Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,874 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,178
- Phase 1584
- Phase 3466
- Phase 1/Phase 2389
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer294
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)103
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University89
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California465
- Arizona175
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,874 total
- NCT07554521RecruitingPhase 2
Tislelizumab Plus Chemotherapy for Advanced Stomach or Esophageal Cancer
This study tests a combination of two drugs—tislelizumab (an immunotherapy) and chemotherapy—to treat advanced stomach, gastroesophageal junction, or esophageal cancer that cannot be surgically removed. The trial focuses on recruiting patients from racial and ethnic minority communities to ensure the treatment is studied in diverse populations.
Cerritos, CaliforniaAges 18 years+ - NCT07191418Recruiting
Study of ERCP with RFA for pancreatic cancer with liver spread
This study tests a combination of endoscopic procedures (ERCP and RFA) to open the blocked bile duct and treat the tumor with heat in people with pancreatic cancer that has spread to the liver. The goal is to see if this approach can help relieve symptoms and improve outcomes while you continue chemotherapy.
UmeåAges 18–85 - NCT06354088RecruitingPhase 1
Study of alpelisib for insulin resistance
This study tests a single dose of a drug called alpelisib (a PI3K inhibitor) to see how it affects insulin and blood sugar in people who are either insulin sensitive or insulin resistant. The goal is to understand why some people become resistant to insulin, which may help find new treatments for diabetes and related conditions.
New York, New YorkAges 18–70 - NCT06989437RecruitingPhase 2/Phase 3
Study of Ponsegromab for Pancreatic Cancer with Weight Loss
This study tests an experimental drug called ponsegromab for people with advanced pancreatic cancer who experience severe weight loss and fatigue. It aims to see if the drug can help improve weight and energy levels while you continue standard chemotherapy.
Birmingham, AlabamaAges 18 years+ - NCT07428538RecruitingPhase 3
Testing larsucosterol for severe alcohol-related hepatitis
This trial tests a new medicine called larsucosterol to see if it helps people with severe alcohol-related hepatitis (liver inflammation from heavy drinking). If you qualify, the study will monitor your safety and recovery over 90 days.
Birmingham, AlabamaAges 18 years+ - NCT07470879RecruitingPhase 2
Etrasimod for Children with Ulcerative Colitis
This trial tests if the medicine etrasimod can help children with moderate to severe ulcerative colitis. You may still be able to join even if you are already taking other treatments for your condition.
New York, New YorkAges 2–11 - NCT04664634RecruitingPhase 3
Digital treatment for drooling and swallowing in Parkinson’s
This trial tests a smartphone/tablet digital program meant to help with drooling (sialorrhea) and swallowing problems in people with Parkinson’s disease. If you’re eligible, you’ll use the platform during clinic study visits to see whether it can improve symptoms and safety.
Evanston, IllinoisAges 22 years+ - NCT07499544RecruitingPhase 3
Testing Libevitug for chronic hepatitis D
This study tests a new drug, Libevitug, for people with chronic hepatitis D (HDV). It aims to see if the drug can help control the virus and improve liver health.
Garden Grove, CaliforniaAges 12–70 - NCT07629960RecruitingPhase 1/Phase 2
New KRAS-Targeting Drug for Advanced Solid Tumors
This early-stage trial tests BLU-924, a new drug designed to target cancer cells with specific KRAS mutations (a common genetic change in pancreatic, lung, and colon cancers). The study aims to find the right dose and see how well it works in patients whose cancers have progressed despite standard treatments.
Sarasota, FloridaAges 18 years+ - NCT04901234RecruitingPhase 2
Adaptive radiation for advanced throat cancer
This study tests an approach called “adaptive radiotherapy,” where the radiation plan may be adjusted based on how your tumor and anatomy look during treatment. It is for adults with biopsy-proven oropharyngeal (throat) squamous cell carcinoma who are planning curative radiation, with or without chemotherapy.
MelbourneAges 18 years+ - NCT07403968RecruitingPhase 2
Study of Zasocitinib for Active Crohn's Disease
This trial tests a new oral medicine called Zasocitinib for people with active Crohn's disease who have tried other treatments that no longer work or are not tolerated. The goal is to see if it can reduce inflammation and improve symptoms.
OxfordAges 18–75 - NCT07237984Recruiting
COCO study for colorectal cancer screening
This trial looks at substances in your body to help find colorectal cancer earlier. It is for people who are already scheduled for a colonoscopy, either because of a positive stool test or cancer symptoms.
HillerødAges 18 years+ - NCT07775950Recruiting
Monitoring and treating colorectal cancer based on tumor DNA
This study looks at using a blood test to find cancer DNA and guide treatment for people with stage IV colorectal cancer that has a specific genetic pattern. The goal is to see if this approach can help monitor the cancer and personalize treatment.
Guangzhou, GuangdongAges 18 years+ - NCT07775794Recruiting
Moderate exercise for quiet bowel disease
This study looks at whether a moderate exercise program can help people with inflammatory bowel disease (IBD) feel better and manage their condition. It aims to see if exercise improves overall health without worsening symptoms.
Bangkok Noi, BangkokAges 18–65 - NCT07710352Recruiting
Comparing gas pressure settings for robotic surgery
This study compares two different gas pressure levels used during robotic surgery to see if one is better for patients. If you are having robotic surgery, it may help doctors improve safety and recovery.
New York, New YorkAges 18 years+ - NCT07776353Recruiting
Understanding weight loss in advanced cancer
This study looks at how weight loss and muscle loss affect people with advanced cancer. It aims to find different types of weight loss to better guide treatment and care.
Pleasanton, CaliforniaAges 18 years+ - NCT07775352Recruiting
Ultrasound-guided care for inflammatory bowel disease
This study tests whether using ultrasound to guide treatment can help manage inflammatory bowel disease. You may join if you are having an endoscopy to assess your disease.
BangkokAges 18 years+ - NCT07776561Recruiting
Short-stay IV fluids to prevent pancreatitis after ERCP
This trial tests whether giving extra IV fluids before, during, and after an ERCP procedure can help prevent a common complication called post-ERCP pancreatitis (inflammation of the pancreas). If you are scheduled for an ERCP, you may be eligible to participate.
Westmead, New South WalesAges 18 years+ - NCT05269381RecruitingPhase 1/Phase 2
Personalized cancer vaccine with pembrolizumab for advanced solid tumors
This trial tests a personalized vaccine made from your tumor's unique markers, combined with the drug pembrolizumab, to help your immune system fight cancer. It is for people with advanced solid tumors who have already tried standard treatments.
Jacksonville, FloridaAges 16 years+ - NCT04410302Recruiting
Personalized tumor research for bladder, lung, stomach, and liver cancers
This study uses a small sample of your tumor to grow it in the lab, which may help researchers understand your cancer better and find treatments that work for you.
Orange, CaliforniaAges 21–100 - NCT07524114Recruiting
Blood test to find leftover cancer after treatment
This study uses a blood test to look for tiny bits of cancer DNA after you finish treatment. It may help doctors know if cancer is still there and guide next steps.
Toronto, OntarioAges 18 years+ - NCT07779772Recruiting
Diet changes for children with eosinophilic gut disorders
This trial compares different elimination diets to see which one best reduces inflammation in children with eosinophilic gastrointestinal disorders. Your child might have fewer symptoms and a better outcome if the right diet is found.
Adana, SarıcamAges 2–18 - NCT07040189Recruiting
AI nutritional plan for taste changes from chemo
This study tests an AI-created diet plan to help with taste problems caused by chemotherapy. It may help manage taste issues by suggesting recipes tailored to you.
Munich, BavariaAges 18 years+ - NCT05205343Recruiting
Compare minimally invasive and full stomach surgery for upper cancer
This study compares two minimally invasive ways to operate on the stomach area for cancers near the stomach and esophagus (GEJ). It looks at whether one surgical approach is better for long-term outcomes when the goal is cure.
Rochester, MinnesotaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,874 recruiting gastroenterology studies from the U.S. registry right now, out of 12,294 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.