Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,771
- Phase 2284
- Phase 1235
- Phase 3216
- Phase 1/Phase 2203
- Phase 497
- Phase 2/Phase 352
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis128
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome55
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California341
- Maryland161
- Alabama131
- Massachusetts116
- New York84
- Arizona78
- Texas72
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT06007547RecruitingPhase 4
Preventive surfactant therapy for preterm babies
This trial tests whether giving surfactant (a foam that helps lungs stay open) before breathing problems start can help very premature babies (born before 30 weeks) breathe better. It might reduce the need for a breathing tube.
Evanston, IllinoisAges Up to 15 minutes - NCT06008938Recruiting
Study tracking HEMGENIX for hemophilia B
This study watches how well HEMGENIX works and how safe it is for people with hemophilia B who are getting the treatment. It also compares data from adults on standard factor IX shots.
Rochester, New YorkAges 18 years+ - NCT06016946Recruiting
Friedreich's Ataxia Natural History Study
This study follows people with Friedreich's ataxia (FA) over time to learn more about the disease. It helps researchers understand how FA affects people of all ages and may lead to better treatments.
Los Angeles, CaliforniaAges Any age - NCT06018792Recruiting
New blood test for faster sepsis diagnosis in children
This trial tests a new, faster way to find bacteria in the blood of children with suspected sepsis. It uses a molecular test that may give results sooner than standard cultures, helping doctors treat infections more quickly.
AmsterdamAges birth–18 years - NCT06019182Recruiting
MEHMO syndrome: Understanding the condition over time
This study follows people with or at risk for MEHMO syndrome over time to better understand the condition and identify biological markers. It may include both affected individuals and their family members to see how the condition runs in families.
Bethesda, MarylandAges 1 week–100 years - NCT06023472Recruiting
Comparing sperm sorting methods for better genetic testing in IVF
This study compares two ways of preparing sperm for IVF (a microfluidic chip versus a centrifuge method). It aims to see which method leads to more genetically normal embryos (euploid) when doing PGT (pre-implantation genetic testing).
Hong Kong, Hong KongAges Up to 43 years - NCT06026163RecruitingPhase 2/Phase 3
Caffeine for breathing help in late preterm babies
This trial tests if giving caffeine to late preterm babies with breathing problems helps them need less breathing support. It could be an extra treatment alongside standard care.
Madinah, Medina RegionAges 1 day–3 days - NCT06025734Recruiting
Nerve stimulation for bladder control in spina bifida
This study tests whether stimulating a nerve in the leg (the tibial nerve) with a small device can help children with spina bifida who leak urine even when using a catheter. The treatment is non-invasive, like a tiny electrical patch near the ankle, and aims to improve bladder control.
Dallas, TexasAges 8–18 - NCT06028646Recruiting
Using CT scans to diagnose airway collapse in children
This trial tests if a special CT scan can help diagnose tracheomalacia (a condition where the airway collapses during breathing) in children who have already had a bronchoscopy.
New York, New YorkAges birth–18 years - NCT06030349Recruiting
Breathing support for kids with Down syndrome and sleep apnea
This trial looks at how well non-invasive breathing machines help children with Down syndrome who have obstructive sleep apnea. It tracks their health and sleep over time to see if the treatment works and improves daily life.
DublinAges 6 months–16 years - NCT06031025Recruiting
Study of tummy problems in at-risk infants
This study looks at how common stomach and gut issues are in babies who were born early or had problems at birth, and how these issues change over time.
RomaAges 3 months–2 years - NCT06032273Recruiting
Lung Transplant Study for CF Patients and Their Caregivers
This study looks at a website-based program to support people with cystic fibrosis (CF) and their caregivers, helping them prepare for a possible lung transplant. It aims to ease stress, provide information, and improve the transplant journey.
Seattle, WashingtonAges 18 years+ - NCT06034405Recruiting
Checking spine tissue for heart amyloidosis signs
This trial is looking at leftover tissue from past spine surgeries to see if it contains signs of a heart condition called TTR amyloidosis. It may help find people who have this condition early.
Beverly Hills, CaliforniaAges 50 years+ - NCT06035939Recruiting
SCD support study using mobile app
This trial tests a mobile app to help people with sickle cell disease manage their health. It's designed for those who have a compatible smartphone and internet access.
Charleston, South CarolinaAges 14–21 - NCT06036693Recruiting
MPS Long-Term Study
This study follows people with MPS, a rare genetic condition, to learn more about the disease over time. If you have a confirmed MPS diagnosis, you may be able to join.
AngersAges Any age - NCT06039241Recruiting
Long-term Dupilumab treatment for atopic dermatitis
This study looks at how well Dupilumab works over time for people with atopic dermatitis (eczema). It includes adults, teens, and children ages 6 and up.
AachenAges 6 years+ - NCT06040242Recruiting
Exercise and heart rhythm study for ARVC patients
This study looks at how exercise affects heart rhythm in people with ARVC, a genetic heart condition. Participation involves supervised exercise sessions and heart monitoring to better understand safe activity levels.
Zurich, Canton of ZurichAges 14 years+ - NCT06040567Recruiting
Polyneuropathy, Impairments and Physical Activity Study
This study looks at how polyneuropathy (nerve damage) affects your daily physical activity and overall function. It aims to understand the link between nerve damage and movement, which could help improve care.
CopenhagenAges 18–100 - NCT06041620Recruiting
Gene-edited stem cell therapy for beta-thalassemia
This trial tests a new treatment that uses your own blood stem cells, edited with CRISPR technology, to reduce or eliminate the need for blood transfusions in people with beta-thalassemia.
Tianjin, Tianjin MunicipalityAges 3–35 - NCT06041334Recruiting
Spina Bifida blood vessel study
This trial studies blood vessels in people with spina bifida using safe, non-invasive methods. It aims to better understand how the condition affects the body over time.
Rennes, CHU de RennesAges 6 years+ - NCT06041685Recruiting
Warming for artery catheter in children under 2
This trial tests if warming the skin before placing an artery line helps children having heart surgery. It may make the procedure easier and more comfortable.
Yangsan, Gyeongsangnam-doAges Up to 2 years - NCT06042140Recruiting
Umbilical cord patch for spina bifida repair before birth
This study tests whether a patch made from donated umbilical cord can help repair spina bifida in the womb using a minimally invasive fetoscopic approach. If successful, it may reduce the need for more invasive open fetal surgery.
Houston, TexasAges 18 years+ - NCT06043440RecruitingPhase 2
Oxygen therapy for sleep apnea in Down syndrome
This study tests whether oxygen therapy can help children with Down syndrome who have sleep apnea. It compares oxygen treatment to no treatment to see if it improves breathing during sleep and thinking skills.
Los Angeles, CaliforniaAges 5–18 - NCT06043518Recruiting
Brain changes after losing an arm or hand
This study uses MRI scans to see how the brain changes in people born without a hand or who lost an arm. You might join as a participant with upper-limb loss or as a healthy volunteer for comparison.
Zurich, Canton of ZurichAges 18–75
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,764 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.