Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,269 recruiting studies in this area right now.
By phase
- Not applicable890
- Phase 2154
- Phase 3103
- Phase 147
- Phase 431
- Phase 1/Phase 230
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma73
- Dysphagia66
- Hearing Loss61
- Tinnitus29
- Hearing Loss, Sensorineural24
- Nasopharyngeal Carcinoma (NPC)24
- Head and Neck Cancer23
- Allergic Rhinitis22
- Oropharynx Cancer21
- Nasopharyngeal Cancinoma (NPC)18
- Sensorineural Hearing Loss18
- Stroke17
- Oropharyngeal Cancer14
- Vestibular Schwannoma14
- Chronic Rhinosinusitis With Nasal Polyps13
- Deafness13
- Head and Neck Squamous Cell Carcinoma13
- Nasopharyngeal Cancer13
Leading sponsors
- Sun Yat-sen University57
- Assistance Publique - Hôpitaux de Paris14
- Eye & ENT Hospital of Fudan University14
- National Cancer Institute (NCI)14
- Cairo University13
- NYU Langone Health13
- Mayo Clinic12
- Johns Hopkins University11
- Ming-Yuan Chen11
- Massachusetts Eye and Ear Infirmary10
Where studies are running
- California61
- Maryland38
- Florida32
- New York32
- Massachusetts24
- Illinois20
- Texas20
- Alabama15
- Arizona15
- Colorado15
Recruiting studies1,269 total
- NCT03042962Recruiting
Brain imaging study of focal dystonia and related conditions
This trial uses brain scans to understand how brain networks work in people with focal dystonia, and to compare with family members and healthy volunteers. It may help researchers better understand what goes wrong in the brain and guide future treatments.
Boston, MassachusettsAges 21–80 - NCT05656365Recruiting
Study of genes and immunity in PFAPA and other tonsil problems
This study looks at genetic markers and immune system patterns in people with PFAPA (periodic fevers with mouth sores and throat/neck gland symptoms) or similar tonsil problems. It may help researchers understand why these conditions happen and how they might be better diagnosed or treated.
Washington D.C., District of ColumbiaAges 1 month–99 years - NCT05670496Recruiting
NIDCD medical data and sample collection for communication disorders
This study collects medical information and specimens to support research on problems with hearing, balance, taste, smell, voice, speech, and language. It may help you (or your child) get additional evaluation and follow-up through NIDCD, especially if your clinician thinks it could be useful.
Bethesda, MarylandAges 2–99 - NCT05668338Recruiting
Hearing-device registry study for MED-EL users
This is an observational study that collects information from people using MED-EL hearing devices (with or without an implant) to better understand real-world hearing care. It may help improve future planning, support, and device use for patients like you.
BochumAges Any age - NCT05665777RecruitingPhase 2
Chinese herbs for long-lasting throat pain and irritation
This trial tests if Chinese medicine can help people with ongoing throat pain, dryness, or a lump-like feeling that lasts more than 3 weeks. You may qualify if you have moderate to severe throat discomfort and fit specific Chinese medicine patterns.
Hong KongAges 18 years+ - NCT05639972RecruitingPhase 1/Phase 2
HPV cancer trial using immune T cells made for you
This Phase 1/2 trial tests a one-time infusion of special immune T cells made to recognize your HPV16 tumor. It may help your body attack the cancer, while researchers closely monitor safety and early effectiveness.
New Brunswick, New JerseyAges 18 years+ - NCT05665244Recruiting
Cryotherapy for long-lasting cough from nerve signals
This trial tests a cold-treatment procedure (cryotherapy) to treat a stubborn cough caused by nerve signaling (not infections or common allergy/acid problems). It may help people whose cough has lasted at least 8 weeks and who have already tried to rule out other causes.
Dallas, TexasAges 18 years+ - NCT05641142Recruiting
Testing blood thinners in adults with inherited bleeding vessel disease
This study looks at people with Rendu-Osler (hereditary hemorrhagic telangiectasia) who have just started blood-thinning medicines. It aims to understand how antiplatelet and/or anticoagulant therapy affects safety and outcomes soon after starting.
AngersAges 18 years+ - NCT05592626RecruitingPhase 1/Phase 2
T cell activator STAR0602 for advanced solid tumors
This study tests an experimental drug called STAR0602 that aims to boost your immune system's T cells to fight advanced solid tumors. It's for patients whose cancer has not responded to standard treatments or for whom such treatments are not suitable.
Sacramento, CaliforniaAges 18 years+ - NCT05593484Recruiting
School hearing screenings with telemedicine referral
This trial helps check children’s hearing at participating schools in rural Alaska, and then connects families with specialty care by video (telemedicine) if needed. It may help children get faster evaluation and support for hearing problems.
Anchorage, AlaskaAges 3–21 - NCT05607888Recruiting
Study of treatment for sinus and skull-base tumors
This study looks at how doctors manage tumors that start in the nose/sinuses and spread to the skull base. It may help improve planning of care for people with this specific type and location of tumor.
Ljubljana, LjubljanaAges Any age - NCT05625191Recruiting
Study of voice strain with and without vocal fold injury
This study compares people with “phonotrauma” (injury from voice overuse/strain) to people without voice injury. It may help researchers better understand voice changes and how they develop, which could guide future treatment.
Dallas, TexasAges 18–65 - NCT05600842Recruiting
Lower-dose radiation for HPV-positive throat cancer
This trial tests whether using a de-escalated (lower/intensity-reduced) radiation approach can treat HPV-positive oropharyngeal squamous cell carcinoma. It may help reduce side effects while still keeping the cancer under control.
Orange, CaliforniaAges 18 years+ - NCT05603897Recruiting
Testing dysphagia screening methods after recent stroke
This study compares two ways of checking for swallowing problems (dysphagia) in people who were recently hospitalized for an acute ischemic stroke. If the new screening method works better, it could help catch swallowing issues earlier and improve safety.
Miami, FloridaAges 18 years+ - NCT05622344Recruiting
Neurofeedback training to improve balance in vestibular schwannoma
This study tests whether brain “neurofeedback” training, along with a balance rehab plan, can help people with dizziness/balance symptoms from unilateral vestibular schwannoma. You may qualify if you can follow the study schedule and safely move your head and walk during testing.
Baltimore, MarylandAges 21–70 - NCT05575401Recruiting
Track surgery results in kids getting tonsil removal
This trial looks at how well a specific throat surgery technique works in children who are having their tonsils removed (with or without removing adenoids). It may help improve how doctors choose and perform surgery for safer, better recovery.
Murrieta, CaliforniaAges 3–17 - NCT05587543RecruitingEarly Phase 1
Test of EBV CAR-T or TCR-T cells for nasopharyngeal cancer
This early-phase study tests personalized immune cells (EBV CAR-T or TCR-T) to treat nasopharyngeal cancer that has returned or spread. It aims to help the immune system find and attack the cancer after other treatments have not worked.
ShanghaiAges 18–75 - NCT05582837RecruitingPhase 4
Using migraine medicines to treat Meniere’s disease symptoms
This Phase 4 study tests whether migraine-type medications can help people with active or frequent Meniere’s disease. If you have symptoms like inner-ear episodes, the trial may help find a better way to control them.
Orange, CaliforniaAges 25–85 - NCT05591040Recruiting
Biofeedback to help swallow problems after stroke
This trial studies whether using “biofeedback” (seeing your body’s muscle signals on a screen) along with standard care can improve swallowing after a stroke. You might be eligible if you have ongoing swallow trouble and can safely do the training sessions.
Venice-LidoAges 18–89 - NCT05554692Enrolling by invitation
Study how aging and cochlear implants affect speech timing
This study looks at how the brain processes the timing of sounds and speech in people with cochlear implants and in people with typical hearing. It may help researchers understand what changes with age and how implant hearing works in the real world.
College Park, MarylandAges 18–85 - NCT05582551Recruiting
Screening test program for childhood cancer survivor senses
This trial helps improve how doctors check senses like hearing and vision after childhood cancer. It may help you (or your child) get better screening and support early for new or lasting side effects.
St Louis, MissouriAges 7–17 - NCT05572073Recruiting
Study of otoferlin hearing loss over time
This study follows people with hearing loss caused by changes (mutations) in the otoferlin gene to better understand how hearing and hearing-related test results change over time. It may help researchers prepare for future treatments by building a clear picture of the natural course of the condition.
Iowa City, IowaAges Up to 44 years - NCT03556228RecruitingPhase 1/Phase 2
Tested medicine for tumors with TrkA changes, alone or with pembrolizumab
This early-phase study tests VMD-928, a targeted cancer medicine, for cancers that have TrkA-related tumor changes. It may be given by itself or with pembrolizumab to see if it can shrink tumors when standard treatments have not worked.
Santa Rosa, CaliforniaAges 18–80 - NCT05531630Enrolling by invitation
Xylitol versus saline rinses for sinus symptoms in adults with CF
This study compares two kinds of nasal rinse packets—xylitol versus plain saline—to see which better reduces sinus symptoms. It may help adults with cystic fibrosis and long-term sinus inflammation feel better with routine, at-home nasal care.
LeuvenAges 18 years+
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,269 recruiting otolaryngology studies from the U.S. registry right now, out of 2,074 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.