Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable2,677
- Phase 2277
- Phase 1238
- Phase 3210
- Phase 1/Phase 2208
- Phase 497
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease134
- Atopic Dermatitis125
- Congenital Heart Disease84
- Cystic Fibrosis76
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)37
- Duchenne Muscular Dystrophy37
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)28
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
- Massachusetts General Hospital22
Where studies are running
- California325
- Maryland161
- Alabama133
- Massachusetts107
- Arizona86
- New York85
- Texas70
- Minnesota68
- Pennsylvania62
- Florida59
Recruiting studies3,756 total
- NCT07816107Recruiting
Comparing sinus lift techniques for dental implants
This study tests different ways of doing a sinus lift (adding bone to the upper jaw) and placing a dental implant at the same time, using a personalized surgical guide. The goal is to see which method gives better bone support around the implant, which may help the implant last longer and feel more stable.
CairoAges 18 years+ - NCT07811674Recruiting
Foot stimulation and vibration exercises for muscle strength in young adults
This study tests if foot stimulation, whole-body vibration, and a gentle exercise routine can improve muscle activation. It might help young adults strengthen their muscles safely.
Guangzhou, GuangdongAges 18–25 - NCT07809867RecruitingPhase 4
How Trikafta moves through the body in cystic fibrosis
This study looks at how the medicine elexacaftor/tezacaftor/ivacaftor (often called Trikafta) works in the body in people with cystic fibrosis. It helps doctors understand the right dose and how the drug is processed, which may improve treatment for children and adults.
GenovaAges 6 years+ - NCT02021604RecruitingPhase 1
Fluorodopa scan for congenital hyperinsulinism and insulinoma
This Phase 1 study tests a special imaging medicine (fluorodopa F 18) to help doctors better understand congenital hyperinsulinism (HI) patterns in the body. It may help guide treatment decisions to prevent dangerous low blood sugar and protect brain function.
Fort Worth, TexasAges Up to 18 years - NCT07802041Enrolling by invitation
Early induction vs waiting for labor after water breaks
This trial compares inducing labor soon after your water breaks to waiting and seeing if labor starts on its own. It aims to find the safest approach for you and your baby.
IslamabadAges 18–45 - NCT07807163RecruitingPhase 2
Study of ficerafusp alfa with pembrolizumab for head and neck cancer
This study tests a new drug called ficerafusp alfa combined with pembrolizumab (an immunotherapy) in people with head and neck cancer that has returned or spread. The drug targets a protein that may help the immune system fight the cancer. The study is comparing two different schedules of giving the drug to see which is better.
Fort Myers, FloridaAges 18 years+ - NCT07807111RecruitingPhase 1/Phase 2
Gene therapy for advanced rod-cone dystrophy
This study tests a new gene therapy for people with advanced rod-cone dystrophy, a genetic condition that causes progressive vision loss. The treatment is given as an injection into the eye, and the study aims to see if it is safe and if it can help improve or preserve vision.
GhentAges 18 years+ - NCT06505330Recruiting
Probiotics for kids with cleft palate
This study looks at whether giving probiotics (helpful bacteria) to children with cleft palate can improve the bacteria in their airways and possibly prevent infections. Researchers want to see if this simple treatment helps keep kids healthier.
Edegem, AntwerpAges 6 months–2 years - NCT07802639Recruiting
Botulinum toxin injections for uneven lower lip in children
This study tests a weekly injection of botulinum toxin type A (a muscle-relaxing medication, like Botox) to see if it can improve the appearance and movement of an uneven lower lip in children with craniofacial microsomia. If successful, this treatment might reduce the visible asymmetry when smiling or baring teeth.
BeijingAges 5–18 - NCT07807046Recruiting
Guided atracurium dosing in ICU patients
This trial tests whether using a device to guide the dosing of atracurium (a muscle relaxant) improves outcomes in critically ill ICU patients who need this medication for more than 48 hours. It focuses on patients with severe lung or heart conditions, such as ARDS or ECMO support.
New Taipei CityAges 20 years+ - NCT07807228Recruiting
Skin microbiome changes with lebrikizumab for eczema
This study looks at how lebrikizumab, a biologic medicine for atopic dermatitis (eczema), affects the skin's microbiome (the natural community of microorganisms on your skin). It aims to see if changes in the skin's microbiome are linked to treatment response.
CopenhagenAges 18 years+ - NCT04478409Recruiting
Test to screen Mediterranean family fever in children and adults
This study checks how well a specific blood test works for people who may have Mediterranean family fever (FMF). It may help doctors recognize FMF more accurately and decide on follow-up and treatment.
BronAges 4 years+ - NCT06510881Recruiting
One surgery vs. multiple surgeries for cleft nose and gum repair
This trial compares doing a single surgery to fix both the nose and gum problems caused by a cleft lip and palate, versus doing multiple surgeries over time. It aims to find out which approach works better for children and teens.
AsyutAges 5–18 - NCT03966612Recruiting
Monitoring people with MEN1 and related hormone gland tumors
This study follows people who have Multiple Endocrine Neoplasia type 1 (MEN1), a genetic condition that can cause tumors in hormone glands. It aims to monitor symptoms and lesions over time to better understand how the condition progresses and how to manage it.
DijonAges Any age - NCT07798609RecruitingPhase 1/Phase 2
Testing SFL-0821 for people with FSHD
This study is testing a new medicine, SFL-0821, to see if it is safe and useful for people with FSHD. It may help if it works, but it is still experimental.
Concord, New South WalesAges 18–65 - NCT07800104RecruitingPhase 1
Study of a new pill for moderate-to-severe eczema
This trial tests an experimental medicine called QX-4533. The study has two parts: one tests the drug in healthy volunteers, and the other tests it in people with moderate-to-severe atopic dermatitis (a type of eczema) that hasn't responded well to standard creams. The goal is to see if the drug is safe and how well it works.
Shanghai, Shanghai MunicipalityAges 1.5 years–65 years - NCT07799870Recruiting
Checking vital signs in newborns with Lifelight software
This study tests a new camera-based software called Lifelight to measure vital signs like heart rate and breathing in newborns in the neonatal intensive care unit (NICU), compared to the usual monitors. It may offer a less intrusive way to monitor your baby.
London, LondonAges birth–1 year - NCT06519552RecruitingPhase 1
Gene therapy study for adults with MPS type I
This study tests a new gene therapy called JWK008 for adults with MPS type I. The goal is to see if it is safe and can help improve symptoms. You may be able to join if you are 18 or older and have not had serious side effects from enzyme replacement therapy.
Chengdu, SichuanAges 18 years+ - NCT06520410RecruitingPhase 4
Short vitrectomy tool for children's eye surgery
This trial tests a shorter, 18-millimeter tool for vitrectomy surgery in children. It aims to see if this smaller tool is safe and works well for treating various eye problems in kids.
TaoyuanAges birth–18 years - NCT05593679Recruiting
Registry study for heart PYP scans in possible ATTR amyloidosis
This study collects information from adults who have been diagnosed with, or are being checked for, ATTR amyloidosis (a condition where abnormal protein builds up in the body) using a heart PYP scan. Your participation may help doctors better understand how these scans relate to diagnosis and follow-up over time.
New Taipei CityAges 20 years+ - NCT06523582Recruiting
Genetic study of neuroendocrine tumors in Mexican patients
This study aims to find genetic causes of neuroendocrine tumors in Mexican patients. By understanding your DNA, researchers hope to improve diagnosis and treatment for people with these rare conditions.
Mexico City, Mexico CityAges 18 years+ - NCT07798011Recruiting
Faster breathing tube removal after pediatric heart surgery
This study compares two ways of helping children wake up and breathe on their own after minimally invasive heart surgery. One group gets a drug to quickly reverse the muscle relaxant, while the other group waits for it to wear off naturally. The goal is to see which method allows a safer, earlier breathing tube removal.
HanoiAges 2–18 - NCT07800247Recruiting
Sickle cell disease registry for young patients
This study collects information about children, teens, and young adults with sickle cell disease to better understand the condition in Egypt. It may help improve care and treatments for people with sickle cell disease.
CairoAges Up to 39 years - NCT07798674Recruiting
Natural history study for ataxias and spastic paraplegias
This study tracks how ataxias and related movement disorders progress over time. By joining, you help researchers learn more about these conditions and prepare for future treatments.
InnsbruckAges 5 years+
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting medical genetics studies from the U.S. registry right now, out of 5,439 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.