Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,762 recruiting studies in this area right now.
By phase
- Not applicable2,682
- Phase 2280
- Phase 1239
- Phase 3209
- Phase 1/Phase 2208
- Phase 495
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease133
- Atopic Dermatitis124
- Congenital Heart Disease83
- Cystic Fibrosis77
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)37
- Duchenne Muscular Dystrophy36
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)29
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- Children's Hospital of Philadelphia23
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
Where studies are running
- California324
- Maryland160
- Alabama133
- Massachusetts107
- Arizona88
- New York84
- Texas70
- Minnesota68
- Pennsylvania64
- Florida59
Recruiting studies3,762 total
- NCT06590974Recruiting
Study of human protein C concentrate for protein C deficiency
This trial is studying a medication called TAK-662 (freeze-dried human protein C concentrate) in people with congenital protein C deficiency. The goal is to see how well it works and how safe it is for patients who need this replacement therapy.
Tokyo, TokyoAges Any age - NCT06599411Recruiting
Skin biomarkers for inflammatory disease treatment
This study looks for clues in your skin and blood that could predict how well you'll respond to treatments for conditions like eczema, psoriasis, or lupus. It aims to help doctors choose the best therapy for you.
ParisAges 18 years+ - NCT06593951Recruiting
EPM1 natural history study
This study will follow people with EPM1 over time to better understand the disease. It is a registry, meaning you will share information through video calls and questionnaires, with no experimental treatments involved.
Boston, MassachusettsAges Any age - NCT06585618Recruiting
Pediatric Deep Brain Stimulation Registry
This study creates a list of children who already have or plan to get Deep Brain Stimulation (DBS) to see how it helps with movement problems. Joining helps doctors learn more about how DBS works in kids.
Boston, MassachusettsAges birth–18 years - NCT06588543Recruiting
Planning brain blood vessel procedures using patient scans
This trial uses your medical images (like MRI or angiography) to create a personalized map of your brain's blood vessels. The goal is to help doctors better plan minimally invasive treatments for aneurysms or arteriovenous malformations.
GhentAges Any age - NCT06589245RecruitingPhase 1
Ciclesonide study for breathing support in preterm infants
This study tests an inhaled anti-inflammatory drug called ciclesonide for premature babies who need a breathing tube. It aims to see if the drug can help their lungs heal and reduce the need for steroids.
Kansas City, MissouriAges 1 week–1 month - NCT06595420Recruiting
Kidney health in people with cystic fibrosis on new treatments
This study looks at how the kidneys work in people with cystic fibrosis, especially those taking highly effective new treatments. It aims to understand kidney function in different groups, including those who are hospitalized frequently or rarely.
Birmingham, AlabamaAges 7 years+ - NCT06599619Recruiting
Study of PD1 therapy on atypical moles in melanoma patients
This trial tests if an immunotherapy drug (anti-PD1) can change atypical (dysplastic) moles in people who have had melanoma. It may help understand how these drugs affect mole cells.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT02611089Recruiting
Study of forearm development and reconstruction in limb conditions
This study looks at how connective tissue in the forearm develops and how it behaves in people needing reconstructive surgery. It may help surgeons better plan and improve reconstruction for conditions like radial dysplasia, or for other injuries requiring similar surgery.
Oxford, OxfordshireAges Any age - NCT04261127Recruiting
Testing a genetic tool to diagnose recessive ataxia
This study checks how well a computer algorithm (called RADIAL) can find the cause of autosomal recessive cerebellar ataxia using genetic information. It may help confirm diagnoses when the genetic cause is still unknown and other causes have already been ruled out.
BesançonAges 5 years+ - NCT06578507RecruitingPhase 2
Twice-daily hydroxyurea liquid for children with sickle cell disease
This trial tests a new twice-daily liquid form of hydroxyurea (a common SCD medicine) in children ages 9 months to 11 years with sickle cell disease. It will check how the medicine works in the body, if it is safe, and if it helps reduce pain crises and other complications.
CréteilAges 9 months–11 years - NCT06569758RecruitingPhase 1
A study of GenSci098 for active thyroid eye disease
This study tests a new medication called GenSci098 for people with active thyroid eye disease. It aims to reduce eye symptoms like redness, swelling, and bulging, and improve quality of life.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06573723Recruiting
Rare disease registry at Hospital Italiano
This study collects information from patients with certain rare diseases to better understand them. If you have one of these conditions and receive care at Hospital Italiano de Buenos Aires, you may be able to join.
Buenos Aires, Buenos AiresAges Any age - NCT06575270Recruiting
Study of skin color and pulse oximeters in children with heart disease
This trial checks how well pulse oximeters (devices that measure oxygen levels) work in children with congenital heart disease who have different skin colors. It aims to make sure these devices are accurate for all children during heart surgery.
New York, New YorkAges Up to 18 years - NCT06576323Recruiting
Support for mothers with opioid use disorder and babies in the NICU
This study aims to improve care for mothers with opioid use disorder and their babies with neonatal abstinence syndrome. Researchers will interview healthcare providers and mothers to develop better support programs.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06572046Recruiting
Registry for hereditary spastic paraplegia (HSP)
This registry collects information from people with hereditary spastic paraplegia or spastic ataxia to help plan future treatments. It aims to better understand the condition and connect patients with potential therapies.
PisaAges Any age - NCT06570577Recruiting
Nerve block for pain after cervical spine surgery
This trial tests whether a nerve block can reduce the need for opioid pain medication after back-of-neck spine surgery. It may help patients have better pain control with fewer side effects.
Stony Brook, New YorkAges 18–75 - NCT06581484Recruiting
Improving care for adults with congenital heart disease
This study aims to improve care for adults with congenital heart disease. If you join, researchers will work to better understand your needs and help enhance your treatment.
San Francisco, CaliforniaAges 18 years+ - NCT06569316Recruiting
Genetic testing for cancer prevention in American Indian communities
This trial offers genetic testing to American Indian adults who have or have had cancer, to help prevent future cancers. It aims to make testing more accessible to these communities.
Scottsdale, ArizonaAges 18 years+ - NCT06578637Enrolling by invitation
BHB supplement study for familial adenomatous polyposis
This trial tests whether taking a supplement called beta-hydroxybutyrate (BHB) can help prevent polyps in people with familial adenomatous polyposis (FAP), a condition that causes many polyps in the colon. The study has two parts: one for people who have already had colon surgery, and another for those who still have their colon.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06576726Recruiting
Tracking tic disorder in teens over time
This study follows teens with chronic tic disorders (like Tourette syndrome) for a few years to understand how their symptoms and social life change. It also looks at brain signals using EEG, but you can join the main study even if you can't do the EEG part.
Nashvile, TennesseeAges 11–17 - NCT06579157Recruiting
Using pressure-sensing mattresses to help newborns breathe on their own
This trial tests whether a special mattress that senses breathing movements can help doctors decide when to remove breathing support from newborns. It may reduce the time babies need a breathing machine.
New Taipei CityAges Up to 1 year - NCT05130606Recruiting
Story-based program to improve genetic cancer counseling for Latina women
This study tests a Spanish/English narrative (story-based) program designed to help improve genetic counseling and genetic testing for hereditary breast and ovarian cancer risk. It may help you better understand your options and feel more prepared to get the right type of genetic care.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06007365Recruiting
Z5m dental implant registry study
This study looks at how well Z-Systems' Z5m dental implants work in patients. It may be a good fit if you have received or will receive up to 5 of these implants.
OltenAges 18 years+
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,762 recruiting medical genetics studies from the U.S. registry right now, out of 5,482 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.