Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,771
- Phase 2284
- Phase 1235
- Phase 3216
- Phase 1/Phase 2203
- Phase 497
- Phase 2/Phase 352
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis128
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome55
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California341
- Maryland161
- Alabama131
- Massachusetts116
- New York84
- Arizona78
- Texas72
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT06535542Recruiting
Gene testing and digital twins for high cholesterol in Emiratis
This study uses whole genome sequencing and digital twin technology to better understand and manage very high cholesterol in Emirati adults. It aims to identify genetic causes and personalize treatment.
Abu Dhabi, Abu Dhabi EmirateAges 18–55 - NCT06538571Recruiting
Infant heart study using light to check oxygen levels
This study uses a light-based sensor placed on the skin to measure oxygen levels in infants with a single heart ventricle before their Glenn surgery. The goal is to see if these measurements can help predict how well they do between surgeries.
Oak Lawn, IllinoisAges Up to 6 months - NCT06538402Recruiting
Comparing two J-pouch sizes in pouch surgery
This trial compares two different J-pouch sizes (10 cm vs. 15 cm) during surgery for ulcerative colitis or FAP. The goal is to see if one size leads to better outcomes.
AarhusAges 18–60 - NCT06538870Recruiting
Dental implant healing and TNF-alpha blockers
This study looks at how dental implants heal in people who take TNF-alpha inhibitors (medicines that lower inflammation) compared to those who don't. It aims to see if the drug affects healing after implant surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06539169Recruiting
Following people with rare diseases over time
This study follows people with rare diseases over time to learn more about how these conditions progress and how they are treated. Joining may help researchers understand your disease better and find better ways to care for others.
Los Altos, CaliforniaAges Any age - NCT06539507RecruitingPhase 1
Study of BCX17725 for Netherton syndrome safety
This trial tests a new drug called BCX17725 in people with Netherton syndrome to see if it is safe and how the body handles it. It may help by reducing skin symptoms like redness and scaling.
Palo Alto, CaliforniaAges 12–65 - NCT06539624Recruiting
Testing a new gene therapy for Fabry disease
This trial is testing a new treatment called EXG110 for people with Fabry disease. It's designed to see if it's safe and if it can help. You may be able to join if you have a confirmed diagnosis and at least one symptom of Fabry disease.
Shanghai, Shanghai MunicipalityAges 7 years+ - NCT06540222Recruiting
Keeping cord attached longer at emergency cesarean
This study tests keeping the umbilical cord attached longer during an emergency cesarean to see if it helps the baby. If you are having a full-term emergency cesarean with spinal or epidural anesthesia, your baby may be able to benefit from this practice.
GothenburgAges 9 months–10 months - NCT06540937RecruitingPhase 2
Leflunomide for MEN-1 related neuroendocrine tumors
This trial tests if leflunomide, a medication usually used for arthritis, can shrink or slow the growth of neuroendocrine tumors in people with MEN-1 gene mutations. It is for patients whose tumors have worsened after standard treatment.
BeijingAges 18–75 - NCT06541847RecruitingPhase 2
Testing HLX-1502 for NF1 with Plexiform Neurofibromas
This trial tests an experimental drug called HLX-1502 for people with NF1 who have a plexiform neurofibroma (a type of nerve tumor) that is growing or causing problems. It aims to see if the drug is safe and can shrink or stop the tumor from worsening.
Birmingham, AlabamaAges 12 years+ - NCT06542237RecruitingPhase 1/Phase 2
Study of a new male birth control pill for healthy men
This trial tests an experimental birth control pill (YCT-529) taken daily. It aims to see if the drug can safely and effectively prevent pregnancy in healthy men who do not plan to have children in the future.
Grafton, AucklandAges 28–70 - NCT06544018Recruiting
Sleep and body clock study for CAPS patients and family members
This study looks at how CAPS (a genetic condition that causes inflammation) affects sleep and daily body rhythms. It compares people with CAPS to healthy family members living in the same home, to understand differences without any treatment being tested.
BronAges 6 years+ - NCT06544473RecruitingPhase 4
Estrogen pill vs. patch for Turner syndrome
This trial compares oral and transdermal (patch) estrogen to find the right dose for women with Turner syndrome. It aims to see which method works best for hormone replacement.
Aarhus, Aarhus NAges 18–50 - NCT06546137Recruiting
Registry for inherited heart conditions in Brazil
This study is building a national registry in Brazil to learn more about inherited heart conditions and improve care. If you have a family-related heart disease, you may be able to join and help advance cardiovascular healthcare.
Rio Branco, AcreAges Any age - NCT06545526RecruitingPhase 3
Celecoxib and metformin for familial adenomatous polyposis
This trial tests whether a combination of two drugs, celecoxib and metformin, can prevent the growth of polyps in the colon or duodenum (the first part of the small intestine) in people with familial adenomatous polyposis (FAP). FAP is a condition that causes many polyps to form, raising the risk of cancer. If you have FAP, are between 20 and 55, and have at least 5 polyps that are 2mm or larger, this study may be for you.
SeoulAges 20–55 - NCT06545565RecruitingPhase 3
Preventing acid buildup in preterm babies on IV nutrition
This trial tests if replacing sodium chloride with sodium acetate in IV nutrition can prevent metabolic acidosis (too much acid in the blood) in preterm babies born before 33 weeks. If your baby is in the NICU and needs IV nutrition, this study may help keep their blood chemistry balanced.
Karachi, SindhAges 1 day–3 days - NCT06546488Recruiting
Cognitive Testing for Huntington's Disease Study
This study tests new ways to measure thinking and memory skills in people with Huntington's disease. It aims to find better tools for tracking the disease and could help you understand your cognitive changes.
Columbus, OhioAges 30–65 - NCT06547372Recruiting
Dietary changes for eczema relief
This study tests whether a specific diet can help manage mild to moderate eczema. It involves eating whole foods provided by the researchers for a set period and tracking your skin health.
Singapore, SingaporeAges 21–65 - NCT06547684Recruiting
Shock wave therapy for foot stiffness after stroke
This trial tests whether shock wave therapy can help relax the tight calf muscles that cause foot drop after a stroke. It may help you walk better and reduce foot stiffness.
Vila-real, CastellonAges 18 years+ - NCT06549725Recruiting
Lipidica software for pancreatic cancer screening
This trial tests a software that analyzes fats (lipids) in your blood to find pancreatic cancer early. You may join if you have pancreatic cancer that can be removed with surgery, or if you are at very high risk due to family history or certain gene mutations.
Prague, CzechiaAges 18 years+ - NCT06550219Recruiting
Using a face mask breathing support in premature babies with breathing trouble
This study tests whether delivering breathing support through a soft face mask (nasal non-invasive ventilation) can help premature babies who are having trouble breathing. Doctors will also use ultrasound to monitor their lungs.
AlexandriaAges 1 hour–1 day - NCT06551961Recruiting
How two fibers affect your gut health
This study tests how two types of fiber (inulin and methylcellulose) affect your gut when eaten regularly. You'll eat provided meals and have your breath tested to see how your gut breaks down the fiber.
Nottingham, NottinghamshireAges 18–65 - NCT06553339RecruitingPhase 1
A study of HS-10516 for VHL syndrome tumors
This trial tests a new drug called HS-10516 in people with VHL syndrome or advanced kidney cancer. The goal is to see if the drug can shrink tumors and what side effects it might have.
Beijing, Beijing MunicipalityAges 18–80 - NCT06553443RecruitingPhase 3
Comparing coated and plain balloons for dialysis access narrowing
This trial tests whether a drug-coated balloon works better than a plain balloon to open up narrowed spots in your dialysis access. If you have a failing AVF with a narrowing that can be treated, this study may help improve your dialysis.
SingaporeAges 21 years+
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,764 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.