Ophthalmology
Eyes & vision clinical trials
Eye disease and conditions that affect sight. We’re tracking 1,760 recruiting studies in this area right now.
By phase
- Not applicable1,199
- Phase 3133
- Phase 2119
- Phase 1117
- Phase 492
- Phase 1/Phase 286
- Phase 2/Phase 314
Top conditions
- Glaucoma107
- Myopia88
- Cataract76
- Diabetic Retinopathy51
- Dry Eye38
- Keratoconus34
- Retinitis Pigmentosa33
- Age-Related Macular Degeneration31
- Amblyopia26
- Eye Diseases24
- Graves Disease24
- Sjogren's Syndrome24
- Dry Eye Disease (DED)23
- Multiple Sclerosis22
- Astigmatism21
- Ocular Hypertension21
- Diabetic Macular Edema20
- Macular Degeneration20
Leading sponsors
- Zhongshan Ophthalmic Center, Sun Yat-sen University25
- Medical University of Vienna20
- Second Affiliated Hospital, Zhejiang University, School of Medicine19
- Fondation Ophtalmologique Adolphe de Rothschild18
- Assistance Publique - Hôpitaux de Paris16
- The Hong Kong Polytechnic University16
- Eye & ENT Hospital of Fudan University15
- National Eye Institute (NEI)15
- National Taiwan University Hospital15
- Shanghai Eye Disease Prevention and Treatment Center15
Where studies are running
- California133
- Arizona69
- Florida43
- Maryland39
- Texas37
- Massachusetts35
- New York35
- Alabama26
- North Carolina20
- Pennsylvania20
Recruiting studies1,760 total
- NCT05504291RecruitingPhase 2
Treatment delivered inside the eye for retinoblastoma
This Phase 2 study tests a way to deliver cancer treatment directly inside the eye to treat retinoblastoma. It may help shrink the tumor while limiting treatment to the eye when possible.
Birmingham, AlabamaAges Up to 18 years - NCT01962415RecruitingPhase 2
Reduced-intensity stem cell transplant for non-cancer disorders
This trial tests whether a gentler (reduced-intensity) conditioning treatment before a stem cell transplant works for non-cancer diseases. It uses specific donor stem cell matches and checks heart, lung, liver, and kidney function to help lower transplant stress while still aiming for benefit.
Pittsburgh, PennsylvaniaAges 2 months–55 years - NCT05481827Enrolling by invitationPhase 2
Safety follow-up for GT005 in geographic eye damage
This study checks the long-term safety of GT005, a treatment you received in an earlier study, for geographic atrophy related to age-related macular degeneration. It mainly asks you to come to follow-up visits and confirm how you are doing over time.
Poway, CaliforniaAges 55 years+ - NCT03949881RecruitingPhase 1/Phase 2
Cell graft for severe damage to both eyes’ surface
This Phase 1/2 trial tests a treatment made from your own mouth tissue cells to help regrow the front surface of the eye when both eyes have severe limbal stem cell deficiency. If you qualify, you may receive an autologous (made from your own tissue) cell sheet to improve eye healing and vision.
LyonAges 18 years+ - NCT05463289Recruiting
AI helps children with diabetes get eye exams
This study tests an AI-based way to help check children’s eyes for signs of diabetic retinopathy (diabetes-related eye disease). It may improve how quickly and consistently eye screening is done for kids with diabetes.
Baltimore, MarylandAges 8–21 - NCT05465252Recruiting
Omega-3 supplement to slow early dry macular degeneration
This trial studies whether taking omega-3 fatty acids can slow the worsening of dry age-related macular degeneration (AMD) in people with early or intermediate disease. It may help by testing if omega-3 changes how the retina changes over time.
ShanghaiAges 50–85 - NCT05432245Enrolling by invitation
Glaucoma implant placed during cataract surgery
This trial looks at whether placing a small glaucoma implant at the same time as cataract surgery can better control eye pressure in people with primary open-angle glaucoma. It may help reduce the need for medicines or improve control, depending on how your eyes respond.
Panama CityAges 40 years+ - NCT05454124Recruiting
Study of brain-eye learning changes in macular degeneration
This study looks at how the eye’s “central vision” area and connected brain learning/adjustment work in people with advanced macular degeneration. You may be asked to do vision testing using special eye-scanning equipment and follow study procedures that could help researchers better understand the disease.
Birmingham, AlabamaAges 18–89 - NCT05439200Recruiting
Video-based treatment for lazy eye in young children
This trial tests whether a video treatment can improve “lazy eye” (amblyopia) in children ages 3–7. It may help if your child’s vision difference is present despite glasses worn consistently, and you’re able to skip the usual patching during the study.
Dallas, TexasAges 3–7 - NCT05419713Recruiting
Test of how the brain processes depth and space
This study tests how people perceive depth and space using visual tasks. It may help researchers better understand normal (or well-corrected) vision and how the brain handles visual information.
Louisville, KentuckyAges 18–40 - NCT05435547RecruitingPhase 4
Pre-surgery steroid medicine for autoimmune thyroid disease
This trial tests whether taking corticosteroids (anti-inflammatory medicines) before thyroid surgery is safe and helpful for people with autoimmune thyroid disease. It focuses on Graves’ or Hashimoto’s disease patients who are planning total thyroid removal.
Indianapolis, IndianaAges 18 years+ - NCT05414994Recruiting
Study eye bacteria in healthy and eye disease
This study compares the tiny living organisms (“ocular microbiome,” meaning eye-surface bacteria) in different eye conditions. It may help researchers understand how these eye bacteria relate to diseases and why some people develop problems with vision.
Nashville, TennesseeAges 18 years+ - NCT05440448Recruiting
Patch-free therapy for lazy eye in children
This study tests a patch-free treatment approach for “lazy eye” (amblyopia) in children. It may help some kids improve vision without using traditional eye patches, but it requires a willingness to skip standard patching during the study.
Dallas, TexasAges 3–12 - NCT05458323Recruiting
Vision testing and glasses change to improve thinking
This study checks whether better distance and near vision (through eye exams and correct glasses) can improve thinking and memory. You may be randomly assigned to receive eye care, and your ability to see and think will be measured.
Hyderabad, TelanganaAges 60 years+ - NCT05370287Recruiting
Adaptive-eye imaging for adults with primary open-angle glaucoma
This study uses a special “adaptive optics” camera to take very detailed pictures of the retina (the light-sensing layer at the back of the eye). It is meant for adults with primary open-angle glaucoma to improve how well the images can be captured and studied.
Silver Spring, MarylandAges 21 years+ - NCT05390801Recruiting
Congenital aniridia patient survey for adults and families
This trial collects information from people born with congenital aniridia (a rare eye condition) using a questionnaire or survey. It may help researchers better understand patient needs and experiences to improve future care.
ParisAges Any age - NCT05394987Recruiting
Testing new glasses and vision function in amblyopia adults
This study looks at how changing your glasses prescription affects vision and visual function in adults with amblyopia (often called “lazy eye”). It may help researchers understand which optical correction best supports clearer, more balanced vision.
Waterloo, OntarioAges 18–39 - NCT05355415Recruiting
Eye imaging study for outer retina diseases using adaptive optics
This study uses a special, high-detail eye imaging machine to take clear pictures of the outer retina. It may help researchers understand these eye conditions better, and how the eye images look when people have an outer retinal disease.
Bethesda, MarylandAges 21 years+ - NCT04439552Recruiting
MRI study during cornea cross-linking for keratoconus
This trial uses an MRI scan (and a close-up eye scan) to study what happens in the cornea during treatment for keratoconus. It may help doctors better understand how treatment works and who benefits most.
Boston, MassachusettsAges 8–35 - NCT05300698Recruiting
Eye imaging test: MRI compared with ultrasound
This study compares two ways to look at the layers of your eye: MRI and a special, non-contact ultrasound. It may help find which test gives clearer information for diagnosing or evaluating eye conditions.
Paris, ParisAges 18 years+ - NCT05275972RecruitingPhase 3
Compare cornea surgery thickness results for FECD
This Phase 3 trial compares outcomes from two cornea transplant procedures in people with FECD, a disease that makes the cornea swell and affect vision. It may help you and others by identifying which approach best supports clear vision and stable corneal thickness after surgery.
Palo Alto, CaliforniaAges 18 years+ - NCT05296447Enrolling by invitationPhase 2
Long-term safety study for diabetic retinopathy gene therapy
This study follows people who already received an injection of RGX-314 (an experimental gene therapy) in a previous clinical trial for diabetic retinopathy, with or without swelling in the macula. It checks the long-term safety and how the treatment works over time.
Phoenix, ArizonaAges Any age - NCT02841553Recruiting
Online registry for Wolfram syndrome worldwide
This study builds an international online registry to learn how Wolfram syndrome (and related WFS1 conditions) changes over time. It may help researchers understand the disease course and improve future care by collecting health and family history data.
St Louis, MissouriAges birth+ - NCT05210803Enrolling by invitationPhase 2
Long-term safety follow-up for wet AMD treatment
This study is a follow-up for people who have already received an injection of RGX-314 for wet age-related macular degeneration (AMD) in an earlier trial. It looks at how the treatment works over a longer time and any long-term effects.
Phoenix, ArizonaAges Any age
Common questions
- How many eyes & vision clinical trials are recruiting?
- Clin2 is tracking 1,760 recruiting ophthalmology studies from the U.S. registry right now, out of 2,756 we cover in this area in total.
- What does “Eyes & vision” cover here?
- Eye disease and conditions that affect sight. We group each study into eyes & vision based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a eyes & vision trial near me?
- Use the search to filter eyes & vision studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Infections
- Genetic & congenital
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- Pain
- Injuries & trauma
- Mouth & dental
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.