Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,771
- Phase 2284
- Phase 1235
- Phase 3216
- Phase 1/Phase 2203
- Phase 497
- Phase 2/Phase 352
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis128
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome55
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California341
- Maryland161
- Alabama131
- Massachusetts116
- New York84
- Arizona78
- Texas72
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT05979506Recruiting
Wraps for skin comfort in hereditary ichthyosis
This study tests whether special body wraps can reduce skin discomfort for people with hereditary ichthyosis, a condition that causes dry, scaly skin. If you have ichthyosis and are bothered by skin tightness or itching, this treatment might help you feel better.
ToulouseAges 15 years+ - NCT05981664Recruiting
Can adaptive gaming help kids with arm differences?
This study explores whether playing video games with adapted controls can help children aged 7 to 17 who have a missing or different arm or hand. It tests how fun and useful these games are for improving movement and daily life.
Winnipeg, ManitobaAges 7–17 - NCT05982119Recruiting
Assessing muscle disease patients with activity monitors
This study assesses physical activity in people with different muscle diseases (like Duchenne, FSHD, and others) and in healthy volunteers. It helps doctors understand how these conditions affect daily movement and function.
LiègeAges 1–80 - NCT05982795Recruiting
How CF modulators affect lung bacteria
This study looks at how highly effective CF modulator therapies change the bacteria living in the lungs of people with cystic fibrosis. Understanding these changes may help improve future treatments.
Lebanon, New HampshireAges 18–99 - NCT05983159RecruitingPhase 2
Targeted therapy for slow-flow or fast-flow vascular malformations
This trial tests two targeted medicines for people with certain types of vascular malformations (abnormal blood vessels). If you have a slow-flow malformation, you may receive alpelisib; if you have a fast-flow malformation, you may receive mirdametinib. Genetic testing is needed to see if your malformation has a specific change that these drugs target.
Parkville, VictoriaAges 2 years+ - NCT05985161RecruitingPhase 2
Selinexor for wilms tumor and other solid tumors
This trial tests a drug called selinexor for children and young adults with certain types of solid tumors (like Wilms tumor, rhabdoid tumors, MPNST, or others with specific genetic changes) that have come back or not responded to standard treatment. Participants take selinexor pills to see if it can shrink or control their cancer.
Los Angeles, CaliforniaAges 1 year+ - NCT05985486Recruiting
Lifestyle change for brain health in Down syndrome
This study looks at how a healthy lifestyle program can improve brain health in adults with Down syndrome who are overweight or obese. You will attend a medical center three times over a year for tests, and you'll need a caregiver to support you.
Kansas City, KansasAges 18–64 - NCT05989620Recruiting
Long-term study of muscular dystrophy functions
This study tracks changes in muscle strength and breathing over time in people with certain types of muscular dystrophy. It helps researchers develop better tests to measure how the disease progresses.
Richmond, VirginiaAges 6–50 - NCT05992532Recruiting
Study of rare enzyme disorders in monoclonal gammopathy or myeloma
This study looks for two rare inherited disorders—Gaucher disease and acid sphingomyelinase deficiency (ASMD)—in people who already have a blood condition like monoclonal gammopathy (abnormal protein) or multiple myeloma. If you have an enlarged spleen or low platelets, you may be eligible to help researchers understand if these rare diseases are more common in this group.
Vitoria-Gasteiz, AlavaAges 18–99 - NCT05994976Recruiting
Collecting skin samples from people with skin conditions
This study collects skin samples (like small biopsies or swabs) from people with certain skin conditions and from healthy volunteers. The samples help researchers learn more about these conditions and may lead to better treatments.
Montreal, QuebecAges 18 years+ - NCT05994664Recruiting
Heart Coherence Training for Vascular Ehlers-Danlos
This study tests whether a breathing and heart-rate training program (called Heart Coherence Training) can help people with Vascular Ehlers-Danlos syndrome feel better. It's done from home using your phone and a computer or tablet.
Houston, TexasAges 12–45 - NCT05995171Recruiting
Long-term health in teens born with esophageal atresia
This study looks at teenagers born with esophageal atresia (a birth defect where the esophagus doesn't connect to the stomach) to see how they are doing in the long term. It uses special tests to understand health patterns and may help improve care for others with this condition.
Lille, NordAges 13–14 - NCT05996003RecruitingPhase 2
Exon 44 skipping drug for Duchenne muscular dystrophy
This trial tests a new drug (NS-089/NCNP-02) that aims to help boys with Duchenne muscular dystrophy produce a shorter but still working version of the dystrophin protein. It's for boys who are still walking and have a specific genetic type that can be fixed by skipping a part of the gene called exon 44.
Aurora, ColoradoAges 4–14 - NCT05996133RecruitingPhase 4
Neck Numbing Shot vs. Sham for Neck Surgery Pain
This trial tests whether a numbing injection (called a multifidus cervicis plane block) in the neck muscles helps reduce pain after back-of-the-neck fusion surgery. Half the participants will get the real block, the other half a sham (fake) block, to see if it really works.
Hartford, ConnecticutAges 40–80 - NCT05995964RecruitingPhase 2
Study of two new medicines for eczema
This study tests two new study medicines (PF-07275315 and PF-07264660) for people with moderate to severe eczema that hasn't responded well to other treatments, including biologics. The goal is to see if these medicines can help reduce itching and clear the skin.
Birmingham, AlabamaAges 18 years+ - NCT05996731Recruiting
Using RNA tests to help diagnose rare genetic diseases
This study uses RNA sequencing to find genetic causes of rare diseases that standard DNA tests might miss. It may help people who have symptoms of a rare disease but no clear genetic diagnosis yet.
Ranica, BGAges Any age - NCT05996211Recruiting
Swiss Study on Brain Development in Children with Heart Defects
This study follows children with severe heart problems born recently to see how their brain development progresses. It helps doctors understand what support these children might need as they grow.
BernAges 1 week–1 month - NCT05997680Recruiting
Yoga for attention in kids with heart disease
This study tests if a parent-child yoga program can help improve attention in children aged 4 to 6 with congenital heart disease who have attention difficulties. You and your child would attend yoga sessions together for 8 weeks.
Montreal, QuebecAges 4–6 - NCT05998629Recruiting
Sweat sensor test for cystic fibrosis
This trial tests a new skin sensor that measures sweat to help diagnose cystic fibrosis. It compares results from people with CF and healthy volunteers to see if the device works accurately.
Hershey, PennsylvaniaAges 18–80 - NCT06000761Recruiting
Mouth care with human milk for premature babies
This trial is testing whether giving gentle mouth care with human milk to very premature babies in the NICU can help their health. It focuses on babies born early and with low birth weight whose mothers can provide milk.
Gainesville, FloridaAges 1 hour–3 days - NCT06001827Recruiting
Study of a wrap to help new dialysis access points heal
This trial tests a special wrap placed around a new arm access point for dialysis (called an AV fistula) to see if it helps the access stay healthy and work better. It is for people who need a new AV fistula for kidney dialysis.
Bullhead City, ArizonaAges 18 years+ - NCT06003023Recruiting
Physical activity study for teens with congenital heart disease
This study looks at how teens and young adults with moderate to complex congenital heart disease can improve their physical activity. You might be eligible if you're between 15 and 25, have a heart condition, and get care at Nationwide Children's Hospital or Ohio State University.
Columbus, OhioAges 15–25 - NCT06004986RecruitingPhase 4
Lowering Dupilumab Dose in Controlled Eczema
This study looks at whether people with well-controlled eczema can safely lower their dose of dupilumab (an injected medication). It aims to see if a reduced dose still keeps eczema under control.
Amsterdam, North HollandAges 18 years+ - NCT06007365Recruiting
Z5m dental implant registry study
This study looks at how well Z-Systems' Z5m dental implants work in patients. It may be a good fit if you have received or will receive up to 5 of these implants.
OltenAges 18 years+
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,764 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.