Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,771
- Phase 2283
- Phase 1235
- Phase 3216
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 352
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis128
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona78
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT06546488Recruiting
Cognitive Testing for Huntington's Disease Study
This study tests new ways to measure thinking and memory skills in people with Huntington's disease. It aims to find better tools for tracking the disease and could help you understand your cognitive changes.
Columbus, OhioAges 30–65 - NCT06547372Recruiting
Dietary changes for eczema relief
This study tests whether a specific diet can help manage mild to moderate eczema. It involves eating whole foods provided by the researchers for a set period and tracking your skin health.
Singapore, SingaporeAges 21–65 - NCT06547684Recruiting
Shock wave therapy for foot stiffness after stroke
This trial tests whether shock wave therapy can help relax the tight calf muscles that cause foot drop after a stroke. It may help you walk better and reduce foot stiffness.
Vila-real, CastellonAges 18 years+ - NCT06549725Recruiting
Lipidica software for pancreatic cancer screening
This trial tests a software that analyzes fats (lipids) in your blood to find pancreatic cancer early. You may join if you have pancreatic cancer that can be removed with surgery, or if you are at very high risk due to family history or certain gene mutations.
Prague, CzechiaAges 18 years+ - NCT06550219Recruiting
Using a face mask breathing support in premature babies with breathing trouble
This study tests whether delivering breathing support through a soft face mask (nasal non-invasive ventilation) can help premature babies who are having trouble breathing. Doctors will also use ultrasound to monitor their lungs.
AlexandriaAges 1 hour–1 day - NCT06551961Recruiting
How two fibers affect your gut health
This study tests how two types of fiber (inulin and methylcellulose) affect your gut when eaten regularly. You'll eat provided meals and have your breath tested to see how your gut breaks down the fiber.
Nottingham, NottinghamshireAges 18–65 - NCT06553339RecruitingPhase 1
A study of HS-10516 for VHL syndrome tumors
This trial tests a new drug called HS-10516 in people with VHL syndrome or advanced kidney cancer. The goal is to see if the drug can shrink tumors and what side effects it might have.
Beijing, Beijing MunicipalityAges 18–80 - NCT06553443RecruitingPhase 3
Comparing coated and plain balloons for dialysis access narrowing
This trial tests whether a drug-coated balloon works better than a plain balloon to open up narrowed spots in your dialysis access. If you have a failing AVF with a narrowing that can be treated, this study may help improve your dialysis.
SingaporeAges 21 years+ - NCT06553976Recruiting
Research network for hereditary spastic paraplegia
This trial aims to build a research network and gather information from people with two genetic types of hereditary spastic paraplegia (SPG4 and SPG5A). It will help doctors better understand these conditions and improve care.
Miami, FloridaAges Any age - NCT06555120Recruiting
Screening kids for inherited high cholesterol
This study checks children for a genetic condition that causes very high cholesterol from a young age. If found early, steps can be taken to lower heart disease risk later in life.
AmiensAges 2–18 - NCT06555237RecruitingPhase 2
MEK inhibitors for heart thickening in RASopathies
This trial tests a targeted drug (MEK inhibitor) to treat thickened heart muscle caused by a group of genetic conditions called RASopathies. It may help improve heart function in people with hypertrophic cardiomyopathy.
WarsawAges 1 day–18 years - NCT06555939Recruiting
Resilience program for teens and young adults with sickle cell disease
This study tests a program called PRISM that helps teens and young adults with sickle cell disease build resilience and manage stress, anxiety, or depression. You may be eligible if you have sickle cell disease and feel down or worried.
Boston, MassachusettsAges 8–25 - NCT06555965Recruiting
STXBP1 and SYNGAP1 natural history study
This study follows people with STXBP1 or SYNGAP1 gene changes over time to learn more about how these conditions affect the body and mind. It does not test a treatment but helps researchers understand the natural course of the disorder.
Palo Alto, CaliforniaAges Any age - NCT06556615Recruiting
Quality of life in classical homocystinuria
This study surveys how classical homocystinuria (CBS deficiency) affects daily life and well-being. It includes patients age 8 and up, parents of younger or cognitively impaired children, and medical experts.
ZurichAges 8 years+ - NCT06557369Recruiting
New light therapy for intermediate age-related macular degeneration
This trial tests a new light-based treatment for intermediate age-related macular degeneration (AMD), a common eye condition that can lead to vision loss. The goal is to see if it is safe and helps slow down the disease.
BergamoAges 50 years+ - NCT06557551Recruiting
Surfactant for preterm babies born before 28 weeks
This trial tests giving surfactant through a thin tube into the windpipe right after birth for babies born before 28 weeks. It aims to help their lungs work better and reduce breathing problems.
Dublin, None SelectedAges Up to 30 minutes - NCT06558994Recruiting
Surgery comparison for undescended testicles in children
This study compares two surgical methods for fixing undescended testicles that cannot be felt during a physical exam. The goal is to see which technique leads to better outcomes.
Asyut, EgyptAges Up to 12 years - NCT06560736Recruiting
Anxiety help for teens with PKU
This study tests a brief therapy program designed to help teens with PKU manage anxiety or depression symptoms. It aims to see if this approach can prevent or treat these issues in this group.
Columbia, MissouriAges 10–17 - NCT06562283Recruiting
Reproducibility of a fatigue test for spinal muscular atrophy
This study checks how consistent a fatigue test is for people with spinal muscular atrophy (SMA). It helps doctors better understand fatigue in SMA and may improve future care.
Saint-Etienne, FranceAges 6 years+ - NCT06563414Recruiting
A study tracking eye scrapes in people with DEB
This study follows people with dystrophic epidermolysis bullosa (DEB) who get scrapes on the surface of their eye (corneal abrasions). It collects information to better understand how often and how severely these eye injuries happen.
Pittsburgh, PennsylvaniaAges 6 months+ - NCT06564740Recruiting
Stem cell therapy for infants with biliary atresia and cirrhosis
This study is testing whether stem cells can help infants with liver cirrhosis from biliary atresia (a blocked bile duct condition) who have already had Kasai surgery. It aims to see if stem cell therapy can improve liver function and reduce complications.
Istanbul, IstanbulAges 2 months–18 years - NCT06565026RecruitingEarly Phase 1
CS-206 treatment for sickle cell disease patients
This trial tests CS-206, an experimental therapy for people with sickle cell disease. It aims to reduce severe complications like pain crises, acute chest syndrome, strokes, and other serious events. You may qualify if you have a specific genetic type of sickle cell disease and have experienced complications despite standard treatments.
Nanning, GuangxiAges 12–35 - NCT06565481Recruiting
Testing movement and function in people with hemophilia
This study looks at how well certain tests measure movement and function in people with hemophilia. It may help improve how doctors track your condition.
ZurichAges 18 years+ - NCT06566066Recruiting
Thyroid hormone resistance patient registry
This study creates a registry for people with thyroid hormone resistance caused by specific genetic mutations. It helps doctors collect data to better understand and treat the condition.
BerlinAges Any age
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,779 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.