Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable2,677
- Phase 2277
- Phase 1238
- Phase 3210
- Phase 1/Phase 2208
- Phase 497
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease134
- Atopic Dermatitis125
- Congenital Heart Disease84
- Cystic Fibrosis76
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)37
- Duchenne Muscular Dystrophy37
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)28
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
- Massachusetts General Hospital22
Where studies are running
- California325
- Maryland161
- Alabama133
- Massachusetts107
- Arizona86
- New York85
- Texas70
- Minnesota68
- Pennsylvania62
- Florida59
Recruiting studies3,756 total
- NCT07725926Recruiting
Combining therapy techniques for tic-like OCD
This study tests a therapy that combines two approaches—one for tics and one for OCD—to help people whose OCD feels like it's linked to tics. The goal is to see if this combined treatment reduces distressing urges and repetitive behaviors.
London, LondonAges 18–65 - NCT07726771Recruiting
Pouch endoscopy study in FAP patients
This study uses a tiny camera to look at the pouch created after FAP surgery. It aims to see how well the pouch is doing and if any polyps are growing there.
London, LondonAges 18 years+ - NCT07728175RecruitingPhase 1
Sirolimus for Alzheimer's risk in women with ApoE4 gene
This study tests whether sirolimus, a medication that may help the body clear damaged cells, can lower Alzheimer's risk in women with the ApoE4 gene variant. It is an early-stage trial that looks at safety and how the drug affects certain blood markers.
Columbia, MissouriAges 45–65 - NCT07728032Recruiting
How diet and medicine affect gut health in PKU children
This study looks at how a phenylalanine-restricted diet or certain PKU medicines affect gut health in children with PKU. It also includes healthy siblings or household members as a comparison group.
Birmingham, BirminghamAges 3–17 - NCT07729982Recruiting
Study tracking vision changes in OPA1 optic atrophy
This study follows people with a genetic form of optic atrophy over time to understand how vision changes. It does not test a treatment but helps doctors learn more about the condition to improve care.
Munich, BavariaAges Any age - NCT07726043Recruiting
Rehab with vibration therapy for balance in CMT1A
This trial tests whether adding a special vibration device to an intensive rehab program helps improve balance in people with Charcot-Marie-Tooth disease type 1A. If you are between 18 and 65 and have mild to moderate leg weakness, you may be able to join.
MarseilleAges 18–65 - NCT07732244Recruiting
Testing a wireless brain oxygen monitor in the NICU
This study is testing a new wireless device that monitors oxygen levels in the brain. It is for babies already using a similar wired monitor, to see if the wireless version works just as well.
Montreal, QuebecAges Any age - NCT07730788Recruiting
Skin imaging study in eczema patients receiving nemolizumab
This trial tests whether a special skin imaging technique (reflectance confocal microscopy) can see how nemolizumab changes the skin structure in people with moderate-to-severe eczema. It may help researchers understand how this treatment works.
Romans-sur-Isère, DrômeAges 18 years+ - NCT07727200Recruiting
Tooth color and enamel loss in children with MIH
This study looks at how the color of white, yellow, or brown spots on children's first permanent molars (the back teeth that come in around age 6) relates to the breakdown of the enamel (the outer layer). It aims to help dentists better identify and treat this condition early.
Basel, Canton of Basel-CityAges 5–8 - NCT07729787Recruiting
Autogenic drainage vs. chest percussion for kids with CF
This trial compares two breathing techniques to help clear mucus from the lungs of children with cystic fibrosis. It aims to see if one method (autogenic drainage) works better than another (mechanical percussion with a vest).
Multan Khurd, Punjab ProvinceAges 6–12 - NCT07732257Recruiting
Wireless button sensor study for premature infants
This study tests a small, wireless button-like sensor to monitor vital signs in premature infants in the NICU. It may offer a gentler way to track your baby's health.
Montreal, QuebecAges Any age - NCT07724171Recruiting
Long-term results after PFO closure surgery
This study looks at how well patients do over time after having a hole in their heart (patent foramen ovale, or PFO) closed with a small device inserted through a vein. It may help doctors understand the benefits and risks of the procedure.
SeoulAges 19 years+ - NCT07727044Recruiting
Color and sensitivity of MIH teeth in children
This study looks at whether the color of spotted first permanent molars (caused by MIH) is linked to tooth sensitivity. It compares children with MIH to children with healthy teeth to understand the connection between color and pain.
Basel, Canton of Basel-CityAges 5–8 - NCT07725263Recruiting
Low-dose antifungal for kids with low white blood cells
This trial tests a low dose of an antifungal medicine (liposomal amphotericin B) to prevent serious fungal infections in children whose immune system is weak after cancer treatment or a stem cell transplant. It's for kids aged 3 to 17 who are at high risk for these infections.
Haikou, HainanAges 3–17 - NCT06600269Recruiting
Cycling training for ataxia recovery in SCA
This study tests whether cycling-based coordination training can help people with spinocerebellar ataxia (SCA) improve balance and movement by priming the brain for recovery.
TaoyuanAges 18 years+ - NCT02647827RecruitingPhase 2
Acupuncture or metformin for insulin resistance in PCOS
This study tests whether acupuncture or the diabetes medicine metformin can improve insulin resistance in women with PCOS. It may help with hormone-related symptoms and metabolic health, comparing the two approaches against usual care for non-PCOS controls.
BeijingAges 18–40 - NCT04598750Recruiting
Assessing bleeding risk in very premature babies with low platelets
This trial looks at how to estimate bleeding risk in newborns who are very premature and have a low platelet count. The goal is to guide safer care by better identifying which babies may be at higher risk of bleeding.
Boston, MassachusettsAges 1 day+ - NCT05129605Recruiting
Prostate cancer genetic risk screening study for men
This study looks at your personal and family risk for prostate cancer and helps decide who should have extra screening like MRI. It may help you find cancer earlier if you are at higher genetic risk.
Boston, MassachusettsAges 35–74 - NCT06111950Recruiting
Study of RNU4ATAC and RTTN gene conditions
This study looks at rare genetic syndromes caused by changes in the RNU4ATAC or RTTN genes. It aims to understand how these changes affect the body by studying patients, their parents, and fetal tissue.
BordeauxAges Any age - NCT07723248RecruitingPhase 3
Oral Rinzimetostat for Advanced Prostate Cancer After Abiraterone
This study tests an experimental pill called rinzimetostat (ORIC-944) for men with advanced prostate cancer that has spread and stopped responding to abiraterone. It may offer a new option if you have not had many other treatments yet.
Coral Springs, FloridaAges 18 years+ - NCT07717346RecruitingEarly Phase 1
KB111 topical gel for Hailey-Hailey disease
This trial tests a new topical gel called KB111 for treating Hailey-Hailey disease, a genetic skin condition that causes painful blisters. The study will check if the gel is safe and helps reduce symptoms.
Miami, FloridaAges 12 years+ - NCT07721025RecruitingPhase 2
Gene therapy trial for Friedreich ataxia heart disease
This trial tests a one-time gene therapy called LX2006 for heart problems caused by Friedreich ataxia. The goal is to see if it can improve heart function and structure.
Tampa, FloridaAges 6 years+ - NCT07723560Recruiting
Surgery study for hemophilia A patients using Altuvoct
This study looks at how people with hemophilia A do when they have surgery while using the medicine Altuvoct (efanesoctocog alfa). It helps doctors learn more about surgical practices for this condition.
BronAges Any age - NCT07716488Recruiting
Screening for high cholesterol in children with chronic conditions
This study screens children and teens with certain chronic conditions (like heart defects or inflammatory bowel disease) for early signs of high cholesterol or other lipid problems. The goal is to find and manage these risks sooner.
JenaAges 6–18
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting medical genetics studies from the U.S. registry right now, out of 5,439 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.