable but serious health condition.
MalatyaAges 18–65 - NCT06648551Recruiting
Nutrition screening tool for inflammatory bowel disease
This study checks if a simple nutrition test can accurately identify malnutrition in people with ulcerative colitis. It may help doctors better monitor your nutritional health.
Mexico City, CuauhtemocAges 18–80 - NCT07358130Recruiting
Comparing two treatments for H. pylori infection
This trial tests two different ways to treat Helicobacter pylori (H. pylori), a bacteria that can cause stomach ulcers. One treatment combines three medicines (bismuth, amoxicillin, and vonoprazan), and the other uses four medicines (bismuth quadruple therapy). The goal is to see which works better.
Kaohsiung CityAges 18 years+ - NCT06650085Recruiting
Comparing temporary stoma types after rectal cancer surgery
This trial compares two types of temporary stomas (a bag on the belly to collect stool) after rectal cancer surgery. It aims to see which type—ileostomy (small intestine) or colostomy (large intestine)—works better for patients.
HelsinkiAges 18 years+ - NCT06644274Recruiting
PET scan for tracking immunotherapy in gastrointestinal cancers
This trial uses a special PET scan called 68Ga-grazytracer to see how well immunotherapy is working in people with stomach, colon, or other gastrointestinal cancers. The goal is to find out if this scan can help doctors track your response to treatment.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06417567Recruiting
Preventing nausea and vomiting after GI cancer surgery
This study tests whether the medication NEPA (Netupitant and Palonosetron) can prevent nausea and vomiting in people who have had surgery for liver, gallbladder, or pancreatic cancer. It may help those who want to avoid post-surgery sickness.
Tianjin, Tianjin MunicipalityAges 18–65 - NCT07366138Recruiting
Nerve blocks for pain after sleeve gastrectomy surgery
This trial compares two ultrasound-guided nerve blocks to manage pain after laparoscopic sleeve gastrectomy. If you are having this weight-loss surgery, these blocks might help reduce your need for pain medicine and improve your recovery.
Banhā, BenhaAges 18–65 - NCT06627634Recruiting
Surgery for stomach cancer that spread to the liver
This trial tests if removing the stomach tumor and liver spots together can help people with stomach cancer that has spread only to the liver. It is for those who are healthy enough for surgery and chemotherapy.
Aarhus, JyllandAges 18 years+ - NCT06631872Recruiting
Surgery school prehabilitation via telehealth for lung or abdominal cancer
This trial tests a telehealth program to help you get ready (prehab) before lung or major abdominal cancer surgery. It aims to improve your recovery and might be easier than attending in person.
New Lambton Heights, New South WalesAges 18 years+ - NCT06631001Recruiting
Abdominal massage for digestion in ICU patients on tube feeding
This study tests if gentle abdominal massage can improve digestion in intensive care patients who are on a breathing machine and receiving liquid food through a tube. It might help prevent gastrointestinal issues like bloating or slow digestion.
MersinAges 18 years+ - NCT06630000Recruiting
Short therapy for parents of kids with feeding disorders
This study tests a short, talk-based therapy for parents of young children with feeding disorders. It aims to help parents manage their own stress, anxiety, or depression so they can better support their child.
Kansas City, MissouriAges 18 years+ - NCT06942195Recruiting
Calcium's effect on gut function and blood sugar in type 2 diabetes
This study tests if calcium can help control blood sugar and gut function in men with type 2 diabetes. You'll take calcium or a placebo and have a tube inserted into your stomach to measure digestion.
Adelaide, South AustraliaAges 18–70 - NCT06618911Recruiting
Electroacupuncture for functional dyspepsia
This study tests whether acupuncture with a mild electric current (electroacupuncture) can help relieve symptoms of functional dyspepsia, a condition where you have stomach pain or discomfort but no obvious cause. It may offer a non-drug option for managing your symptoms.
Hangzhou, None SelectedAges 18–80 - NCT06617013Recruiting
GERD in children with cystic fibrosis
This study looks at GERD (reflux) in children with cystic fibrosis. It aims to understand how common it is and how it affects them, which could lead to better care.
Durham, North CarolinaAges 2–18 - NCT07527026RecruitingPhase 2
Camrelizumab and chemotherapy with radiation for advanced rectal cancer
This trial tests a combination of an immunotherapy drug (camrelizumab) with chemotherapy and radiation to shrink advanced rectal cancer before surgery. The goal is to help more patients have successful surgery with complete tumor removal.
Beijing, Beijing MunicipalityAges 18–75 - NCT06613945Recruiting
Comparing two ways to open blocked bile ducts in liver cancer
This study compares two procedures to drain bile from the liver in people with blocked bile ducts caused by cancer that cannot be removed. It looks at whether using an ultrasound-guided approach along with standard ERCP works better than ERCP alone.
Al Mansurah, Dakahlia GovernorateAges 18 years+ - NCT07377045RecruitingPhase 1
New combo for advanced pancreatic cancer
This trial tests a new drug (OMTX705) combined with standard chemotherapy (gemcitabine/nab-paclitaxel) and an immunotherapy (tislelizumab) for people with advanced pancreatic cancer. It may be an option if you have had little or no prior chemotherapy.
Boston, MassachusettsAges 18 years+ - NCT05539105Recruiting
Watching recovery after surgery for upper stomach cancer
This study keeps track of how people recover after surgery to remove the upper part of the stomach and nearby lymph nodes. It mainly helps doctors understand which surgical reconstruction methods work best and how patients do over time.
Shanghai, Shanghai MunicipalityAges 18–80
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.